Neeraj Fuloria - Academia.edu (original) (raw)

Papers by Neeraj Fuloria

International Journal of Nanomedicine, 2021

Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a global... more Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a global health issue affecting millions of women annually. Poor prognosis in BC patients is often linked to drug resistance as well as the lack of effective therapeutic options for metastatic and triple-negative BC. In response to these unmet needs, extensive research efforts have been devoted to exploring the anti-BC potentials of natural products owing to their multi-target mechanisms of action and good safety profiles. Various medicinal plant extracts/essential oils and natural bioactive compounds have demonstrated anti-cancer activities in preclinical BC models. Despite the promising preclinical results, however, the clinical translation of natural products has often been hindered by their poor stability, aqueous solubility and bioavailability. There have been attempts to overcome these limitations, particularly via the use of nano-based drug delivery systems (NDDSs). This review highlights the tumour targeting mechanisms of NDDSs, the advantages and disadvantages of the major classes of NDDSs and their current clinical status in BC treatment. Besides, it also discusses the proposed anti-BC mechanisms and nanoformulations of nine medicinal plants' extracts/essential oils and nine natural bioactive compounds; selected via the screening of various scientific databases, including PubMed, Scopus and Google Scholar, based on the following keywords: "Natural Product AND Nanoparticle AND Breast Cancer". Overall, these nanoformulations exhibit improved anti-cancer efficacy against preclinical BC models, with some demonstrating biocompatibility with normal cell lines and mouse models. Further clinical studies are, however, warranted to ascertain their efficacy and biocompatibility in humans.

Microbiome in Inflammatory Lung Diseases

Open Access Macedonian Journal of Medical Sciences, 2020

BACKGROUND: The condition of dyslexia is a learning disability leading to difficulty in acquiring... more BACKGROUND: The condition of dyslexia is a learning disability leading to difficulty in acquiring basic skills of reading, spelling, and writing. It is a disorder with a neurological origin that does not affect the intelligence of a person. It is estimated that between 5% and 10% of the population suffering from dyslexia, but this number can also be as high as 17% because dyslexia may not be recognized and diagnosed in some individuals and because some of them may not disclose that they are diagnosed. In Malaysia, it is estimated that 4% to 8% of children attending school have dyslexia. Dyslexics tend to be more artistic and creative than others. AIM: This study examines the awareness of dyslexia disorder among university students. METHODS: The data are collected from the participants through self-made survey questionnaires that consist of 25 questions per questionnaire. A descriptive cross-sectional study is conducted from April 2019 to May 2019. RESULTS: The current study reflecte...

Asian Pacific Journal of Tropical Medicine, 2021

In the current pandemic, COVID-19 patients with predisposing factors are at an increased risk of ... more In the current pandemic, COVID-19 patients with predisposing factors are at an increased risk of mucormycosis, an uncommon angioinvasive infection that is caused by fungi with Mucor genus which is mainly found in plants and soil. Mucormycosis development in COVID-19 patient is related to various factors, such as diabetes, immunocompromise and neutropenia. Excessive use of glucocorticoids for the treatment of critically ill COVID-19 patients also leads to opportunistic infections, such as pulmonary aspergillosis. COVID-19 patients with mucormycosis have a very high mortality rate. This review describes the pathogenesis and various treatment approaches for mucormycosis in COVID-19 patients, including medicinal plants, conventional therapies, adjunct and combination therapies.

Drug Development Research, 2021

One of the most remarkable results in 2019 is the reduced prevalence and death of children from c... more One of the most remarkable results in 2019 is the reduced prevalence and death of children from coronavirus infection (COVID-19). In 2019, a worldwide pandemic impacted around 0.1 billion individuals, with over 3.5 million mortality reported in the literature. There is minimal knowledge on SARS-CoV-2 infection immunological responses in kids. Studies have been focused mostly on adults and children since the course of pediatric sickness is often short. In adults, severe COVID-19 is related to an excessive inflammatory reaction. Macrophages and monocytes are well known to contribute to this systemic response, although numerous lines are indicative of the importance of neutrophils. An increased number of neutrophils and neutrophil to lymphocyte ratios are early signs of SARS-CoV-2 and a worse prognosis. In this study that it is crucial to monitor PAR2 and PAR4 expression and function (since nursing children have elevated levels) and the inhibiting the normal physiology through the use of anticoagulants may exacerbate the problem in adults. Thus, in COVID-19 infection, we propose the use of antiplatelet (thromboxane A2 inhibitors), if required rather than anticoagulants (FXa and thrombin Inhibitors).

Esterification of p-bromo-m-cresol led to formation of 2-(4-bromo-3-methylphenoxy)aceta... more Esterification of p-bromo-m-cresol led to formation of 2-(4-bromo-3-methylphenoxy)acetate (1). 2-(4-Bromo-3-methyl phenoxy)acetohydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield N-(substituted benzylidiene)-2-(4-bromo-3-methyl phenoxy)acetamide(3a-c). Cyclization of compound (3a-c) with thioglycolic acid yielded 2-(4-bromo-3-methylphenoxy)-N-(4-oxo-2- arylthiazolidin-3-yl) acetamide (4a-c). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities.

Asian Journal of Chemistry, 2020

Present study was intended to synthesize silver nanoparticles (AgNPs) using corn silk aqueous ext... more Present study was intended to synthesize silver nanoparticles (AgNPs) using corn silk aqueous extract (CSAE) and evaluate for antimicrobial and antiurolithiatic potential. The aqueous decoction of corn silk offered light yellow CSAE. Treatment of AgNO3 with CSAE offered AgNPs with absorbance 430 nm. Optimization study established 5 mM silver nitrate, 2.5:7.5 extract to AgNO3 ratio, pH 8, and 24 h time as parametric requirement for synthesis of AgNPs using CSAE. Stability study supported the AgNPs stability based on retention of SPR signal between 428 to 450 nm. The synthesis of AgNPs was confirmed on broad and shifted FTIR bands; XRD signals at 2θ values of 32.27º, 40.72º, 46.20º, 65.69º, 69.31º and 76.49º indexed to 111, 200, 220 and 311 planes, respectively; particle size range from 22.05-36.69 nm in FESEM; and elemental silver content of 62.17% as per EDX spectrum. The synthesized AgNPs exhibited high antibacterial and antiurolithiatic potential. Present study recommends that syn...

Archiv der Pharmazie, 2021

Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived... more Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties. The estrogenic activity, immunosuppressive activity, cytotoxicity, vasorelaxant activity, and other properties possessed by cyclic peptides from seeds of plants make these congeners attractive leads for the drug discovery process. The current study covers the important structural features, structure–activity relationship, synthesis methods, and bioproperties of plant seeds‐originated bioactive peptides from Vaccaria segetalis, Linum usitatissimum, and Goniothalamus leiocarpus, which may prove vital for the development of novel therapeutics based on a peptide skeleton.

Crystals, 2021

The present study was planned to characterize and analyze the antimicrobial activity of silver na... more The present study was planned to characterize and analyze the antimicrobial activity of silver nanoparticles (AgNP) biosynthesized using a Coccinia indica leaf (CIL) ethanolic extract. The present study included the preparation of CIL ethanolic extract using the maceration process, which was further used for AgNP biosynthesis by silver nitrate reduction. Biosynthetic AgNPs were characterized using UV–Visible spectrometry, zeta potential analysis, transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), and energy-dispersive X-ray (EDX) spectrometry. The biogenic AgNP and CIL extracts were further investigated against different bacterial strains for their antimicrobial activity. The surface plasmon resonance (SPR) signal at 425 nm confirmed AgNP formation. The SEM and TEM data revealed the spherical shape of biogenic AgNPs and size in the range of 8 to 48 nm. The EDX results verified the presence of Ag. The Ag...

SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY, 2012

Various substituted acetophenones on treatment. with iodine and thiourea yielded 2-amino-4-( subs... more Various substituted acetophenones on treatment. with iodine and thiourea yielded 2-amino-4-( substituted-phenyl)-thiazole, which on further treatment with acetic anhydride generated N-(4-(substituted phenyl)thiazol-2-ylacetamide(1-5). All the synthesized compounds were characterized by their respective FTIR, 1H NMR, and mass data. Synthesized compounds (l, 2, 3, 4, 5) when subjected to investigation for their antimicrobial activities i.e. antibacterial and antifungal studies against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus flavus, and Aspergillus fumigatus by disk diffusion method, revealed that compound 2 deemed to be most potent with the largest zone of inhibition.

International Journal of Research in Pharmaceutical Sciences, 2020

Gallic acid (GA) inhibitory potential against oxidative stress and associated diseases, creates t... more Gallic acid (GA) inhibitory potential against oxidative stress and associated diseases, creates the importance for GA standardization in plant medicines. The present investigation was intended to quantify the amount of GA in Erythrina fusca leaves hydro-alcoholic extract (EFLHE) by the development of UV/Visible-spectrophotometric method and its validation. The study involved of EFLHE preparation via ethanolic maceration, followed by estimation of total phenolic content (TPC) or GA through the development of Folin-Ciocalteu reagent-based UV/Visible-spectrometric method and standard GA calibration curve. Developed method to estimate GA was validated using linearity, accuracy, precision, repeatability and ruggedness studies. The TPC analysis of EFLHE in concentration of 0.5, 1.0, 2.5, 3.0, 5.0, 10.0 µg/ml exhibited amount of GA as 98.0±8.71, 117.0±1.73, 217.1±3.45, 276.0±0.80, 289.1±1.11 and 295.2±1.19 GA equivalent (mg/g, dry weight) respectively. The linearity study revealed the rang...

Current stem cell research & therapy, 2020

Current decade witnesses the regenerative potential of stem cells (SCs) based life-saving therapi... more Current decade witnesses the regenerative potential of stem cells (SCs) based life-saving therapies for the treatment of various disease and conditions. Human teeth act as reservoir for SCs that exist with high abundance in baby, wisdom, and permanent teeth. The collection of stem cells from human exfoliated deciduous teeth (SHED) is considered as a simple process as it offers the convenience of little or no pain. In comparison to the SCs from dental or bone marrow or other tissues, the SHED offers the benefit of higher cellular differentiation and proliferation. Massive in vitro and in vivo studies reveal the regenerative potential of SHED in the engineering of dental pulp tissue, neuronal tissue, root, bio root, cardiovascular tissues, lymphatic tissues, renal tissues, dermal tissues, hepatic tissues, and bone tissues. Current review describes the methods of collection/isolation/storage, various biomarkers, and types of SHED. This review highlights the regenerative potential of SH...

World Academy of Science, Engineering and Technology, International Journal of Pharmacological and Pharmaceutical Sciences, 2017

journal of applied pharmaceutical science, 2018

In the present investigation a method for simultaneous determination of rifampicin, isoniazid and... more In the present investigation a method for simultaneous determination of rifampicin, isoniazid and piperine by liquid chromatography has been developed and optimized in terms of specificity, accuracy, precision, sensitivity and stability. The purpose of this investigation concerns the effect of piperine on the pharmacokinetic of rifampicin and isoniazid in rat model. Suspension of rifampicin, isoniazid and piperine were administered orally in Swiss albino rat and the drug concentration in plasma was estimated by high performance liquid chromatography. The chromatic separation of rifampicin, isoniazid and piperine were achieved by carrying out on a Zorbax Eclipse XDP C18 column (150 mmA—4.6 mmA—5 Âµm) using potassium dihydrogen phosphate (pH 4.5) and acetonitrile as the mobile phase (30:70) at a flow rate of 0.8 mL/min with detection at 270 nm. After oral administration the observed pharmacokinetic parameter of rifampicin along with piperine indicates significant enhancement in Cmax a...

Pharmacognosy Magazine, 2020

Background: Capsicum annuum (CA) fruits are consumed in the human diet for more than six centurie... more Background: Capsicum annuum (CA) fruits are consumed in the human diet for more than six centuries. Less research evidence for critical isolation experiment over CA fruits methanolic extract (CAFME) is an important concern for the investigators. Objectives: The present investigation was intended to explore the CAFME for the presence of any new phytoisolate. Materials and Methods: The study involved the preparation of CAFME, followed by critical isolation through normal phase silica-gel based column chromatography using various combinations of petroleum ether and chloroform. The phytoisolate was characterized using ultraviolet, Fourier transformed infrared, Nuclear magnetic resonance (1H, 13C, Distortion less enhancement by polarization transfer and correlation spectroscopy), and mass spectrometry. Results: The chromatographic critical isolation and spectrometric experiment over CAFME offered a new phytoisolate characterized as 3,11,15-trimethyl-14 β-hydroxy-n-hexadeca-7-en-4,18-olid...

Background: The standard chemotherapy for ovarian cancer includes the combination of paclitaxel a... more Background: The standard chemotherapy for ovarian cancer includes the combination of paclitaxel and a platinum compound. Comparing cisplatin and paclitaxel, with carboplatin and paclitaxel, it has been found that substitution of the analog carboplatin for cisplatin in this combination may improve the toxicity profile. Methodology: 40 patients diagnosed with advanced epithelial ovarian cancer (stage III and stage IV), were recruited for the study and were divided into two groups. One group received cisplatin-paclitaxel and the other received carboplatin-paclitaxel. Results: Hematological toxicity namely decrease RBC, WBC, PLT, Hb and renal parameters urea creatinine, GFR decreases in cisplatin group.

International Journal of Drug Development and Research, 2012

The purpose of present article is to discuss the concept of pharmaceutical Quality by Design (QbD... more The purpose of present article is to discuss the concept of pharmaceutical Quality by Design (QbD) and describe how it can be help to ensure pharmaceutical quality. Quality by design is an essential part of the modern approach to pharmaceutical quality. The elements of quality by design are examined and a consistent nomenclature for quality by design, critical quality attribute, critical process parameter, critical material attribute, and control strategy is proposed. The use of QbD was contrasted with the evaluation of product quality by testing alone. The QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include defining target product quality profile, designing product and manufacturing processes, identifying critical quality attributes, process parameters, and sources of variability & controlling manufacturing processes to produce cons...

Present study was intended to review the antibiotic use in dental infections or diseases and its ... more Present study was intended to review the antibiotic use in dental infections or diseases and its implications. Present study was based on literature from Google Scholar, Google, Scihub, PubMed, and link provided by AIMST and MAHSA Universities, Malaysia. Antimicrobials are extensively applied as therapeutic and prophylactic agents in dental infections. Inappropriate antibiotics use leads to antimicrobial resistance. Study suggests periodontal disease and dental caries are the two leading causes for tooth loss that are considered as a maximum burden over oral health which affects 1/5 to 1/2 of the global population. Present study suggests that irrational and over prescribing of antimicrobials in dental disease leads to antimicrobial resistance. Inclusion of the primary oral health care in national primary health care program will promote the dental health care.

Vascular Health and Risk Management, 2021

Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both d... more Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both developed and developing countries, affecting millions of individuals each year. Despite the fact that successful therapeutic drugs for the management and treatment of CVDs are available on the market, nutritional fruits appear to offer the greatest benefits to the heart and have been proved to alleviate CVDs. Experimental studies have also demonstrated that nutritional fruits have potential protective effects against CVDs. The aim of the review was to provide a comprehensive summary of scientific evidence on the effect of 10 of the most commonly available nutritional fruits reported against CVDs and describe the associated mechanisms of action. Relevant literatures were searched and collected from several scientific databases including PubMed, ScienceDirect, Google Scholar and Scopus. In the context of CVDs, 10 commonly consumed nutritious fruits including apple, avocado, grapes, mango, orange, kiwi, pomegranate, papaya, pineapple, and watermelon were analysed and addressed. The cardioprotective mechanisms of the 10 nutritional fruits were also compiled and highlighted. Overall, the present review found that the nutritious fruits and their constituents have significant benefits for the management and treatment of CVDs such as myocardial infarction, hypertension, peripheral artery disease, coronary artery disease, cardiomyopathies, dyslipidemias, ischemic stroke, aortic aneurysm, atherosclerosis, cardiac hypertrophy and heart failure, diabetic cardiovascular complications, drug-induced cardiotoxicity and cardiomyopathy. Among the 10 nutritional fruits, pomegranate and grapes have been well explored, and the mechanisms of action are well documented against CVDs. All of the nutritional fruits mentioned are edible and readily accessible on the market. Consuming these fruits, which may contain varying amounts of active constituents depending on the food source and season, the development of nutritious fruits-based health supplements would be more realistic for consistent CVD protection.

COVID-19 has spread globally, affecting almost 160 million individuals. Elderly and pre-existing ... more COVID-19 has spread globally, affecting almost 160 million individuals. Elderly and pre-existing patients (such as diabetes, heart disease and asthma), seems more susceptible to serious illness with COVID-19. Roflumilast was licensed for usage in the European Union in July 2010 as a phosphodiesterase-4 (PDE4) inhibitor. Roflumilast has been shown to decrease bleomycin-induced lung fibrosis, lung hydroxyproline, right heart thickning in animal prophylactic. The current study reviewed existing data that the PDE-4 inhibitor protects not just renal tissues but also other major organ systems after COVID-19 infection by decreasing immune cell infiltration. These immune-balancing effects of roflumilast were related with a decrease in oxidative and inflammatory burden, caspase-3 suppression, and increased PKA/cAMP levels in renal and other organ tissue.