Nelly H Alieldin - Academia.edu (original) (raw)

Papers by Nelly H Alieldin

International Journal of Hematology, 2011

ABSTRACT The prognostic value of absolute lymphocytic count (ALC) has been a recent matter of deb... more ABSTRACT The prognostic value of absolute lymphocytic count (ALC) has been a recent matter of debate in the study of non-Hodgkin-lymphoma. To evaluate the prognostic value of ALC at diagnosis in patients with diffuse large B-cell lymphoma (DLBCL), we performed a meta-analysis of published studies that provided survival information with reference to ALC at diagnosis. Six studies covering a total of 1,206 subjects were included in this analysis. The summary hazard ratios of low ALC for overall survival were 2.72 (95% confidence interval (CI) 2.15-3.45, P < 0.001) in the entire population, 2.96 (95% CI 2.04-4.29, P < 0.001) in the population that received CHOP, and 2.78 (95% CI 1.87-4.13, P < 0.001) in the population that received R-CHOP. The corresponding ratios for progression-free survival were 2.79 (95% CI 1.90-4.11, P < 0.001) in the entire population, and 2.56 (95% CI 1.66-3.96, P < 0.001) in the population that received R-CHOP. In conclusion, our systematic analysis suggests that low ALC has an adverse effect on outcome in DLBCL. Although it should be borne in mind that this meta-analysis was mainly based on data abstracted from observational studies, these results may justify risk-adapted therapeutic strategies for DLBCL to account for ALC at diagnosis.

Eastern Mediterranean Health Journal, Nov 1, 2007

Journal of cancer science and clinical therapeutics, 2019

Introduction: Emphasizing and evaluating different prognostic factors including the age, size of ... more Introduction: Emphasizing and evaluating different prognostic factors including the age, size of the tumor, type of surgery, capsular infiltration and administration of adjuvant chemotherapy, which may affect the disease free survival (DFS) and overall survival (OS) in patients with malignant Granulosa cell tumors (MGCTs). Patients and Methods: A retrospective study of 36 female patients diagnosed with MGCTs and managed at the National Cancer Institute-Cairo University-Egypt, in the period from May 2007-October 2012. Follow-up reached up to 116 months (3-116 mo.) with a median of 72 months. Prognostic factors as the age, size of the tumor, type of surgery, capsular infiltration and administration of adjuvant chemotherapy with number of cycles in correlation with DFS and OS were statistically analyzed to detect any significant correlation.

Journal of the Egyptian National Cancer Institute, Dec 1, 2018

Background: The spectrum of lung neuroendocrine tumors (NETs) encompasses low grade typical carci... more Background: The spectrum of lung neuroendocrine tumors (NETs) encompasses low grade typical carcinoid (TC), intermediate grade atypical carcionid (AC) and high grade, both large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), with extreme differences in management and survival. Objective: To study clinicopathologic and prognostic factors affecting survival of lung NETs. Patients and methods: This is a retrospective study evaluating 35 patients with primary lung NETs treated at National Cancer Institute of Egypt (NCI-E) between January 2010 and December 2014. Pathological diagnosis depended on definite morphology and positivity to at least one of the neuroendocrine markers by immunohistochemistry. Results: The mean age of the patients was 53 ± 11.2 years with male predominance. Performance status (PS) I was encountered in 48.6%. SCLC was the prevalent histology in 68.6%, followed by LCNEC & TC in 20 & 11.4%, respectively. Curative surgery was employed in 100 & 57% of TC & LCNEC patients, respectively. Stage IV was anticipated in 87.5 & 43% of SCLC & LCNEC, respectively. For the entire cohort, the median event-free survival (EFS) and overall survival (OS) were 8.0 and 13.7 months, respectively, whereas the 3year EFS and OS were 17.8 & 20%, respectively. SCLC patients showed significantly the worst OS compared to other NETs (p = 0.001). Patients who presented with stage IV and PS > I demonstrated significantly shorter OS than those with locoregional and PS I (p = 0.00001 & p = 0.002, respectively). Conclusions: SCLC subtype, stage IV and initial PS > I are poor prognostic factors for lung NETs associated with shorter survival. This conclusion needs to be confirmed by larger studies.

European Journal of Pain, Jul 11, 2018

Radiofrequency ablation (RFA) of the splanchnic nerves has been reported as a predictable and saf... more Radiofrequency ablation (RFA) of the splanchnic nerves has been reported as a predictable and safe technique for abdominal pain management. We compare between RFA and chemical neurolysis of bilateral thoracic splanchnic nerves in the management of refractory cancer pain.

Frontiers in Oncology, 2020

Journal of Research and Education in Indian Medicine (Est.1982), 2017

Background: Cancer cachexia is characterized as a multi-factorial syndrome, identified by the con... more Background: Cancer cachexia is characterized as a multi-factorial syndrome, identified by the continuing decline of skeletal muscle mass where nutritional support does not completely reverse the effects. Finding a cure for cachexia will impact cancer patients' worldwide, improving quality of life and potentially increasing survival in response to standard care. In turn, an accurate diagnostic tool would assist in the identification and translation of therapeutic targets to the clinic. The Glasgow Prognostic Score (GPS), is determined from combining circulating albumin and C-reactive protein (CRP) concentrations to form a score of 0 (normal) and 1 or 2 (abnormal) (albumin < 35g/L=1, and CRP> 10mg/L=1). The GPS has been used as an indicator in various cancer types, due to the presence of systemic inflammation, but not in cancer cachexia. The GPS has been validated in a wide range of clinical situation for a systemic inflammatory response so it may be beneficial in assessing the prognosis of cancer cachexia patients. Method / Design: A retrospective cohort study was conducted to assess the GPS as a valuable tool for diagnosing cancer cachexia. The relationship between BMI and the GPS was examined, along with other parameters for controls and cases. Clinical audit data was collected for 357 participants, 185 cases and 172 controls. Results: The GPS was abnormal (2; with albumin < 35 g/L and CRP > 10mg/L) in 123 (66.5%) cases and in 13 (7.6) controls. The GPS scored was also abnormal (1; with albumin < 35 g/L or CRP > 10 mg/L) in 53 (28.6%) cases and 89 (51.7%) controls. It was normal (0) in 9 (4.9%) cases and in 70 (40.7%) controls. There was a significant correlation between the GPS and a decrease in BMI as P value was 0.019. Conclusion: The GPS could be a useful indicator for the onset of cancer cachexia as advanced cancer is usually associated with a marked systemic inflammatory response which is manifested by an increase in CRP which led to a decrease in albumin. It would be beneficial to investigate if the GPS could be used for early diagnosis of cancer cachexia so it must be included in the basic assessment for all patients with cancer.

Hepatitis Monthly, 2016

Background: MicroRNAs (miRNAs) have been repeatedly shown to play important roles in liver pathol... more Background: MicroRNAs (miRNAs) have been repeatedly shown to play important roles in liver pathologies, including hepatitis, liver cirrhosis, and liver cancer. Egypt has the highest hepatitis C virus (HCV) infection rate worldwide, predominantly involving genotype-4. Objectives: In this study, we attempted to characterize the miRNA profile of the poorly studied genotype 4 of HCV in chronically infected Egyptian patients to obtain a better understanding of the disease and its complications and help in the design of better management protocols. Patients and Methods: We analyzed the expression levels of a selected panel of 94 miRNAs in fresh liver biopsies collected from 50 Egyptian patients diagnosed with chronic HCV infection using quantitative real-time polymerase chain reaction (PCR) assay. Nonparametric tests were used to analyze the expression level of each miRNA and association with the clinicopathological features of enrolled patients in this study. Results: Our results revealed differential expression levels of the analyzed miRNAs compared to the normal controls. Twenty-seven miRNAs (including miR-105, miR-147, miR-149-3p, and miR-196b) showed up-regulation, while 17 miRNAs (including miR-21, miR-122, miR-199a-3p, and miR-223) showed down-regulation. An inverse correlation was observed between levels of miR-95, miR-130a, and miR-142-5p with the blood albumin level. Increased expression levels of seven miRNAs (miR-29c, miR-30c, miR-126, miR-145, miR-199a, miR-199a-3p, and miR-222) were observed with severe chronic hepatic inflammation. Several deregulated miRNAs found in this study have been previously linked to chronic liver inflammation and the risk of hepatocellular carcinoma (HCC) development. Conclusions: The identified expression profiles of some examined miRNAs might offer important points to consider for the treatment of naive patients and the management of chronically infected HCV patients in Egypt and around the world.

Journal of Medical Microbiology, 2002

A prospective study was conducted in 1999 at the National Cancer Institute, Cairo University, to ... more A prospective study was conducted in 1999 at the National Cancer Institute, Cairo University, to estimate the incidence, morbidity and mortality of fungal infections along with the evaluation of risk factors influencing outcome of infections among paediatric cancer patients. Of 1917 infectious episodes, the fungal infection rate as documented both clinically and microbiologically was 3.7% (70 cases). Fungal pathogens isolated were yeasts in 55 patients (78.6%) and moulds in 15 patients (21.11%). Among yeasts, Candida parapsilosis was the commonest, followed by C. tropicalis. Pneumonia was the most common fungal infection (n 25, 35.7%), followed by fungaemia (n 18, 25.7%). The overall mortality rate was 40% (n 28), with an infection-related mortality of 28.5% (n 20). Risk factors that accompanied mortality were relapsing or recurrent disease, profound neutropenia, ADE (Ara-C, daunorubocin and etoposide) protocol of chemotherapy, C. tropicalis isolated and fungaemia as a site of infection. Early use of empirical antifungal therapy (day 4) was not associated with a better outcome. In the light of the poor outcome of patients with fungaemia and fungal pneumonia, every effort should be made to prevent these infections in paediatric cancer patients.

Acta neurologica Belgica, 2021

Status epilepticus (SE) is one of the most dreadful neurological emergencies; unfortunately, stud... more Status epilepticus (SE) is one of the most dreadful neurological emergencies; unfortunately, studies targeting SE are still inadequate. This study aims to identify factors associated with the use of CIVAD in patients presenting with status epilepticus and detect those impact the clinical outcome. A prospective study involving 144 episodes of SE in 144 patients. Patients were categorized according to whether or not they received CIVAD. Subjects underwent clinical assessment, brain imaging, and EEG. The consciousness level was assessed using the Glasgow coma scale (GCS) and the Full outline of responsiveness (FOUR) scale. SE severity score (STESS) and Epidemiology-based mortality score (EMSE) were used as scales for outcome prediction. Continuous IV anesthetic drug infusion was initiated in 36% of patients (+ CIVAD). Such groups showed a significantly worse initial level of consciousness (< 0.001), an unstable course of seizure evolution (0.009), and all of them showed abnormal EEG...

Acta Neurologica Scandinavica, 2021

Status epilepticus (SE) is an important cause of mortality worldwide. Information regarding assoc... more Status epilepticus (SE) is an important cause of mortality worldwide. Information regarding associations of mortality outcome in Egypt is limited. The main objective of this study was to describe the clinical characteristics and factors associated with mortality of patients with SE admitted to Cairo University Hospitals.

Epilepsy & Behavior, 2020

PURPOSE There is a lack of data concerning the performance of the outcome prediction scores in pa... more PURPOSE There is a lack of data concerning the performance of the outcome prediction scores in patients with status epilepticus (SE) in developing countries. The aim of this study was to compare the predictive performances of the status epilepticus severity score (STESS) and the epidemiology-based mortality score in status epilepticus (EMSE) and adaptation of such scoring system to be compatible with the nature of society. METHOD This is a prospective study, conducted in Egypt from the period of January 2017 to June 2018. The main outcome measure was survival versus death, on hospital discharge. The cutoff point with the best sensitivity and specificity to predict mortality was determined through a receiver operating characteristic (ROC) curve. RESULTS Among the 144 patients with SE with a mean age of 39.3 ± 19.5 years recruited into the study, 38 patients (26.3%) died in the hospital with the survival of 99 patients while 7 patients (4.9%) were referred to other centers with an unknown outcome. Although EMSE had a bit larger area under the curve (AUC) (0.846) than STESS-3 (AUC 0.824), STESS-3 had the best performance as in-hospital death prediction score as it has a higher negative predictive value (94.6%) than that of EMSE (90.9%) in order not to miss high-risk patients. CONCLUSION In the Egyptian population, STESS and EMSE are useful tools in predicting mortality outcome of SE. The STESS performed significantly better than EMSEE combinations as a mortality prediction score.

Asian Pacific Journal of Cancer Prevention, 2020

Background: Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form ... more Background: Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form of heterogeneous cancer, there is interplay between genetic and environmental factors. We aimed at probing the association of life style factors and Microsatellite Instability (MSI) status that could provide more insights on carcinogenic process of CRC. Methods: One hundred incident sporadic CRC patients were involved. Information on risk factors of CRC was obtained and microsatellite instability status was predicted through evaluation of MMR protein expression via immunohistochemistry (IHC). Results: Median age was 47.50 years, females represented 54.0% and 36% of patients were Microsatellite Instability High (MSI-H). Most patients with right sided colon cancer (78.3%) were MSI-H while mostly stable or low MSS/MSI-L for left-sided colon and rectum (78.6%, 74.3% respectively, p<0.001). Patients with low physical activity had higher risk of MSS/MSI-L than those with moderate or high activity p =0.026. Patients with BMI greater than 30 Kg/m 2 had higher MSS/MSI-L (75.5%) than those with BMI between 25-30 Kg/m 2 (60.6%) and those with normal BMI <25 (38.9%), p for trend = 0.006. On subgroup analyses, the association of high BMI with MSS/ MSI-L was only shown in patients younger than 40 years, females, stage III, non-mucin secreting adenocarcinoma and a significant interaction with physical activity. Conclusion: In Conclusion, the present study confirms the increased risk of MSS/MSI-L with increased BMI and speculates this association to be modified by patient's life style and tumor characteristics. Further research is needed to validate present results.

The Breast, 2019

provide good local control in patients followed for inflammatory breast cancer while reducing the... more provide good local control in patients followed for inflammatory breast cancer while reducing the duration and cost of treatment. Conflict of Interest: No significant relationships.

Journal of the Egyptian National Cancer Institute, 2013

Objective: Hepatocellular carcinoma (HCC) is a major health problem in Egypt as well as in many c... more Objective: Hepatocellular carcinoma (HCC) is a major health problem in Egypt as well as in many countries. Transarterial chemoembolization (TACE) is a treatment modality applicable to locally advanced HCC beyond surgery or ablative therapies and is associated with survival improvements. The aim of this study was to assess the outcomes of TACE in our center over the past four years. Methods: This is a retrospective cohort study that included 221 patients with locally advanced HCC treated with TACE in a single center between the years 2007 and 2010. The median age was 57 years with male predominance. Liver cirrhosis, viral hepatitis and Bilharziasis were encountered in 64%, 31% and 8% of patients, respectively. Abdominal pain was the most common presenting symptom (67%). Most cases were diagnosed based on radiology (57%) with a TNM stage I or II (73%) and a median AFP value of 15Ong/mL. Results: The 221 patients received 440 cycles of TACE with a median of 2 cycles per patient. Cisplatin and doxorubicin (50 mg per cycle, each) were the most commonly used drugs. Impaired liver function was the most common toxicity. Whereas liver failure occurred in 17% of patients, post-embolization syndrome was encountered in almost all cases. An objective tumor response was achieved in 44% of cases. The median overall survival (OS) was 16 months (95% CI, 13-19 months) and the median progression free survival (PFS) was 9 months (95% CI, 6-12 months). Responding patients, Child-Pugh class A and patients receiving standard doses of chemotherapy had a significantly better OS than their counterparts. Only Child-Pugh class A was associated with significantly longer PFS (p<0.001). Conclusions: TACE produces reasonable responses and fair survival rates in locally advanced HCC but with noticeable toxicities. Proper patients' selection and prompt liver support are mandates for improving TACE outcomes.

European Journal of Pain, 2018

Sensors

This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVI... more This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected cases, especially in rural areas, to limit the spread of the virus. Herein, a proof-of-concept is presented for a portable laboratory device for the detection of the SARS-CoV-2 virus using electromagnetic biosensors. This device is a microwave cavity resonator (MCR) composed of a sensor operating at industrial, scientific and medical (ISM) 2.45 GHz inserted in 3D housing. The changes of electrical properties of measured serum samples after passing the sensor surface are presented. The three change parameters of the sensor are resonating frequency value, amplitude and phase of the reflection coefficient |S11|. This immune-sensor offers a portable, rapid and accurate diagnostic method for ...

Annals of Diagnostic Pathology