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Papers by Nelly Patricia Calderón Rodríguez
Clinical Journal of the American Society of Nephrology, 2010
Background and objectives: Cognitive impairment is common among persons with ESRD, but the underl... more Background and objectives: Cognitive impairment is common among persons with ESRD, but the underlying mechanisms are unknown. This study evaluated the prevalence of cognitive impairment and association with modifiable ESRD-and dialysis-associated factors in a large group of hemodialysis patients. Design, setting, participants, & measurements: Cross-sectional analyses were conducted on baseline data collected from 383 subjects participating in the Frequent Hemodialysis Network trials. Global cognitive impairment was defined as a score <80 on the Modified Mini-Mental State Exam, and impaired executive function was defined as a score >300 seconds on the Trailmaking B test. Five main categories of explanatory variables were examined: urea clearance, nutritional markers, hemodynamic measures, anemia, and central nervous system (CNS)-active medications. Results: Subjects had a mean age of 51.6 ؎ 13.3 years and a median ESRD vintage of 2.6 years. Sixty-one subjects (16%) had global cognitive impairment, and 110 subjects (29%) had impaired executive function. In addition to several nonmodifiable factors, the use of H1-receptor antagonists and opioids were associated with impaired executive function. No strong association was found between several other potentially modifiable factors associated with ESRD and dialysis therapy, such as urea clearance, proxies of dietary protein intake and other nutritional markers, hemodynamic measures, and anemia with global cognition and executive function after adjustment for case-mix factors. Conclusions: Cognitive impairment, especially impaired executive function, is common among hemodialysis patients, but with the exception of CNS-active medications, is not strongly associated with several ESRD-and dialysis-associated factors.
La enfermedad renal cronica es el dano estructural o funcional de los rinones por un tiempo mayor... more La enfermedad renal cronica es el dano estructural o funcional de los rinones por un tiempo mayor a tres meses y es considerado un problema de salud publica; la hemodialisis es una modalidad terapeutica que sustituye las funciones renales mejorando la calidad y los anos de vida en los pacientes que padecen enfermedad renal cronica. No obstante, las practicas clinicas empleadas varian en cada pais, encontrandose fluctuaciones en Mexico y en Colombia en la duracion de las sesiones de dialisis y en el tipo de acceso vascular empleado por lo que se hace necesario analizar el impacto que tiene esto en la mortalidad y en la presentacion de infecciones del paciente con enfermedad renal cronica que se encuentra en hemodialisis.
Mexican Journal of Medical Research ICSA
Chronic kidney disease is the structural or functional damage of the kidneys for more than three ... more Chronic kidney disease is the structural or functional damage of the kidneys for more than three months and is considered a public health problem, since one out of every ten adults suffer from; the hemodialysis is a therapeutic modality that replaces kidney function (excretion of waste products, regulation of water balance and regulation of the acid-base balance) improving the quality and years of life in patients with chronic kidney disease. However, clinical practices used (dialyzers, duration of hemodialysis sessions, vascular access and health personnel) vary in each country, which has an impact on the quality of life and patient mortality. Objective: To describe the differences in the reuse of dialyzers, duration of hemodialysis sessions, goals for the type of vascular access used and the health personnel who are in each renal unit, from the rules, between Mexico and Colombia. Conclusions: The differences that exist in clinical practices of hemodialysis between Mexico and Colom...
Clinical Journal of the American Society of Nephrology, 2010
Background and objectives: Cognitive impairment is common among persons with ESRD, but the underl... more Background and objectives: Cognitive impairment is common among persons with ESRD, but the underlying mechanisms are unknown. This study evaluated the prevalence of cognitive impairment and association with modifiable ESRD-and dialysis-associated factors in a large group of hemodialysis patients. Design, setting, participants, & measurements: Cross-sectional analyses were conducted on baseline data collected from 383 subjects participating in the Frequent Hemodialysis Network trials. Global cognitive impairment was defined as a score <80 on the Modified Mini-Mental State Exam, and impaired executive function was defined as a score >300 seconds on the Trailmaking B test. Five main categories of explanatory variables were examined: urea clearance, nutritional markers, hemodynamic measures, anemia, and central nervous system (CNS)-active medications. Results: Subjects had a mean age of 51.6 ؎ 13.3 years and a median ESRD vintage of 2.6 years. Sixty-one subjects (16%) had global cognitive impairment, and 110 subjects (29%) had impaired executive function. In addition to several nonmodifiable factors, the use of H1-receptor antagonists and opioids were associated with impaired executive function. No strong association was found between several other potentially modifiable factors associated with ESRD and dialysis therapy, such as urea clearance, proxies of dietary protein intake and other nutritional markers, hemodynamic measures, and anemia with global cognition and executive function after adjustment for case-mix factors. Conclusions: Cognitive impairment, especially impaired executive function, is common among hemodialysis patients, but with the exception of CNS-active medications, is not strongly associated with several ESRD-and dialysis-associated factors.
La enfermedad renal cronica es el dano estructural o funcional de los rinones por un tiempo mayor... more La enfermedad renal cronica es el dano estructural o funcional de los rinones por un tiempo mayor a tres meses y es considerado un problema de salud publica; la hemodialisis es una modalidad terapeutica que sustituye las funciones renales mejorando la calidad y los anos de vida en los pacientes que padecen enfermedad renal cronica. No obstante, las practicas clinicas empleadas varian en cada pais, encontrandose fluctuaciones en Mexico y en Colombia en la duracion de las sesiones de dialisis y en el tipo de acceso vascular empleado por lo que se hace necesario analizar el impacto que tiene esto en la mortalidad y en la presentacion de infecciones del paciente con enfermedad renal cronica que se encuentra en hemodialisis.
Mexican Journal of Medical Research ICSA
Chronic kidney disease is the structural or functional damage of the kidneys for more than three ... more Chronic kidney disease is the structural or functional damage of the kidneys for more than three months and is considered a public health problem, since one out of every ten adults suffer from; the hemodialysis is a therapeutic modality that replaces kidney function (excretion of waste products, regulation of water balance and regulation of the acid-base balance) improving the quality and years of life in patients with chronic kidney disease. However, clinical practices used (dialyzers, duration of hemodialysis sessions, vascular access and health personnel) vary in each country, which has an impact on the quality of life and patient mortality. Objective: To describe the differences in the reuse of dialyzers, duration of hemodialysis sessions, goals for the type of vascular access used and the health personnel who are in each renal unit, from the rules, between Mexico and Colombia. Conclusions: The differences that exist in clinical practices of hemodialysis between Mexico and Colom...