Nevzat Tarhan - Academia.edu (original) (raw)

Papers by Nevzat Tarhan

Research paper thumbnail of Assessment of Oxidative Stress Effects in Serum Determined by FT-IR Spectroscopy in Cholangiocarcinoma Patients

Biointerface Research in Applied Chemistry

Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepa... more Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepatic bile ducts and gallbladder carcinoma. Mostly diagnosed at an advanced stage with a <5% cure chance. Early-stage diagnosis may increase the number of patients who reach curative treatment. Fourier Transform InfraRed (FT-IR) spectroscopy was used to detect chemical changes in serum collected from CCA patients vs. healthy individuals. The study aims to correlate the FTIR spectra with biochemical indices such as TAS, TOS, OSI, and total protein levels. Decreased TAS and increased TOS, OSI, and total protein levels in CCA patients vs. healthy individuals were found. FTIR spectra showed higher absorbance of the peaks corresponding to C–O and bending vibration of C–O–H groups in CCA patients, while more CH2 functional groups than lipids could be seen in the FTIR spectra of controls serum. PLS analysis showed IR ranges of 1500 cm-1 to 1700 cm-1, and 2700 cm-1 to 3000 cm-1 were able to dis...

Research paper thumbnail of Maternal and neonatal outcomes of borderline hyperglycemia during pregnancy diagnosed with abnormal screening test

Clinical and Experimental Obstetrics & Gynecology, 2017

Aim: The authors aimed to determine whether mild maternal glucose intolerance detected by abnorma... more Aim: The authors aimed to determine whether mild maternal glucose intolerance detected by abnormal screening by one-hour 50-gram glucose challenge test (GCT) and normal 100-gram oral glucose tolerance test (OGTT), which can be called as borderline hyperglycemia, is associated with increased risk of maternal and fetal adverse outcomes or not compared to normal and gestational diabetes mellitus (GDM) patients. Materials and Materials: Pregnant women with normal 50-gram GCT (198 cases), abnormal 50-gram GCT and normal 100-gram OGTT (160 cases), and impaired glucose tolerance (IGT) or GDM diagnosed with 100-gram OGTT (212 cases) were included. Data was collected from hospital automation system and clinical records. The authors compared demographic, obstetric, and neonatal outcomes among these three groups. Results: Mean maternal age (31.5 ± 5.2 years), history of GDM (4.2%), and the rate of cesarean section delivery in previous pregnancy (41,5%) were statistically higher in group 3 (IGT+GDM group) compared to both group 1 (normal 50-gram GCT) and group 2 (borderline hyperglycemia), respectively (p < 0.01, p < 0.01, and p < 0.01). The duration of maternal hospitalization was longer (2.40 ± 1.28 and 2.39 ± 1.25 vs. 1.79 ± 1.15 day, p = 0.001, p = 0.001, respectively) and postoperative hemoglobin values were lower (10.71 ± 1.44 and 10.69 ± 10.90 vs. 11.22 ± 1.43, p = 0.015, p = 0.006, respectively) both in groups 2 and 3 when compared with group 1. However preeclampsia was statistically more commonly developed in group 3 than in groups 1 and 2 (16% vs. 6.1% and 11.3%; p < 0.05). Neonatal hypoglycemia was more common both in groups 2 and 3 compared to group 1 (11.8%, 4.6% vs. 0%; p < 0.001, p = 0.045, respectively) and first minute apgar scores were higher in group 1 than in groups 2 and 3 (7.97 ± 0.55 vs. 7.65 ± 1.19 and 7.60 ± 1.17; p = 0.003, p = 0.001, respectively). Duration of hospitalization period for neonates was longer in groups 2 and 3 than in group 1 (2.22 ± 1.28 and 2.42 ± 1.48 vs. 1.82 ± 1.17 day; p = 0.006, p = 0.001). Conclusion: Borderline hyperglycemia can cause maternal, perinatal, and neonatal adverse outcomes. Both obstetricians and neonatologists must keep in mind the unfavorable pregnancy outcomes of borderline hyperglycemia cases and careful follow up is needed even if it is not accepted as GDM and IGT.

Research paper thumbnail of Is Therapeutic Drug Monitoring and Pharmacokinetic Genotyping Sufficient in a Personalized Treatment Approach? Is Pharmacodynamic Genotyping Necessary?: Three Cases

Research paper thumbnail of A Systematical Characterization of TeO2–V2O5 Glass System Using Boron (III) Oxide and Neodymium (III) Oxide Substitution: Resistance Behaviors against Ionizing Radiation

Applied sciences, Mar 29, 2021

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of The Validity and Reliability Study on the Üsküdar Spiritual Life in Family Scale

Medya ve Din Araştırmaları Dergisi

Değerler ve manevi yaşantılar insan hayatının temel ihtiyaçlarıdır ve bu yaşantıların temeli aile... more Değerler ve manevi yaşantılar insan hayatının temel ihtiyaçlarıdır ve bu yaşantıların temeli ailede atılır. Aile içerisinde sadece maddi değil manevi olarak da birlikteliği güçlendiren birtakım değerler vardır ve aile yaşantısı içerisine dahil edilerek çocuğun değerler eğitiminin temelinin atılmasında hayati önem taşımaktadır. Bunlar; Meşveret, eşitlik, özerklik, hakkaniyet, sevgi, saygı, güven, paylaşımcılık, maddi ve manevi kazanımlar olarak sıralanabilir. Dolayısıyla bu değerlerin aile yaşantılarına ne derece katıldığının belirlenebilmesi öz farkındalık açısından gerekli olup ölçüm aracı ihtiyacını gündeme getirmiştir. Böylece, ailenin değerler ve manevi eğitimdeki tutumlarının ölçümlenmesi amacıyla 994 kişiden oluşan bir çalışma grubunda Üsküdar Ailede Manevi Yaşantı Ölçeğinin geliştirilmesi amaçlanmıştır. Ayrıca, günümüzde yaygın kullanılan sosyal medyanın günlük kullanım süresinin manevi yaşantıda fark yaratıp yaratmadığı da incelenmiştir. Yapılan geçerlilik ve güvenilirlik ça...

Research paper thumbnail of Electroconvulsive Therapy for the Anti-NMDA Receptor Encephalitis: A Case Report

Journal of Biomedical Research & Environmental Sciences

Anti-NMDA encephalitis is a rare autoimmune disorder that affects the central nervous system. We ... more Anti-NMDA encephalitis is a rare autoimmune disorder that affects the central nervous system. We report a case of a 22-year-old male patient with a history of prodromal flu-like symptoms followed by brief aggression episodes, paranoid symptoms, and stereotypic movements. Routine blood work, a brain MRI, and an EEG were normal. Cerebrospinal Fluid (CSF) studies show no abnormality, and the neuronal antibody panel was administered. Antipsychotics and benzodiazepines did not have any benefits, and Electroconvulsive Treatment (ECT) was recommended for the ongoing symptoms of catatonia. Movement disorders and cognition gradually improved after the second session of ECT. Later, CSF study results demonstrated the presence of anti-NMDA antibodies, and standard therapy was administered. Our case suggests that ECT may be an effective treatment option for patients with anti-NMDA encephalitis. Further studies are needed to confirm the efficacy and safety of ECT in this patient population.

Research paper thumbnail of Measuring the Awareness Levels of Individuals with Alcohol and Substance Use Disorders: Tertiary Prevention Standards and Development of Uskudar Result Awareness and Harm Perception Scales

Brain Sciences

Rationale: Alcohol and substance use disorders are types of brain diseases that have psychologica... more Rationale: Alcohol and substance use disorders are types of brain diseases that have psychological components which damage many life areas of the affected individual. Since investigating alcohol use alone is insufficient in the diagnostic evaluation process, self-awareness and the individual’s long-term psychological well-being are important in the treatment process. Primary prevention is used for preventing disease in healthy people, whereas secondary prevention is used for early diagnosis of people at risk. Tertiary prevention is important to prevent the recurrence of the disease. Since substance use disorders are a chronic problems, a new need has emerged for tertiary protection in rehabilitation standards. Methodology: In this study, we aimed to develop two scales that can provide ideas about rehabilitation standards by determining the awareness of individuals with or without alcohol and substance use disorders. By so, experts in the field can have information about the risk sta...

Research paper thumbnail of Low-frequency prefrontal cortex magnetic stimulation improves autism spectrum disorder symptoms: A pilot study

Journal of neurobehavioral sciences, 2023

Research paper thumbnail of An application of raman spectroscopy in combination with machine learning to determine gastric cancer spectroscopy marker

Computer Methods and Programs in Biomedicine

Research paper thumbnail of Analysis of follicular fluid and serum markers of oxidative stress in women with unexplained infertility by Raman and machine learning methods

Journal of Raman Spectroscopy

Oocytes are surrounded by a fluid called follicular fluid, which provides an essential microenvir... more Oocytes are surrounded by a fluid called follicular fluid, which provides an essential microenvironment for developing oocytes in human fertility. Various molecules exist in antral follicles, including proteins, steroid hormones, polysaccharides, metabolites, reactive oxygen species, and antioxidants. Oxidative stress is involved in the etiology of defective oocyte development or poor oocyte and embryo quality. Raman spectroscopy, a noninvasive method, can be used for biological diagnostics and direct chemical identification of follicular fluid. Therefore, we measured the oxidative index of follicular fluids and then attempted Raman spectroscopy on the follicular fluids combined with machine learning techniques to identify, detect, and quantify follicular fluid of unexplained infertility‐diagnosed women as a safe and effective tool to use as adjacent for clinical studies. This was a retrospective study set in an academic hospital where the patients were selected from an unexplained ...

Research paper thumbnail of Instagram Addiction Scale--Turkish Version

Research paper thumbnail of Multi-class classification model for psychiatric disorder discrimination

International Journal of Medical Informatics

Research paper thumbnail of PERMA Modeline Göre Pozitif Psikoloji Eğitiminin İyi Oluş Üzerine Etkisi

Üsküdar Üniversitesi Sosyal Bilimler Dergisi

Bu araştırmanın amacı, Pozitif Psikoloji eğitiminin PERMA modeline göre üniversite öğrencilerinin... more Bu araştırmanın amacı, Pozitif Psikoloji eğitiminin PERMA modeline göre üniversite öğrencilerinin iyi oluşu üzerine olan etkisini incelemektir. Araştırmada, öntest-sontest kontrol grubu olmayan yarı-deneysel desen kullanılmıştır. Araştırmanın örneklemi Üsküdar Üniversitesi’nde öğrenim gören ve araştırmaya katılmayı kabul eden 1209 öğrenciden oluşmaktadır. Araştırmada veri toplama aracı olarak PERMA Ölçeği kullanılmıştır. Araştırmada, öğrencilerin PERMA skorlarının ön-ölçüm ve son-ölçümünün karşılaştırılması için Eşleşmiş Örneklem t Testi uygulanmıştır. Ayrıca, cinsiyete göre PERMA alt boyut ve toplam skorlarının karşılaştırılması için Bağımsız Örneklem t testi yapılmıştır. Analizler, verilerin normallik ölçütünü sağlayan çarpıklık ve basıklık değerleri kontrol edildikten sonra SPSS 25.0 üzerinden gerçekleştirilmiştir. Araştırma bulgularına göre bir dönem boyunca (14 hafta) alınan Pozitif Psikoloji dersi PERMA modeliyle anlamlı ilişkili bulunmuştur. Çalışma üniversite öğrencilerinin ...

Research paper thumbnail of Y Kuşağının Dijital Oyun Bağımlılığının İncelenmesi

Online Journal of Technology Addiction and Cyberbullying, Jun 30, 2021

Bu araştırmanın amacı Y kuşağının dijital oyun bağımlılığının incelenmesidir. Araştırmada var ola... more Bu araştırmanın amacı Y kuşağının dijital oyun bağımlılığının incelenmesidir. Araştırmada var olan durumun tespit edilmesi amaçlandığından niceliksel betimleme yöntemi kullanılmıştır. Örneklemi; 1980-1999 yılları arasında doğan dijital oyunlara ilgisi olan 497 kişi oluşturmuştur. Katılımcıların yaşları 20 ile 40 arasında değişmektedir. Araştırmada veriler araştırmacılar tarafından hazırlanan "Kişisel Bilgi Formu" ve üniversite öğrencilerinin dijital oyun bağımlılığını ölçebilmek amacıyla Hazar ve Hazar (2019) tarafından geliştirilen ve geçerlilik ve güvenilirlik çalışması yapılan "Üniversite Öğrencileri için Dijital Oyun Bağımlılığı Ölçeği" kullanılarak toplanmıştır. Araştırmada, veri toplama araçları katılımcılara hem basılı hem dijital olarak uygulanmıştır. Verilerin analizi SPSS 25 programı ile yapılmış ve %95 güven düzeyi ile çalışılmıştır. Analizlerde parametrik yöntemler kullanılmıştır. Araştırma elde edilen birtakım bulgular şu şekildedir: (a) Y kuşağının dijital oyun bağımlılığı Riskli Grup'ta bulunmuştur; (b) Erkeklerin aşırı odaklanma ve erteleme, duygu değişimi ve dalma, dijital oyun bağımlılığı düzeylerinin kadınlardan daha yüksek olduğu belirlenmiştir; (c) Lise mezunlarının aşırı odaklanma ve erteleme, yoksunluk ve arayış, dijital oyun bağımlılığı düzeyleri en yüksektir; (d) İlkokul mezunlarının duygu değişimi ve dalma düzeyi en yüksektir. Araştırma

Research paper thumbnail of A Proposed Brain-, Spine-, and Mental- Health Screening Methodology (NEUROSCREEN) for Healthcare Systems: Position of the Society for Brain Mapping and Therapeutics

Journal of Alzheimer's Disease, 2022

The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive i... more The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive issues. However, there is a lack of inexpensive and efficient brain evaluation and screening systems. As a result, a considerable fraction of patients with neurocognitive or psychobehavioral predicaments either do not get timely diagnosed or fail to receive personalized treatment plans. This is especially true in the elderly populations, wherein only 16% of seniors say they receive regular cognitive evaluations. Therefore, there is a great need for development of an optimized clinical brain screening workflow methodology like what is already in existence for prostate and breast exams. Such a methodology should be designed to facilitate objective early detection and cost-effective treatment of such disorders. In this paper we have reviewed the existing clinical protocols, recent technological advances and suggested reliable clinical workflows for brain screening. Such protocols range from ...

Research paper thumbnail of The effect of memorizing the quran on cognitive functions

The Journal of Neurobehavioral Sciences, 2021

Background: Memorizing the Quran is an education continuing from the early periods of Islamic edu... more Background: Memorizing the Quran is an education continuing from the early periods of Islamic education until today. Although this education started in the past to protect the Quran, nowadays, it is continuing as a tradition. Aims and Objectives: The main purpose of this study is to investigate the effects of memorizing the Quran on certain cognitive functions of individuals. Materials and Methods: The scope of the study is limited to 18 female and 15 male students who have been studying in the 5th, 6th, and 7th grades of Anatolian Imam Preacher Secondary Schools in different districts of İstanbul. After Demographic Information Questionnaire was used, California Verbal Learning Test children's version, Wechsler Memory Scale revised visual reproduction subtest, Trail Making Test, and Verbal Fluency Test were applied twice to collect data about individuals before and after memorization training. Results: Findings demonstrated that there is a statistically significant difference in verbal learning, visual learning, attention speed, and phonemic and semantic fluency before and after memorization training. Conclusion: In conclusion, memorizing the Quran has positive impacts on verbal and visual memory, attention processes, and lexical and semantic fluency of individuals. It is important with regard to eliminate emptiness in the literature. In future studies, it can be investigated the effects of textual memorization in a foreign language on brain structures and connections.

Research paper thumbnail of Health Literacy and Cyberchondria

Advances in Media, Entertainment, and the Arts, 2022

Although newly developing technologies contribute positively to human life, many studies have sho... more Although newly developing technologies contribute positively to human life, many studies have shown that it has some health risks. The widespread use of computers and mobile devices, in particular, have allowed the internet to be accessible by almost everyone and thus exposes them to health problems resulting from internet use. The aims of this study are to investigate negative health problems associated with internet use, the impact of new media tools on the health of individuals, to understand cyberchondria and to present solutions to reduce its effects. Furthermore, it was aimed to assess the status of cyberchondria and related factors as well health literacy in individuals using the internet to determine the necessary treatment options for cyberchondria, to clarify the conceptual status of cyberchondria for future research, and to develop evidence-based approaches. Findings indicate that when considering the relationship between health literacy and cyberchondria, the effect of h...

Research paper thumbnail of 25th European Congress of Psychiatry

Research paper thumbnail of A deep learning approach to evaluating sex differences in antidepressant response to neuromodulation using EEG in major depressive disorder

Research paper thumbnail of The adaptation of gender identity / gender dysphoria questionnaire for adults: Turkish validity and reliability studies

The Journal of Neurobehavioral Sciences, 2021

Background: The fact that the concepts of sexual identity and gender dysphoria have become more i... more Background: The fact that the concepts of sexual identity and gender dysphoria have become more important all over the world and in Turkey has led clinicians to need powerful measuring tools to evaluate and comment on this structure. Aims and Objectives: The aim of this study is to investigate language equivalence, validity, and reliability studies of the Turkish version of the Gender Identity / Gender Dysphoria Questionnaire for Adult (GIDQ), which was developed by Deogracias et al. (2007). Materials and Methods: The scale was applied to 368 individuals (heterosexual and nonheterosexual) consisting of university students and trans-oriented individuals. Pearson's correlation coefficients revealed positive and significant values in the consistency analysis between the English and Turkish forms for linguistic equivalence studies of the GIDQ Adult Form for ages 18 and over. Results: The factor analysis performed to determine the construct validity of the 5-item Likert type scale, the original of which has a single factor and 27 items, a single factor, and 25-item structure were obtained which accounted for 51.8% of the total variance. When the internal consistency of the scale was calculated, the Cronbach Alpha value was found to be 0.89. Conclusion: According to the comparison of three groups (heterosexual, nonheterosexual, and those with gender dysphoria), average calculations, and effect size (d) analyses in the discrimination validity studies, it was observed that the gender dissatisfaction of university students was at a low level. It was found to be close to the intermediate level in the nonheterosexual male group. The results show that the Turkish form of the scale is valid and reliable.

Research paper thumbnail of Assessment of Oxidative Stress Effects in Serum Determined by FT-IR Spectroscopy in Cholangiocarcinoma Patients

Biointerface Research in Applied Chemistry

Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepa... more Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepatic bile ducts and gallbladder carcinoma. Mostly diagnosed at an advanced stage with a <5% cure chance. Early-stage diagnosis may increase the number of patients who reach curative treatment. Fourier Transform InfraRed (FT-IR) spectroscopy was used to detect chemical changes in serum collected from CCA patients vs. healthy individuals. The study aims to correlate the FTIR spectra with biochemical indices such as TAS, TOS, OSI, and total protein levels. Decreased TAS and increased TOS, OSI, and total protein levels in CCA patients vs. healthy individuals were found. FTIR spectra showed higher absorbance of the peaks corresponding to C–O and bending vibration of C–O–H groups in CCA patients, while more CH2 functional groups than lipids could be seen in the FTIR spectra of controls serum. PLS analysis showed IR ranges of 1500 cm-1 to 1700 cm-1, and 2700 cm-1 to 3000 cm-1 were able to dis...

Research paper thumbnail of Maternal and neonatal outcomes of borderline hyperglycemia during pregnancy diagnosed with abnormal screening test

Clinical and Experimental Obstetrics & Gynecology, 2017

Aim: The authors aimed to determine whether mild maternal glucose intolerance detected by abnorma... more Aim: The authors aimed to determine whether mild maternal glucose intolerance detected by abnormal screening by one-hour 50-gram glucose challenge test (GCT) and normal 100-gram oral glucose tolerance test (OGTT), which can be called as borderline hyperglycemia, is associated with increased risk of maternal and fetal adverse outcomes or not compared to normal and gestational diabetes mellitus (GDM) patients. Materials and Materials: Pregnant women with normal 50-gram GCT (198 cases), abnormal 50-gram GCT and normal 100-gram OGTT (160 cases), and impaired glucose tolerance (IGT) or GDM diagnosed with 100-gram OGTT (212 cases) were included. Data was collected from hospital automation system and clinical records. The authors compared demographic, obstetric, and neonatal outcomes among these three groups. Results: Mean maternal age (31.5 ± 5.2 years), history of GDM (4.2%), and the rate of cesarean section delivery in previous pregnancy (41,5%) were statistically higher in group 3 (IGT+GDM group) compared to both group 1 (normal 50-gram GCT) and group 2 (borderline hyperglycemia), respectively (p < 0.01, p < 0.01, and p < 0.01). The duration of maternal hospitalization was longer (2.40 ± 1.28 and 2.39 ± 1.25 vs. 1.79 ± 1.15 day, p = 0.001, p = 0.001, respectively) and postoperative hemoglobin values were lower (10.71 ± 1.44 and 10.69 ± 10.90 vs. 11.22 ± 1.43, p = 0.015, p = 0.006, respectively) both in groups 2 and 3 when compared with group 1. However preeclampsia was statistically more commonly developed in group 3 than in groups 1 and 2 (16% vs. 6.1% and 11.3%; p < 0.05). Neonatal hypoglycemia was more common both in groups 2 and 3 compared to group 1 (11.8%, 4.6% vs. 0%; p < 0.001, p = 0.045, respectively) and first minute apgar scores were higher in group 1 than in groups 2 and 3 (7.97 ± 0.55 vs. 7.65 ± 1.19 and 7.60 ± 1.17; p = 0.003, p = 0.001, respectively). Duration of hospitalization period for neonates was longer in groups 2 and 3 than in group 1 (2.22 ± 1.28 and 2.42 ± 1.48 vs. 1.82 ± 1.17 day; p = 0.006, p = 0.001). Conclusion: Borderline hyperglycemia can cause maternal, perinatal, and neonatal adverse outcomes. Both obstetricians and neonatologists must keep in mind the unfavorable pregnancy outcomes of borderline hyperglycemia cases and careful follow up is needed even if it is not accepted as GDM and IGT.

Research paper thumbnail of Is Therapeutic Drug Monitoring and Pharmacokinetic Genotyping Sufficient in a Personalized Treatment Approach? Is Pharmacodynamic Genotyping Necessary?: Three Cases

Research paper thumbnail of A Systematical Characterization of TeO2–V2O5 Glass System Using Boron (III) Oxide and Neodymium (III) Oxide Substitution: Resistance Behaviors against Ionizing Radiation

Applied sciences, Mar 29, 2021

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of The Validity and Reliability Study on the Üsküdar Spiritual Life in Family Scale

Medya ve Din Araştırmaları Dergisi

Değerler ve manevi yaşantılar insan hayatının temel ihtiyaçlarıdır ve bu yaşantıların temeli aile... more Değerler ve manevi yaşantılar insan hayatının temel ihtiyaçlarıdır ve bu yaşantıların temeli ailede atılır. Aile içerisinde sadece maddi değil manevi olarak da birlikteliği güçlendiren birtakım değerler vardır ve aile yaşantısı içerisine dahil edilerek çocuğun değerler eğitiminin temelinin atılmasında hayati önem taşımaktadır. Bunlar; Meşveret, eşitlik, özerklik, hakkaniyet, sevgi, saygı, güven, paylaşımcılık, maddi ve manevi kazanımlar olarak sıralanabilir. Dolayısıyla bu değerlerin aile yaşantılarına ne derece katıldığının belirlenebilmesi öz farkındalık açısından gerekli olup ölçüm aracı ihtiyacını gündeme getirmiştir. Böylece, ailenin değerler ve manevi eğitimdeki tutumlarının ölçümlenmesi amacıyla 994 kişiden oluşan bir çalışma grubunda Üsküdar Ailede Manevi Yaşantı Ölçeğinin geliştirilmesi amaçlanmıştır. Ayrıca, günümüzde yaygın kullanılan sosyal medyanın günlük kullanım süresinin manevi yaşantıda fark yaratıp yaratmadığı da incelenmiştir. Yapılan geçerlilik ve güvenilirlik ça...

Research paper thumbnail of Electroconvulsive Therapy for the Anti-NMDA Receptor Encephalitis: A Case Report

Journal of Biomedical Research & Environmental Sciences

Anti-NMDA encephalitis is a rare autoimmune disorder that affects the central nervous system. We ... more Anti-NMDA encephalitis is a rare autoimmune disorder that affects the central nervous system. We report a case of a 22-year-old male patient with a history of prodromal flu-like symptoms followed by brief aggression episodes, paranoid symptoms, and stereotypic movements. Routine blood work, a brain MRI, and an EEG were normal. Cerebrospinal Fluid (CSF) studies show no abnormality, and the neuronal antibody panel was administered. Antipsychotics and benzodiazepines did not have any benefits, and Electroconvulsive Treatment (ECT) was recommended for the ongoing symptoms of catatonia. Movement disorders and cognition gradually improved after the second session of ECT. Later, CSF study results demonstrated the presence of anti-NMDA antibodies, and standard therapy was administered. Our case suggests that ECT may be an effective treatment option for patients with anti-NMDA encephalitis. Further studies are needed to confirm the efficacy and safety of ECT in this patient population.

Research paper thumbnail of Measuring the Awareness Levels of Individuals with Alcohol and Substance Use Disorders: Tertiary Prevention Standards and Development of Uskudar Result Awareness and Harm Perception Scales

Brain Sciences

Rationale: Alcohol and substance use disorders are types of brain diseases that have psychologica... more Rationale: Alcohol and substance use disorders are types of brain diseases that have psychological components which damage many life areas of the affected individual. Since investigating alcohol use alone is insufficient in the diagnostic evaluation process, self-awareness and the individual’s long-term psychological well-being are important in the treatment process. Primary prevention is used for preventing disease in healthy people, whereas secondary prevention is used for early diagnosis of people at risk. Tertiary prevention is important to prevent the recurrence of the disease. Since substance use disorders are a chronic problems, a new need has emerged for tertiary protection in rehabilitation standards. Methodology: In this study, we aimed to develop two scales that can provide ideas about rehabilitation standards by determining the awareness of individuals with or without alcohol and substance use disorders. By so, experts in the field can have information about the risk sta...

Research paper thumbnail of Low-frequency prefrontal cortex magnetic stimulation improves autism spectrum disorder symptoms: A pilot study

Journal of neurobehavioral sciences, 2023

Research paper thumbnail of An application of raman spectroscopy in combination with machine learning to determine gastric cancer spectroscopy marker

Computer Methods and Programs in Biomedicine

Research paper thumbnail of Analysis of follicular fluid and serum markers of oxidative stress in women with unexplained infertility by Raman and machine learning methods

Journal of Raman Spectroscopy

Oocytes are surrounded by a fluid called follicular fluid, which provides an essential microenvir... more Oocytes are surrounded by a fluid called follicular fluid, which provides an essential microenvironment for developing oocytes in human fertility. Various molecules exist in antral follicles, including proteins, steroid hormones, polysaccharides, metabolites, reactive oxygen species, and antioxidants. Oxidative stress is involved in the etiology of defective oocyte development or poor oocyte and embryo quality. Raman spectroscopy, a noninvasive method, can be used for biological diagnostics and direct chemical identification of follicular fluid. Therefore, we measured the oxidative index of follicular fluids and then attempted Raman spectroscopy on the follicular fluids combined with machine learning techniques to identify, detect, and quantify follicular fluid of unexplained infertility‐diagnosed women as a safe and effective tool to use as adjacent for clinical studies. This was a retrospective study set in an academic hospital where the patients were selected from an unexplained ...

Research paper thumbnail of Instagram Addiction Scale--Turkish Version

Research paper thumbnail of Multi-class classification model for psychiatric disorder discrimination

International Journal of Medical Informatics

Research paper thumbnail of PERMA Modeline Göre Pozitif Psikoloji Eğitiminin İyi Oluş Üzerine Etkisi

Üsküdar Üniversitesi Sosyal Bilimler Dergisi

Bu araştırmanın amacı, Pozitif Psikoloji eğitiminin PERMA modeline göre üniversite öğrencilerinin... more Bu araştırmanın amacı, Pozitif Psikoloji eğitiminin PERMA modeline göre üniversite öğrencilerinin iyi oluşu üzerine olan etkisini incelemektir. Araştırmada, öntest-sontest kontrol grubu olmayan yarı-deneysel desen kullanılmıştır. Araştırmanın örneklemi Üsküdar Üniversitesi’nde öğrenim gören ve araştırmaya katılmayı kabul eden 1209 öğrenciden oluşmaktadır. Araştırmada veri toplama aracı olarak PERMA Ölçeği kullanılmıştır. Araştırmada, öğrencilerin PERMA skorlarının ön-ölçüm ve son-ölçümünün karşılaştırılması için Eşleşmiş Örneklem t Testi uygulanmıştır. Ayrıca, cinsiyete göre PERMA alt boyut ve toplam skorlarının karşılaştırılması için Bağımsız Örneklem t testi yapılmıştır. Analizler, verilerin normallik ölçütünü sağlayan çarpıklık ve basıklık değerleri kontrol edildikten sonra SPSS 25.0 üzerinden gerçekleştirilmiştir. Araştırma bulgularına göre bir dönem boyunca (14 hafta) alınan Pozitif Psikoloji dersi PERMA modeliyle anlamlı ilişkili bulunmuştur. Çalışma üniversite öğrencilerinin ...

Research paper thumbnail of Y Kuşağının Dijital Oyun Bağımlılığının İncelenmesi

Online Journal of Technology Addiction and Cyberbullying, Jun 30, 2021

Bu araştırmanın amacı Y kuşağının dijital oyun bağımlılığının incelenmesidir. Araştırmada var ola... more Bu araştırmanın amacı Y kuşağının dijital oyun bağımlılığının incelenmesidir. Araştırmada var olan durumun tespit edilmesi amaçlandığından niceliksel betimleme yöntemi kullanılmıştır. Örneklemi; 1980-1999 yılları arasında doğan dijital oyunlara ilgisi olan 497 kişi oluşturmuştur. Katılımcıların yaşları 20 ile 40 arasında değişmektedir. Araştırmada veriler araştırmacılar tarafından hazırlanan "Kişisel Bilgi Formu" ve üniversite öğrencilerinin dijital oyun bağımlılığını ölçebilmek amacıyla Hazar ve Hazar (2019) tarafından geliştirilen ve geçerlilik ve güvenilirlik çalışması yapılan "Üniversite Öğrencileri için Dijital Oyun Bağımlılığı Ölçeği" kullanılarak toplanmıştır. Araştırmada, veri toplama araçları katılımcılara hem basılı hem dijital olarak uygulanmıştır. Verilerin analizi SPSS 25 programı ile yapılmış ve %95 güven düzeyi ile çalışılmıştır. Analizlerde parametrik yöntemler kullanılmıştır. Araştırma elde edilen birtakım bulgular şu şekildedir: (a) Y kuşağının dijital oyun bağımlılığı Riskli Grup'ta bulunmuştur; (b) Erkeklerin aşırı odaklanma ve erteleme, duygu değişimi ve dalma, dijital oyun bağımlılığı düzeylerinin kadınlardan daha yüksek olduğu belirlenmiştir; (c) Lise mezunlarının aşırı odaklanma ve erteleme, yoksunluk ve arayış, dijital oyun bağımlılığı düzeyleri en yüksektir; (d) İlkokul mezunlarının duygu değişimi ve dalma düzeyi en yüksektir. Araştırma

Research paper thumbnail of A Proposed Brain-, Spine-, and Mental- Health Screening Methodology (NEUROSCREEN) for Healthcare Systems: Position of the Society for Brain Mapping and Therapeutics

Journal of Alzheimer's Disease, 2022

The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive i... more The COVID-19 pandemic has accelerated neurological, mental health disorders, and neurocognitive issues. However, there is a lack of inexpensive and efficient brain evaluation and screening systems. As a result, a considerable fraction of patients with neurocognitive or psychobehavioral predicaments either do not get timely diagnosed or fail to receive personalized treatment plans. This is especially true in the elderly populations, wherein only 16% of seniors say they receive regular cognitive evaluations. Therefore, there is a great need for development of an optimized clinical brain screening workflow methodology like what is already in existence for prostate and breast exams. Such a methodology should be designed to facilitate objective early detection and cost-effective treatment of such disorders. In this paper we have reviewed the existing clinical protocols, recent technological advances and suggested reliable clinical workflows for brain screening. Such protocols range from ...

Research paper thumbnail of The effect of memorizing the quran on cognitive functions

The Journal of Neurobehavioral Sciences, 2021

Background: Memorizing the Quran is an education continuing from the early periods of Islamic edu... more Background: Memorizing the Quran is an education continuing from the early periods of Islamic education until today. Although this education started in the past to protect the Quran, nowadays, it is continuing as a tradition. Aims and Objectives: The main purpose of this study is to investigate the effects of memorizing the Quran on certain cognitive functions of individuals. Materials and Methods: The scope of the study is limited to 18 female and 15 male students who have been studying in the 5th, 6th, and 7th grades of Anatolian Imam Preacher Secondary Schools in different districts of İstanbul. After Demographic Information Questionnaire was used, California Verbal Learning Test children's version, Wechsler Memory Scale revised visual reproduction subtest, Trail Making Test, and Verbal Fluency Test were applied twice to collect data about individuals before and after memorization training. Results: Findings demonstrated that there is a statistically significant difference in verbal learning, visual learning, attention speed, and phonemic and semantic fluency before and after memorization training. Conclusion: In conclusion, memorizing the Quran has positive impacts on verbal and visual memory, attention processes, and lexical and semantic fluency of individuals. It is important with regard to eliminate emptiness in the literature. In future studies, it can be investigated the effects of textual memorization in a foreign language on brain structures and connections.

Research paper thumbnail of Health Literacy and Cyberchondria

Advances in Media, Entertainment, and the Arts, 2022

Although newly developing technologies contribute positively to human life, many studies have sho... more Although newly developing technologies contribute positively to human life, many studies have shown that it has some health risks. The widespread use of computers and mobile devices, in particular, have allowed the internet to be accessible by almost everyone and thus exposes them to health problems resulting from internet use. The aims of this study are to investigate negative health problems associated with internet use, the impact of new media tools on the health of individuals, to understand cyberchondria and to present solutions to reduce its effects. Furthermore, it was aimed to assess the status of cyberchondria and related factors as well health literacy in individuals using the internet to determine the necessary treatment options for cyberchondria, to clarify the conceptual status of cyberchondria for future research, and to develop evidence-based approaches. Findings indicate that when considering the relationship between health literacy and cyberchondria, the effect of h...

Research paper thumbnail of 25th European Congress of Psychiatry

Research paper thumbnail of A deep learning approach to evaluating sex differences in antidepressant response to neuromodulation using EEG in major depressive disorder

Research paper thumbnail of The adaptation of gender identity / gender dysphoria questionnaire for adults: Turkish validity and reliability studies

The Journal of Neurobehavioral Sciences, 2021

Background: The fact that the concepts of sexual identity and gender dysphoria have become more i... more Background: The fact that the concepts of sexual identity and gender dysphoria have become more important all over the world and in Turkey has led clinicians to need powerful measuring tools to evaluate and comment on this structure. Aims and Objectives: The aim of this study is to investigate language equivalence, validity, and reliability studies of the Turkish version of the Gender Identity / Gender Dysphoria Questionnaire for Adult (GIDQ), which was developed by Deogracias et al. (2007). Materials and Methods: The scale was applied to 368 individuals (heterosexual and nonheterosexual) consisting of university students and trans-oriented individuals. Pearson's correlation coefficients revealed positive and significant values in the consistency analysis between the English and Turkish forms for linguistic equivalence studies of the GIDQ Adult Form for ages 18 and over. Results: The factor analysis performed to determine the construct validity of the 5-item Likert type scale, the original of which has a single factor and 27 items, a single factor, and 25-item structure were obtained which accounted for 51.8% of the total variance. When the internal consistency of the scale was calculated, the Cronbach Alpha value was found to be 0.89. Conclusion: According to the comparison of three groups (heterosexual, nonheterosexual, and those with gender dysphoria), average calculations, and effect size (d) analyses in the discrimination validity studies, it was observed that the gender dissatisfaction of university students was at a low level. It was found to be close to the intermediate level in the nonheterosexual male group. The results show that the Turkish form of the scale is valid and reliable.