Nguyễn Tam Phong - Academia.edu (original) (raw)
Papers by Nguyễn Tam Phong
Journal of Infection, Jun 1, 2021
Emerging Infectious Diseases, May 1, 2023
BMC Infectious Diseases, Sep 3, 2022
Background: Dengue is a neglected tropical disease, for which no therapeutic agents have shown cl... more Background: Dengue is a neglected tropical disease, for which no therapeutic agents have shown clinical efficacy to date. Clinical trials have used strikingly variable clinical endpoints, which hampers reproducibility and comparability of findings. We investigated a delta modified Sequential Organ Failure Assessment (delta mSOFA) score as a uniform composite clinical endpoint for use in clinical trials investigating therapeutics for moderate and severe dengue. Methods: We developed a modified SOFA score for dengue, measured and evaluated its performance at baseline and 48 h after enrolment in a prospective observational cohort of 124 adults admitted to a tertiary referral hospital in Vietnam with dengue shock. The modified SOFA score included pulse pressure in the cardiovascular component. Binary logistic regression, cox proportional hazard and linear regression models were used to estimate association between mSOFA, delta mSOFA and clinical outcomes. Results: The analysis included 124 adults with dengue shock. 29 (23.4%) patients required ICU admission for organ support or due to persistent haemodynamic instability: 9/124 (7.3%) required mechanical ventilation, 8/124 (6.5%) required vasopressors, 6/124 (4.8%) required haemofiltration and 5/124 (4.0%) patients died. In univariate analyses, higher baseline and delta (48 h) mSOFA score for dengue were associated with admission to ICU, requirement for organ support and mortality, duration of ICU and hospital admission and IV fluid use. Conclusions: The baseline and delta mSOFA scores for dengue performed well to discriminate patients with dengue shock by clinical outcomes, including duration of ICU and hospital admission, requirement for organ support and death. We plan to use delta mSOFA as the primary endpoint in an upcoming host-directed therapeutic trial and investigate the performance of this score in other phenotypes of severe dengue in adults and children.
medRxiv (Cold Spring Harbor Laboratory), Apr 29, 2020
Guy Thwaites 2,5 , and Le Van Tan 2 , for OUCRU COVID-19 research group* *Members of the Group ar... more Guy Thwaites 2,5 , and Le Van Tan 2 , for OUCRU COVID-19 research group* *Members of the Group are listed in the acknowledgements
Critical Care
Background Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU)... more Background Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training available. Despite recent advances in the use of Artificial Intelligence (AI) to automate many ultrasound imaging analysis tasks, no AI-enabled LUS solutions have been proven to be clinically useful in ICUs, and specifically in LMICs. Therefore, we developed an AI solution that assists LUS practitioners and assessed its usefulness in a low resource ICU. Methods This was a three-phase prospective study. In the first phase, the performance of four different clinical user groups in interpreting LUS clips was assessed. In the second phase, the performance of 57 non-expert clinicians with and without the aid of a bespoke AI tool for LUS interpretation was assessed in retrospective offline clips. In the third phase, we conducted a prospective study in the ICU where 14 clinicia...
The Lancet
In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simp... more In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation.
ABSTRACTIn 2021, Vietnam experienced a large nationwide outbreak of COVID-19, with over 1.7 milli... more ABSTRACTIn 2021, Vietnam experienced a large nationwide outbreak of COVID-19, with over 1.7 million infections and 32,000 deaths. We generated 1,303 SARS-CoV-2 whole-genome sequences, and mapped out the public health measures alongside the evolutionary trajectory of the pathogen. The Alpha variant caused sporadic outbreaks in early 2021 prior to the upsurge in cases associated with the Delta variant from June onward. The Delta variant outbreak was almost entirely confined to the AY.57 lineage, accounting for 99.2% of 1,212 Delta variant sequences, and resulting from a single introduction. Viral dispersal from the north, where it was first introduced into Vietnam, to the south, marked the start of the nationwide outbreak, with the south subsequently seeding the virus back to the other regions. Distinct AY.57 phylogenetic clusters in different regions of Vietnam were documented, pointing to the impact of in-country lockdown. Genomic surveillance is critical to inform pandemic response.
SUMMARYBackgroundLow-dose corticosteroids have been shown to reduce mortality for hypoxic COVID-1... more SUMMARYBackgroundLow-dose corticosteroids have been shown to reduce mortality for hypoxic COVID-19 patients requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation or extra-corporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.MethodsThis randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (i.e. receiving oxygen or with oxygen saturation <92% on room air) were randomly allocated (1:1) to either usual care with higher dose corticosteroids (dexamethasone 20 mg once daily for 5 days followed by 10 mg once daily for 5 days or until discharge if sooner) or usual standard of care alone (which includes dexamethasone 6 mg once daily for 10 days or until discharge if sooner)....
PROCEEDINGS
Lựa chọn được người kỹ sư quản lý thi công có năng lực sẽ giúp việc thực hiện các dự án đầu tư xâ... more Lựa chọn được người kỹ sư quản lý thi công có năng lực sẽ giúp việc thực hiện các dự án đầu tư xây dựng công trình của nhà thầu xây dựng hoàn thành đúng thời hạn, đúng chi phí nhưng vẫn đảm bảo chất lượng đề ra. Mục tiêu của nghiên cứu này là nhằm nhận dạng một số tiêu chí quan trọng trong quá trình đánh giá và lựa chọn người kỹ sư quản lý thi công công trình dân dụng và công nghiệp. Dựa trên khảo lược tài liệu nghiên cứu kết hợp phỏng vấn chuyên gia và phương pháp khảo sát bằng bảng câu hỏi, có 31 tiêu chí đánh giá và lựa chọn kỹ sư quản lý thi công xây dựng đã được đề xuất, bao gồm 3 nhóm chính: (i) Nhóm các tiêu chí liên quan kiến thức chuyên môn; (ii) Nhóm các tiêu chí liên quan kỹ năng mềm; và (iii) Nhóm các tiêu chí liên quan đến kinh nghiệm và thái độ làm việc. Selecting a capable construction management engineer will help the construction contractor's construction investment projects to be completed on time, at the right cost but still with good quality. The objective of...
HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY
This paper aims to find out the current state of the high-class apartment market. Qualitative res... more This paper aims to find out the current state of the high-class apartment market. Qualitative research is done to adjust and supplement the observed variables for the scale. Quantitative research is conducted through a survey of customers who have bought a high-class apartment or are intending to buy an apartment to build a research model and test the scale. After collecting data, the study conducted the descriptive statistical analysis, testing the reliability of scale. Then, the Exploratory Factor Analysis (EFA) was performed to group the related factors into groups of factors that are independent. The research results showed that there are eight main groups of factors with 31 related observational variables that affected customers' decisions to choose high-class apartments.
KỶ YẾU HỘI NGHỊ KHOA HỌC CÔNG NGHỆ QUỐC GIA LẦN THỨ XII NGHIÊN CỨU CƠ BẢN VÀ ỨNG DỤNG CÔNG NGHỆ THÔNG TIN, 2019
Tại Đài Tiếng nói Việt Nam (TNVN), các kênh âm thanh số hiện nay đang được mã hóa theo chuẩn khôn... more Tại Đài Tiếng nói Việt Nam (TNVN), các kênh âm thanh số hiện nay đang được mã hóa theo chuẩn không nén. Do bản chất mà những tệp âm thanh dạng không nén có dung lượng cực lớn, vì vậy yêu cầu dung lượng ổ cứng lưu trữ các chương trình phát thanh rất lớn và việc thao tác trên các đoạn âm thanh rất khó khăn. Nghiên cứu được thực hiện nhằm kiểm tra việc áp dụng thử nghiệm các chuẩn nén âm thanh tại Đài TNVN, chuẩn bị cho việc triển khai mã hóa nén âm thanh tại Đài theo kế hoạch. Hai chuẩn nén âm thanh số có tổn hao chất lượng cao được chọn để đánh giá hiệu năng và chất lượng là MP3 (Moving Picture Experts Group 1-Layer 3) và AAC (Moving Picture Experts Group 2-Advanced Audio Coding). Lần lượt các chuẩn MP3 và AAC được áp dụng cho 18 tệp âm thanh trích chọn từ các chương trình khác nhau gần đây của Đài với tổng dung lượng là 5546MB (tương đương thời lượng hơn 8 giờ), sau đó được đánh giá dựa trên các tiêu chí về hiệu năng bao gồm thời gian thực thi và tỷ lệ nén. Tiêu chí chất lượng nén được đánh giá bằng phương pháp chủ quan dựa vào nghe thử. Thí nghiệm nghe thử được tiến hành trên 24 đoạn âm thanh ngắn nhiều thể loại, mỗi đoạn kéo dài trung bình là 20 giây, với số lượng tình nguyện viên tham gia là 35 người. Kết quả nghiên cứu cho thấy tính khả thi của việc áp dụng các chuẩn nén âm thanh mới tại đài TNVN, đặc biệt giúp xác định tập giá trị các tham số phù hợp nhất đối với từng chuẩn nén nhằm tiết kiệm dung lượng lưu trữ dữ liệu và giảm thời gian thao tác trên tín hiệu trong khi vẫn đảm bảo chất lượng dịch vụ phát thanh.
eClinicalMedicine, 2021
Background: Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals ar... more Background: Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals are limited. Methods: We studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam. We collected demographic and clinical data alongside serial PCR testing, measurement of SARS-CoV-2 antibodies, and viral whole-genome sequencing. Findings: Between 11 th À25 th June 2021 (7-8 weeks after the second dose), 69 staff tested positive for SARS-CoV-2. 62 participated in the study. Most were asymptomatic or mildly symptomatic and all recovered. Twenty-two complete-genome sequences were obtained; all were Delta variant and were phylogenetically distinct from contemporary viruses obtained from the community or from hospital patients admitted prior to the outbreak. Viral loads inferred from Ct values were 251 times higher than in cases infected with the original strain in March/April 2020. Median time from diagnosis to negative PCR was 21 days (range 8À33). Neutralizing antibodies (expressed as percentage of inhibition) measured after the second vaccine dose, or at diagnosis, were lower in cases than in uninfected, fully vaccinated controls (median (IQR): 69.4 (50.7-89.1) vs. 91.3 (79.6-94.9), p=0.005 and 59.4 (32.5-73.1) vs. 91.1 (77.3-94.2), p=0.002). There was no correlation between vaccine-induced neutralizing antibody levels and peak viral loads or the development of symptoms. Interpretation: Breakthrough Delta variant infections following Oxford-AstraZeneca vaccination may cause asymptomatic or mild disease, but are associated with high viral loads, prolonged PCR positivity and low levels of vaccine-induced neutralizing antibodies. Epidemiological and sequence data suggested ongoing transmission had occurred between fully vaccinated individuals.
SSRN Electronic Journal, 2021
Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited. Methods: We stu... more Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited. Methods: We studied breakthrough infections among healthcare workers of a major infectious diseases hospital in Vietnam. We collected demographics, vaccination history and results of PCR diagnosis alongside clinical data. We measured SARS-CoV-2 (neutralizing) antibodies at diagnosis, and at week 1, 2 and 3 after diagnosis. We sequenced the viruses using ARTIC protocol. Findings: Between 11 th-25 th June 2021 (week 7-8 after dose 2), 69 healthcare workers were tested positive for SARS-CoV-2. 62 participated in the clinical study. 49 were (pre)symptomatic with one requiring oxygen supplementation. All recovered uneventfully. 23 complete-genome sequences were obtained. They all belonged to the Delta variant, and were phylogenetically distinct from the contemporary Delta variant sequences obtained from community transmission cases, suggestive of ongoing transmission between the workers. Viral loads of breakthrough Delta variant infection cases were 251 times higher than those of cases infected with old strains detected between March-April 2020. Time from diagnosis to PCR negative was 8-33 days (median: 21). Neutralizing antibody levels after vaccination and at diagnosis of the cases were lower than those in the matched uninfected controls. There was no correlation between vaccine-induced neutralizing antibody levels and viral loads or the development of symptoms. Interpretation: Breakthrough Delta variant infections are associated with high viral loads, prolonged PCR positivity, and low levels of vaccine-induced neutralizing antibodies, explaining the transmission between the vaccinated people. Physical distancing measures remain critical to reduce SARS-CoV-2 Delta variant transmission.
PLOS ONE, 2021
Increasing numbers of people are surviving critical illness throughout the world, but survivorshi... more Increasing numbers of people are surviving critical illness throughout the world, but survivorship is associated with long-term disability. In high-income settings physical rehabilitation is commonly employed to counter this and improve outcomes. These utilize highly-trained multidisciplinary teams and are unavailable and unaffordable in most low and middle income countries (LMICs). We aimed to design a sustainable intensive care unit (ICU) rehabilitation program and to evaluate its feasibility in a LMIC setting. In this project patients, care-givers and experts co-designed an innovative rehabilitation programme that can be delivered by non-expert ICU staff and family care-givers in a LMIC. We implemented this programme in adult patient with patients with tetanus at the Hospital for Tropical Diseases, Ho Chi Minh City over a 5-month period, evaluating the programme’s acceptability, enablers and barriers. A 6-phase programme was designed, supported by written and video material. The ...
Wellcome Open Research, 2020
Background: COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and caus... more Background: COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent COVID-19 or therapeutic agent to treat COVID-19. This clinical trial is designed to evaluate chloroquine as a potential therapeutic for the treatment of hospitalised people with COVID-19. We hypothesise that chloroquine slows viral replication in patients with COVID-19, attenuating the infection, and resulting in more rapid decline of viral load in throat/nose swabs. This viral attenuation should be associated with improved patient outcomes. Method: The study will start with a 10-patient prospective observational pilot study following the same entry and exclusion criteria as for the randomized trial and undergoing the same procedures. The main study is an open label, randomised, controlled trial with two parallel arms of standard of care (control arm) versus standard of care with 10 days of chloroquine (inte...
Wellcome Open Research, 2020
Background: Dengue is a disease of major global importance. While most symptomatic infections ar... more Background: Dengue is a disease of major global importance. While most symptomatic infections are mild, a small proportion of patients progress to severe disease with risk of hypovolaemic shock, organ dysfunction and death. In the absence of effective antiviral or disease modifying drugs, clinical management is solely reliant on supportive measures. Obesity is a growing problem among young people in Vietnam and is increasingly recognised as an important risk factor for severe dengue, likely due to alterations in host immune and inflammatory pathways. Metformin, a widely used anti-hyperglycaemic agent with excellent safety profile, has demonstrated potential as a dengue therapeutic in vitro and in a retrospective observational study of adult dengue patients with type 2 diabetes. This study aims to assess the safety and tolerability of metformin treatment in overweight and obese dengue patients, and investigate its effects on several clinical, immunological and virological markers ...
Metagenomics could detect SARS-CoV-2 in all eight nasopharyngeal/throat swabs with high/low viral... more Metagenomics could detect SARS-CoV-2 in all eight nasopharyngeal/throat swabs with high/low viral loads, and rhinovirus in a co-infected patient. The sequenced viruses belonged to lineage B1. Because metagenomics could detect novel pathogen and co-infection, and generate sequence data for epidemiological investigation, it is an attractive approach for infectious-disease diagnosis.
Science and Technology Development Journal, 2009
This study has investigated in a comparative fashion the effect of cation, polysaccharide, and Po... more This study has investigated in a comparative fashion the effect of cation, polysaccharide, and Polyelectrolyte on the flocculation dynamics and final properties of both synthetic and activated sludge. The results from experiments indicate that cation, polysaccharide, and Polyelectrolyte could influence sludge floc characteristics as they relate to sludge conditioning. The relationship between polysaccharide and cation concentration was examined at laboratory scale during flocculation with both synthetic and activated sludge; an increase in feed cation concentration led to a decrease in final polysaccharide concentration of the supernatant. The effects of a polyelectrolyte conditioner on sludge conditioning were determined. The results indicated that the cationic Polyelectrolyte had the critical effect on sludge dewatering, and made the improvement of the final properties of sludge. A qualitative link exists between polyelectrolyte conditioner dosage and sludge conditioning for both ...
Journal of Infection, 2020
SARS-CoV-2 and co-infections detection in nasopharyngeal throat swabs of COVID-19 patients by met... more SARS-CoV-2 and co-infections detection in nasopharyngeal throat swabs of COVID-19 patients by metagenomics
Jurnal Ekonomi & Studi Pembangunan, 2020
This research is to identify the impacts of natural disaster risk on households of local resident... more This research is to identify the impacts of natural disaster risk on households of local residents and to identify the adaptation of households with natural disaster risk in Giao Thien commune, Giao Thuy district, Nam Dinh province, Vietnam. Both qualitative and quantitative methods are applied in this study to assess the overall impact of disasters on the livelihood strategies of households in response to natural disaster. The findings show that the risks of natural disasters affecting the livelihood of the local population in the study area are typhoons, floods, coastal erosion/ sea level rise, and saltwater intrusion. Currently, people in the researching area are not merely affected by one disaster but usually 2-3 or even 4 types of disasters in a short period of time. Therefore, this leads to economic losses, in the form of assets of the households. There are 6 solutions to cope with disaster risks that people often used to reduce the damage include: (1) regularly monitor information; (2) Change season calendar; (3) Change crop varieties; (4) Buy insurance; (5) Save of fertilizer and pesticide inputs; (6) Save seed production.
Journal of Infection, Jun 1, 2021
Emerging Infectious Diseases, May 1, 2023
BMC Infectious Diseases, Sep 3, 2022
Background: Dengue is a neglected tropical disease, for which no therapeutic agents have shown cl... more Background: Dengue is a neglected tropical disease, for which no therapeutic agents have shown clinical efficacy to date. Clinical trials have used strikingly variable clinical endpoints, which hampers reproducibility and comparability of findings. We investigated a delta modified Sequential Organ Failure Assessment (delta mSOFA) score as a uniform composite clinical endpoint for use in clinical trials investigating therapeutics for moderate and severe dengue. Methods: We developed a modified SOFA score for dengue, measured and evaluated its performance at baseline and 48 h after enrolment in a prospective observational cohort of 124 adults admitted to a tertiary referral hospital in Vietnam with dengue shock. The modified SOFA score included pulse pressure in the cardiovascular component. Binary logistic regression, cox proportional hazard and linear regression models were used to estimate association between mSOFA, delta mSOFA and clinical outcomes. Results: The analysis included 124 adults with dengue shock. 29 (23.4%) patients required ICU admission for organ support or due to persistent haemodynamic instability: 9/124 (7.3%) required mechanical ventilation, 8/124 (6.5%) required vasopressors, 6/124 (4.8%) required haemofiltration and 5/124 (4.0%) patients died. In univariate analyses, higher baseline and delta (48 h) mSOFA score for dengue were associated with admission to ICU, requirement for organ support and mortality, duration of ICU and hospital admission and IV fluid use. Conclusions: The baseline and delta mSOFA scores for dengue performed well to discriminate patients with dengue shock by clinical outcomes, including duration of ICU and hospital admission, requirement for organ support and death. We plan to use delta mSOFA as the primary endpoint in an upcoming host-directed therapeutic trial and investigate the performance of this score in other phenotypes of severe dengue in adults and children.
medRxiv (Cold Spring Harbor Laboratory), Apr 29, 2020
Guy Thwaites 2,5 , and Le Van Tan 2 , for OUCRU COVID-19 research group* *Members of the Group ar... more Guy Thwaites 2,5 , and Le Van Tan 2 , for OUCRU COVID-19 research group* *Members of the Group are listed in the acknowledgements
Critical Care
Background Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU)... more Background Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training available. Despite recent advances in the use of Artificial Intelligence (AI) to automate many ultrasound imaging analysis tasks, no AI-enabled LUS solutions have been proven to be clinically useful in ICUs, and specifically in LMICs. Therefore, we developed an AI solution that assists LUS practitioners and assessed its usefulness in a low resource ICU. Methods This was a three-phase prospective study. In the first phase, the performance of four different clinical user groups in interpreting LUS clips was assessed. In the second phase, the performance of 57 non-expert clinicians with and without the aid of a bespoke AI tool for LUS interpretation was assessed in retrospective offline clips. In the third phase, we conducted a prospective study in the ICU where 14 clinicia...
The Lancet
In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simp... more In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation.
ABSTRACTIn 2021, Vietnam experienced a large nationwide outbreak of COVID-19, with over 1.7 milli... more ABSTRACTIn 2021, Vietnam experienced a large nationwide outbreak of COVID-19, with over 1.7 million infections and 32,000 deaths. We generated 1,303 SARS-CoV-2 whole-genome sequences, and mapped out the public health measures alongside the evolutionary trajectory of the pathogen. The Alpha variant caused sporadic outbreaks in early 2021 prior to the upsurge in cases associated with the Delta variant from June onward. The Delta variant outbreak was almost entirely confined to the AY.57 lineage, accounting for 99.2% of 1,212 Delta variant sequences, and resulting from a single introduction. Viral dispersal from the north, where it was first introduced into Vietnam, to the south, marked the start of the nationwide outbreak, with the south subsequently seeding the virus back to the other regions. Distinct AY.57 phylogenetic clusters in different regions of Vietnam were documented, pointing to the impact of in-country lockdown. Genomic surveillance is critical to inform pandemic response.
SUMMARYBackgroundLow-dose corticosteroids have been shown to reduce mortality for hypoxic COVID-1... more SUMMARYBackgroundLow-dose corticosteroids have been shown to reduce mortality for hypoxic COVID-19 patients requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation or extra-corporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.MethodsThis randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (i.e. receiving oxygen or with oxygen saturation <92% on room air) were randomly allocated (1:1) to either usual care with higher dose corticosteroids (dexamethasone 20 mg once daily for 5 days followed by 10 mg once daily for 5 days or until discharge if sooner) or usual standard of care alone (which includes dexamethasone 6 mg once daily for 10 days or until discharge if sooner)....
PROCEEDINGS
Lựa chọn được người kỹ sư quản lý thi công có năng lực sẽ giúp việc thực hiện các dự án đầu tư xâ... more Lựa chọn được người kỹ sư quản lý thi công có năng lực sẽ giúp việc thực hiện các dự án đầu tư xây dựng công trình của nhà thầu xây dựng hoàn thành đúng thời hạn, đúng chi phí nhưng vẫn đảm bảo chất lượng đề ra. Mục tiêu của nghiên cứu này là nhằm nhận dạng một số tiêu chí quan trọng trong quá trình đánh giá và lựa chọn người kỹ sư quản lý thi công công trình dân dụng và công nghiệp. Dựa trên khảo lược tài liệu nghiên cứu kết hợp phỏng vấn chuyên gia và phương pháp khảo sát bằng bảng câu hỏi, có 31 tiêu chí đánh giá và lựa chọn kỹ sư quản lý thi công xây dựng đã được đề xuất, bao gồm 3 nhóm chính: (i) Nhóm các tiêu chí liên quan kiến thức chuyên môn; (ii) Nhóm các tiêu chí liên quan kỹ năng mềm; và (iii) Nhóm các tiêu chí liên quan đến kinh nghiệm và thái độ làm việc. Selecting a capable construction management engineer will help the construction contractor's construction investment projects to be completed on time, at the right cost but still with good quality. The objective of...
HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY
This paper aims to find out the current state of the high-class apartment market. Qualitative res... more This paper aims to find out the current state of the high-class apartment market. Qualitative research is done to adjust and supplement the observed variables for the scale. Quantitative research is conducted through a survey of customers who have bought a high-class apartment or are intending to buy an apartment to build a research model and test the scale. After collecting data, the study conducted the descriptive statistical analysis, testing the reliability of scale. Then, the Exploratory Factor Analysis (EFA) was performed to group the related factors into groups of factors that are independent. The research results showed that there are eight main groups of factors with 31 related observational variables that affected customers' decisions to choose high-class apartments.
KỶ YẾU HỘI NGHỊ KHOA HỌC CÔNG NGHỆ QUỐC GIA LẦN THỨ XII NGHIÊN CỨU CƠ BẢN VÀ ỨNG DỤNG CÔNG NGHỆ THÔNG TIN, 2019
Tại Đài Tiếng nói Việt Nam (TNVN), các kênh âm thanh số hiện nay đang được mã hóa theo chuẩn khôn... more Tại Đài Tiếng nói Việt Nam (TNVN), các kênh âm thanh số hiện nay đang được mã hóa theo chuẩn không nén. Do bản chất mà những tệp âm thanh dạng không nén có dung lượng cực lớn, vì vậy yêu cầu dung lượng ổ cứng lưu trữ các chương trình phát thanh rất lớn và việc thao tác trên các đoạn âm thanh rất khó khăn. Nghiên cứu được thực hiện nhằm kiểm tra việc áp dụng thử nghiệm các chuẩn nén âm thanh tại Đài TNVN, chuẩn bị cho việc triển khai mã hóa nén âm thanh tại Đài theo kế hoạch. Hai chuẩn nén âm thanh số có tổn hao chất lượng cao được chọn để đánh giá hiệu năng và chất lượng là MP3 (Moving Picture Experts Group 1-Layer 3) và AAC (Moving Picture Experts Group 2-Advanced Audio Coding). Lần lượt các chuẩn MP3 và AAC được áp dụng cho 18 tệp âm thanh trích chọn từ các chương trình khác nhau gần đây của Đài với tổng dung lượng là 5546MB (tương đương thời lượng hơn 8 giờ), sau đó được đánh giá dựa trên các tiêu chí về hiệu năng bao gồm thời gian thực thi và tỷ lệ nén. Tiêu chí chất lượng nén được đánh giá bằng phương pháp chủ quan dựa vào nghe thử. Thí nghiệm nghe thử được tiến hành trên 24 đoạn âm thanh ngắn nhiều thể loại, mỗi đoạn kéo dài trung bình là 20 giây, với số lượng tình nguyện viên tham gia là 35 người. Kết quả nghiên cứu cho thấy tính khả thi của việc áp dụng các chuẩn nén âm thanh mới tại đài TNVN, đặc biệt giúp xác định tập giá trị các tham số phù hợp nhất đối với từng chuẩn nén nhằm tiết kiệm dung lượng lưu trữ dữ liệu và giảm thời gian thao tác trên tín hiệu trong khi vẫn đảm bảo chất lượng dịch vụ phát thanh.
eClinicalMedicine, 2021
Background: Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals ar... more Background: Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals are limited. Methods: We studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam. We collected demographic and clinical data alongside serial PCR testing, measurement of SARS-CoV-2 antibodies, and viral whole-genome sequencing. Findings: Between 11 th À25 th June 2021 (7-8 weeks after the second dose), 69 staff tested positive for SARS-CoV-2. 62 participated in the study. Most were asymptomatic or mildly symptomatic and all recovered. Twenty-two complete-genome sequences were obtained; all were Delta variant and were phylogenetically distinct from contemporary viruses obtained from the community or from hospital patients admitted prior to the outbreak. Viral loads inferred from Ct values were 251 times higher than in cases infected with the original strain in March/April 2020. Median time from diagnosis to negative PCR was 21 days (range 8À33). Neutralizing antibodies (expressed as percentage of inhibition) measured after the second vaccine dose, or at diagnosis, were lower in cases than in uninfected, fully vaccinated controls (median (IQR): 69.4 (50.7-89.1) vs. 91.3 (79.6-94.9), p=0.005 and 59.4 (32.5-73.1) vs. 91.1 (77.3-94.2), p=0.002). There was no correlation between vaccine-induced neutralizing antibody levels and peak viral loads or the development of symptoms. Interpretation: Breakthrough Delta variant infections following Oxford-AstraZeneca vaccination may cause asymptomatic or mild disease, but are associated with high viral loads, prolonged PCR positivity and low levels of vaccine-induced neutralizing antibodies. Epidemiological and sequence data suggested ongoing transmission had occurred between fully vaccinated individuals.
SSRN Electronic Journal, 2021
Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited. Methods: We stu... more Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited. Methods: We studied breakthrough infections among healthcare workers of a major infectious diseases hospital in Vietnam. We collected demographics, vaccination history and results of PCR diagnosis alongside clinical data. We measured SARS-CoV-2 (neutralizing) antibodies at diagnosis, and at week 1, 2 and 3 after diagnosis. We sequenced the viruses using ARTIC protocol. Findings: Between 11 th-25 th June 2021 (week 7-8 after dose 2), 69 healthcare workers were tested positive for SARS-CoV-2. 62 participated in the clinical study. 49 were (pre)symptomatic with one requiring oxygen supplementation. All recovered uneventfully. 23 complete-genome sequences were obtained. They all belonged to the Delta variant, and were phylogenetically distinct from the contemporary Delta variant sequences obtained from community transmission cases, suggestive of ongoing transmission between the workers. Viral loads of breakthrough Delta variant infection cases were 251 times higher than those of cases infected with old strains detected between March-April 2020. Time from diagnosis to PCR negative was 8-33 days (median: 21). Neutralizing antibody levels after vaccination and at diagnosis of the cases were lower than those in the matched uninfected controls. There was no correlation between vaccine-induced neutralizing antibody levels and viral loads or the development of symptoms. Interpretation: Breakthrough Delta variant infections are associated with high viral loads, prolonged PCR positivity, and low levels of vaccine-induced neutralizing antibodies, explaining the transmission between the vaccinated people. Physical distancing measures remain critical to reduce SARS-CoV-2 Delta variant transmission.
PLOS ONE, 2021
Increasing numbers of people are surviving critical illness throughout the world, but survivorshi... more Increasing numbers of people are surviving critical illness throughout the world, but survivorship is associated with long-term disability. In high-income settings physical rehabilitation is commonly employed to counter this and improve outcomes. These utilize highly-trained multidisciplinary teams and are unavailable and unaffordable in most low and middle income countries (LMICs). We aimed to design a sustainable intensive care unit (ICU) rehabilitation program and to evaluate its feasibility in a LMIC setting. In this project patients, care-givers and experts co-designed an innovative rehabilitation programme that can be delivered by non-expert ICU staff and family care-givers in a LMIC. We implemented this programme in adult patient with patients with tetanus at the Hospital for Tropical Diseases, Ho Chi Minh City over a 5-month period, evaluating the programme’s acceptability, enablers and barriers. A 6-phase programme was designed, supported by written and video material. The ...
Wellcome Open Research, 2020
Background: COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and caus... more Background: COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent COVID-19 or therapeutic agent to treat COVID-19. This clinical trial is designed to evaluate chloroquine as a potential therapeutic for the treatment of hospitalised people with COVID-19. We hypothesise that chloroquine slows viral replication in patients with COVID-19, attenuating the infection, and resulting in more rapid decline of viral load in throat/nose swabs. This viral attenuation should be associated with improved patient outcomes. Method: The study will start with a 10-patient prospective observational pilot study following the same entry and exclusion criteria as for the randomized trial and undergoing the same procedures. The main study is an open label, randomised, controlled trial with two parallel arms of standard of care (control arm) versus standard of care with 10 days of chloroquine (inte...
Wellcome Open Research, 2020
Background: Dengue is a disease of major global importance. While most symptomatic infections ar... more Background: Dengue is a disease of major global importance. While most symptomatic infections are mild, a small proportion of patients progress to severe disease with risk of hypovolaemic shock, organ dysfunction and death. In the absence of effective antiviral or disease modifying drugs, clinical management is solely reliant on supportive measures. Obesity is a growing problem among young people in Vietnam and is increasingly recognised as an important risk factor for severe dengue, likely due to alterations in host immune and inflammatory pathways. Metformin, a widely used anti-hyperglycaemic agent with excellent safety profile, has demonstrated potential as a dengue therapeutic in vitro and in a retrospective observational study of adult dengue patients with type 2 diabetes. This study aims to assess the safety and tolerability of metformin treatment in overweight and obese dengue patients, and investigate its effects on several clinical, immunological and virological markers ...
Metagenomics could detect SARS-CoV-2 in all eight nasopharyngeal/throat swabs with high/low viral... more Metagenomics could detect SARS-CoV-2 in all eight nasopharyngeal/throat swabs with high/low viral loads, and rhinovirus in a co-infected patient. The sequenced viruses belonged to lineage B1. Because metagenomics could detect novel pathogen and co-infection, and generate sequence data for epidemiological investigation, it is an attractive approach for infectious-disease diagnosis.
Science and Technology Development Journal, 2009
This study has investigated in a comparative fashion the effect of cation, polysaccharide, and Po... more This study has investigated in a comparative fashion the effect of cation, polysaccharide, and Polyelectrolyte on the flocculation dynamics and final properties of both synthetic and activated sludge. The results from experiments indicate that cation, polysaccharide, and Polyelectrolyte could influence sludge floc characteristics as they relate to sludge conditioning. The relationship between polysaccharide and cation concentration was examined at laboratory scale during flocculation with both synthetic and activated sludge; an increase in feed cation concentration led to a decrease in final polysaccharide concentration of the supernatant. The effects of a polyelectrolyte conditioner on sludge conditioning were determined. The results indicated that the cationic Polyelectrolyte had the critical effect on sludge dewatering, and made the improvement of the final properties of sludge. A qualitative link exists between polyelectrolyte conditioner dosage and sludge conditioning for both ...
Journal of Infection, 2020
SARS-CoV-2 and co-infections detection in nasopharyngeal throat swabs of COVID-19 patients by met... more SARS-CoV-2 and co-infections detection in nasopharyngeal throat swabs of COVID-19 patients by metagenomics
Jurnal Ekonomi & Studi Pembangunan, 2020
This research is to identify the impacts of natural disaster risk on households of local resident... more This research is to identify the impacts of natural disaster risk on households of local residents and to identify the adaptation of households with natural disaster risk in Giao Thien commune, Giao Thuy district, Nam Dinh province, Vietnam. Both qualitative and quantitative methods are applied in this study to assess the overall impact of disasters on the livelihood strategies of households in response to natural disaster. The findings show that the risks of natural disasters affecting the livelihood of the local population in the study area are typhoons, floods, coastal erosion/ sea level rise, and saltwater intrusion. Currently, people in the researching area are not merely affected by one disaster but usually 2-3 or even 4 types of disasters in a short period of time. Therefore, this leads to economic losses, in the form of assets of the households. There are 6 solutions to cope with disaster risks that people often used to reduce the damage include: (1) regularly monitor information; (2) Change season calendar; (3) Change crop varieties; (4) Buy insurance; (5) Save of fertilizer and pesticide inputs; (6) Save seed production.