Nhu Nguyen - Academia.edu (original) (raw)

Papers by Nhu Nguyen

Research paper thumbnail of Nine new Candida species near C. membranifaciens isolated from insects

Mycological Research, 2005

Research paper thumbnail of Communities of microbes that inhabit the changing hindgut landscape of a subsocial beetle

Arthropod Structure & Development, 2006

Microbes that have adopted endosymbiotic life styles not only have evolved to live in specialized... more Microbes that have adopted endosymbiotic life styles not only have evolved to live in specialized habitats within living organisms, but the living habitats also have evolved to accommodate them. The hindgut of the passalid beetle (Odontotaenius disjunctus) is lined with a cuticle that undergoes dramatic topographic changes during the life cycle of the beetle. This manuscript addresses the changes that have been observed in time and space for the cuticular landscape of the hindgut as well as for the microbial communities within the hindgut. Microbial identity is based on morphology, culture, and extrapolation from previously reported passalid gut inhabitants. q

Research paper thumbnail of Metschnikowia noctiluminum sp. nov., Metschnikowia corniflorae sp. nov., and Candida chrysomelidarum sp. nov., isolated from green lacewings and beetles

Mycological Research, 2006

Research paper thumbnail of The status and characterization of Enteroramus dimorphus: a xylose-fermenting yeast attached to the gut of beetles

Enteroramus dimorphus from the gut of the passalid beetle Odontotaenius disjunctus was described ... more Enteroramus dimorphus from the gut of the passalid beetle Odontotaenius disjunctus was described originally as a yeast-like fungus of unknown taxonomic affiliation. The fungus can be observed in situ, attached by a specialized cell to the beetle hindgut wall. In a recent study of yeast endosymbionts from a variety of beetles, we discovered that E. dimorphus is a member of the Pichia stipitis (Saccharomycetes) clade, known for xylose fermentation and assimilation. The closest relative of E. dimorphus is the PASS1 isolate, repeatedly acquired from passalid beetles in eastern North America from Pennsylvania to Louisiana. In addition to xylose fermentation and assimilation, these yeasts are characterized by the production of hat-shaped ascospores in culture, assimilation of a wide range of sugars, and synthesis of several vitamins. Enteroramus dimorphus, however, can be distinguished from close relatives by several physiological characteristics and rDNA sequences, which vary slightly from the more widespread PASS1 genotype. We present an amended description of E. dimorphus and discuss its symbiotic phase in association with O. disjunctus, including a holdfast that parallels those of unrelated symbiotic yeasts associated with nematodes.

Research paper thumbnail of No trend toward a spontaneous improvement of hyperparathyroidism and high bone turnover in normocalcemic long-term renal transplant recipients

American Journal of Kidney Diseases, 1997

Although hyperparathyroidism is a common feature in renal transplant recipients, the long-term co... more Although hyperparathyroidism is a common feature in renal transplant recipients, the long-term course of parathyroid hormone (PTH) secretion in these patients is not well established, and the actual contribution of PTH to posttransplant bone disease remains incompletely understood. Therefore, we studied calcium-regulating hormones and serum osteocalcin, as a marker of bone remodeling, in 82 normocalcemic renal transplant recipients with good renal function who had received a graft 6 to 73 months previously and in 82 healthy subjects matched for age and sex. In all subjects, fasting serum and 24-hour urinary samples were collected. The transplant recipients had excessive PTH secretion (serum PTH, 6.9 ± 0.5 pmol/L in recipients v 3.0 ± 0.1 pmol/L in healthy subjects; P < 0.001) and high bone turnover (osteocalcin, 16.6 ± 0.8 μg/L v 8.0 ± 0.3 μg/L; P < 0.001). (Values are mean SEM.) In addition, transplant recipients had a slightly higher ionized calcium than the healthy subjects, providing definite evidence of an inappropriate PTH secretion in renal transplant recipients. Furthermore, in subgroups of 25 recipients and 25 healthy controls matched for creatinine clearance, the results superimposed those obtained in the whole groups, suggesting that excessive PTH secretion and high bone turnover in renal transplant recipients did not merely reflect the moderately reduced renal function of some recipients. In the whole group of transplant recipients, PTH correlated positively with osteocalcin (r = 0.40; P < 0.001), suggesting that PTH contributes at least partly to posttransplant bone disease. Conversely, there was no correlation between serum PTH or osteocalcin and the delay from grafting. Therefore, our results provide no evidence for a spontaneous improvement of either persistent hyperparathyroidism or high bone turnover in normocalcemic long-term renal transplant recipients.

Research paper thumbnail of LACK OF EVIDENCE THAT CYCLOSPORINE TREATMENT IMPAIRS CALCIUM-PHOSPHORUS HOMEOSTASIS AND BONE REMODELING IN NORMOCALCEMIC LONG-TERM RENAL TRANSPLANT RECIPIENTS

Transplantation, 1995

Since the effects of cyclosporine on mineral and bone metabolism are controversial, we studied ca... more Since the effects of cyclosporine on mineral and bone metabolism are controversial, we studied calcium regulating hormones, calcium-phosphorus (Ca-P) metabolism, and bone remodeling, assessed by serum osteocalcin, in long-term renal transplant recipients (RT). Forty-seven normocalcemic patients with good renal function receiving cyclosporine (CT, n = 27) or not (NC, n = 20) were studied at baseline and after an oral Ca load. CT and NC had similar age, daily dose of steroids, GFR level, and duration of transplantation. Baseline evaluation included 24-hr urinary Ca, P, TRP, TmP/GFR, fasting serum intact PTH, 1,25-(OH)2D, 25OHD, osteocalcin, Ca, and P. Subjects of the two groups had excessive secretion of PTH, tubular P wasting, and high serum osteocalcin level, as is usual in RT. However, there was no difference between CT and NC regarding any baseline variable. Ten CT and ten NC, matched for duration of transplantation and serum PTH level, ingested 1g Ca to achieve an acute dynamic study of PTH secretion and Ca-P metabolism. In both CT and NC, this Ca load caused the same decreases in serum PTH (P &amp;amp;amp;amp;lt; 0.001), NcAMP (P &amp;amp;amp;amp;lt; 0.05), and urinary P (P &amp;amp;amp;amp;lt; 0.001) and the same increases in serum and urinary Ca (P &amp;amp;amp;amp;lt; 0.001), and in both TmP/GFR and TRP (P &amp;amp;amp;amp;lt; 0.001). These results strongly suggest that cyclosporine treatment had no significant effect on calcium-regulating hormone secretion, P-Ca metabolism, and bone remodeling level. We therefore consider that cyclosporine is unlikely to have any prominent role in the abnormalities of bone endocrine and mineral metabolism that are common in long-term kidney recipients.

Research paper thumbnail of Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis

Metabolism-clinical and Experimental, 2007

Adipokines such as leptin and adiponectin are involved in the regulation of inflammation. Ghrelin... more Adipokines such as leptin and adiponectin are involved in the regulation of inflammation. Ghrelin, a gastric peptide playing a role in the appetite regulation, possesses anti-inflammatory properties. In this study, we evaluated the circulating levels of adipokines (leptin as potential proinflammatory and adiponectin as anti-inflammatory marker) and ghrelin and the fat mass in patients with ankylosing spondylitis (AS). Serum leptin, adiponectin, and ghrelin were evaluated in 53 AS patients with active disease (mean Bath Ankylosing Spondylitis Disease Activity Index N40) and 35 controls. Fat and lean masses were determined using dual-energy x-ray absorptiometry. Fat and lean masses did not differ between patients and controls. Ankylosing spondylitis patients had lower leptin levels compared with controls, even after adjustment for fat mass (AS vs controls: leptin, 7.6 ± 1.3 ng/mL vs 10.3 ± 1.5 ng/mL; leptin [in nanograms per milliliter]/fat mass [in kilograms], 0.28 ± 0.04 vs 0.44 ± 0.04; P = .006 and P = .0003, respectively). Serum adiponectin did not differ between patients and controls, whereas circulating ghrelin was higher in AS patients (1354.6 ± 70.5 pg/mL vs 1008.0 ± 82.5 pg/mL; P = .001). However, all these results were significant only for male patients. No correlation was found between leptin and adiponectin, and erythrocyte sedimentation rate, C-reactive protein levels, tumor necrosis factor α, or Bath Ankylosing Spondylitis Disease Activity Index. Ankylosing spondylitis patients had no changes in fat mass. Leptin production was reduced in contrast with normal levels of adiponectin. These adipokine results, together with high serum ghrelin levels, may influence the inflammatory response in AS.

Research paper thumbnail of Marketing mix

Foreign trade university -Lecturer: Ch iến Phạm Văn Office: 2rd building B, 91 Chua Lang Str., Do... more Foreign trade university -Lecturer: Ch iến Phạm Văn Office: 2rd building B, 91 Chua Lang Str., DongDa Dist., Hanoi M: 0945 6666 75 , E: chienpv@ftu.edu.vn Nội dung môn học Khái quát chung về marketing Môi trường marketing Nghiên cứu thị trường Xây dựng chiến lược marketing Chương 1 Chương 2 Chương 3 Chương 4 Marketing mix Chương 5 Chương 1 Khái quát chung về marketing Định nghĩa m arketing Marketing là hoạt động của doanh nghiệp nhằm hướng các luồng hàng hóa từ nhà sản xuất đến người tiêu dùng. (American Marketing Association -AMA, 1960) Giới hạn trong tiêu thụ sản phẩm. Định nghĩa m arketing Marketing là quá trình lên kế hoạch, triển khai việc thực hiện kế hoạch, xác định sản phẩm, giá cả, xúc tiến, phân phối hàng hóa, truyền bá ý tưởng, cung cấp dịch vụ hướng tới trao đổi nhằm thỏa mãn mục tiêu của các cá nhân và tổ chức. (AMA, 1985)

Research paper thumbnail of Nine new Candida species near C. membranifaciens isolated from insects

Mycological Research, 2005

Research paper thumbnail of Communities of microbes that inhabit the changing hindgut landscape of a subsocial beetle

Arthropod Structure & Development, 2006

Microbes that have adopted endosymbiotic life styles not only have evolved to live in specialized... more Microbes that have adopted endosymbiotic life styles not only have evolved to live in specialized habitats within living organisms, but the living habitats also have evolved to accommodate them. The hindgut of the passalid beetle (Odontotaenius disjunctus) is lined with a cuticle that undergoes dramatic topographic changes during the life cycle of the beetle. This manuscript addresses the changes that have been observed in time and space for the cuticular landscape of the hindgut as well as for the microbial communities within the hindgut. Microbial identity is based on morphology, culture, and extrapolation from previously reported passalid gut inhabitants. q

Research paper thumbnail of Metschnikowia noctiluminum sp. nov., Metschnikowia corniflorae sp. nov., and Candida chrysomelidarum sp. nov., isolated from green lacewings and beetles

Mycological Research, 2006

Research paper thumbnail of The status and characterization of Enteroramus dimorphus: a xylose-fermenting yeast attached to the gut of beetles

Enteroramus dimorphus from the gut of the passalid beetle Odontotaenius disjunctus was described ... more Enteroramus dimorphus from the gut of the passalid beetle Odontotaenius disjunctus was described originally as a yeast-like fungus of unknown taxonomic affiliation. The fungus can be observed in situ, attached by a specialized cell to the beetle hindgut wall. In a recent study of yeast endosymbionts from a variety of beetles, we discovered that E. dimorphus is a member of the Pichia stipitis (Saccharomycetes) clade, known for xylose fermentation and assimilation. The closest relative of E. dimorphus is the PASS1 isolate, repeatedly acquired from passalid beetles in eastern North America from Pennsylvania to Louisiana. In addition to xylose fermentation and assimilation, these yeasts are characterized by the production of hat-shaped ascospores in culture, assimilation of a wide range of sugars, and synthesis of several vitamins. Enteroramus dimorphus, however, can be distinguished from close relatives by several physiological characteristics and rDNA sequences, which vary slightly from the more widespread PASS1 genotype. We present an amended description of E. dimorphus and discuss its symbiotic phase in association with O. disjunctus, including a holdfast that parallels those of unrelated symbiotic yeasts associated with nematodes.

Research paper thumbnail of No trend toward a spontaneous improvement of hyperparathyroidism and high bone turnover in normocalcemic long-term renal transplant recipients

American Journal of Kidney Diseases, 1997

Although hyperparathyroidism is a common feature in renal transplant recipients, the long-term co... more Although hyperparathyroidism is a common feature in renal transplant recipients, the long-term course of parathyroid hormone (PTH) secretion in these patients is not well established, and the actual contribution of PTH to posttransplant bone disease remains incompletely understood. Therefore, we studied calcium-regulating hormones and serum osteocalcin, as a marker of bone remodeling, in 82 normocalcemic renal transplant recipients with good renal function who had received a graft 6 to 73 months previously and in 82 healthy subjects matched for age and sex. In all subjects, fasting serum and 24-hour urinary samples were collected. The transplant recipients had excessive PTH secretion (serum PTH, 6.9 ± 0.5 pmol/L in recipients v 3.0 ± 0.1 pmol/L in healthy subjects; P < 0.001) and high bone turnover (osteocalcin, 16.6 ± 0.8 μg/L v 8.0 ± 0.3 μg/L; P < 0.001). (Values are mean SEM.) In addition, transplant recipients had a slightly higher ionized calcium than the healthy subjects, providing definite evidence of an inappropriate PTH secretion in renal transplant recipients. Furthermore, in subgroups of 25 recipients and 25 healthy controls matched for creatinine clearance, the results superimposed those obtained in the whole groups, suggesting that excessive PTH secretion and high bone turnover in renal transplant recipients did not merely reflect the moderately reduced renal function of some recipients. In the whole group of transplant recipients, PTH correlated positively with osteocalcin (r = 0.40; P < 0.001), suggesting that PTH contributes at least partly to posttransplant bone disease. Conversely, there was no correlation between serum PTH or osteocalcin and the delay from grafting. Therefore, our results provide no evidence for a spontaneous improvement of either persistent hyperparathyroidism or high bone turnover in normocalcemic long-term renal transplant recipients.

Research paper thumbnail of LACK OF EVIDENCE THAT CYCLOSPORINE TREATMENT IMPAIRS CALCIUM-PHOSPHORUS HOMEOSTASIS AND BONE REMODELING IN NORMOCALCEMIC LONG-TERM RENAL TRANSPLANT RECIPIENTS

Transplantation, 1995

Since the effects of cyclosporine on mineral and bone metabolism are controversial, we studied ca... more Since the effects of cyclosporine on mineral and bone metabolism are controversial, we studied calcium regulating hormones, calcium-phosphorus (Ca-P) metabolism, and bone remodeling, assessed by serum osteocalcin, in long-term renal transplant recipients (RT). Forty-seven normocalcemic patients with good renal function receiving cyclosporine (CT, n = 27) or not (NC, n = 20) were studied at baseline and after an oral Ca load. CT and NC had similar age, daily dose of steroids, GFR level, and duration of transplantation. Baseline evaluation included 24-hr urinary Ca, P, TRP, TmP/GFR, fasting serum intact PTH, 1,25-(OH)2D, 25OHD, osteocalcin, Ca, and P. Subjects of the two groups had excessive secretion of PTH, tubular P wasting, and high serum osteocalcin level, as is usual in RT. However, there was no difference between CT and NC regarding any baseline variable. Ten CT and ten NC, matched for duration of transplantation and serum PTH level, ingested 1g Ca to achieve an acute dynamic study of PTH secretion and Ca-P metabolism. In both CT and NC, this Ca load caused the same decreases in serum PTH (P &amp;amp;amp;amp;lt; 0.001), NcAMP (P &amp;amp;amp;amp;lt; 0.05), and urinary P (P &amp;amp;amp;amp;lt; 0.001) and the same increases in serum and urinary Ca (P &amp;amp;amp;amp;lt; 0.001), and in both TmP/GFR and TRP (P &amp;amp;amp;amp;lt; 0.001). These results strongly suggest that cyclosporine treatment had no significant effect on calcium-regulating hormone secretion, P-Ca metabolism, and bone remodeling level. We therefore consider that cyclosporine is unlikely to have any prominent role in the abnormalities of bone endocrine and mineral metabolism that are common in long-term kidney recipients.

Research paper thumbnail of Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis

Metabolism-clinical and Experimental, 2007

Adipokines such as leptin and adiponectin are involved in the regulation of inflammation. Ghrelin... more Adipokines such as leptin and adiponectin are involved in the regulation of inflammation. Ghrelin, a gastric peptide playing a role in the appetite regulation, possesses anti-inflammatory properties. In this study, we evaluated the circulating levels of adipokines (leptin as potential proinflammatory and adiponectin as anti-inflammatory marker) and ghrelin and the fat mass in patients with ankylosing spondylitis (AS). Serum leptin, adiponectin, and ghrelin were evaluated in 53 AS patients with active disease (mean Bath Ankylosing Spondylitis Disease Activity Index N40) and 35 controls. Fat and lean masses were determined using dual-energy x-ray absorptiometry. Fat and lean masses did not differ between patients and controls. Ankylosing spondylitis patients had lower leptin levels compared with controls, even after adjustment for fat mass (AS vs controls: leptin, 7.6 ± 1.3 ng/mL vs 10.3 ± 1.5 ng/mL; leptin [in nanograms per milliliter]/fat mass [in kilograms], 0.28 ± 0.04 vs 0.44 ± 0.04; P = .006 and P = .0003, respectively). Serum adiponectin did not differ between patients and controls, whereas circulating ghrelin was higher in AS patients (1354.6 ± 70.5 pg/mL vs 1008.0 ± 82.5 pg/mL; P = .001). However, all these results were significant only for male patients. No correlation was found between leptin and adiponectin, and erythrocyte sedimentation rate, C-reactive protein levels, tumor necrosis factor α, or Bath Ankylosing Spondylitis Disease Activity Index. Ankylosing spondylitis patients had no changes in fat mass. Leptin production was reduced in contrast with normal levels of adiponectin. These adipokine results, together with high serum ghrelin levels, may influence the inflammatory response in AS.

Research paper thumbnail of Marketing mix

Foreign trade university -Lecturer: Ch iến Phạm Văn Office: 2rd building B, 91 Chua Lang Str., Do... more Foreign trade university -Lecturer: Ch iến Phạm Văn Office: 2rd building B, 91 Chua Lang Str., DongDa Dist., Hanoi M: 0945 6666 75 , E: chienpv@ftu.edu.vn Nội dung môn học Khái quát chung về marketing Môi trường marketing Nghiên cứu thị trường Xây dựng chiến lược marketing Chương 1 Chương 2 Chương 3 Chương 4 Marketing mix Chương 5 Chương 1 Khái quát chung về marketing Định nghĩa m arketing Marketing là hoạt động của doanh nghiệp nhằm hướng các luồng hàng hóa từ nhà sản xuất đến người tiêu dùng. (American Marketing Association -AMA, 1960) Giới hạn trong tiêu thụ sản phẩm. Định nghĩa m arketing Marketing là quá trình lên kế hoạch, triển khai việc thực hiện kế hoạch, xác định sản phẩm, giá cả, xúc tiến, phân phối hàng hóa, truyền bá ý tưởng, cung cấp dịch vụ hướng tới trao đổi nhằm thỏa mãn mục tiêu của các cá nhân và tổ chức. (AMA, 1985)