Nicolas Paquet pelletier - Academia.edu (original) (raw)
Papers by Nicolas Paquet pelletier
Revue Internationale de Géomatique
Cet article a pour objectif de présenter la méthodologie de diagnostic qualité et d’apurement des... more Cet article a pour objectif de présenter la méthodologie de diagnostic qualité et d’apurement des données, expérimentée à partir d’une enquête de mobilité individuelle (programme Mobi’Kids). Une première partie revient sur la démarche suivie et pointe l’enjeu de l’évaluation de la qualité de données hétérogènes issues d’une méthode mixte et longitudinale de collecte (suivis GPS, enquêtes, observations). Une deuxième partie établit un diagnostic qualité selon l’origine (GPS, algorithme, enquête) et la nature des erreurs (complétude, précision, cohérence). Ces typologies permettent, dans une troisième partie, de définir d’une chaîne de traitements reproductible visant à améliorer la qualité interne et externe des données.
Journal of Hazardous Materials
Marine Pollution Bulletin, 2019
Through collaboration with Inuit hunters, we examined the stomach contents of 142 seals (ringed s... more Through collaboration with Inuit hunters, we examined the stomach contents of 142 seals (ringed seals [Phoca hispida; n = 135], bearded seals [Erignathus barbatus; n = 6], and one harbour seal [Phoca vitualina; n = 1]) hunted between 2007 and 2019 from communities around Nunavut to assess whether seals in the eastern Canadian Arctic ingest and retain plastics in their stomachs. The seals in this study ranged from juveniles to adults of up to 30 years of age, and 55% of the seals were males. We found no evidence of plastic ingestion in any of the seals suggesting that seals in Nunavut are not accumulating plastics (> 425 μm) in their stomachs. These data provide important baseline information for future plastic pollution monitoring programs in the Arctic.
Alzheimer's & Dementia, 2017
P3-214 ADFLAG , A DIAGNOSTIC BLOOD TEST FOR PRE-DEMENTIA STAGES OF ALZHEIMER’S DISEASE Beatrice B... more P3-214 ADFLAG , A DIAGNOSTIC BLOOD TEST FOR PRE-DEMENTIA STAGES OF ALZHEIMER’S DISEASE Beatrice Blanc, Nicolas Pelletier, Clotilde Biscarrat, Pauline Picamal, Nathalie Compagnone, Samantha Galluzzi, Moira Marizzoni, Jorge Jovicich, Giovanni B. Frisoni, Gianluigi Forloni, Diego Albani, Jill Richardson, Lucilla Parnetti, Magda Tsolaki, Flavio Nobili, David Bartrez-faz, Mira Didic, Peter Schoenknecht, Pierre Payoux, Andrea Soricelli, Paolo Rossini, Pieter Jelle Visser, Regis Bordet, Ute Fiedler, Olivier Blin, Julien Dupouey, Joelle Micallef, Laura Lanteaume, Bernard Michel, ICDD, Gemenos, France; IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; University of Trento, Trento, Italy; Memory Clinic and LANVIE Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland; Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy; IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; GSK R&D, China-United Kingdom, Middlesex, United Kingdom; Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy; Aristotle University of Thessaloniki, Thessaloniki, Greece; University of Genoa, Italy, Genoa, Italy; Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d’Investigacions Biom ediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Service de Neurologie et Neuropsychologie, Marseille, France; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; INSERM, Imagerie C er ebrale et Handicaps Neurologiques, Toulouse, France; Fondazione SDN per la Ricerca e l’Alta Formazione in Diagnostica Nucleare, Naples, Italy; Department of Gerontology, Neurosciences & Orthopedics, Catholic University, Rome, Italy; VU University Medical Center, Amsterdam, Netherlands; Service de Pharmacologie-Hôpital Huriez-CHRU, Lille, France; Institutes and Clinics of the University Duisburg-Essen, Essen, Germany; Mediterranean Institute of Cognitive Neurosciences, Marseille, France; Service de Neurologie et Neuropsychologie, CHU la Timone, Marseille, France; Assistance Publique Hôpitaux de Marseille, Marseille, France; Service de Neurologie Comportementale, Hôpital Sainte Marguerite, Marseille, France, CNRS LNIAUMR 7260 FR3C FR 3512, Aix-Marseille Universit e, Marseille, France. Contact e-mail: bblanc@icdd-sas.com
Journal of Applied Physiology, 1995
Thoroughbred horses (TB) have no ventilatory response to added CO2 during near-maximal exercise. ... more Thoroughbred horses (TB) have no ventilatory response to added CO2 during near-maximal exercise. To see whether that reflects mechanical limits to ventilation or the control of breathing, we examined the effects of varying inspired O2 fraction (0.16, 0.21, or 0.30) in five normal TB standing quietly and galloping at 10 and 14 m/s on a level treadmill. We measured gas exchange (O2 consumption and CO2 production) and ventilation with a flow-through mask system. We also measured PO2, PCO2, and O2 contents in arterial and mixed venous blood and calculated cardiac output by using the Fick equation. Low inspired O2 fraction (0.16 vs. 0.21) had significant effects in TB galloping at 14 m/s. Arterial PO2 then was 38 Torr compared with 56 Torr for horses on air. Tidal volume and minute ventilation were 20% greater than their corresponding values on air, which were 12 liters and 1,475 l/min, respectively, whereas respiratory frequency did not change. O2 consumption and CO2 production were unc...
The Holocene, 2017
Permafrost in peatlands strongly influences ecosystem characteristics, including vegetation compo... more Permafrost in peatlands strongly influences ecosystem characteristics, including vegetation composition, hydrological functions, and carbon cycling. Large amounts of organic carbon are stored in permafrost peatlands in northwestern Canada. Their possible degradation into permafrost-free wetlands including thermokarst bogs may affect carbon (C) stocks, but the direction and magnitude of change are uncertain. Using peat core reconstructions, we characterized the temporal and spatial variability in vegetation macrofossil, testate amoebae, C content, and peat decomposition along a permafrost thaw chronosequence in the southern portion of the Scotty Creek watershed near Fort Simpson, Northwest Territories. The accumulation of limnic and minerotrophic peat prevailed at the site until permafrost formed around 5000 cal. yr BP. Three distinct permafrost periods were identified in the permafrost peat plateau profile, while permafrost only aggraded once in the thermokarst bog profile. Permafro...
Http Www Theses Fr, 2009
La proteomique ouvre de nouvelles perspectives dans la caracterisation des facteurs de virulence ... more La proteomique ouvre de nouvelles perspectives dans la caracterisation des facteurs de virulence des bacteries associees au bio-terrorisme. L’electrophorese en 2 dimensions (2-DE) est une des techniques les plus couramment utilisee permettant une separation tres resolutive des proteines. Cependant au cours de mes travaux de these nous avons developpe au laboratoire une nouvelle technique plus performante, la 2D-DIGE (Two-Dimensional Differential Gel Electrophoresis) afin d’etudier plus precisement les proteines synthetisees par ces agents du bio-terrorisme. En effet, cette technique permet de comparer plusieurs conditions dans un meme gel avec une meilleure sensibilite, reproductibilite et efficacite que la 2-DE. L’utilisation de cette technique pour la comparaison de souches virulentes et avirulentes chez Francisella tularensis et Rickettsia prowazekii est une premiere, et a permis d’identifier de nouvelles proteines presentant des niveaux d’expressions differents ainsi que confirmer des resultats obtenus avec d’autres approches (genomique, transcriptomique). D’autre part l’etude de l’immunogenicite de F. Tularensis, avec l’utilisation de la 2-DE associee aux Western blots, a permis d’identifier de nouvelles proteines immunoreactives et de comprendre l’origine de la reaction croisee avec Mimivirus. De plus, l’etude proteique presente un avantage considerable par rapport aux approches geniques ou transcriptionnelles, qui est de pouvoir apprecier les modifications post-traductionnelles. Nous avons donc decide d’etudier les methylations lors de l’analyse du proteome de R. Prowazekii. L’approche proteomique de ces bacteries potentielles du bio-terrorisme est donc essentielle pour une meilleure comprehension des mecanismes responsables de la virulence et de la maladie. Ces nouvelles pistes ouvrent des perspectives interessantes dans le developpement de nouveaux outils diagnostics et therapeutiques. Des etudes plus precises sur les modifications posttraductionnelles mais aussi sur des fractions enrichies en proteines membranaires pourraient permettre de mieux comprendre ces bacteries et leurs interactions avec l’hote
Respiration Physiology, 1993
Horses have high mean pulmonary artery pressure (Ppa) both at rest and during exercise (~ 30 and ... more Horses have high mean pulmonary artery pressure (Ppa) both at rest and during exercise (~ 30 and > 80 mmHg, respectively). The mechanisms are unknown. To see if hypoxic pulmonary vasoconstriction (HPV) plays a role, we compared pulmonary artery pressure-flow (Ppa-Q) curves when inspired 02 fraction (FIo2) was 0.16, 0.21, and 0.30, in 5 normal Thoroughbred horses standing quietly and while galloping at 10 and 14 m/sec on a level treadmill. We calculated 02 consumption (Xto2) from measurements of respired gas composition and flow, and calculated 0 from ~Zo: and measurements of oxygen content in arterial and mixed venous blood (Cao2 and Crlo2). Vo2 was 3.8, 74 and 128 ml-min-l.kg-1, at rest and at 10 and 14 m/sec, and did not vary with FIo2 at any speed. At 14 m/sec only, when Fio2 was lowered to 0.16, Cao2 fell (to 14.7 from 20 ml/dl on air), Q increased (to 0.86 from 0.66 L'min-l.kg-I on air), and stroke volume increased (to 4.1 from 3.2 ml.kg-1 on air). Slopes and intercepts of Ppa-Q curves did not vary with FIo2. We conclude that HPV does not contribute to the high Ppa of exercising horses breathing air near sea level.
Canadian journal of comparative medicine. Revue canadienne de médecine comparée, 1985
The determination of the arterial blood pressure was done on 12 healthy mixed breed dogs in both ... more The determination of the arterial blood pressure was done on 12 healthy mixed breed dogs in both the anesthetized and the conscious state, to evaluate two instruments (Doppler flow detector and infrasonde D4000), in their ability to indirectly determine arterial blood pressure. The coefficients of variation were higher with indirect methods when compared with the results obtained by cannulation. These coefficients were lower with the Doppler flow detector. The correlation study showed that both apparatuses were reliable in most situations. The infrasonde D4000 was more accurate than the Doppler in the conscious animals. However the results showed a lack of precision in hypertensive conscious dogs. The diastolic arterial blood pressure was particularly precise in the case of the anesthetized hypotensive dogs. Its sensitivity allowed it to register muscle movement artifacts. The Doppler flow detector showed less variation and was particularly accurate in both anesthetized and consciou...
JFORL. Journal français d'oto-rhino-laryngologie; audiophonologie et chirurgie maxillo-faciale, 1974
SPIE Proceedings, 2008
Signal-to-noise ratio is a crucial issue in microarray fluorescence read-out. Several strategies ... more Signal-to-noise ratio is a crucial issue in microarray fluorescence read-out. Several strategies are proposed for its improvement. First, light collection in conventional microarrays scanners is quite limited. It was recently shown that almost full collection can be achieved in an integrated lens-free biosensor, with labelled species hybridizing practically on the surface of a sensitive silicon detector [L. Martinelli et al. Appl. Phys. Lett. 91, 083901 (2007)]. However, even with such an improvement, the ultimate goal of real-time measurements during hybridization is challenging: the detector is dazzled by the large fluorescence of labelled species in the solution. In the present paper we show that this unwanted signal can effectively be reduced if the excitation light is confined in a waveguide. Moreover, the concentration of excitation light in a waveguide results in a huge signal gain. In our experiment we realized a structure consisting of a high index sol-gel waveguide deposited on a low-index substrate. The fluorescent molecules deposited on the surface of the waveguide were excited by the evanescent part of a wave travelling in the guide. The comparison with free-space excitation schemes confirms a huge gain (by several orders of magnitude) in favour of waveguide-based excitation. An optical guide deposited onto an integrated biosensor thus combines both advantages of ideal light collection and enhanced surface localized excitation without compromising the imaging properties. Modelling predicts a negligible penalty from spatial cross-talk in practical applications. We believe that such a system would bring microarrays to hitherto unattained sensitivities.
Proceedings of IEEE Sensors, 2004.
A new approach to designing heat sensors is presented. The basic principle relies on the differen... more A new approach to designing heat sensors is presented. The basic principle relies on the differential thermal behavior regarding both active arms of a micro Mach-Zehnder interferometer (MZI). Based on modeling results, an experimental sensor is realised as an integrated device made up of SU-8 polymer mounted on a standard silicon wafer. When subjected to a radiant source, such as
… of the American …, 2004
Inhibition of VEGF with Avastin has been shown to be an efficacious approach to treat colorectal ... more Inhibition of VEGF with Avastin has been shown to be an efficacious approach to treat colorectal tumors when combined with irinotecan/fluorouracil/leucovorin (CPT-11/5-FU/LV; IFL). Xeloda (Capecitabine), an oral fluoropyrimidine pro-drug approved for hte treatment of colorectal ...
Sensors and Actuators A: Physical, 2007
The authors present a successful modeling, realization and characterization of a new micro-sensor... more The authors present a successful modeling, realization and characterization of a new micro-sensor based on a convenient optical principle, namely an integrated Mach–Zehnder interferometer (MZI). This MZI device is designed with a view to measuring pressure disturbances due to optical path variations. Such a system is arranged in order to work in intensity modulation scheme. Moreover, the MZI is made
Optics Communications, 2004
The authors present a successful design, realisation and characterisation of single-mode TE00–TM0... more The authors present a successful design, realisation and characterisation of single-mode TE00–TM00 rib optical waveguides composed of SU-8 polymer. The linear absorption coefficient of energy αTE–TM of such rib waveguides have been measured and estimated, respectively, near 0.32 and 0.46 cm−1 for both optical modes TE00 and TM00. These values yield optical losses of 1.36 and 2.01 dB/cm. Hence, as
Laval théologique et philosophique, 2002
Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y ... more Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y compris la reproduction) est assujettie à sa politique d'utilisation que vous pouvez consulter en ligne. https://apropos.erudit.org/fr/usagers/politique-dutilisation/ Cet article est diffusé et préservé par Érudit. Érudit est un consortium interuniversitaire sans but lucratif composé de l'
Revue Internationale de Géomatique
Cet article a pour objectif de présenter la méthodologie de diagnostic qualité et d’apurement des... more Cet article a pour objectif de présenter la méthodologie de diagnostic qualité et d’apurement des données, expérimentée à partir d’une enquête de mobilité individuelle (programme Mobi’Kids). Une première partie revient sur la démarche suivie et pointe l’enjeu de l’évaluation de la qualité de données hétérogènes issues d’une méthode mixte et longitudinale de collecte (suivis GPS, enquêtes, observations). Une deuxième partie établit un diagnostic qualité selon l’origine (GPS, algorithme, enquête) et la nature des erreurs (complétude, précision, cohérence). Ces typologies permettent, dans une troisième partie, de définir d’une chaîne de traitements reproductible visant à améliorer la qualité interne et externe des données.
Journal of Hazardous Materials
Marine Pollution Bulletin, 2019
Through collaboration with Inuit hunters, we examined the stomach contents of 142 seals (ringed s... more Through collaboration with Inuit hunters, we examined the stomach contents of 142 seals (ringed seals [Phoca hispida; n = 135], bearded seals [Erignathus barbatus; n = 6], and one harbour seal [Phoca vitualina; n = 1]) hunted between 2007 and 2019 from communities around Nunavut to assess whether seals in the eastern Canadian Arctic ingest and retain plastics in their stomachs. The seals in this study ranged from juveniles to adults of up to 30 years of age, and 55% of the seals were males. We found no evidence of plastic ingestion in any of the seals suggesting that seals in Nunavut are not accumulating plastics (> 425 μm) in their stomachs. These data provide important baseline information for future plastic pollution monitoring programs in the Arctic.
Alzheimer's & Dementia, 2017
P3-214 ADFLAG , A DIAGNOSTIC BLOOD TEST FOR PRE-DEMENTIA STAGES OF ALZHEIMER’S DISEASE Beatrice B... more P3-214 ADFLAG , A DIAGNOSTIC BLOOD TEST FOR PRE-DEMENTIA STAGES OF ALZHEIMER’S DISEASE Beatrice Blanc, Nicolas Pelletier, Clotilde Biscarrat, Pauline Picamal, Nathalie Compagnone, Samantha Galluzzi, Moira Marizzoni, Jorge Jovicich, Giovanni B. Frisoni, Gianluigi Forloni, Diego Albani, Jill Richardson, Lucilla Parnetti, Magda Tsolaki, Flavio Nobili, David Bartrez-faz, Mira Didic, Peter Schoenknecht, Pierre Payoux, Andrea Soricelli, Paolo Rossini, Pieter Jelle Visser, Regis Bordet, Ute Fiedler, Olivier Blin, Julien Dupouey, Joelle Micallef, Laura Lanteaume, Bernard Michel, ICDD, Gemenos, France; IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; University of Trento, Trento, Italy; Memory Clinic and LANVIE Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland; Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy; IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; GSK R&D, China-United Kingdom, Middlesex, United Kingdom; Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy; Aristotle University of Thessaloniki, Thessaloniki, Greece; University of Genoa, Italy, Genoa, Italy; Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona and Institut d’Investigacions Biom ediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Service de Neurologie et Neuropsychologie, Marseille, France; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; INSERM, Imagerie C er ebrale et Handicaps Neurologiques, Toulouse, France; Fondazione SDN per la Ricerca e l’Alta Formazione in Diagnostica Nucleare, Naples, Italy; Department of Gerontology, Neurosciences & Orthopedics, Catholic University, Rome, Italy; VU University Medical Center, Amsterdam, Netherlands; Service de Pharmacologie-Hôpital Huriez-CHRU, Lille, France; Institutes and Clinics of the University Duisburg-Essen, Essen, Germany; Mediterranean Institute of Cognitive Neurosciences, Marseille, France; Service de Neurologie et Neuropsychologie, CHU la Timone, Marseille, France; Assistance Publique Hôpitaux de Marseille, Marseille, France; Service de Neurologie Comportementale, Hôpital Sainte Marguerite, Marseille, France, CNRS LNIAUMR 7260 FR3C FR 3512, Aix-Marseille Universit e, Marseille, France. Contact e-mail: bblanc@icdd-sas.com
Journal of Applied Physiology, 1995
Thoroughbred horses (TB) have no ventilatory response to added CO2 during near-maximal exercise. ... more Thoroughbred horses (TB) have no ventilatory response to added CO2 during near-maximal exercise. To see whether that reflects mechanical limits to ventilation or the control of breathing, we examined the effects of varying inspired O2 fraction (0.16, 0.21, or 0.30) in five normal TB standing quietly and galloping at 10 and 14 m/s on a level treadmill. We measured gas exchange (O2 consumption and CO2 production) and ventilation with a flow-through mask system. We also measured PO2, PCO2, and O2 contents in arterial and mixed venous blood and calculated cardiac output by using the Fick equation. Low inspired O2 fraction (0.16 vs. 0.21) had significant effects in TB galloping at 14 m/s. Arterial PO2 then was 38 Torr compared with 56 Torr for horses on air. Tidal volume and minute ventilation were 20% greater than their corresponding values on air, which were 12 liters and 1,475 l/min, respectively, whereas respiratory frequency did not change. O2 consumption and CO2 production were unc...
The Holocene, 2017
Permafrost in peatlands strongly influences ecosystem characteristics, including vegetation compo... more Permafrost in peatlands strongly influences ecosystem characteristics, including vegetation composition, hydrological functions, and carbon cycling. Large amounts of organic carbon are stored in permafrost peatlands in northwestern Canada. Their possible degradation into permafrost-free wetlands including thermokarst bogs may affect carbon (C) stocks, but the direction and magnitude of change are uncertain. Using peat core reconstructions, we characterized the temporal and spatial variability in vegetation macrofossil, testate amoebae, C content, and peat decomposition along a permafrost thaw chronosequence in the southern portion of the Scotty Creek watershed near Fort Simpson, Northwest Territories. The accumulation of limnic and minerotrophic peat prevailed at the site until permafrost formed around 5000 cal. yr BP. Three distinct permafrost periods were identified in the permafrost peat plateau profile, while permafrost only aggraded once in the thermokarst bog profile. Permafro...
Http Www Theses Fr, 2009
La proteomique ouvre de nouvelles perspectives dans la caracterisation des facteurs de virulence ... more La proteomique ouvre de nouvelles perspectives dans la caracterisation des facteurs de virulence des bacteries associees au bio-terrorisme. L’electrophorese en 2 dimensions (2-DE) est une des techniques les plus couramment utilisee permettant une separation tres resolutive des proteines. Cependant au cours de mes travaux de these nous avons developpe au laboratoire une nouvelle technique plus performante, la 2D-DIGE (Two-Dimensional Differential Gel Electrophoresis) afin d’etudier plus precisement les proteines synthetisees par ces agents du bio-terrorisme. En effet, cette technique permet de comparer plusieurs conditions dans un meme gel avec une meilleure sensibilite, reproductibilite et efficacite que la 2-DE. L’utilisation de cette technique pour la comparaison de souches virulentes et avirulentes chez Francisella tularensis et Rickettsia prowazekii est une premiere, et a permis d’identifier de nouvelles proteines presentant des niveaux d’expressions differents ainsi que confirmer des resultats obtenus avec d’autres approches (genomique, transcriptomique). D’autre part l’etude de l’immunogenicite de F. Tularensis, avec l’utilisation de la 2-DE associee aux Western blots, a permis d’identifier de nouvelles proteines immunoreactives et de comprendre l’origine de la reaction croisee avec Mimivirus. De plus, l’etude proteique presente un avantage considerable par rapport aux approches geniques ou transcriptionnelles, qui est de pouvoir apprecier les modifications post-traductionnelles. Nous avons donc decide d’etudier les methylations lors de l’analyse du proteome de R. Prowazekii. L’approche proteomique de ces bacteries potentielles du bio-terrorisme est donc essentielle pour une meilleure comprehension des mecanismes responsables de la virulence et de la maladie. Ces nouvelles pistes ouvrent des perspectives interessantes dans le developpement de nouveaux outils diagnostics et therapeutiques. Des etudes plus precises sur les modifications posttraductionnelles mais aussi sur des fractions enrichies en proteines membranaires pourraient permettre de mieux comprendre ces bacteries et leurs interactions avec l’hote
Respiration Physiology, 1993
Horses have high mean pulmonary artery pressure (Ppa) both at rest and during exercise (~ 30 and ... more Horses have high mean pulmonary artery pressure (Ppa) both at rest and during exercise (~ 30 and > 80 mmHg, respectively). The mechanisms are unknown. To see if hypoxic pulmonary vasoconstriction (HPV) plays a role, we compared pulmonary artery pressure-flow (Ppa-Q) curves when inspired 02 fraction (FIo2) was 0.16, 0.21, and 0.30, in 5 normal Thoroughbred horses standing quietly and while galloping at 10 and 14 m/sec on a level treadmill. We calculated 02 consumption (Xto2) from measurements of respired gas composition and flow, and calculated 0 from ~Zo: and measurements of oxygen content in arterial and mixed venous blood (Cao2 and Crlo2). Vo2 was 3.8, 74 and 128 ml-min-l.kg-1, at rest and at 10 and 14 m/sec, and did not vary with FIo2 at any speed. At 14 m/sec only, when Fio2 was lowered to 0.16, Cao2 fell (to 14.7 from 20 ml/dl on air), Q increased (to 0.86 from 0.66 L'min-l.kg-I on air), and stroke volume increased (to 4.1 from 3.2 ml.kg-1 on air). Slopes and intercepts of Ppa-Q curves did not vary with FIo2. We conclude that HPV does not contribute to the high Ppa of exercising horses breathing air near sea level.
Canadian journal of comparative medicine. Revue canadienne de médecine comparée, 1985
The determination of the arterial blood pressure was done on 12 healthy mixed breed dogs in both ... more The determination of the arterial blood pressure was done on 12 healthy mixed breed dogs in both the anesthetized and the conscious state, to evaluate two instruments (Doppler flow detector and infrasonde D4000), in their ability to indirectly determine arterial blood pressure. The coefficients of variation were higher with indirect methods when compared with the results obtained by cannulation. These coefficients were lower with the Doppler flow detector. The correlation study showed that both apparatuses were reliable in most situations. The infrasonde D4000 was more accurate than the Doppler in the conscious animals. However the results showed a lack of precision in hypertensive conscious dogs. The diastolic arterial blood pressure was particularly precise in the case of the anesthetized hypotensive dogs. Its sensitivity allowed it to register muscle movement artifacts. The Doppler flow detector showed less variation and was particularly accurate in both anesthetized and consciou...
JFORL. Journal français d'oto-rhino-laryngologie; audiophonologie et chirurgie maxillo-faciale, 1974
SPIE Proceedings, 2008
Signal-to-noise ratio is a crucial issue in microarray fluorescence read-out. Several strategies ... more Signal-to-noise ratio is a crucial issue in microarray fluorescence read-out. Several strategies are proposed for its improvement. First, light collection in conventional microarrays scanners is quite limited. It was recently shown that almost full collection can be achieved in an integrated lens-free biosensor, with labelled species hybridizing practically on the surface of a sensitive silicon detector [L. Martinelli et al. Appl. Phys. Lett. 91, 083901 (2007)]. However, even with such an improvement, the ultimate goal of real-time measurements during hybridization is challenging: the detector is dazzled by the large fluorescence of labelled species in the solution. In the present paper we show that this unwanted signal can effectively be reduced if the excitation light is confined in a waveguide. Moreover, the concentration of excitation light in a waveguide results in a huge signal gain. In our experiment we realized a structure consisting of a high index sol-gel waveguide deposited on a low-index substrate. The fluorescent molecules deposited on the surface of the waveguide were excited by the evanescent part of a wave travelling in the guide. The comparison with free-space excitation schemes confirms a huge gain (by several orders of magnitude) in favour of waveguide-based excitation. An optical guide deposited onto an integrated biosensor thus combines both advantages of ideal light collection and enhanced surface localized excitation without compromising the imaging properties. Modelling predicts a negligible penalty from spatial cross-talk in practical applications. We believe that such a system would bring microarrays to hitherto unattained sensitivities.
Proceedings of IEEE Sensors, 2004.
A new approach to designing heat sensors is presented. The basic principle relies on the differen... more A new approach to designing heat sensors is presented. The basic principle relies on the differential thermal behavior regarding both active arms of a micro Mach-Zehnder interferometer (MZI). Based on modeling results, an experimental sensor is realised as an integrated device made up of SU-8 polymer mounted on a standard silicon wafer. When subjected to a radiant source, such as
… of the American …, 2004
Inhibition of VEGF with Avastin has been shown to be an efficacious approach to treat colorectal ... more Inhibition of VEGF with Avastin has been shown to be an efficacious approach to treat colorectal tumors when combined with irinotecan/fluorouracil/leucovorin (CPT-11/5-FU/LV; IFL). Xeloda (Capecitabine), an oral fluoropyrimidine pro-drug approved for hte treatment of colorectal ...
Sensors and Actuators A: Physical, 2007
The authors present a successful modeling, realization and characterization of a new micro-sensor... more The authors present a successful modeling, realization and characterization of a new micro-sensor based on a convenient optical principle, namely an integrated Mach–Zehnder interferometer (MZI). This MZI device is designed with a view to measuring pressure disturbances due to optical path variations. Such a system is arranged in order to work in intensity modulation scheme. Moreover, the MZI is made
Optics Communications, 2004
The authors present a successful design, realisation and characterisation of single-mode TE00–TM0... more The authors present a successful design, realisation and characterisation of single-mode TE00–TM00 rib optical waveguides composed of SU-8 polymer. The linear absorption coefficient of energy αTE–TM of such rib waveguides have been measured and estimated, respectively, near 0.32 and 0.46 cm−1 for both optical modes TE00 and TM00. These values yield optical losses of 1.36 and 2.01 dB/cm. Hence, as
Laval théologique et philosophique, 2002
Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y ... more Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y compris la reproduction) est assujettie à sa politique d'utilisation que vous pouvez consulter en ligne. https://apropos.erudit.org/fr/usagers/politique-dutilisation/ Cet article est diffusé et préservé par Érudit. Érudit est un consortium interuniversitaire sans but lucratif composé de l'