Nihat Arıkan - Academia.edu (original) (raw)

Papers by Nihat Arıkan

Research paper thumbnail of Kriptorkizm Etiyopatogenezinde Ailevi İnsidans ve Kromozomal Bozuklukların Rolü

Turkiye Klinikleri Journal of Case Reports, 1990

Research paper thumbnail of İşeme Bozukluklarında Alt Üriner Sistem Fonksiyon Bozukluklarının (Nörojenik-Nonnörojenik) Değerlendirilmesi

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2005

Research paper thumbnail of Postprostatektomik İdrar Kaçırmada Güncel Tedavi

Turkiye Klinikleri Uroloji Ozel Dergisi, 2008

Research paper thumbnail of Alt Üriner Sistemde Yaşlanma İleOrtaya Çıkan Değişilikler veBunların Benign Prostat Hiperplazisi İle İlişkisi

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2005

Research paper thumbnail of Diagnosis modelling of urethral obstructions using fuzzy expert system

Proceedings of the 9th International Conference on Computer Systems and Technologies and Workshop For Phd Students in Computing, Jun 12, 2008

Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system il... more Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system illnesses that causes obstruction in the urethra and the bladder. There are several reasons that cause obstructions in the urinary system. The common causes of these obstructions are prostate ...

Research paper thumbnail of Spinal Kord Travmalı HastalardaMesane Büyültme Ameliyatları ve Klinik Deneyimlerimiz

Turkiye Klinikleri Journal of Physical Medicine Rehabilitation, 2001

... Devamı... Fiziksel Tıp ve Rehabilitasyon Dergisi Year: 2001 / Volume: 1 / No: 2. Spinal Kord ... more ... Devamı... Fiziksel Tıp ve Rehabilitasyon Dergisi Year: 2001 / Volume: 1 / No: 2. Spinal Kord Travmalı Hastalardamesane Büyültme Ameliyatları Ve Klinik Deneyimlerimiz Nihat ARIKAN * * Prof.Dr., Ankara Üniversitesi Tıp Fakültesi Üroloji AD, ANKARA. ...

Research paper thumbnail of Patients with urinary incontinence often benefit from surgical detethering of tight filum terminale. Editorial comment

Child S Nervous System Chns Official Journal of the International Society For Pediatric Neurosurgery, Mar 1, 2000

Research paper thumbnail of Idiopatim: Detrüsör Instabiliteli Kadınlarda Oxybutinin Hidroklorid Tedavisi

Research paper thumbnail of Assessment of vasculogenic impotence in diabetic men: Using color Doppler flow sonography

Turkiye Klinikleri Journal of Case Reports, 1993

- We evaluated 26 male diabetics for sexual dysfuntion. We used color Doppler flow sonography to ... more - We evaluated 26 male diabetics for sexual dysfuntion. We used color Doppler flow sonography to assess the hemodynamic function of the penis in patients with diabetes mellitus (DM) to detect the presence of arterial disease or venous incompetence. In addition, penile venous ...

Research paper thumbnail of DONÖR SPESİFİK TRANSFÜZYONLARIN (DST) ERKEN ve GEÇ DÖNEM RENAL ALLOGREFT FONKSİYONU ÜZERİNE ETKİSİ THE EFFECT OF DONOR-SPECIFIC TRANSFUSIONS (DST) ON SHORT AND LONG-TERM RENAL ALLOGRAFT FUNCTION

SUMMARY In order to evaluate the effect of donor-speclfl c blood transfusions (DST) on short- and... more SUMMARY In order to evaluate the effect of donor-speclfl c blood transfusions (DST) on short- and long-term re- nal allograft function, a group consisted of 20 pati- ents who underwent DST was compared to 35 patients who received HLA-identical living related donor graft and 25 patients who received one-haplotyplc donor graft. After transplantation, the time in which serum cre- atinine

Research paper thumbnail of Distal Hipospadias Olgularinda Mathieu Yöntemi̇ni̇n Değerlendi̇ri̇lmesi̇

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2000

Postoperatif erken dönemde 5 olguda yara yeri enfeksiyonu, 1 olguda hematom, 2 olguda ise glans p... more Postoperatif erken dönemde 5 olguda yara yeri enfeksiyonu, 1 olguda hematom, 2 olguda ise glans penisin lateral fleplerinde açılma izlendi. Glans lateral flepleri açılan 2 olguya ek olarak geç dönemde ayrıca 8 olguda da (3 olguda meatal stenozla birlikte fistül, 1 olguda yalnızca meatal stenoz ve 4 olguda stenoz olmaksızın fistül) komplikasyon izlenmiştir. Geç dönemde 54 olgunun 44' ünde (%81.4) herhangi bir ek girişim gereksinimi olmamıştır. Belirgin kordesi olmayan distal peni! yerleşimli hipospadias olgularında usulüne uygun yapılan Mathieu operasyonunun sonuçları yüz güldürücüdür.

Research paper thumbnail of Clinical comparision of intravesical hyaluronic acid and hyaluronic acid-chondroitin sulphate therapy for patients with bladder pain syndrome/interstitital cystitis

Canadian Urological Association Journal, 2014

Introduction: Patients with a history of bladder pain syndrome/interstitial cystitis (BPS/IC) and... more Introduction: Patients with a history of bladder pain syndrome/interstitial cystitis (BPS/IC) and who responded poorly or unsatisfactorily with previous treatment were compared taking intravesical hyaluronic acid (HA) or hyaluronic acid-chondroitin sulphate (HA-CS).Methods: Patients were treated with intravesical instillation with 50 mL sterile sodium hyalurinic acid (Hyacyst, Syner-Med, Surrey, UK) (n = 32) and sodium hyaluronate 1.6% sodium chondroitin sulphate 2% (Ialuril, Aspire Pharma, UK) (n = 33). Intravesical instillations were performed weekly in first month, every 15 days in the second month and monthly in third and fourth months, for a total of 8 doses. Patients were evaluated using a visual analog pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), voiding diary for frequency/nocturia, cystometric bladder capacity and voided volume at the beginning and at 6 months. All patients had a potassium sensitivity test (PST) i...

Research paper thumbnail of Extraperitoneal laparoscopic bladder neck suspension using hernia mesh and tacker

Urology, 2000

To report our initial experience with extraperitoneal bladder neck suspension for female stress i... more To report our initial experience with extraperitoneal bladder neck suspension for female stress incontinence due to urethral hypermobility. Between September 1996 and September 1999, 35 patients (mean age 49.5 years) underwent extraperitoneal bladder neck suspension at our institution. An extraperitoneal space was created by a trocar-mounted balloon device, and suspension was created using a 5-mm endoscopic hernia stapler and polypropylene mesh. The mean operative time was 39.5 minutes. In 2 patients, the bladder was inadvertently perforated during the bladder neck dissection. The perforation was repaired by laparoscopic suture ligation. The mean urethral catheterization and hospitalization time was 2.1 and 2.3 days, respectively. Urethral recatheterization because of temporary urinary retention was required in 11.4% of the patients. Symptoms of bladder instability were experienced by 13.5% of the patients in the early postoperative period. A total of 28 patients (80.0%) reported that they were totally dry after a mean of 23.2 months. Extraperitoneal bladder neck suspension using hernia mesh and a stapler seems to be an effective and safe procedure, with a shorter operative time, in selected patient groups.

Research paper thumbnail of Functional Outcomes and Long-term Durability of Artificial Urinary Sphincter Application: Review of 56 Patients With Long-term Follow-up

Korean Journal of Urology, 2013

Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation an... more Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation and to report the complication rates, including mechanical failure, erosion, and infection. Materials and Methods: From June 1990 to May 2011, AUS (AMS 800) implantations were performed in 56 adult males by one surgeon. Various demographic and preoperative variables, surgical variables, and postoperative outcomes, including success and complication rates with a median follow-up of 96 months, were recorded retrospectively. Results: The mean age of the patients at the time of AUS implantation was 61.8 (±14.2) years. During the follow-up period, the total complication rate was 41.1% (23 patients). The incidence of complications was significantly lower during the follow-up period after 48 months (p<0.05). Kaplan-Meier analysis revealed that 5-and 10-year failure-free rates were 50.3% and 45.2%, respectively. Conclusions: Long-term durability and functional outcomes are achievable for the AMS 800, but there are appreciable complication rates for erosion, mechanical failure, and infection of up to 30%.

Research paper thumbnail of Diagnosis modelling of urethral obstructions using fuzzy expert system

Proceedings of the 9th International Conference on Computer Systems and Technologies and Workshop for PhD Students in Computing, CompSysTech'08, 2008

Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system il... more Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system illnesses that causes obstruction in the urethra and the bladder. There are several reasons that cause obstructions in the urinary system. The common causes of these obstructions are prostate ...

Research paper thumbnail of Multiparametric Evaluation of Testicular Atrophy Due to Varicocele

Urologia Internationalis, 1991

63 men with palpable left varicoceles were evaluated by semen analysis, scrotal ultrasonography, ... more 63 men with palpable left varicoceles were evaluated by semen analysis, scrotal ultrasonography, Doppler sonography, scrotal contact thermography, and radionuclide scanning. 11 (17.4%) patients had bilateral varicoceles detected by scrotal ultrasonography as compared with an incidence of 3.1% by scrotal palpation. Testicular atrophy was found in 29 (46%) patients by scrotal ultrasonography. This was found to be 39.6% by scrotal palpation alone. In this study using advanced diagnostic procedures, the incidences of bilateral varicocele and testicular atrophy due to varicocele were found to be much higher than when scrotal palpation alone was performed.

Research paper thumbnail of Instillation of Hyaluronic Acid via Electromotive Drug Administration Can Improve the Efficacy of Treatment in Patients With Interstitial Cystitis/Painful Bladder Syndrome: A Randomized Prospective Study

Korean Journal of Urology, 2014

In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be sugges... more In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be suggested as a treatment option. In this randomized prospective study, the authors aimed to identify whether instilling the hyaluronic acid with electromotive drug administration (EMDA) would increase the tissue uptake and improve the efficacy. Materials and Methods: The data of 31 patients who had been diagnosed with bladder pain syndrome/interstitial cystitis (BPS/IC) between 2004 and 2005 were examined. The patients were randomized to two groups: patients in group A received hyaluronic acid directly with a catheter and patients in group B received hyaluronic acid with EMDA. The patients were followed for 24 months and the two groups were compared at certain time intervals. The primary end points of the study were visual analogue scale (VAS) score, global response assessment, and micturition frequency in 24 hours. Results: There were 6 males and 25 females. The two groups were similar in baseline parameters. The decrease in VAS score and the micturition frequency in 24 hours were significantly lower with EMDA at months 6 and 12. The difference between the two groups was not significant at months 1 and 24. Also, treatment with EMDA, positive KCl test, and pretreatment voiding frequency >17 were associated with higher response rates. Conclusions: Hyaluronic acid installation is an effective glycosaminoglycan substitution therapy in patients with BPS/IC. Instillation of hyaluronic acid via EMDA can improve the efficacy of the treatment; however, lack of long-term efficacy is the major problem with this glycosaminoglycan substitution therapy.

Research paper thumbnail of Diagnosis of Bladder Outlet Obstruction in Men With Lower Urinary Tract Symptoms: Comparison of Near Infrared Spectroscopy Algorithm and Pressure Flow Study in a Prospective Study

Research paper thumbnail of Results of dorsal midline plication in children with penile curvature and hypospadias

Urology, 2004

Objectives. To present our initial results using dorsal midline (12-o'clock position) plication i... more Objectives. To present our initial results using dorsal midline (12-o'clock position) plication in children with penile curvature and hypospadias. Methods. Twenty-five children with hypospadias and ventral curvature confirmed after artificial erection underwent dorsal midline plication and hypospadias repair. Ventral curvature was corrected by making a 5 to 10-mm-long vertical incision through the tunica albuginea at the dorsal midline and approximating the outer edges of the incision with a monofilament polydioxanone stitch. Results. One plication suture was needed in 15 patients. In 8 patients with mid-shaft hypospadias and 2 with proximal penile hypospadias, two and three sutures were needed, respectively. In none of the patients was division of the urethral plate needed, except for one with proximal hypospadias. No complications were encountered during a mean follow-up of 9 months (range 5 to 34). Conclusions. We believe that most cases of penile curvature with hypospadias can be corrected using dorsal midline plication of the tunica albuginea. Although long-term follow-up is necessary after puberty to confirm any erectile or sensory advantage, this approach might be considered whenever plication is to be performed.

Research paper thumbnail of Changes in neuropeptide y tissue concentration in the wall of the rat urinary bladder after acute distension

Urological Research, 2005

Neuropeptide Y (NPY) is known to be associated with the adrenergic system. The relationship among... more Neuropeptide Y (NPY) is known to be associated with the adrenergic system. The relationship among the late micturition disorders following acute urinary distension, the adrenergic system and NPY was investigated. A total of 90 rats were included in the study of which 30 acted as the control group. Acute urinary distension was created in 60 rats. The NPY concentration within their bladders was assessed by the use of radioimmunoassay (RIA) at 3 h after distension and subsequently on days 2, 7 and 21, then the third and sixth months. The NPY concentrations assessed in the third and sixth months were compared with the control group in the same age group. By means of the RIA method, a substantial decline of NPY concentration was observed at 2 days after distension, while the concentration started to increase after day 7 (P=0.003). This increase continued until the twenty first day (P=0.004). However, a significant decline was maintained when compared to the concentration before distension. In the third and sixth months, a significant decline were observed in the NPY concentration in comparison to the control group (P=0.004 and P=0.005, respectively). Early and late micturition disorders experienced after acute urinary distension may be the result of adrenergic denervation which may be related to NPY.

Research paper thumbnail of Kriptorkizm Etiyopatogenezinde Ailevi İnsidans ve Kromozomal Bozuklukların Rolü

Turkiye Klinikleri Journal of Case Reports, 1990

Research paper thumbnail of İşeme Bozukluklarında Alt Üriner Sistem Fonksiyon Bozukluklarının (Nörojenik-Nonnörojenik) Değerlendirilmesi

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2005

Research paper thumbnail of Postprostatektomik İdrar Kaçırmada Güncel Tedavi

Turkiye Klinikleri Uroloji Ozel Dergisi, 2008

Research paper thumbnail of Alt Üriner Sistemde Yaşlanma İleOrtaya Çıkan Değişilikler veBunların Benign Prostat Hiperplazisi İle İlişkisi

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2005

Research paper thumbnail of Diagnosis modelling of urethral obstructions using fuzzy expert system

Proceedings of the 9th International Conference on Computer Systems and Technologies and Workshop For Phd Students in Computing, Jun 12, 2008

Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system il... more Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system illnesses that causes obstruction in the urethra and the bladder. There are several reasons that cause obstructions in the urinary system. The common causes of these obstructions are prostate ...

Research paper thumbnail of Spinal Kord Travmalı HastalardaMesane Büyültme Ameliyatları ve Klinik Deneyimlerimiz

Turkiye Klinikleri Journal of Physical Medicine Rehabilitation, 2001

... Devamı... Fiziksel Tıp ve Rehabilitasyon Dergisi Year: 2001 / Volume: 1 / No: 2. Spinal Kord ... more ... Devamı... Fiziksel Tıp ve Rehabilitasyon Dergisi Year: 2001 / Volume: 1 / No: 2. Spinal Kord Travmalı Hastalardamesane Büyültme Ameliyatları Ve Klinik Deneyimlerimiz Nihat ARIKAN * * Prof.Dr., Ankara Üniversitesi Tıp Fakültesi Üroloji AD, ANKARA. ...

Research paper thumbnail of Patients with urinary incontinence often benefit from surgical detethering of tight filum terminale. Editorial comment

Child S Nervous System Chns Official Journal of the International Society For Pediatric Neurosurgery, Mar 1, 2000

Research paper thumbnail of Idiopatim: Detrüsör Instabiliteli Kadınlarda Oxybutinin Hidroklorid Tedavisi

Research paper thumbnail of Assessment of vasculogenic impotence in diabetic men: Using color Doppler flow sonography

Turkiye Klinikleri Journal of Case Reports, 1993

- We evaluated 26 male diabetics for sexual dysfuntion. We used color Doppler flow sonography to ... more - We evaluated 26 male diabetics for sexual dysfuntion. We used color Doppler flow sonography to assess the hemodynamic function of the penis in patients with diabetes mellitus (DM) to detect the presence of arterial disease or venous incompetence. In addition, penile venous ...

Research paper thumbnail of DONÖR SPESİFİK TRANSFÜZYONLARIN (DST) ERKEN ve GEÇ DÖNEM RENAL ALLOGREFT FONKSİYONU ÜZERİNE ETKİSİ THE EFFECT OF DONOR-SPECIFIC TRANSFUSIONS (DST) ON SHORT AND LONG-TERM RENAL ALLOGRAFT FUNCTION

SUMMARY In order to evaluate the effect of donor-speclfl c blood transfusions (DST) on short- and... more SUMMARY In order to evaluate the effect of donor-speclfl c blood transfusions (DST) on short- and long-term re- nal allograft function, a group consisted of 20 pati- ents who underwent DST was compared to 35 patients who received HLA-identical living related donor graft and 25 patients who received one-haplotyplc donor graft. After transplantation, the time in which serum cre- atinine

Research paper thumbnail of Distal Hipospadias Olgularinda Mathieu Yöntemi̇ni̇n Değerlendi̇ri̇lmesi̇

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2000

Postoperatif erken dönemde 5 olguda yara yeri enfeksiyonu, 1 olguda hematom, 2 olguda ise glans p... more Postoperatif erken dönemde 5 olguda yara yeri enfeksiyonu, 1 olguda hematom, 2 olguda ise glans penisin lateral fleplerinde açılma izlendi. Glans lateral flepleri açılan 2 olguya ek olarak geç dönemde ayrıca 8 olguda da (3 olguda meatal stenozla birlikte fistül, 1 olguda yalnızca meatal stenoz ve 4 olguda stenoz olmaksızın fistül) komplikasyon izlenmiştir. Geç dönemde 54 olgunun 44' ünde (%81.4) herhangi bir ek girişim gereksinimi olmamıştır. Belirgin kordesi olmayan distal peni! yerleşimli hipospadias olgularında usulüne uygun yapılan Mathieu operasyonunun sonuçları yüz güldürücüdür.

Research paper thumbnail of Clinical comparision of intravesical hyaluronic acid and hyaluronic acid-chondroitin sulphate therapy for patients with bladder pain syndrome/interstitital cystitis

Canadian Urological Association Journal, 2014

Introduction: Patients with a history of bladder pain syndrome/interstitial cystitis (BPS/IC) and... more Introduction: Patients with a history of bladder pain syndrome/interstitial cystitis (BPS/IC) and who responded poorly or unsatisfactorily with previous treatment were compared taking intravesical hyaluronic acid (HA) or hyaluronic acid-chondroitin sulphate (HA-CS).Methods: Patients were treated with intravesical instillation with 50 mL sterile sodium hyalurinic acid (Hyacyst, Syner-Med, Surrey, UK) (n = 32) and sodium hyaluronate 1.6% sodium chondroitin sulphate 2% (Ialuril, Aspire Pharma, UK) (n = 33). Intravesical instillations were performed weekly in first month, every 15 days in the second month and monthly in third and fourth months, for a total of 8 doses. Patients were evaluated using a visual analog pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), voiding diary for frequency/nocturia, cystometric bladder capacity and voided volume at the beginning and at 6 months. All patients had a potassium sensitivity test (PST) i...

Research paper thumbnail of Extraperitoneal laparoscopic bladder neck suspension using hernia mesh and tacker

Urology, 2000

To report our initial experience with extraperitoneal bladder neck suspension for female stress i... more To report our initial experience with extraperitoneal bladder neck suspension for female stress incontinence due to urethral hypermobility. Between September 1996 and September 1999, 35 patients (mean age 49.5 years) underwent extraperitoneal bladder neck suspension at our institution. An extraperitoneal space was created by a trocar-mounted balloon device, and suspension was created using a 5-mm endoscopic hernia stapler and polypropylene mesh. The mean operative time was 39.5 minutes. In 2 patients, the bladder was inadvertently perforated during the bladder neck dissection. The perforation was repaired by laparoscopic suture ligation. The mean urethral catheterization and hospitalization time was 2.1 and 2.3 days, respectively. Urethral recatheterization because of temporary urinary retention was required in 11.4% of the patients. Symptoms of bladder instability were experienced by 13.5% of the patients in the early postoperative period. A total of 28 patients (80.0%) reported that they were totally dry after a mean of 23.2 months. Extraperitoneal bladder neck suspension using hernia mesh and a stapler seems to be an effective and safe procedure, with a shorter operative time, in selected patient groups.

Research paper thumbnail of Functional Outcomes and Long-term Durability of Artificial Urinary Sphincter Application: Review of 56 Patients With Long-term Follow-up

Korean Journal of Urology, 2013

Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation an... more Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation and to report the complication rates, including mechanical failure, erosion, and infection. Materials and Methods: From June 1990 to May 2011, AUS (AMS 800) implantations were performed in 56 adult males by one surgeon. Various demographic and preoperative variables, surgical variables, and postoperative outcomes, including success and complication rates with a median follow-up of 96 months, were recorded retrospectively. Results: The mean age of the patients at the time of AUS implantation was 61.8 (±14.2) years. During the follow-up period, the total complication rate was 41.1% (23 patients). The incidence of complications was significantly lower during the follow-up period after 48 months (p<0.05). Kaplan-Meier analysis revealed that 5-and 10-year failure-free rates were 50.3% and 45.2%, respectively. Conclusions: Long-term durability and functional outcomes are achievable for the AMS 800, but there are appreciable complication rates for erosion, mechanical failure, and infection of up to 30%.

Research paper thumbnail of Diagnosis modelling of urethral obstructions using fuzzy expert system

Proceedings of the 9th International Conference on Computer Systems and Technologies and Workshop for PhD Students in Computing, CompSysTech'08, 2008

Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system il... more Abstract: The aim of this study is to help the doctors for diagnosis process of urinary system illnesses that causes obstruction in the urethra and the bladder. There are several reasons that cause obstructions in the urinary system. The common causes of these obstructions are prostate ...

Research paper thumbnail of Multiparametric Evaluation of Testicular Atrophy Due to Varicocele

Urologia Internationalis, 1991

63 men with palpable left varicoceles were evaluated by semen analysis, scrotal ultrasonography, ... more 63 men with palpable left varicoceles were evaluated by semen analysis, scrotal ultrasonography, Doppler sonography, scrotal contact thermography, and radionuclide scanning. 11 (17.4%) patients had bilateral varicoceles detected by scrotal ultrasonography as compared with an incidence of 3.1% by scrotal palpation. Testicular atrophy was found in 29 (46%) patients by scrotal ultrasonography. This was found to be 39.6% by scrotal palpation alone. In this study using advanced diagnostic procedures, the incidences of bilateral varicocele and testicular atrophy due to varicocele were found to be much higher than when scrotal palpation alone was performed.

Research paper thumbnail of Instillation of Hyaluronic Acid via Electromotive Drug Administration Can Improve the Efficacy of Treatment in Patients With Interstitial Cystitis/Painful Bladder Syndrome: A Randomized Prospective Study

Korean Journal of Urology, 2014

In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be sugges... more In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be suggested as a treatment option. In this randomized prospective study, the authors aimed to identify whether instilling the hyaluronic acid with electromotive drug administration (EMDA) would increase the tissue uptake and improve the efficacy. Materials and Methods: The data of 31 patients who had been diagnosed with bladder pain syndrome/interstitial cystitis (BPS/IC) between 2004 and 2005 were examined. The patients were randomized to two groups: patients in group A received hyaluronic acid directly with a catheter and patients in group B received hyaluronic acid with EMDA. The patients were followed for 24 months and the two groups were compared at certain time intervals. The primary end points of the study were visual analogue scale (VAS) score, global response assessment, and micturition frequency in 24 hours. Results: There were 6 males and 25 females. The two groups were similar in baseline parameters. The decrease in VAS score and the micturition frequency in 24 hours were significantly lower with EMDA at months 6 and 12. The difference between the two groups was not significant at months 1 and 24. Also, treatment with EMDA, positive KCl test, and pretreatment voiding frequency >17 were associated with higher response rates. Conclusions: Hyaluronic acid installation is an effective glycosaminoglycan substitution therapy in patients with BPS/IC. Instillation of hyaluronic acid via EMDA can improve the efficacy of the treatment; however, lack of long-term efficacy is the major problem with this glycosaminoglycan substitution therapy.

Research paper thumbnail of Diagnosis of Bladder Outlet Obstruction in Men With Lower Urinary Tract Symptoms: Comparison of Near Infrared Spectroscopy Algorithm and Pressure Flow Study in a Prospective Study

Research paper thumbnail of Results of dorsal midline plication in children with penile curvature and hypospadias

Urology, 2004

Objectives. To present our initial results using dorsal midline (12-o'clock position) plication i... more Objectives. To present our initial results using dorsal midline (12-o'clock position) plication in children with penile curvature and hypospadias. Methods. Twenty-five children with hypospadias and ventral curvature confirmed after artificial erection underwent dorsal midline plication and hypospadias repair. Ventral curvature was corrected by making a 5 to 10-mm-long vertical incision through the tunica albuginea at the dorsal midline and approximating the outer edges of the incision with a monofilament polydioxanone stitch. Results. One plication suture was needed in 15 patients. In 8 patients with mid-shaft hypospadias and 2 with proximal penile hypospadias, two and three sutures were needed, respectively. In none of the patients was division of the urethral plate needed, except for one with proximal hypospadias. No complications were encountered during a mean follow-up of 9 months (range 5 to 34). Conclusions. We believe that most cases of penile curvature with hypospadias can be corrected using dorsal midline plication of the tunica albuginea. Although long-term follow-up is necessary after puberty to confirm any erectile or sensory advantage, this approach might be considered whenever plication is to be performed.

Research paper thumbnail of Changes in neuropeptide y tissue concentration in the wall of the rat urinary bladder after acute distension

Urological Research, 2005

Neuropeptide Y (NPY) is known to be associated with the adrenergic system. The relationship among... more Neuropeptide Y (NPY) is known to be associated with the adrenergic system. The relationship among the late micturition disorders following acute urinary distension, the adrenergic system and NPY was investigated. A total of 90 rats were included in the study of which 30 acted as the control group. Acute urinary distension was created in 60 rats. The NPY concentration within their bladders was assessed by the use of radioimmunoassay (RIA) at 3 h after distension and subsequently on days 2, 7 and 21, then the third and sixth months. The NPY concentrations assessed in the third and sixth months were compared with the control group in the same age group. By means of the RIA method, a substantial decline of NPY concentration was observed at 2 days after distension, while the concentration started to increase after day 7 (P=0.003). This increase continued until the twenty first day (P=0.004). However, a significant decline was maintained when compared to the concentration before distension. In the third and sixth months, a significant decline were observed in the NPY concentration in comparison to the control group (P=0.004 and P=0.005, respectively). Early and late micturition disorders experienced after acute urinary distension may be the result of adrenergic denervation which may be related to NPY.