Nilgun Sogutcu - Academia.edu (original) (raw)
Papers by Nilgun Sogutcu
European Journal of Trauma and Emergency Surgery, 2010
Purpose This paper provides an overview of the literature on appendicular tuberculosis (ATB) bet... more Purpose This paper provides an overview of the literature on appendicular tuberculosis (ATB) between 1909 and 2010. Methods We present two cases of primary ATB and a literature review of studies on ATB published in English and accessed via the Pubmed and Google Scholar databases. Results One hundred fifty-five published cases of ATB were reviewed, and two patients with primary ATB, treated and
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY, 2021
OBJECTIVE: Testicular torsion is a common urological complication mostly affecting adolescents an... more OBJECTIVE: Testicular torsion is a common urological complication mostly affecting adolescents and young men. In this study we investigated biochemical and immunohistochemical effects of gallic acid on the damage induced by testicular torsion-detorsion. STUDY DESIGN: Forty male rats were divided into 4 groups of 10 animals each: control, torsion, torsion/ detorsion, and torsion/detorsion+gallic acid. Testicles were removed from the scrotum, and 2.5-hour ischemia was applied to the left testis by twisting the spermatic cord 720° clockwise. Then 3-hour reperfusion was allowed for detorsion. Gallic acid 20 mg/kg was orally administered to the torsion/detorsion+gallic acid group before reperfusion. Biochemical parameters of testicular tissue (MDA, SOD, CAT, and GSH levels) were
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY, 2020
Objective: Numerous studies have been conducted on risk factors for meningioma, mostly investigat... more Objective: Numerous studies have been conducted on risk factors for meningioma, mostly investigating the relationship between meningioma tumor somatostatin receptor 2 status (SSTR2), tumor size, age at diagnosis, and tumor grade. This single-center study performed in patients undergoing meningioma resection was performed to investigate the relationships between tumor characteristics.
Study Design: This study involved a retrospective analysis of patients undergoing meningioma resection at our hospital. Univariate and multivariate logistic regression models were used to investigate the relationships between tumor SSTR2 expression status, progesterone receptor status, Ki-67 proliferation index, grade, and size, as well as to identify factors.
Results: A total of 81 patients had a median age at diagnosis of 50 (21–80) years. The overall survival (OS) periods in female and male patients were 100.2 and 56.4 months, respectively (p=0.02). There was a significant difference in OS rates between the patients ≤65 years of age and those >65 (99.1 and 58.8 months, respectively) (p=0.008). The patients with tumors >3 cm had poorer OS than patients with tumors ≤3 cm (p=0.004). There was no association between tumor SSTR2 expression status and OS; i.e., the OS periods were 75 months in patients with SSTR2-negative tumors, 100.2 months in those with weakly SSTR2-positive tumors, and 89 months in those with strongly SSTR2-positive tumors (p=0.472).
Conclusion: Interestingly, despite the high positive expression rate of SSTR2, there was no relation between SSTR2 expression status and characteristic features of meningiomas. Therefore, further investigations of the role of SSTR2 receptor expression in meningiomas other than its diagnostic value are required.
Ann Ital Chir, Digital Edition 2020; , 2020
Recent classifications systems for gastroenteropancreatic neuroendocrine tumors. A single-center ... more Recent classifications systems for gastroenteropancreatic neuroendocrine tumors. A single-center experience AIM: In this study, we aimed to review the demographic histopathological and clinical findings and long-term results of our GEP-NET cases, as well as to re-evaluate our cases according to the new classification systems. MATERIAL AND METHOD: 46 patients diagnosed as GEPNETs were presented. Immunohistochemical studies were performed in all cases. The cases were divided into 3 groups according to their embryogenic origin (Foregut, Midgut and Hindgut). All cases re-evaluated according to recent WHO (2019) and AJCC (2017) TNM calcification. Investigation was made to find differences between the embryonic origins and to find correlation between stage and grading systems with each other. RESULTS: The most common localization was appendix (52.3%) The distribution of cases according to embryologic origin were as follows: foregut tumors 13 cases (27.7%), midgut tumors 27 cases (57.4%) and hindgut tumors in 6 cases (12.8%). The Ki-67 ratio was evaluated in all patients, with a mean of 6.34%±2.51 (range: 1-80). The Ki-67 ratio was less than 3% in 82.6% of patients. Mitotic count was less than 2 per/10 HPF in 76% of patients. According to WHO 2019 most of patients were Grade 1 Neuroendocrine Tumor (65.2%) and there were only 2 Neuroendocrine Carcinoma (NEC) cases. According to AJCC 2017 most cases were Stage 1 (52.1%) and only 4 cases were Stage 4. The grades and stages of our cases were statistically significantly correlated. Overall survival did not differ significantly with regard to embryologic origin (log-rank test, p=0.062). The median overall survival was 106±7.4 months. The 5-year cumulative survival rate was 84.1±5.6 years. Seven patients died during this time with a median time of 5 months (range: 1-31 months). In the Cox regression analysis, the percentage of Ki-67 was found to have a statistically significant effect on overall survival (p=0.000) CONCLUSION: Correlation was noticed between WHO 2019 and AJCC 2017 classification for grade and stage and controlled trials must be undertaken to develop a single diagnostic algorithm and to change the future management of such patients.
World journal of surgery, 2011
Background While tuberculosis (TB) has been found in many parts of the body, involvement of the t... more Background While tuberculosis (TB) has been found in many parts of the body, involvement of the thyroid gland is rare. In this study we describe the clinicopathological characteristics of seven patients with primary thyroid tuberculosis (TTB). Methods This report is a retrospective case study of seven patients with thyroid tuberculosis who were treated surgically in our clinic between 2004 and 2010. Data collected from the cases included age, sex, clinical presentation, concurrent medical illness, initial diagnosis, and history of pulmonary tuberculosis. Testing used to establish the diagnosis of TTB included thyroid function tests, histopathological examination, a tuberculin skin test, and FNAC (fine needle aspiration cytology). Surgical procedures, antitubercular therapy, and follow-up data were also analyzed. Results All seven cases were females between the age of 30 and 60 years (mean = 44.1 ± 9.5 years). Four cases had neck swelling and three had additional complaints of dysphagia and dyspnea. While total thyroidectomy was performed in six patients with multinodular goiter, a lobectomy was performed in one patient in whom a solitary thyroid nodule was detected. Histopathologic changes consistent with thyroid tuberculosis were detected in all patients. Thoracic X-ray, erythrocyte sedimentation rate (ESR) test, and tuberculin skin test (PPD) were performed and all patients were screened for other possible foci of infection. In conclusion, all seven cases were diagnosed with primary tuberculosis. While the lobectomy patient was administered a 6-month antitubercular treatment, the total-thyroidectomy patients did not receive any medical treatment postoperatively. During the postoperative follow-up period, which lasted between 6 and 53 months (mean = 37.3 ± 18.6 months), none of the patients had a recurrence of disease. Conclusion Tuberculosis should be considered in the list of differential diagnoses for thyroid abscesses and nodular lesions in people living in geographic regions with a high tuberculosis prevalence.
European Journal of Trauma and Emergency Surgery, 2010
Purpose This paper provides an overview of the literature on appendicular tuberculosis (ATB) bet... more Purpose This paper provides an overview of the literature on appendicular tuberculosis (ATB) between 1909 and 2010. Methods We present two cases of primary ATB and a literature review of studies on ATB published in English and accessed via the Pubmed and Google Scholar databases. Results One hundred fifty-five published cases of ATB were reviewed, and two patients with primary ATB, treated and
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY, 2021
OBJECTIVE: Testicular torsion is a common urological complication mostly affecting adolescents an... more OBJECTIVE: Testicular torsion is a common urological complication mostly affecting adolescents and young men. In this study we investigated biochemical and immunohistochemical effects of gallic acid on the damage induced by testicular torsion-detorsion. STUDY DESIGN: Forty male rats were divided into 4 groups of 10 animals each: control, torsion, torsion/ detorsion, and torsion/detorsion+gallic acid. Testicles were removed from the scrotum, and 2.5-hour ischemia was applied to the left testis by twisting the spermatic cord 720° clockwise. Then 3-hour reperfusion was allowed for detorsion. Gallic acid 20 mg/kg was orally administered to the torsion/detorsion+gallic acid group before reperfusion. Biochemical parameters of testicular tissue (MDA, SOD, CAT, and GSH levels) were
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY, 2020
Objective: Numerous studies have been conducted on risk factors for meningioma, mostly investigat... more Objective: Numerous studies have been conducted on risk factors for meningioma, mostly investigating the relationship between meningioma tumor somatostatin receptor 2 status (SSTR2), tumor size, age at diagnosis, and tumor grade. This single-center study performed in patients undergoing meningioma resection was performed to investigate the relationships between tumor characteristics.
Study Design: This study involved a retrospective analysis of patients undergoing meningioma resection at our hospital. Univariate and multivariate logistic regression models were used to investigate the relationships between tumor SSTR2 expression status, progesterone receptor status, Ki-67 proliferation index, grade, and size, as well as to identify factors.
Results: A total of 81 patients had a median age at diagnosis of 50 (21–80) years. The overall survival (OS) periods in female and male patients were 100.2 and 56.4 months, respectively (p=0.02). There was a significant difference in OS rates between the patients ≤65 years of age and those >65 (99.1 and 58.8 months, respectively) (p=0.008). The patients with tumors >3 cm had poorer OS than patients with tumors ≤3 cm (p=0.004). There was no association between tumor SSTR2 expression status and OS; i.e., the OS periods were 75 months in patients with SSTR2-negative tumors, 100.2 months in those with weakly SSTR2-positive tumors, and 89 months in those with strongly SSTR2-positive tumors (p=0.472).
Conclusion: Interestingly, despite the high positive expression rate of SSTR2, there was no relation between SSTR2 expression status and characteristic features of meningiomas. Therefore, further investigations of the role of SSTR2 receptor expression in meningiomas other than its diagnostic value are required.
Ann Ital Chir, Digital Edition 2020; , 2020
Recent classifications systems for gastroenteropancreatic neuroendocrine tumors. A single-center ... more Recent classifications systems for gastroenteropancreatic neuroendocrine tumors. A single-center experience AIM: In this study, we aimed to review the demographic histopathological and clinical findings and long-term results of our GEP-NET cases, as well as to re-evaluate our cases according to the new classification systems. MATERIAL AND METHOD: 46 patients diagnosed as GEPNETs were presented. Immunohistochemical studies were performed in all cases. The cases were divided into 3 groups according to their embryogenic origin (Foregut, Midgut and Hindgut). All cases re-evaluated according to recent WHO (2019) and AJCC (2017) TNM calcification. Investigation was made to find differences between the embryonic origins and to find correlation between stage and grading systems with each other. RESULTS: The most common localization was appendix (52.3%) The distribution of cases according to embryologic origin were as follows: foregut tumors 13 cases (27.7%), midgut tumors 27 cases (57.4%) and hindgut tumors in 6 cases (12.8%). The Ki-67 ratio was evaluated in all patients, with a mean of 6.34%±2.51 (range: 1-80). The Ki-67 ratio was less than 3% in 82.6% of patients. Mitotic count was less than 2 per/10 HPF in 76% of patients. According to WHO 2019 most of patients were Grade 1 Neuroendocrine Tumor (65.2%) and there were only 2 Neuroendocrine Carcinoma (NEC) cases. According to AJCC 2017 most cases were Stage 1 (52.1%) and only 4 cases were Stage 4. The grades and stages of our cases were statistically significantly correlated. Overall survival did not differ significantly with regard to embryologic origin (log-rank test, p=0.062). The median overall survival was 106±7.4 months. The 5-year cumulative survival rate was 84.1±5.6 years. Seven patients died during this time with a median time of 5 months (range: 1-31 months). In the Cox regression analysis, the percentage of Ki-67 was found to have a statistically significant effect on overall survival (p=0.000) CONCLUSION: Correlation was noticed between WHO 2019 and AJCC 2017 classification for grade and stage and controlled trials must be undertaken to develop a single diagnostic algorithm and to change the future management of such patients.
World journal of surgery, 2011
Background While tuberculosis (TB) has been found in many parts of the body, involvement of the t... more Background While tuberculosis (TB) has been found in many parts of the body, involvement of the thyroid gland is rare. In this study we describe the clinicopathological characteristics of seven patients with primary thyroid tuberculosis (TTB). Methods This report is a retrospective case study of seven patients with thyroid tuberculosis who were treated surgically in our clinic between 2004 and 2010. Data collected from the cases included age, sex, clinical presentation, concurrent medical illness, initial diagnosis, and history of pulmonary tuberculosis. Testing used to establish the diagnosis of TTB included thyroid function tests, histopathological examination, a tuberculin skin test, and FNAC (fine needle aspiration cytology). Surgical procedures, antitubercular therapy, and follow-up data were also analyzed. Results All seven cases were females between the age of 30 and 60 years (mean = 44.1 ± 9.5 years). Four cases had neck swelling and three had additional complaints of dysphagia and dyspnea. While total thyroidectomy was performed in six patients with multinodular goiter, a lobectomy was performed in one patient in whom a solitary thyroid nodule was detected. Histopathologic changes consistent with thyroid tuberculosis were detected in all patients. Thoracic X-ray, erythrocyte sedimentation rate (ESR) test, and tuberculin skin test (PPD) were performed and all patients were screened for other possible foci of infection. In conclusion, all seven cases were diagnosed with primary tuberculosis. While the lobectomy patient was administered a 6-month antitubercular treatment, the total-thyroidectomy patients did not receive any medical treatment postoperatively. During the postoperative follow-up period, which lasted between 6 and 53 months (mean = 37.3 ± 18.6 months), none of the patients had a recurrence of disease. Conclusion Tuberculosis should be considered in the list of differential diagnoses for thyroid abscesses and nodular lesions in people living in geographic regions with a high tuberculosis prevalence.