Niraldo Paulino - Academia.edu (original) (raw)

Papers by Niraldo Paulino

Hepatoprotective effect of green propolis is related with antioxidant action in vivo and in vitro

Journal of Applied Oral Science, 2012

I ntracanal medication in pulpectomy therapy is used between appointments with the REMHFWLYH RI U... more I ntracanal medication in pulpectomy therapy is used between appointments with the REMHFWLYH RI UHGXFLQJ SDLQ DQG LQÀDPPDWRU\ SURFHVVHV LQ SXOS DQG SHULDSLFDO WLVVXHV Propolis has been known as a natural antibiotic and has been subject of medical and dental research due to its therapeutic properties such as antibiotic, analgesic and anti-LQÀDPPDWRU\ HIIHFWV 2EMHFWLYH 7KH DLP ZDV WR FDUU\ RXW DQ in vivo evaluation of the periapical tissue response to propolis paste when used as an intracanal medication in the teeth of dogs after pulpectomy. Material and Methods: 72 dog's incisors were selected for the H[SHULPHQW $IWHU ELRPHFKDQLFDO SUHSDUDWLRQ WKH URRW FDQDO ZDV ¿OOHG ZLWK D FRUWLFRVWHURLG antibiotic preparation, experimental propolis paste, non-medicament (negative control) or non-pulpectomy at all (positive control). The medications were left inside the root canal for 7, 14 or 28 days. At the end of the experimental period histological sections were prepared and all laboratories processes for Harris hematoxylin and eosin staining was SURFHHGHG IROORZHG E\ WKH DQDO\VLV XVLQJ DQ RSWLFDO PLFURVFRSH 6HFWLRQV ZHUH FODVVL¿HG DFFRUGLQJ WR D VFRUH UHSUHVHQWLQJ WKH LQÀDPPDWRU\ HYHQWV REVHUYHG WKH SUHVHQFH RI polymorphonuclear neutrophils, polymorphonuclear eosinophils, lymphocytes and plasma FHOOV PDFURSKDJHV DQGRU JLDQW FHOOV ¿EURXV FRQGHQVDWLRQ DQG DEVFHVVHV 5HVXOWV 7KHUH ZHUH VWDWLVWLFDOO\ VLJQL¿FDQW GLIIHUHQFHV EHWZHHQ WKH WLVVXH UHDFWLRQV FDXVHG E\ WKH WZR substances being tested, after different experimental periods, with the periapical tissue that ZDV LQ FRQWDFW ZLWK SURSROLV SDVWH H[KLELWLQJ IHZHU LQÀDPPDWRU\ UHDFWLRQV LQ FRPSDULVRQ WR corticosteroid-antibiotic preparation. Conclusions: The low tissue responses from propolis paste suggest that this material could be considered as an option for root canal medication after pulpectomy.

European Journal of Pharmacology, 2008

Brazilian green propolis from Baccharis dracunculifolia. Our aim in this study was to investigate... more Brazilian green propolis from Baccharis dracunculifolia. Our aim in this study was to investigate the anti-inflammatory effects, absorption, and bioavailability of Artepillin C in mice. The animals used were male Swiss mice subjected to: paw oedema by carrageenan (300 μg/paw), carrageenan-induced peritonitis, and prostaglandin E 2 determination. We also measured in vitro nitric oxide production by RAW 264.7 cells and NF-κB activity in HEK 293 cells. Finally, we measured the absorption and bioavailability of Artepillin C in plasma from mice by means of GC-MS after a single oral dose (10 mg/kg). In vivo, Artepillin C produced a maximal inhibition of 38% after 360 min on paw oedema. Artepillin C also decreased the number of neutrophils during peritonitis (IC 50 : 0.9 (0.5-1.4) mg/kg). Treatment with Artepillin C decreased prostaglandin E 2 by 29 ± 3% and 58 ± 5% at 1 and 10 mg/kg, respectively, with a mean ID 50 of 8.5 (8.0-8.7)mg/kg). Similarly, in in vitro models, Artepillin C (3, 10, or 100 μM) decreased nitric oxide production by RAW 264.7 cells with a mean IC 50 of 8.5 (7.8-9.2) μM. In HEK 293 cells, Artepillin C reduced NF-κB activity with a mean IC 50 of 26 (22-30) μg/ml), suggesting anti-inflammatory activity, particularly during acute inflammation. Lastly, Artepillin C was absorbed after an oral dose (10 mg/kg) with maximal peaks found at 1 h (22 μg/ml). Collectively, Artepillin C showed anti-inflammatory effects mediated, at least in part, by prostaglandin E 2 and nitric oxide inhibition through NF-κB modulation, and exhibited bioavailability by oral administration.

Natural Product Research, 2021

Pupils with hearing impairment have their own form of communication. They also get the opportunit... more Pupils with hearing impairment have their own form of communication. They also get the opportunity to learn Islamic Education subject at the primary level in the Special Primary Schools (SPK) and Special Education Integrated Programme (PPKI). Islamic Education subject has six main areas namely al-Quran, Akidah, Ibadah, Akhlak, Sirah and Jawi. Since the level of hearing and speech impairment of the pupils with special needs are limited, it is essential that the communication aspect in teaching should be taken into the teachers' consideration. The objective of this study is to explain the method of communication used by the teachers as well as the challenges in communication during teaching Islamic Education subject to pupils with hearing impairment. This study utilized the qualitative approach in the form of a case study, using the interview technique and document analysis to obtain data. The findings showed there were inconsistencies in the teachers' communication in delivering the Islamic Education subject to the pupils. Lack of proper codes or signs related to Islamic Education and lack of skills in using sign language are the reasons for inconsistencies in the teachers' communication in delivering the subject to the pupils.

Journal of Pharmacological Sciences, 2003

Arruda, AOD and Souza, LGE and Biz, MT and Ramos, IFDAS and Figueiredo, JAP and Mazzuco, C and To... more Arruda, AOD and Souza, LGE and Biz, MT and Ramos, IFDAS and Figueiredo, JAP and Mazzuco, C and Tokarski, C and Paulino, AS and Paulino, N (2004) Analysis - macroscopic and SEM - of root canal surface after irrigation with 0.25% propolis solution. Jornal Brasileiro ...

International Journal of Phytocosmetics and Natural Ingredients, Dec 26, 2019

Brazil is the country with the biggest biodiversity on the planet, but it does not avail itself e... more Brazil is the country with the biggest biodiversity on the planet, but it does not avail itself enough of this potential to produce herbal medicines. Maytenus ilicifolia Mart. Ex Reissek is popularly known as "Espinheira-Santa" and in Brazil is widely used in popular medicine to treat a number of diseases such as gastritis and dyspepsia, and also displays laxative, diuretic, analgesic, antiseptic and healing properties and antineoplastic and antimicrobial activities. Among the reasons that hinder a better exploration of such biodiversity, the absence of an innovative culture draws a lot of attention, besides the inherent difficulties in the characteristics of the research and the development of this product modality. The aim of this study was developing an effervescent powder containing medicinal extract of M. ilicifolia. The methodologies to determine quality of the plant and extract including the organoleptic characteristics, the moisture content and volatiles, total ashes, extractive content, pH, and the bulk density. In our experiments, we demonstrated that the plant has been identified and has displayed the appropriate organoleptic characteristics to the preparation of the extract; we also demonstrated that the extract has been incorporated into a formulation that maintained its organoleptic characteristics, pH and content, as well as the formation of stable gases. With these experiments, we demonstrate for the first time that the developed formulation can serve as a prototype for the development of pharmaceutics effervescent product containing standardized extract of M. ilicifolia.

Journal of Health Sciences

Na atualidade, as questões que envolvem o uso de anticoagulantes com o sangramento gengival aumen... more Na atualidade, as questões que envolvem o uso de anticoagulantes com o sangramento gengival aumentado ainda não são bem esclarecidas, havendo necessidade de avaliação se realmente estes medicamentos podem condicionar a mudança na inflamação gengival. Buscou-se neste estudo questionar e avaliar a saúde gengival de indivíduos cardiopatas, que utilizam anticoagulantes em período de internação. Foram aplicados questionários para coleta de dados socioeconômicos dos pacientes cardiopatas internados e realizou-se exame dos índices de placa visível (IPV) e sangramento gengival (ISG). Os pacientes participantes deste estudo eram…

Current drug discovery technologies, Jan 20, 2016

Propolis has been used as a natural health product mainly due to the presence of polyphenols, fla... more Propolis has been used as a natural health product mainly due to the presence of polyphenols, flavonoids, phenolic aldehydes, amino acids, vitamins and others bioactive constituents. To this natural substance are attributed different biological and pharmacological properties which are influenced by its chemical composition and organoleptic properties. The aim of this work was to evaluate the physicochemical properties and parameters of green propolis collected during a period of six years (2008-2013) in the state of Minas Gerais, located at the southeastern region of Brazil. The methodology were in accordance with Brazilian legislation on the identity and quality standards of propolis. The evaluated parameters of hydroalcoholic from green propolis were total flavonoids, antioxidant activity -DPPH method, oxidation index, wax content, humidity and insoluble impurities. Propolis samples collected in different seasons during the years 2008 to 2013 presented mean values of total flavono...

Alzheimer's & Dementia, 2016

Cereal Chemistry Journal, 2016

Gluten is an important protein complex for baking products found in wheat, rye, barley, and some ... more Gluten is an important protein complex for baking products found in wheat, rye, barley, and some oat varieties. However, some people need to avoid these grains and their products because they result in gluten-related disorders. The only treatment for these individuals is to engage in a gluten-free diet. The objective of this work was to verify if the gluten content of several commercial food products sold in Brazil complied with their labeling. The Mendez ELISA R5 sandwich method was used to analyze 437 samples, and of these, 70% were labeled as gluten-free, 26% as containing gluten, and 4% not labeled in relation to gluten. The results indicated that 89% of the products labeled as gluten-free were correctly labeled and 11% were not, which represented a risk for celiac people.

Revista De Pesquisa E Inovacao Farmaceutica, Feb 9, 2011

Jbe J Bras Endodontia, Feb 1, 2005

... Oliveira de; Souza, Larissa Goncalves e; Biz, Michelle Tillmann; Ramos, Isabela Franca de Alm... more ... Oliveira de; Souza, Larissa Goncalves e; Biz, Michelle Tillmann; Ramos, Isabela Franca de Almeida Santos; Figueiredo, José Antonio Poli de ... remocão de smear, sem haver diferenca estatística, porém no Rank de posicão o grupo III apresentou-se mais limpo, havendo smear ...

Revista De Pesquisa E Inovacao Farmaceutica, Nov 4, 2013