Nisha Das - Academia.edu (original) (raw)

Papers by Nisha Das

Research paper thumbnail of Hydrothermal liquefaction of freshwater microalgae biomass using Fe 3 O 4 nanoparticle as a catalyst

Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Research paper thumbnail of A comprehensive review of characterization, pretreatment and its applications on different lignocellulosic biomass for bioethanol production

Biomass Conversion and Biorefinery

With the draining of petroleum derivatives, expanding natural contamination issues, there has bee... more With the draining of petroleum derivatives, expanding natural contamination issues, there has been rising enthusiasm for the examination of lignocellulosic biomass for an alternative fsource of energy. Characterization of various biomass, its intermediate, and products is a need for conversion of any biomass to biofuels. Chemical composition of lignocellulosic biomass is an essential point for developing potent pretreatment technologies to break its rigid structure, conversion of sugar by different enzymes mainly cellulose to glucose and even various microorganisms which can ferment sugars into bioethanol and other value-added green chemicals. In this present review work, the main focus is on the proximate and ultimate analysis of different feedstocks, and altered pretreatment techniques such as physical, chemical, physicochemical, and biological methods for bioethanol production have been addressed, which ultimately will help in overcoming the recalcitrance of lignocellulosic biomass by degrading the lignin fraction, breaking down of lignocellulose components, hydrolysis, and fermentation process. Recently, combined pretreatment is gaining popularity as it is more favorable and profitable for improving chemical yield and process of enzymatic hydrolysis of LBs, but it increases the cost of operation. Acid pretreatment, steam explosion, and hydrothermal processes all together show a comparatively high effect on degrading hemicelluloses fraction. Alkali, oxidative, and organosolv pretreatment are more efficient in removing and degrading of lignin portion. This present study will empower a better idea and knowledge of the available process with the upcoming advanced processes which would help to overcome the limitations and establish technology to facilitate the pretreatment methods to make an authentic concept of biorefinery.

Research paper thumbnail of Arabinosyltransferase C enzyme of Mycobacterium tuberculosis, a potential drug target: An insight from molecular docking study

Heliyon

Multi-drug resistant in Mycobacterium tuberculosis (M.tb) is considered as major bottleneck in th... more Multi-drug resistant in Mycobacterium tuberculosis (M.tb) is considered as major bottleneck in the treatment and cure of tuberculosis (TB). Several anti-tubercular drugs fail in its efficacy due to drug-resistant M.tb developed mechanism for resistance. So, research across globe has been carried out to develop effective anti-TB drugs to improve the treatment of these strains. Traditional drug development methods have been proved unsuccessful as it fails to develop a broad-spectrum drug due to lack of structure based approach. Several studies have been conducted in this regard and identified several drug target sites that influence drug-resistant M.tb strains. In this study, the attempt was to study the interaction between the protein Arabinosyltransferase C with the two existing drugs (Ethambutol and Isoniazid) and five modified molecules derived from Ethambutol by calculating their binding affinity and mode of binding through molecular docking study using AutoDock 4. From the comparison study of the existing drug (EMB and INH) and the five proposed modified molecules (Emb1, Emb2, Emb3, Emb4 and Emb5), it is analysed that Emb1 and Emb3 with binding affinities-5.77 kcal/mol and-5.13 kcal/mol respectively can be considered as potential inhibitors of Arabinosyltransferase C in Mycobacterium tuberculosis which is responsible for cell wall synthesis. The facts provided may be further verified experimentally for future drug discovery process to make a stand against tuberculosis and contribute an advance research for worthy antimycobacterial strategies.

Research paper thumbnail of Hydrothermal liquefaction of freshwater microalgae biomass using Fe 3 O 4 nanoparticle as a catalyst

Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Research paper thumbnail of A comprehensive review of characterization, pretreatment and its applications on different lignocellulosic biomass for bioethanol production

Biomass Conversion and Biorefinery

With the draining of petroleum derivatives, expanding natural contamination issues, there has bee... more With the draining of petroleum derivatives, expanding natural contamination issues, there has been rising enthusiasm for the examination of lignocellulosic biomass for an alternative fsource of energy. Characterization of various biomass, its intermediate, and products is a need for conversion of any biomass to biofuels. Chemical composition of lignocellulosic biomass is an essential point for developing potent pretreatment technologies to break its rigid structure, conversion of sugar by different enzymes mainly cellulose to glucose and even various microorganisms which can ferment sugars into bioethanol and other value-added green chemicals. In this present review work, the main focus is on the proximate and ultimate analysis of different feedstocks, and altered pretreatment techniques such as physical, chemical, physicochemical, and biological methods for bioethanol production have been addressed, which ultimately will help in overcoming the recalcitrance of lignocellulosic biomass by degrading the lignin fraction, breaking down of lignocellulose components, hydrolysis, and fermentation process. Recently, combined pretreatment is gaining popularity as it is more favorable and profitable for improving chemical yield and process of enzymatic hydrolysis of LBs, but it increases the cost of operation. Acid pretreatment, steam explosion, and hydrothermal processes all together show a comparatively high effect on degrading hemicelluloses fraction. Alkali, oxidative, and organosolv pretreatment are more efficient in removing and degrading of lignin portion. This present study will empower a better idea and knowledge of the available process with the upcoming advanced processes which would help to overcome the limitations and establish technology to facilitate the pretreatment methods to make an authentic concept of biorefinery.

Research paper thumbnail of Arabinosyltransferase C enzyme of Mycobacterium tuberculosis, a potential drug target: An insight from molecular docking study

Heliyon

Multi-drug resistant in Mycobacterium tuberculosis (M.tb) is considered as major bottleneck in th... more Multi-drug resistant in Mycobacterium tuberculosis (M.tb) is considered as major bottleneck in the treatment and cure of tuberculosis (TB). Several anti-tubercular drugs fail in its efficacy due to drug-resistant M.tb developed mechanism for resistance. So, research across globe has been carried out to develop effective anti-TB drugs to improve the treatment of these strains. Traditional drug development methods have been proved unsuccessful as it fails to develop a broad-spectrum drug due to lack of structure based approach. Several studies have been conducted in this regard and identified several drug target sites that influence drug-resistant M.tb strains. In this study, the attempt was to study the interaction between the protein Arabinosyltransferase C with the two existing drugs (Ethambutol and Isoniazid) and five modified molecules derived from Ethambutol by calculating their binding affinity and mode of binding through molecular docking study using AutoDock 4. From the comparison study of the existing drug (EMB and INH) and the five proposed modified molecules (Emb1, Emb2, Emb3, Emb4 and Emb5), it is analysed that Emb1 and Emb3 with binding affinities-5.77 kcal/mol and-5.13 kcal/mol respectively can be considered as potential inhibitors of Arabinosyltransferase C in Mycobacterium tuberculosis which is responsible for cell wall synthesis. The facts provided may be further verified experimentally for future drug discovery process to make a stand against tuberculosis and contribute an advance research for worthy antimycobacterial strategies.