Nitesh Sanghai - Academia.edu (original) (raw)

Papers by Nitesh Sanghai

Cells, Sep 19, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Current Molecular Medicine, Aug 1, 2022

During the current global pandemic, it is known that SARS-CoV-2 viral infections show different d... more During the current global pandemic, it is known that SARS-CoV-2 viral infections show different disease patterns and marked variability in host immune responses during the progression of the disease called COronaVIrus Disease 2019 (COVID-19). It is a typical respiratory syndrome (SARS) that emerged in China [1]. COVID-19 can cause a wide range of signs and symptoms, with clinical manifestations changing from patient to patient. Earlier in the pandemic, scientists considered only older patients [2, 3] to be vulnerable to COVID-19, but this has now become a myth. With the passage of time all ages have been shown to be susceptible to COVID-19 with varying degrees. Additionally, it has become an increasingly daunting task to recognize the clinical manifestations of SARS-CoV-2 viral infections in asymptomatic patients. Over the course of time, SARS-CoV-2 infections have been found to hijack the human body from head to toe and have baffled many in the health care community. Therefore, we hope to increase awareness in the health care community of an unusual symptom termed 'COVID toe'. Secondly, we would also like to alert practitioners to be vigilant and diligent during the diagnosis of SARS-CoV-2 infections, as non-serious 'COVID toe' could develop into life-threatening COVID-19. We propose that in addition to physical distancing, it is now imperative to detect viral infections in the early stages of the disease to prevent further infection in the community and develop more serious symptoms [4].

GeroScience, Feb 19, 2021

Why certain people relish healthy aging throughout their life span while others suffer pathologic... more Why certain people relish healthy aging throughout their life span while others suffer pathological consequences? In this review, we focus on some of the dominant paradigms of pathological aging, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD), and predict that the antioxidant superoxide dismutase 1 (SOD1), when post-translationally modified by aging-associated oxidative stress, acts as a mechanism to accelerated aging in these age-related neurodegenerative diseases. Oxidative modifications of natively reduced SOD1 induce pathological confirmations such as misfolding, leading to a subsequent formation of monomeric, oligomeric, and multimeric aggregates. Misfolded SOD1 propagates like prions from cell to cell. These modified conformations are detected in brain tissues in ALS, AD, and PD, and are considered a contributing factor to their initial pathogenesis. We have also elaborated on oxidative stress-induced non-native modifications of SOD1 and offered a logistic argument on their global implication in accelerated or pathological aging in the context of ALS, AD, and PD.

Mini-reviews in Medicinal Chemistry, Jan 29, 2021

Antioxidants, Dec 27, 2021

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Drug Discovery Today, Dec 1, 2020

As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinica... more As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinical complication can arise that is characterized by a hyperinflammatory cytokine profile, often termed a 'cytokine storm'. A protein complex (nuclear factor kappa-light-chain-enhancer of activated B cells; NF-kB) is intricately involved in regulating inflammation and the immune response following viral infections, with a reduction in cytokine production often observed following a decrease in NF-kB activity. An approved asthma drug, montelukast, has been found to modulate the activity of NF-kB, and result in a corresponding decrease in proinflammatory mediators. Herein, we hypothesize that repurposing montelukast to suppress NF-kB activation will result in an attenuation of proinflammatory mediators and a decrease in cytokine production, thereby leading to a reduction in symptom severity and to improved clinical outcomes in patients with Coronavirus 2019 (COVID-19).

Antioxidants, 2021

Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) i... more Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) inside living cells and are implicated in the pathogenesis of various neurodegenerative diseases. One of the most complicated and life-threatening motor neurodegenerative diseases (MND) is amyotrophic lateral sclerosis (ALS) because of the poor understanding of its pathophysiology and absence of an effective treatment for its cure. During the last 25 years, researchers around the globe have focused their interest on copper/zinc superoxide dismutase (Cu/Zn SOD, SOD1) protein after the landmark discovery of mutant SOD1 (mSOD1) gene as a risk factor for ALS. Substantial evidence suggests that toxic gain of function due to redox disturbance caused by reactive oxygen species (ROS) changes the biophysical properties of native SOD1 protein thus, instigating its fibrillization and misfolding. These abnormal misfolding aggregates or inclusions of SOD1 play a role in the pathogenesis of both forms ...

Mini-Reviews in Medicinal Chemistry, 2021

Due to the rapidly developing nature of the current COVID-19 outbreak and its almost immediate hu... more Due to the rapidly developing nature of the current COVID-19 outbreak and its almost immediate humanitarian and economic toll, coronavirus drug discovery efforts have largely focused on generating potential COVID-19 drug candidates as quickly as possible. Globally, scientists are working day and night to find the best possible solution to treat the deadly virus. During the first few months of 2020, the SARS-CoV-2 outbreak quickly developed into a pandemic, with a mortality rate that was increasing at an exponential rate day by day. As a result, scientists have turned to a drug repurposing approach to rediscover the potential use and benefits of existing approved drugs. Currently, there is no single drug approved by the U.S. Food and Drug Administration (FDA), for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV) that causes COVID-19. Based on only in-vitro studies, several active drugs are already in the clinical pipeline, m...

Current Molecular Medicine, 2021

During the current global pandemic, it is known that SARS-CoV-2 viral infections show different d... more During the current global pandemic, it is known that SARS-CoV-2 viral infections show different disease patterns and marked variability in host immune responses during the progression of the disease called COronaVIrus Disease 2019 (COVID-19). It is a typical respiratory syndrome (SARS) that emerged in China [1]. COVID-19 can cause a wide range of signs and symptoms, with clinical manifestations changing from patient to patient. Earlier in the pandemic, scientists considered only older patients [2, 3] to be vulnerable to COVID-19, but this has now become a myth. With the passage of time all ages have been shown to be susceptible to COVID-19 with varying degrees. Additionally, it has become an increasingly daunting task to recognize the clinical manifestations of SARS-CoV-2 viral infections in asymptomatic patients. Over the course of time, SARS-CoV-2 infections have been found to hijack the human body from head to toe and have baffled many in the health care community. Therefore, we hope to increase awareness in the health care community of an unusual symptom termed 'COVID toe'. Secondly, we would also like to alert practitioners to be vigilant and diligent during the diagnosis of SARS-CoV-2 infections, as non-serious 'COVID toe' could develop into life-threatening COVID-19. We propose that in addition to physical distancing, it is now imperative to detect viral infections in the early stages of the disease to prevent further infection in the community and develop more serious symptoms [4].

GeroScience, 2021

Why certain people relish healthy aging throughout their life span while others suffer pathologic... more Why certain people relish healthy aging throughout their life span while others suffer pathological consequences? In this review, we focus on some of the dominant paradigms of pathological aging, such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), and predict that the antioxidant superoxide dismutase 1 (SOD1), when post-translationally modified by aging-associated oxidative stress, acts as a mechanism to accelerated aging in these age-related neurodegenerative diseases. Oxidative modifications of natively reduced SOD1 induce pathological confirmations such as misfolding, leading to a subsequent formation of monomeric, oligomeric, and multimeric aggregates. Misfolded SOD1 propagates like prions from cell to cell. These modified conformations are detected in brain tissues in ALS, AD, and PD, and are considered a contributing factor to their initial pathogenesis. We have also elaborated on oxidative stress-induced non-native modifications of SOD1 and offered a logistic argument on their global implication in accelerated or pathological aging in the context of ALS, AD, and PD.

Med. Chem. Commun., 2014

Novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines that exhibit potent tubulin polymerization i... more Novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines that exhibit potent tubulin polymerization inhibition, anticancer activity, anti-migration of cancer cells, chromosomal damage, and apoptosis have been developed.

Drug Discovery Today, 2020

As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinica... more As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinical complication can arise that is characterized by a hyperinflammatory cytokine profile, often termed a 'cytokine storm'. A protein complex (nuclear factor kappa-light-chain-enhancer of activated B cells; NF-kB) is intricately involved in regulating inflammation and the immune response following viral infections, with a reduction in cytokine production often observed following a decrease in NF-kB activity. An approved asthma drug, montelukast, has been found to modulate the activity of NF-kB, and result in a corresponding decrease in proinflammatory mediators. Herein, we hypothesize that repurposing montelukast to suppress NF-kB activation will result in an attenuation of proinflammatory mediators and a decrease in cytokine production, thereby leading to a reduction in symptom severity and to improved clinical outcomes in patients with Coronavirus 2019 (COVID-19).

Cells, Sep 19, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Current Molecular Medicine, Aug 1, 2022

During the current global pandemic, it is known that SARS-CoV-2 viral infections show different d... more During the current global pandemic, it is known that SARS-CoV-2 viral infections show different disease patterns and marked variability in host immune responses during the progression of the disease called COronaVIrus Disease 2019 (COVID-19). It is a typical respiratory syndrome (SARS) that emerged in China [1]. COVID-19 can cause a wide range of signs and symptoms, with clinical manifestations changing from patient to patient. Earlier in the pandemic, scientists considered only older patients [2, 3] to be vulnerable to COVID-19, but this has now become a myth. With the passage of time all ages have been shown to be susceptible to COVID-19 with varying degrees. Additionally, it has become an increasingly daunting task to recognize the clinical manifestations of SARS-CoV-2 viral infections in asymptomatic patients. Over the course of time, SARS-CoV-2 infections have been found to hijack the human body from head to toe and have baffled many in the health care community. Therefore, we hope to increase awareness in the health care community of an unusual symptom termed 'COVID toe'. Secondly, we would also like to alert practitioners to be vigilant and diligent during the diagnosis of SARS-CoV-2 infections, as non-serious 'COVID toe' could develop into life-threatening COVID-19. We propose that in addition to physical distancing, it is now imperative to detect viral infections in the early stages of the disease to prevent further infection in the community and develop more serious symptoms [4].

GeroScience, Feb 19, 2021

Why certain people relish healthy aging throughout their life span while others suffer pathologic... more Why certain people relish healthy aging throughout their life span while others suffer pathological consequences? In this review, we focus on some of the dominant paradigms of pathological aging, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD), and predict that the antioxidant superoxide dismutase 1 (SOD1), when post-translationally modified by aging-associated oxidative stress, acts as a mechanism to accelerated aging in these age-related neurodegenerative diseases. Oxidative modifications of natively reduced SOD1 induce pathological confirmations such as misfolding, leading to a subsequent formation of monomeric, oligomeric, and multimeric aggregates. Misfolded SOD1 propagates like prions from cell to cell. These modified conformations are detected in brain tissues in ALS, AD, and PD, and are considered a contributing factor to their initial pathogenesis. We have also elaborated on oxidative stress-induced non-native modifications of SOD1 and offered a logistic argument on their global implication in accelerated or pathological aging in the context of ALS, AD, and PD.

Mini-reviews in Medicinal Chemistry, Jan 29, 2021

Antioxidants, Dec 27, 2021

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Drug Discovery Today, Dec 1, 2020

As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinica... more As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinical complication can arise that is characterized by a hyperinflammatory cytokine profile, often termed a 'cytokine storm'. A protein complex (nuclear factor kappa-light-chain-enhancer of activated B cells; NF-kB) is intricately involved in regulating inflammation and the immune response following viral infections, with a reduction in cytokine production often observed following a decrease in NF-kB activity. An approved asthma drug, montelukast, has been found to modulate the activity of NF-kB, and result in a corresponding decrease in proinflammatory mediators. Herein, we hypothesize that repurposing montelukast to suppress NF-kB activation will result in an attenuation of proinflammatory mediators and a decrease in cytokine production, thereby leading to a reduction in symptom severity and to improved clinical outcomes in patients with Coronavirus 2019 (COVID-19).

Antioxidants, 2021

Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) i... more Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) inside living cells and are implicated in the pathogenesis of various neurodegenerative diseases. One of the most complicated and life-threatening motor neurodegenerative diseases (MND) is amyotrophic lateral sclerosis (ALS) because of the poor understanding of its pathophysiology and absence of an effective treatment for its cure. During the last 25 years, researchers around the globe have focused their interest on copper/zinc superoxide dismutase (Cu/Zn SOD, SOD1) protein after the landmark discovery of mutant SOD1 (mSOD1) gene as a risk factor for ALS. Substantial evidence suggests that toxic gain of function due to redox disturbance caused by reactive oxygen species (ROS) changes the biophysical properties of native SOD1 protein thus, instigating its fibrillization and misfolding. These abnormal misfolding aggregates or inclusions of SOD1 play a role in the pathogenesis of both forms ...

Mini-Reviews in Medicinal Chemistry, 2021

Due to the rapidly developing nature of the current COVID-19 outbreak and its almost immediate hu... more Due to the rapidly developing nature of the current COVID-19 outbreak and its almost immediate humanitarian and economic toll, coronavirus drug discovery efforts have largely focused on generating potential COVID-19 drug candidates as quickly as possible. Globally, scientists are working day and night to find the best possible solution to treat the deadly virus. During the first few months of 2020, the SARS-CoV-2 outbreak quickly developed into a pandemic, with a mortality rate that was increasing at an exponential rate day by day. As a result, scientists have turned to a drug repurposing approach to rediscover the potential use and benefits of existing approved drugs. Currently, there is no single drug approved by the U.S. Food and Drug Administration (FDA), for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV) that causes COVID-19. Based on only in-vitro studies, several active drugs are already in the clinical pipeline, m...

Current Molecular Medicine, 2021

During the current global pandemic, it is known that SARS-CoV-2 viral infections show different d... more During the current global pandemic, it is known that SARS-CoV-2 viral infections show different disease patterns and marked variability in host immune responses during the progression of the disease called COronaVIrus Disease 2019 (COVID-19). It is a typical respiratory syndrome (SARS) that emerged in China [1]. COVID-19 can cause a wide range of signs and symptoms, with clinical manifestations changing from patient to patient. Earlier in the pandemic, scientists considered only older patients [2, 3] to be vulnerable to COVID-19, but this has now become a myth. With the passage of time all ages have been shown to be susceptible to COVID-19 with varying degrees. Additionally, it has become an increasingly daunting task to recognize the clinical manifestations of SARS-CoV-2 viral infections in asymptomatic patients. Over the course of time, SARS-CoV-2 infections have been found to hijack the human body from head to toe and have baffled many in the health care community. Therefore, we hope to increase awareness in the health care community of an unusual symptom termed 'COVID toe'. Secondly, we would also like to alert practitioners to be vigilant and diligent during the diagnosis of SARS-CoV-2 infections, as non-serious 'COVID toe' could develop into life-threatening COVID-19. We propose that in addition to physical distancing, it is now imperative to detect viral infections in the early stages of the disease to prevent further infection in the community and develop more serious symptoms [4].

GeroScience, 2021

Why certain people relish healthy aging throughout their life span while others suffer pathologic... more Why certain people relish healthy aging throughout their life span while others suffer pathological consequences? In this review, we focus on some of the dominant paradigms of pathological aging, such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), and predict that the antioxidant superoxide dismutase 1 (SOD1), when post-translationally modified by aging-associated oxidative stress, acts as a mechanism to accelerated aging in these age-related neurodegenerative diseases. Oxidative modifications of natively reduced SOD1 induce pathological confirmations such as misfolding, leading to a subsequent formation of monomeric, oligomeric, and multimeric aggregates. Misfolded SOD1 propagates like prions from cell to cell. These modified conformations are detected in brain tissues in ALS, AD, and PD, and are considered a contributing factor to their initial pathogenesis. We have also elaborated on oxidative stress-induced non-native modifications of SOD1 and offered a logistic argument on their global implication in accelerated or pathological aging in the context of ALS, AD, and PD.

Med. Chem. Commun., 2014

Novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines that exhibit potent tubulin polymerization i... more Novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines that exhibit potent tubulin polymerization inhibition, anticancer activity, anti-migration of cancer cells, chromosomal damage, and apoptosis have been developed.

Drug Discovery Today, 2020

As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinica... more As a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, a clinical complication can arise that is characterized by a hyperinflammatory cytokine profile, often termed a 'cytokine storm'. A protein complex (nuclear factor kappa-light-chain-enhancer of activated B cells; NF-kB) is intricately involved in regulating inflammation and the immune response following viral infections, with a reduction in cytokine production often observed following a decrease in NF-kB activity. An approved asthma drug, montelukast, has been found to modulate the activity of NF-kB, and result in a corresponding decrease in proinflammatory mediators. Herein, we hypothesize that repurposing montelukast to suppress NF-kB activation will result in an attenuation of proinflammatory mediators and a decrease in cytokine production, thereby leading to a reduction in symptom severity and to improved clinical outcomes in patients with Coronavirus 2019 (COVID-19).