Noelia Vanden Braber - Academia.edu (original) (raw)
Papers by Noelia Vanden Braber
Biosensors, May 29, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
International journal of food science & technology, Apr 24, 2024
Food Hydrocolloids, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Food Chemistry, Jul 1, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Nutritional Biochemistry, Dec 1, 2018
Soy genistein administered in soluble chitosan microcapsules maintains antioxidant activity and l... more Soy genistein administered in soluble chitosan microcapsules maintains antioxidant activity and limits intestinal inflammation. Jnb (2018),
LWT, 2019
The aim of this study was to evaluate the effect of the microencapsulation (by spray drying) of t... more The aim of this study was to evaluate the effect of the microencapsulation (by spray drying) of the whey-native probiotic yeast Kluyveromyces marxianus VM004 in matrices of whey protein concentrate (WPC) and watersoluble chitosan (WSCh) on the viability of the yeast during drying and storage and in simulated gastrointestinal conditions. The optimized outlet drying temperature was 68°C. This temperature allowed obtaining an encapsulation efficiency of 91% for a suspension of 10% (w/v) WPC. Yeasts microencapsulated in WSCh showed a significantly improved tolerance to simulated gastrointestinal conditions in comparison to free yeasts and yeasts microencapsulated in WPC. Besides, the solids content showed a significant influence on the probiotic viability during storage, with a suspension with 30% (w/v) solids (29:1 WPC:WSCh) showing 95% of viability after passing through gastrointestinal conditions. The results allow expanding the development of mixtures of encapsulating materials to improve the probiotic aptitude of a food ingredient powder.
International Journal of Biological Macromolecules
Journal of Ethnopharmacology, 2022
ETHNOPHARMACOLOGICAL RELEVANCE Minthostachys verticillata (Griseb.) Epling (Lamiaceae) is a plant... more ETHNOPHARMACOLOGICAL RELEVANCE Minthostachys verticillata (Griseb.) Epling (Lamiaceae) is a plant used in folk medicine for digestive or respiratory disorders. In addition, it is incorporated as condiment, in foods, as beverage flavoring or mate. The ethnopharmacological interest of M. verticillata resides in its essential oil (EO). Our group has demonstrated the immunomodulatory ability of EO giving this oil a biological potential not known until that moment and conducted studies to evaluate their possible application in diseases of veterinary interest. However, the immunomodulatory effects of EO administered orally have not been fully characterized. AIM OF THE STUDY This study evaluated the impact of EO oral administration on gastrointestinal and immune health through measurement of immunological and oxidative parameters in mice. MATERIAL AND METHODS The EO was extracted from the leaves, slender stems and flowers of M. verticillata by hydrodistillation and chemical analyzed by gas chromatography-mass spectrometry (GC-MS). Prior to in vivo study, the cytotoxic effect of EO was determined using the human colon carcinoma Caco-2 cell line. For in vivo study, three groups of male Balb/c mice (n = 3) were orally administered with saline solution (control group) and EO (5 or 10 mg/kg/day) during 10 consecutive days. Subsequently, histological and hematological parameters, cytokines production, oxidative markers and CD4+ and CD8+ T cells were evaluated. RESULTS The chemical analysis of EO revealed the presence of a high content of monoterpenes, being the main pulegone (76.12%) and menthone (14.28%). The EO oral administration improved mice growth performance and modulated systemic adaptive immune response by increasing in the total leukocyte number. A high percentage of CD4+ T cells were observed whereas the number of CD8+ T cells was not altered. EO did not alter the morpho-physiology of intestine and improved total antioxidant capacity by decreasing MDA concentrations. In addition, EO decreased the IL-6 levels and increased in the IL-4 and IL-10 concentrations. CONCLUSION Results indicate that M. verticillata EO modulate inflammatory and oxidative parameters constituting a natural alternative which could be applied to improve gastrointestinal and immune functionality in animals.
Food Hydrocolloids, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Dairy Science, 2014
Microcapsules (MC) made with gum arabic (GA) as shell material without and with β-carotene (βc) a... more Microcapsules (MC) made with gum arabic (GA) as shell material without and with β-carotene (βc) as core material were prepared by the spray-drying technique. The effect of these MC on the photodegradation of riboflavin (Rf) in whole milk by fluorescent daylight lamp irradiation was evaluated at a storage temperature of 4°C. The additions of 1.37 mg/mL of MC without βc (MC-GA) and with 0.54 μg/mL of βc (MC-βc-GA) decreased the apparent first-order rate constant of Rf photodegradation by approximately 26 and 30%, respectively. A systematic kinetic and mechanistic analysis of the results indicates that the global protective effect of the MC is mainly due to the combination of quenching of the electronically excited triplet state of Rf and scavenging of the photogenerated reactive oxygen species, such as singlet molecular oxygen, superoxide radical anion and hydroxyl radical. A minor contribution to the photoprotective effect can be also associated with the inner-filter effect exerted by the MC, which partially blocks the direct excitation of Rf. These results allow us to conclude that photodegradation of Rf in milk can be considerably reduced by the addition of small amounts of MC, avoiding large losses in the nutritional value of milk.
Brazilian Journal of Microbiology, 2013
In the present study, the cells of Bifidobacterium animalis subsp. lactis (BI-01) and Lactobacill... more In the present study, the cells of Bifidobacterium animalis subsp. lactis (BI-01) and Lactobacillus acidophilus (LAC-04) were encapsulated in cocoa butter using spray-chilling technology. Survival assays were conducted to evaluate the resistance of the probiotics to the spray-chilling process, their resistance to the simulated gastric and intestinal fluids (SGF and SIF), and their stability during 90 days of storage. The viability of the cells was not affected by microencapsulation. The free and encapsulated cells of B. animalis subsp. lactis were resistant to both SGF and SIF. The microencapsulated cells of L. acidophilus were more resistant to SGF and SIF than the free cells; the viability of the encapsulated cells was enhanced by 67%, while the free cells reached the detection limit of the method (10 3 CFU/g). The encapsulated probiotics were unstable when they were stored at 20°C. The population of encapsulated L. acidophilus decreased drastically when they were stored at 7°C; only 20% of cells were viable after 90 days of storage. The percentage of viable cells of the encapsulated B. animalis subsp.lactis, however, was 72% after the same period of storage. Promising results were obtained when the microparticles were stored at-18°C; the freeze granted 90 days of shelf life to the encapsulated cells. These results suggest that the spray-chilling process using cocoa butter as carrier protects L. acidophilus from gastrointestinal fluids. However, the viability of the cells during storage must be improved.
Carbohydrate Polymers, 2019
In this study, water-soluble chitosan (Ch) derivatives were synthesized by the Maillard reaction ... more In this study, water-soluble chitosan (Ch) derivatives were synthesized by the Maillard reaction between Ch and lactose. The Ch derivatives were characterized by FT-IR, 1 H-NMR and SLS to determine their structure, degree of deacetylation (DD), and molecular weight (Mw). The solubility at physiological pH, the in vitro antioxidant activity against hydroxyl radical, anion superoxide radical and ABTS cation radical, and the cytotoxicity against epithelial cells of the rat ileum (IEC-18) were also evaluated. The Maillard reaction, derivatives with lower Mw and DD and greater solubility than Ch were obtained. The biological properties of the derivatives were dependent on the concentration, Mw and DD, with antioxidant activity greater than or equal to that of Ch and noncytotoxic in a wide range of concentrations. The results indicate that Ch derivatization with lactose produces new water-soluble polysaccharides, with antioxidant activity and non-cytotoxic, which can be used as biomaterials for food and pharmaceutical applications.
Las enfermedades inflamatorias intestinales son de curso crónico y representan un factor de riesg... more Las enfermedades inflamatorias intestinales son de curso crónico y representan un factor de riesgo para el desarrollo de carcinoma colon-rectal. Los mecanismos por los que se inicia y perpetúa el daño inflamatorio en intestino se estudian empleando modelos experimentales como el de colitis inducida por la administración de dextrán sulfato de sodio (DSS). Numerosa evidencia clínica y experimental demuestra que la inflamación crónica se asocia con una exacerbada producción de especies reactivas de oxígeno (EROS), tales como radical anión superóxido (O2·-), radical hidroxilo (HO·), oxígeno molecular singulete (O2 (1Dg)) y peróxido de hidrógeno (H2O2), que inducen un grado de estrés oxidativo crítico en la patofisiología de la inflamación intestinal. Una forma de reducir los efectos del estrés oxidativo es mediante el consumo o administración de compuestos bioactivos tales como flavonoides, que poseen capacidad antioxidante y efectos benéficos directos sobre la salud por su actividad an...
Journal of Applied Sciences, 2009
LWT - Food Science and Technology, 2013
The Journal of Nutritional Biochemistry, 2018
Journal of Agricultural and Food Chemistry
Biosensors, May 29, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
International journal of food science & technology, Apr 24, 2024
Food Hydrocolloids, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Food Chemistry, Jul 1, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Nutritional Biochemistry, Dec 1, 2018
Soy genistein administered in soluble chitosan microcapsules maintains antioxidant activity and l... more Soy genistein administered in soluble chitosan microcapsules maintains antioxidant activity and limits intestinal inflammation. Jnb (2018),
LWT, 2019
The aim of this study was to evaluate the effect of the microencapsulation (by spray drying) of t... more The aim of this study was to evaluate the effect of the microencapsulation (by spray drying) of the whey-native probiotic yeast Kluyveromyces marxianus VM004 in matrices of whey protein concentrate (WPC) and watersoluble chitosan (WSCh) on the viability of the yeast during drying and storage and in simulated gastrointestinal conditions. The optimized outlet drying temperature was 68°C. This temperature allowed obtaining an encapsulation efficiency of 91% for a suspension of 10% (w/v) WPC. Yeasts microencapsulated in WSCh showed a significantly improved tolerance to simulated gastrointestinal conditions in comparison to free yeasts and yeasts microencapsulated in WPC. Besides, the solids content showed a significant influence on the probiotic viability during storage, with a suspension with 30% (w/v) solids (29:1 WPC:WSCh) showing 95% of viability after passing through gastrointestinal conditions. The results allow expanding the development of mixtures of encapsulating materials to improve the probiotic aptitude of a food ingredient powder.
International Journal of Biological Macromolecules
Journal of Ethnopharmacology, 2022
ETHNOPHARMACOLOGICAL RELEVANCE Minthostachys verticillata (Griseb.) Epling (Lamiaceae) is a plant... more ETHNOPHARMACOLOGICAL RELEVANCE Minthostachys verticillata (Griseb.) Epling (Lamiaceae) is a plant used in folk medicine for digestive or respiratory disorders. In addition, it is incorporated as condiment, in foods, as beverage flavoring or mate. The ethnopharmacological interest of M. verticillata resides in its essential oil (EO). Our group has demonstrated the immunomodulatory ability of EO giving this oil a biological potential not known until that moment and conducted studies to evaluate their possible application in diseases of veterinary interest. However, the immunomodulatory effects of EO administered orally have not been fully characterized. AIM OF THE STUDY This study evaluated the impact of EO oral administration on gastrointestinal and immune health through measurement of immunological and oxidative parameters in mice. MATERIAL AND METHODS The EO was extracted from the leaves, slender stems and flowers of M. verticillata by hydrodistillation and chemical analyzed by gas chromatography-mass spectrometry (GC-MS). Prior to in vivo study, the cytotoxic effect of EO was determined using the human colon carcinoma Caco-2 cell line. For in vivo study, three groups of male Balb/c mice (n = 3) were orally administered with saline solution (control group) and EO (5 or 10 mg/kg/day) during 10 consecutive days. Subsequently, histological and hematological parameters, cytokines production, oxidative markers and CD4+ and CD8+ T cells were evaluated. RESULTS The chemical analysis of EO revealed the presence of a high content of monoterpenes, being the main pulegone (76.12%) and menthone (14.28%). The EO oral administration improved mice growth performance and modulated systemic adaptive immune response by increasing in the total leukocyte number. A high percentage of CD4+ T cells were observed whereas the number of CD8+ T cells was not altered. EO did not alter the morpho-physiology of intestine and improved total antioxidant capacity by decreasing MDA concentrations. In addition, EO decreased the IL-6 levels and increased in the IL-4 and IL-10 concentrations. CONCLUSION Results indicate that M. verticillata EO modulate inflammatory and oxidative parameters constituting a natural alternative which could be applied to improve gastrointestinal and immune functionality in animals.
Food Hydrocolloids, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Dairy Science, 2014
Microcapsules (MC) made with gum arabic (GA) as shell material without and with β-carotene (βc) a... more Microcapsules (MC) made with gum arabic (GA) as shell material without and with β-carotene (βc) as core material were prepared by the spray-drying technique. The effect of these MC on the photodegradation of riboflavin (Rf) in whole milk by fluorescent daylight lamp irradiation was evaluated at a storage temperature of 4°C. The additions of 1.37 mg/mL of MC without βc (MC-GA) and with 0.54 μg/mL of βc (MC-βc-GA) decreased the apparent first-order rate constant of Rf photodegradation by approximately 26 and 30%, respectively. A systematic kinetic and mechanistic analysis of the results indicates that the global protective effect of the MC is mainly due to the combination of quenching of the electronically excited triplet state of Rf and scavenging of the photogenerated reactive oxygen species, such as singlet molecular oxygen, superoxide radical anion and hydroxyl radical. A minor contribution to the photoprotective effect can be also associated with the inner-filter effect exerted by the MC, which partially blocks the direct excitation of Rf. These results allow us to conclude that photodegradation of Rf in milk can be considerably reduced by the addition of small amounts of MC, avoiding large losses in the nutritional value of milk.
Brazilian Journal of Microbiology, 2013
In the present study, the cells of Bifidobacterium animalis subsp. lactis (BI-01) and Lactobacill... more In the present study, the cells of Bifidobacterium animalis subsp. lactis (BI-01) and Lactobacillus acidophilus (LAC-04) were encapsulated in cocoa butter using spray-chilling technology. Survival assays were conducted to evaluate the resistance of the probiotics to the spray-chilling process, their resistance to the simulated gastric and intestinal fluids (SGF and SIF), and their stability during 90 days of storage. The viability of the cells was not affected by microencapsulation. The free and encapsulated cells of B. animalis subsp. lactis were resistant to both SGF and SIF. The microencapsulated cells of L. acidophilus were more resistant to SGF and SIF than the free cells; the viability of the encapsulated cells was enhanced by 67%, while the free cells reached the detection limit of the method (10 3 CFU/g). The encapsulated probiotics were unstable when they were stored at 20°C. The population of encapsulated L. acidophilus decreased drastically when they were stored at 7°C; only 20% of cells were viable after 90 days of storage. The percentage of viable cells of the encapsulated B. animalis subsp.lactis, however, was 72% after the same period of storage. Promising results were obtained when the microparticles were stored at-18°C; the freeze granted 90 days of shelf life to the encapsulated cells. These results suggest that the spray-chilling process using cocoa butter as carrier protects L. acidophilus from gastrointestinal fluids. However, the viability of the cells during storage must be improved.
Carbohydrate Polymers, 2019
In this study, water-soluble chitosan (Ch) derivatives were synthesized by the Maillard reaction ... more In this study, water-soluble chitosan (Ch) derivatives were synthesized by the Maillard reaction between Ch and lactose. The Ch derivatives were characterized by FT-IR, 1 H-NMR and SLS to determine their structure, degree of deacetylation (DD), and molecular weight (Mw). The solubility at physiological pH, the in vitro antioxidant activity against hydroxyl radical, anion superoxide radical and ABTS cation radical, and the cytotoxicity against epithelial cells of the rat ileum (IEC-18) were also evaluated. The Maillard reaction, derivatives with lower Mw and DD and greater solubility than Ch were obtained. The biological properties of the derivatives were dependent on the concentration, Mw and DD, with antioxidant activity greater than or equal to that of Ch and noncytotoxic in a wide range of concentrations. The results indicate that Ch derivatization with lactose produces new water-soluble polysaccharides, with antioxidant activity and non-cytotoxic, which can be used as biomaterials for food and pharmaceutical applications.
Las enfermedades inflamatorias intestinales son de curso crónico y representan un factor de riesg... more Las enfermedades inflamatorias intestinales son de curso crónico y representan un factor de riesgo para el desarrollo de carcinoma colon-rectal. Los mecanismos por los que se inicia y perpetúa el daño inflamatorio en intestino se estudian empleando modelos experimentales como el de colitis inducida por la administración de dextrán sulfato de sodio (DSS). Numerosa evidencia clínica y experimental demuestra que la inflamación crónica se asocia con una exacerbada producción de especies reactivas de oxígeno (EROS), tales como radical anión superóxido (O2·-), radical hidroxilo (HO·), oxígeno molecular singulete (O2 (1Dg)) y peróxido de hidrógeno (H2O2), que inducen un grado de estrés oxidativo crítico en la patofisiología de la inflamación intestinal. Una forma de reducir los efectos del estrés oxidativo es mediante el consumo o administración de compuestos bioactivos tales como flavonoides, que poseen capacidad antioxidante y efectos benéficos directos sobre la salud por su actividad an...
Journal of Applied Sciences, 2009
LWT - Food Science and Technology, 2013
The Journal of Nutritional Biochemistry, 2018
Journal of Agricultural and Food Chemistry