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Research paper thumbnail of Online Education of Clean and Healthy Living Behavior (PHBS) in Overcoming the Spread of SARS COV-2 Virus for Gandul Cinere Village Health Cadre

Journal of Innovation and Community Engagement

Gandul Cinere village is located bordered by South Jakarta. Jakarta has a fairly highnumber of SA... more Gandul Cinere village is located bordered by South Jakarta. Jakarta has a fairly highnumber of SARS-COV 2 positive patients. The Indonesian Government has determined thatIndonesia is entering the New Normal era in June 2020. Many people in the community donot care about health protocols in the New Normal era and consider that the Covid-19pandemic is no longer a threat. Our goals are (1) increasing PHBS knowledge andawareness of health cadres to implement PHBS and to teach the community in everyday lifein the New Normal era, and (2) decreasing incidence of Covid-19 related illness in GandulCinere Village. Therefore, a continuous understanding of health protocols is needed. PHBSis part of the health protocol that must be run in this New Normal era. Continued knowledgeprovision is required in order to prevent the transmission of Covid-19, especially in theGandul Village area, Cinere, which borders the red zone area of Covid-19. Health cadreswho are the vanguard need assistance and guid...

Research paper thumbnail of Educational counselling of patients with combined TB and diabetes mellitus: a randomised trial

Public Health Action, 2021

SETTING: Newly diagnosed pulmonary TB with diabetes mellitus (DM) comorbidity attending clinics i... more SETTING: Newly diagnosed pulmonary TB with diabetes mellitus (DM) comorbidity attending clinics in Bandung City, Indonesia.OBJECTIVE: To describe the effect of educational counselling on patients’ knowledge about TB (transmission, treatment, risk factors) and DM (symptoms, treatment, complications, healthy lifestyle), adherence to medication, and to assess characteristics associated with knowledge.DESIGN: All patients received counselling and were then randomised to either structured education on TB-DM, combined with clinical monitoring and medication adjustment (intervention arm), or routine care (control arm). Knowledge and adherence were assessed using a questionnaire.RESULTS: Baseline and 6-month questionnaires were available for 108 of 150 patients randomised (60/76 in the intervention arm and 48/74 in the control arm). Patients knew less about DM than about TB. There was no significant difference in the proportion with knowledge improvement at 6 months, both for TB (difference...

Research paper thumbnail of Expressions of inhibitory checkpoint molecules in acute and chronic HBV and HCV infections: Implications for therapeutic monitoring and personalized therapy

Reviews in Medical Virology, 2019

The function of T cells is tightly controlled by positive and negative regulations to ensure both... more The function of T cells is tightly controlled by positive and negative regulations to ensure both successful pathogen elimination and limitation of immune-mediated pathology. One of the mechanisms to negatively regulate the magnitude and duration of effector T cells is the expression of inhibitory checkpoint molecules (ICs) on the surface membrane of T cells. During acute viral infections, expression of these molecules is upregulated to limit the effector functions following T-cell activation. The expression is subsequently downregulated following viral clearance. In contrast, these molecules are continuously expressed in virus-specific T cells found in persistently infected patients, including cases of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV). The continuously high expression of ICs is responsible for the dysfunctional states of HBV-and HCV-specific T cells in chronic phases, known as Tcell exhaustion. Hence, understanding the regulation of their expression is essential to give insight into pathogenesis as well as the development of effective immunebased antiviral therapies. This review discusses recent updated research on expression of ICs during acute and chronic phases of HBV and HCV infections as well as during the clinical course of antiviral therapy.

Research paper thumbnail of Kajian Kesediaan Masyarakat Terhadap Vaksinasi COVID-19 DI Indonesia

Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing), Feb 25, 2023

Data epidemiologis menunjukkan bahwa sebagian besar populasi harus divaksinasi untuk mencapai kek... more Data epidemiologis menunjukkan bahwa sebagian besar populasi harus divaksinasi untuk mencapai kekebalan komunitas. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui karakteristik dan kesediaan masyarakat Indonesia menerima vaksinasi COVID-19. Metode: Penelitian ini menggunakan desain studi cross-sectional pada Warga Negara Indonesia (WNI) usia 18-60 tahun. Sampel diambil dengan metode convenience sampling. Data dalam penelitian ini dikumpulkan menggunakan kuesioner anonim yang didistribusikan secara online dari tanggal 3 hingga 12 Maret 2021. Analisa data menggunakan univariate dan bivariate analysis Chi-Square. Hasil: Hasil Penelitian menunjukkan dari total sample sebanyak 483 orang, mayoritas responden berjenis kelamin perempuan (71,9%), berusia 18-25 tahun (57%), tamat S1 (52%), tenaga kesahatan (59,3%), belum menikah (66,2%), berdomisili di jawa (82,7%), dan telah vaksinasi covid tahap 1 (83,5%). Hasil uji Chi-square menunjukkan adanya hubungan yang signifikan antara jenis kelamin (p = 0,015), domisili (p = 0,000), Tingkat Pendidikan (p = 0,000), pekerjaan (p = 0,000), kepemilikan asuransi (p = 0,000), riwayat vaksinasi sebelumnya (p = 0,004) dan kesediaan vaksinasi COVID-19. Sedangkan usia dan riwayat penyakit penyerta (comorbid) tidak berhubungan dengan kesediaan vaksinasi COVID-19. Kesimpulan: Adanya hubungan yang signifikan antara jenis kelamin, domisili, tenaga kesehatan, kepemilikan asuransi kesehatan, dan riwayat vaksin sebelumnya dengan kesediaan menerima vaksin COVID-19 (p <0.05) di Indonesia.

Research paper thumbnail of Beyond Trauma Art Therapy for Post-­-Disaster Recovery #5

Research paper thumbnail of Comparison of the nutritional status and lipid profile of tuberculosis patients with and without type 2 diabetes mellitus in primary health care in Bandung

Bali Medical Journal, 2021

Research paper thumbnail of Type 2 Diabetes and its Impact on the Immune System

Current Diabetes Reviews, 2020

Introduction:: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic disease ... more Introduction:: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic disease is indicated by high blood glucose levels due to insufficient insulin production by the pancreas. An inflammatory response occurs as a result of the immune response to high blood glucose levels as well as the presence of inflammatory mediators produced by adipocytes and macrophages in fat tissue. This low and chronic inflammation damages the pancreatic beta cells and leads to insufficient insulin production, which results in hyperglycemia. : Hyperglycemia in diabetes is thought to cause dysfunction of the immune response, which fails to control the spread of invading pathogens in diabetic subjects. Therefore, diabetic subjects are known to more susceptible to infections. The increased prevalence of T2D will increase the incidence of infectious diseases and related comorbidities. Objective: : This review provides an overview of the immunological aspect of T2D and the possible mechanisms t...

Research paper thumbnail of Performance of Point-of-Care Testing Compared with the Standard Laboratory Diagnostic Test in the Measurement of HbA1c in Indonesian Diabetic and Nondiabetic Subjects

Journal of Diabetes Research, 2020

Objective. This study is aimed at investigating if point-of-care testing for HbA1c (POCT-HbA1c) u... more Objective. This study is aimed at investigating if point-of-care testing for HbA1c (POCT-HbA1c) using the HemoCue® HbA1c 501 system could be an alternative method for diabetes screening and monitoring to replace the HbA1c measurement in a standard diagnostic laboratory. Design. This was a cross-sectional study to assess the agreement between POCT and a standard laboratory measurement method for determining the level of HbA1c. Setting and Participants. In total, 108 participants were recruited to participate in this study, consisting of 61 diabetics and 47 nondiabetics. The diabetic group comprised 37 females and 24 males, diagnosed with type 2 diabetes mellitus (DM) and undergoing diabetes treatment at several community health care centres in Bandung, West Java. The nondiabetic group consisted of 15 female and 32 male patients of several community health care centres and healthy volunteers. Sample Collection and Analysis. A venous blood sample was taken for routine HbA1c analysis by...

Research paper thumbnail of Online Education of Clean and Healthy Living Behavior (PHBS) in Overcoming the Spread of SARS COV-2 Virus for Gandul Cinere Village Health Cadre

Journal of Innovation and Community Engagement

Gandul Cinere village is located bordered by South Jakarta. Jakarta has a fairly highnumber of SA... more Gandul Cinere village is located bordered by South Jakarta. Jakarta has a fairly highnumber of SARS-COV 2 positive patients. The Indonesian Government has determined thatIndonesia is entering the New Normal era in June 2020. Many people in the community donot care about health protocols in the New Normal era and consider that the Covid-19pandemic is no longer a threat. Our goals are (1) increasing PHBS knowledge andawareness of health cadres to implement PHBS and to teach the community in everyday lifein the New Normal era, and (2) decreasing incidence of Covid-19 related illness in GandulCinere Village. Therefore, a continuous understanding of health protocols is needed. PHBSis part of the health protocol that must be run in this New Normal era. Continued knowledgeprovision is required in order to prevent the transmission of Covid-19, especially in theGandul Village area, Cinere, which borders the red zone area of Covid-19. Health cadreswho are the vanguard need assistance and guid...

Research paper thumbnail of Educational counselling of patients with combined TB and diabetes mellitus: a randomised trial

Public Health Action, 2021

SETTING: Newly diagnosed pulmonary TB with diabetes mellitus (DM) comorbidity attending clinics i... more SETTING: Newly diagnosed pulmonary TB with diabetes mellitus (DM) comorbidity attending clinics in Bandung City, Indonesia.OBJECTIVE: To describe the effect of educational counselling on patients’ knowledge about TB (transmission, treatment, risk factors) and DM (symptoms, treatment, complications, healthy lifestyle), adherence to medication, and to assess characteristics associated with knowledge.DESIGN: All patients received counselling and were then randomised to either structured education on TB-DM, combined with clinical monitoring and medication adjustment (intervention arm), or routine care (control arm). Knowledge and adherence were assessed using a questionnaire.RESULTS: Baseline and 6-month questionnaires were available for 108 of 150 patients randomised (60/76 in the intervention arm and 48/74 in the control arm). Patients knew less about DM than about TB. There was no significant difference in the proportion with knowledge improvement at 6 months, both for TB (difference...

Research paper thumbnail of Expressions of inhibitory checkpoint molecules in acute and chronic HBV and HCV infections: Implications for therapeutic monitoring and personalized therapy

Reviews in Medical Virology, 2019

The function of T cells is tightly controlled by positive and negative regulations to ensure both... more The function of T cells is tightly controlled by positive and negative regulations to ensure both successful pathogen elimination and limitation of immune-mediated pathology. One of the mechanisms to negatively regulate the magnitude and duration of effector T cells is the expression of inhibitory checkpoint molecules (ICs) on the surface membrane of T cells. During acute viral infections, expression of these molecules is upregulated to limit the effector functions following T-cell activation. The expression is subsequently downregulated following viral clearance. In contrast, these molecules are continuously expressed in virus-specific T cells found in persistently infected patients, including cases of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV). The continuously high expression of ICs is responsible for the dysfunctional states of HBV-and HCV-specific T cells in chronic phases, known as Tcell exhaustion. Hence, understanding the regulation of their expression is essential to give insight into pathogenesis as well as the development of effective immunebased antiviral therapies. This review discusses recent updated research on expression of ICs during acute and chronic phases of HBV and HCV infections as well as during the clinical course of antiviral therapy.

Research paper thumbnail of Kajian Kesediaan Masyarakat Terhadap Vaksinasi COVID-19 DI Indonesia

Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing), Feb 25, 2023

Data epidemiologis menunjukkan bahwa sebagian besar populasi harus divaksinasi untuk mencapai kek... more Data epidemiologis menunjukkan bahwa sebagian besar populasi harus divaksinasi untuk mencapai kekebalan komunitas. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui karakteristik dan kesediaan masyarakat Indonesia menerima vaksinasi COVID-19. Metode: Penelitian ini menggunakan desain studi cross-sectional pada Warga Negara Indonesia (WNI) usia 18-60 tahun. Sampel diambil dengan metode convenience sampling. Data dalam penelitian ini dikumpulkan menggunakan kuesioner anonim yang didistribusikan secara online dari tanggal 3 hingga 12 Maret 2021. Analisa data menggunakan univariate dan bivariate analysis Chi-Square. Hasil: Hasil Penelitian menunjukkan dari total sample sebanyak 483 orang, mayoritas responden berjenis kelamin perempuan (71,9%), berusia 18-25 tahun (57%), tamat S1 (52%), tenaga kesahatan (59,3%), belum menikah (66,2%), berdomisili di jawa (82,7%), dan telah vaksinasi covid tahap 1 (83,5%). Hasil uji Chi-square menunjukkan adanya hubungan yang signifikan antara jenis kelamin (p = 0,015), domisili (p = 0,000), Tingkat Pendidikan (p = 0,000), pekerjaan (p = 0,000), kepemilikan asuransi (p = 0,000), riwayat vaksinasi sebelumnya (p = 0,004) dan kesediaan vaksinasi COVID-19. Sedangkan usia dan riwayat penyakit penyerta (comorbid) tidak berhubungan dengan kesediaan vaksinasi COVID-19. Kesimpulan: Adanya hubungan yang signifikan antara jenis kelamin, domisili, tenaga kesehatan, kepemilikan asuransi kesehatan, dan riwayat vaksin sebelumnya dengan kesediaan menerima vaksin COVID-19 (p <0.05) di Indonesia.

Research paper thumbnail of Beyond Trauma Art Therapy for Post-­-Disaster Recovery #5

Research paper thumbnail of Comparison of the nutritional status and lipid profile of tuberculosis patients with and without type 2 diabetes mellitus in primary health care in Bandung

Bali Medical Journal, 2021

Research paper thumbnail of Type 2 Diabetes and its Impact on the Immune System

Current Diabetes Reviews, 2020

Introduction:: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic disease ... more Introduction:: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic disease is indicated by high blood glucose levels due to insufficient insulin production by the pancreas. An inflammatory response occurs as a result of the immune response to high blood glucose levels as well as the presence of inflammatory mediators produced by adipocytes and macrophages in fat tissue. This low and chronic inflammation damages the pancreatic beta cells and leads to insufficient insulin production, which results in hyperglycemia. : Hyperglycemia in diabetes is thought to cause dysfunction of the immune response, which fails to control the spread of invading pathogens in diabetic subjects. Therefore, diabetic subjects are known to more susceptible to infections. The increased prevalence of T2D will increase the incidence of infectious diseases and related comorbidities. Objective: : This review provides an overview of the immunological aspect of T2D and the possible mechanisms t...

Research paper thumbnail of Performance of Point-of-Care Testing Compared with the Standard Laboratory Diagnostic Test in the Measurement of HbA1c in Indonesian Diabetic and Nondiabetic Subjects

Journal of Diabetes Research, 2020

Objective. This study is aimed at investigating if point-of-care testing for HbA1c (POCT-HbA1c) u... more Objective. This study is aimed at investigating if point-of-care testing for HbA1c (POCT-HbA1c) using the HemoCue® HbA1c 501 system could be an alternative method for diabetes screening and monitoring to replace the HbA1c measurement in a standard diagnostic laboratory. Design. This was a cross-sectional study to assess the agreement between POCT and a standard laboratory measurement method for determining the level of HbA1c. Setting and Participants. In total, 108 participants were recruited to participate in this study, consisting of 61 diabetics and 47 nondiabetics. The diabetic group comprised 37 females and 24 males, diagnosed with type 2 diabetes mellitus (DM) and undergoing diabetes treatment at several community health care centres in Bandung, West Java. The nondiabetic group consisted of 15 female and 32 male patients of several community health care centres and healthy volunteers. Sample Collection and Analysis. A venous blood sample was taken for routine HbA1c analysis by...