Noor Fatima - Academia.edu (original) (raw)

Papers by Noor Fatima

Journal of Rawalpindi Medical College, 2019

Tuberous sclerosis is an autosomal dominant genetic disease that causes benign lesions in various... more Tuberous sclerosis is an autosomal dominant genetic disease that causes benign lesions in various organs such as the kidneys, heart, liver, eyes, lungs, and skin.1 The pathogenesis of this disease involves mutation of either gene TSC1 or gene TSC2, that code protein hamartin and tuberin respectively. These genes play an important role in suppression of tumor growth.2 Patients with tuberous sclerosis present with variety of symptoms that include seizures, intellectual disability, developmental delay, behavioral disorders, skin, lung and kidney lesions; it accounts to be the most common genetic cause of epilepsy.3 The diagnosis of tuberous sclerosis is made on the presence of major and minor criteria (detailed in table I) which are then analyzed to produce a definite or possible diagnosis. 1) Definite diagnosis: Two major features or one major feature with ≥2 minor features. 2) Possible diagnosis: Either one major feature or ≥2 minor features.4 Here we present a case of tuberous scler...

Lentil is a significant legume crop throughout the world where Pakistan stands at 18th position w... more Lentil is a significant legume crop throughout the world where Pakistan stands at 18th position with 8610 tons from 17457 hectares. It is nutritionally rich in protein, carbohydrates, mineral, fat and fiber that can potentially meet food security resolving malnutrition issues. Lentil 220 collections representing Pakistan 184, Syria 14, USA 22 and 04 of unknown origin were studied for high yield, yield contributing traits and early cooking time. Results revealed high variability, 6122 (Pakistan) was considered as best during both years due to its performance as seed yield (68 ± 1.7), biological yield (264 ± 2.8), pod size (0.61 ± 0.01), seed per pod (2), cooking time (11 minutes) and hard seed (0). Comparatively 6122 (Pakistan) and 6042 (Syria) produced the highest biological yield which could also be an efficient source for fodder. 5698 (Pak) and 6015 (USA) took 161–172 days in 2018 while 24783 (unknown) and 5561 (Pak) were matured early in 2019. Lowest cooking time 10 minutes was o...

The Professional Medical Journal, 2008

Objective: To determine whether or not doctors assess the socio-economicstatus of their patients ... more Objective: To determine whether or not doctors assess the socio-economicstatus of their patients in order to customize treatment and improve compliance. Design: A cross-sectional Setting:Jinnah Hospital and Shalimar Hospital Lahore. Period: From March to June 2005 Methods & Material: Ninety-threepatients were included from each of the two randomly selected tertiary care hospitals (one public, one private) ofLahore. Doctor-patient encounters were observed. Results: No assessment was made for 134/186(72%) patients.51/186(27.4%) received an inadequate assessment. Only 01/186(0.5 %) patient received a thorough assessment ofhis socioeconomic status. Doctors in the private hospital made better effort to assess the socioeconomic backgroundof the patient (albeit inadequately), compared to those in the public hospital (p: < 0.0001). Conclusion: Doctors shouldbe regular and meticulous in patients’ socioeconomic status assessment.

Cureus, 2021

Background: Hepatitis C virus (HCV) is the major cause of liver cirrhosis, chronic liver disease,... more Background: Hepatitis C virus (HCV) is the major cause of liver cirrhosis, chronic liver disease, and hepatocellular carcinoma. More than 10 million individuals are living with HCV infection in Pakistan. Due to unawareness, very little information is known about HCV genotype occurrence in Punjab, the largest province of Pakistan. Identification of HCV genotype is very important for HCV treatment because different genotypes of HCV respond differently to antiviral therapy. Objective: The purpose of this research was to determine the distribution frequency of different HCV genotypes in the Punjab province and to demonstrate the distribution pattern of HCV genotypes in different age groups and sexes. Materials and Methods: In this study, we performed HCV genotyping of 3692 samples collected from different sites of the Punjab province, Pakistan. Among 3692 samples, 1755 (47.5%) were males and 1937 (52.4%) were females. Results: A total of 3692 samples were subjected to HCV genotyping and 2977 (81%) patients were genotyped successfully, whereas 715 (19%) patients were found to be HCV not detected. Our study demonstrated that among typeable genotypes, 3a constituted 2582 (69.9%) patients followed by 1a (n = 280) 7.5%, 1b (n = 64) 1.7%, 2a (n = 6) 0.16%, genotype 4 (n = 10) 0.27%, 3+4 (n = 2) 0.56%, 1a+2a (n = 11) 0.29%, 1b+2a (n = 1) 0.02%, 1a+1b (n = 1) 0.02%, and 1a+1b+3 (n = 1) 0.02% patients. HCV genotype distribution was evaluated gender wise and in different age groups like 0-12, 13-18, 19-59, and >60 years. All the HCV genotypes were equally distributed among men and women. The most affected age group was 19-59 years as compared to other age groups. Conclusion: The most frequently distributed HCV genotype in Punjab was found to be genotype 3a followed by genotype 1a, and only 0.94% of infected patients had a mixed genotype infection. Genotype 1a was found to be increasing significantly in the studied population. With these results, it can be assumed that genotype 3a may be replaced by genotype 1a with the passage of time. If this happens, this situation will be challenging in terms of antiviral therapy.

Journal of Asian Concrete Federation, 2020

This work was designed for the production of geopolymer based lightweight aggregate (LWA) using i... more This work was designed for the production of geopolymer based lightweight aggregate (LWA) using industrial by-products. Combination of fly ash (FA) and silica fume (SF) were used as precursors, whereas, combination of sodium hydroxide and sodium silicate were used as activator. Small amount of sodium bicarbonate was also used for surface hardening and early strength development. Pellets of different sizes were crafted manually and cured by microwave radiations just for 5 minutes. The physicomechanical properties of produced pellets (LWA) were discussed in light of: morphology, density, water absorption, specific gravity, porosity, aggregate impact value, and particle crushing strength. The properties of LWA were also compared with literature reported synthetic LWAs cured with different techniques. The water absorption and specific gravity of LWAs were within the specified range provided by ACI standard. Mechanical strength properties briefed that the produced LWAs were strong enough to resist compressive load comparable to natural LWAs and many other synthetic LWAs. Thus, proposed curing method, microwave irradiation, has been found to be a sustainable and fast curing technique than conventional energy-intensive curing regimes. The results also confirmed that produced LWAs have potential to replace natural LWAs both in cast-in-place and precast concrete elements with possible economic, environmental, and technical benefits.

Oriental Insects, 2020

The genus Myolepta, described by Newman in 1838, comprises four species in the Oriental Realm. In... more The genus Myolepta, described by Newman in 1838, comprises four species in the Oriental Realm. In this paper, we describe a new species Myolepta mahmoodii Hassan & Bodlah sp. nov. from the Pothohar region of Punjab, Pakistan. The new species is characterised by a broadly oval abdomen, unlike the abdomen of M. petiolata (which is strongly constricted) and that of M. graciliventris (which is moderately constricted, tergite 2 longer than wide, whereas the tergite is wider than its length in the new species). In M. himalayana the colouration of the abdomen and legs are different (e.g. the femora are entirely black, tergite 2 entirely orangereddish) and it is the only species with short oval antennae (antennae as long as length of the face in M. orientalis). Photographs of the new species, diagnostic characters, distribution, and adult host plant are provided. Distribution map of all known species from the Oriental Realm is provided, and their species diagnoses are briefly discussed.

Journal of Threatened Taxa, 2020

In Pakistan, a total of 81 species under 42 genera of hoverflies are currently known. As a resul... more In Pakistan, a total of 81 species under 42 genera of hoverflies are currently known. As a result of ongoing studies on the family Syrphidae from the Pothwar region of Punjab, we have updated the list of new and known records of the genus Volucella Geoffroy, 1762. The present study includes the diagnostic key, checklist, and distribution of known species, Volucella peleterii (Macquart, 1834), V. pellucens tabanoides Motschulsky, 1859, and V. ruficauda Brunetti, 1907. Volucella pellucens tabanoides Motschulsky, 1859 is a new record for Pakistan. Detailed photographs of all known species including the new records, their diagnostic characters and newly visited plants are provided.

JPMA. The Journal of the Pakistan Medical Association, 2018

To determine the frequency of reduction of pain in symptomatic knee osteoarthritis by using combi... more To determine the frequency of reduction of pain in symptomatic knee osteoarthritis by using combination injections. The experimental study was conducted from January 1, 2010, to December 31, 2016,at Al-Noor Surgery Hospital, Chakwal, Pakistan, and comprised patients suffering from symptomatic knee osteoarthritis. All patients were injected intra-articularly and peri-articularily with a combination of streptomycin, kenacort and lidocaine. The effects of this injection were recorded immediately after injection, after a month and after a year. Data was analyzed using SPSS 21. Of the 169 patients, there were 70(41.40%) males and 99(58.60%) females. The overall mean age and pain duration was 59.27±7.79 years and10.5±5.1 years respectively. No patient had pain immediately after the injection and after a month of follow-up. After a year, 145(86%) had a complete loss of pain compared to the baseline. Three (1.77%) patients required repetition of injection after a year. None of the patients ...

BMC complementary and alternative medicine, Jan 21, 2017

Although the anti-diabetic activity of Aegle marmelos (AM) is known, however, its anti-glycation ... more Although the anti-diabetic activity of Aegle marmelos (AM) is known, however, its anti-glycation activity is not reported yet. In this study, we have investigated its anti-glycation activity under in vitro and in vivo conditions and determined possible mechanism(s) in streptozotocin-induced diabetic rats. Effective dose of AM (400 mg/kg) was administrated orally to diabetic rats for 42 days. Thereafter, blood glucose, serum insulin, HbA1c, antioxidant status, and advanced glycation end-products (AGEs) were measured. AGEs and its receptor (RAGE) in kidney were analyzed by immunohistochemistry and immunoblotting. Additionally, pancreatic sections were co-stained for insulin and glucagon and images were acquired using NIKON TE2000E fluorescence microscopy. Oral administration of AM extract resulted in a significant increase in serum insulin by better functioning of β-cell and preserving pancreatic β-cell integrity in diabetic rats. Treatment of AM extract significantly (p = 0.000) prev...

Pakistan Journal of Psychological Research, 2008

BMC Medical Ethics, 2008

Background The principles of informed consent, confidentiality and privacy are often neglected du... more Background The principles of informed consent, confidentiality and privacy are often neglected during patient care in developing countries. We assessed the degree to which doctors in Lahore adhere to these principles during outpatient consultations. Material & Method The study was conducted at medical out-patient departments (OPDs) of two tertiary care hospitals (one public and one private hospital) of Lahore, selected using multi-stage sampling. 93 patients were selected from each hospital. Doctors' adherence to the principles of informed consent, privacy and confidentiality was observed through client flow analysis performed by trained personnel. Overall patient perception was also assessed regarding these practices and was compared with the assessment made by our data collectors. Results Some degree of informed consent was obtained from only 9.7% patients in the public hospital and 47.8% in the private hospital. 81.4% of patients in the public hospital and 88.4% in the privat...

European Journal of Nutrition, 2015

The present study was undertaken to explore the possible anti-diabetic mechanism(s) of Emblica of... more The present study was undertaken to explore the possible anti-diabetic mechanism(s) of Emblica officinalis (EO) and its active constituent, ellagic acid (EA), in vitro and in vivo. Neonatal streptozotocin-induced non-obese type 2 diabetic rats were treated with a methanolic extract of EO (250 or 500 mg/kg) for 28 days, and blood glucose, serum insulin, and plasma antioxidant status were measured. Insulin and glucagon immunostaining and morphometry were performed in pancreatic section, and liver TBARS and GSH levels were measured. Additionally, EA was tested for glucose-stimulated insulin secretion and glucose tolerance test. Treatment with EO extract resulted in a significant decrease in the fasting blood glucose in a dose- and time-dependent manner in the diabetic rats. It significantly increased serum insulin in the diabetic rats in a dose-dependent manner. Insulin-to-glucose ratio was also increased by EO treatment. Immunostaining of pancreas showed that EO250 increased β-cell size, but EO500 increased β-cells number in diabetic rats. EO significantly increased plasma total antioxidants and liver GSH and decreased liver TBARS. EA stimulated glucose-stimulated insulin secretion from isolated islets and decreased glucose intolerance in diabetic rats. Ellagic acid in EO exerts anti-diabetic activity through the action on β-cells of pancreas that stimulates insulin secretion and decreases glucose intolerance.