Norma D'accorso - Academia.edu (original) (raw)
Papers by Norma D'accorso
Cellulose and starch nanoparticles: Function and surface modifications for biomedical application
Polysaccharide Nanoparticles
ChemInform Abstract: Synthesis and Characterization of Some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazone. Part 2
ChemInform, Jan 9, 2001
Magnetic materials in oil applications
Fundamentals and Industrial Applications of Magnetic Nanoparticles, 2022
Polybenzimidazole membrane for efficient copper removal from aqueous solutions
Polymer International, 2022
Polymer with tetrazolic pendant groups. Interaction between the heterocyclic groups and heavy metals
Fil: Grassi, Diego. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Est... more Fil: Grassi, Diego. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Estudios Transdisciplinarios del Agua; Argentina;
Cuantificacion del principio activo utilizando su absorcion UV. A partir del aislamiento de una b... more Cuantificacion del principio activo utilizando su absorcion UV. A partir del aislamiento de una benzodiazepina a partir de un producto comercial (realizado segun el procedimiento descripto en la PARTE I) se procedera a la verificacion de la dosis del producto activo por cuantificacion del mismo utilizando metodos espectrofotometricos. Para ello es necesario la utilizacion de un espectrometro de UV, realizandose una curva de calibracion apropiada.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this p... more The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Thiolated biopolymers in drug delivery and biomedical applications
Tailor-Made and Functionalized Biopolymer Systems, 2021
Abstract In medicine, the applications of biopolymers are of great interest because of their easy... more Abstract In medicine, the applications of biopolymers are of great interest because of their easy accessibility, low cost, and high functionality. In this context, collagen, albumin, alginate, gelatin, cyclodextrins (CDs), chitosan (CS), dextran, starch, agarose, cellulose, hyaluronic acid, etc. are the most attractive for their several biomedical uses. The incorporation of thiol groups into these biopolymers leads to the production of thiomers, which show an improved possibility to interact with the glycoproteins on the mucosal surfaces. These mucoadhesive properties of thiomers eventually make them ideal substrates for drug delivery and biomedical applications. In this chapter, recent advances in the synthesis of thiolated biopolymers based on CS, starch, gelatin, β-CD, hyaluronic acid, whey protein, pullulan, and alginate are reported.
In this work, from an endemic and non-significant value-added bamboo argentine, nanofibrils (CNFs... more In this work, from an endemic and non-significant value-added bamboo argentine, nanofibrils (CNFs) of 20 nm in width were obtained. These nanofibrils were chemical modified in surface with three simple steps using a noncommercial low molecular weight polylactic acid. The success of modification was confirmed by FTIR, TGA, DSC and XRD analysis. The modified nanofibrils were taken up for changing surface properties in films based on commercial PLA. The results show that dispersive (γ D/S) component of films increase of 34.7 mN/m to 36.1 mN/m after the addition of modified nanofibrils from 2 to 5% in formulation of the films, comparing with a physical blend. Interesting others result in physical, mechanical, and thermal properties of the nanocomposites, were reported.
Chemically modified chitosan for biomolecule delivery
Chitosan in Drug Delivery, 2022
Antiviral activity against Zika virus of a new formulation of curcumin in poly lactic-co-glycolic acid nanoparticles
Journal of Pharmacy and Pharmacology, 2021
Objectives In the search of an effective antiviral formulation, the natural product curcumin (CUR... more Objectives In the search of an effective antiviral formulation, the natural product curcumin (CUR) was encapsulated into poly(lactic-co-glycolic acid) nanoparticles, a non-toxic bioresorbable and biocompatible copolymer. The resulting CUR containing particles (PLGA-CUR NPs) were characterized and analysed for antiviral activity against Zika virus (ZIKV) infection. Methods The PLGA-CUR NPs were characterized by Fourier transform infrared, differential scanning calorimetry, dynamic light scattering, scanning electron microscopy and thermogravimetric analysis and release profile. Cytotoxicity of PLGA-CUR and the antiviral activity against ZIKV were determined in Vero cells. The effect of PLGA-CUR NPs on viral RNA synthesis and protein expression was analysed by RT–qPCR and immunofluorescence staining, respectively. Key findings The PLGA-CUR NPs showed an appropriate in vitro drug release profile. Our studies of the antiviral activity of PLGA-CUR NPs and CUR against ZIKV by virus yield ...
Industrial Applications of Renewable Biomass Products, 2017
Journal of Petroleum Science and Engineering, 2020
A one-step procedure is presented for developing novel superhydrophobic oil-water separation memb... more A one-step procedure is presented for developing novel superhydrophobic oil-water separation membranes, based on composites of nanoparticles and polymers. The combination of hydrophilic particles with hydrophobic polymers allows obtaining superhydrophobic coatings on metal meshes, with chemical and physical stability. The methodology consists of coating SiO 2 hydrophilic nanoparticles with two hydrophobic polymers (polydimethylsiloxane and polyvinylidene fluoride, PDMS and PVDF, respectively) on metal meshes. The nanoparticles generate roughness in the nanoscale, while the combination of PVDF and PDMS provides hydrophobicity, chemical resistance, and reinforce of mechanical properties. Membranes were characterized by XPS, SEM, TEM, FTIR, TGA, water-contact-angles (WCA) measurements, and elongation tests. The membranes present oil flux in the order of 10 2 Lm-2 s-1 , with stable performance during several months for water/oil separation tests when using saline (Na + , Cl-) and hard water (Ca +2 , Mg +2) solutions. The synergetic mixture of three components, PDMS-PVDF-SiO 2 , provides superhydrophobic behaviour while coatings formed by any combination of only two components do not show the targeted properties.
Polyvinyl alcohol nanofibers reinforced with polybenzimidazole: Facile preparation and properties of an anion exchange membrane
Polymers for Advanced Technologies, 2021
The search of novel materials for anion exchange membranes (AEMs) is a key factor in addressing c... more The search of novel materials for anion exchange membranes (AEMs) is a key factor in addressing challenges of electrochemical energy conversion and storage devices in terms of cost, durability, efficiency, and up‐scalability; and composite materials based in electrospun nanofibers have a great potential in this regard. We report a facile preparation method of an AEM composed by polyvinyl alcohol (PVA) nanofibers crosslinked with glutaraldehyde (GA) and reinforced with poly[2‐2′‐(m‐phenylene)‐5‐5′‐bibenzimidazole] (ABPBI) polymer, characterizing it as an AEM in a liquid alkaline water electrolyzer (LAWE) device. Homogeneous and flexible membranes were obtained, with a good chemical stability in the doping solution (15 wt.% KOH), and better swelling resistance than pure ABPBI membranes. The membranes also showed a specific ionic conductivity of 36 mS·cm−1 at 60°C and 41 mS·cm−1 at 80°C, with an activation energy value of 3.5 kJ·mol−1. Regarding LAWE performances, it attained current d...
![Research paper thumbnail of Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives](https://attachments.academia-assets.com/111444838/thumbnails/1.jpg)
](Carbohydrate Research, 2019
Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-r... more Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The pchlorophenyl derivatives showed antiviral activity in a range of micromolar concentration.
Bioorganic & Medicinal Chemistry Letters, 2019
D-ribofuranosyl azide was synthesized by deacetylation from 5-Oacetyl-2,3-isopropylidene-β-D-ribo... more D-ribofuranosyl azide was synthesized by deacetylation from 5-Oacetyl-2,3-isopropylidene-β-D-ribofuranosyl azide. 10 6-O-Propargyl-Dgalactopyranose was synthesized in two steps from 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose by treatment with NaH, propargyl bromide 11 and subsequent deprotection in acidic media. 12 The reduction of 6-O-propargyl-D-galactopyranose with NaBH 4 yielded the 1-Opropargyl-L-galactitol. All novel compounds (1-17) were obtained by CuAAC reaction under microwave irradiation at 80°C during 40 min with overall satisfactory yields. In addition, 1,2,3-triazole-ribose conjugates 18-20 previously reported 13,14 were also synthesized to test their antiviral activity for comparative purposes.
Abstract 4717: Clinical implications for m-tyrosine, an isomer of p-tyrosine, for the treatment of aggressive prostate tumors
Cancer Research, 2016
Clinical and experimental evidence suggest that primary tumors may exert a controlling action on ... more Clinical and experimental evidence suggest that primary tumors may exert a controlling action on its metastases. The phenomenon, by which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis, is known as concomitant tumor resistance (CR). We have previously showed in murine T-lymphoma (LB) tumors, that meta-tyrosine (m-Tyr) an isomer of tyrosine not present in normal proteins, is the main serum anti-tumoral factor responsible for CR. In this work, we assess for the first time the CR phenomenon in human prostate cancer (PCa). Athymic nude mice were inoculated with PC3 cells (primary implant) and after 14 days the animals received a second inoculation (secondary implant). Strikingly, the growth of the secondary implant was significantly reduced after 27 days, in animals carrying the primary xenograft. When phenylalanine (Phe), a protective amino acid highly present in primary tumors, and precursor of p-tyrosine, was periodically inoculated at the ...
Miscibility, Phase Separation, and Mechanism of Phase Separation of Epoxy/Block-Copolymer Blends
Handbook of Epoxy Blends, 2015
Materials Science and Engineering: C, 2016
A new biomedical material to be used as part of acrylic bone cement formulations is described. Th... more A new biomedical material to be used as part of acrylic bone cement formulations is described. This new material is tough, its Young's Modulus is similar to the one of poly (methylmethacrylate) and the contrast agent, usually employed in acrylic bone cements, is homogeneously distributed among the polymeric matrix. Additionally, its wear coefficient is 66% lower than the one measured in poly(methyl methacrylate). The developed material is a branched polymer with polyisoprene backbone and poly(methyl methacrylate) side chains, which are capable of retaining barium sulphate nanoparticles thus avoiding their aggregation. The grafting reaction was carried out in presence of the nanoparticles, using methyl methacrylate as solvent. From the 1 H-NMR spectra it was possible to determine the average number of MMA units per unit of isoprene (3.75:1). The ability to retain nanoparticles (about 8 wt.%), attributed to their interaction with the polymer branches, was determined by thermogravimetric analysis and confirmed by FTIR and microscopy techniques. By SEM microscopy it was also possible to determine the homogeneous spatial distribution of the barium sulphate nanoparticles along the polymer matrix.
Macromolecules, 2014
Controlling nanodomain morphology of nanostructured epoxy thermosets is critical to modulate the ... more Controlling nanodomain morphology of nanostructured epoxy thermosets is critical to modulate the mechanical properties of the cross-linked matrix. In this contribution, we demonstrate that this can be achieved by using a suitable block copolymer containing an epoxy soluble block with the ability to react toward the epoxy system during curing. For this purpose we designed an epoxidized poly-(styrene-b-isoprene-b-styrene) block copolymer incorporating amine-reactive functionalities (eSIS-AEP) in the epoxidized block as modifier for an epoxy system, which allowed the formation of nanostructured thermosets with controlled spherelike nanodomain morphology. The eSIS-AEP was obtained in two steps from poly(styrene-b-isoprene-b-styrene) (SIS) block copolymer by controlled epoxidation of the olefinic block followed by partial oxirane ring-opening reaction using 1-(2-aminoethyl)piperazine as nucleophile. Before the curing reaction it was observed that poly(styrene) blocks self-assembled to form ordered spherelike nanostructures in blends of eSIS-AEP with epoxy precursors. Since the amine-reactive moiety was incorporated to the block copolymer so that it could react toward diglicidyl ether of bisphenol A (DGEBA) at a similar temperature than the DGEBA/hardener reaction, the epoxy miscible block of eSIS-AEP (ePI-AEP) was able to react with DGEBA during curing. Once the cross-linked network was formed, the initially obtained spherelike nanodomains were preserved, indicating that no reaction-induced microphase separation of ePI-AEP subchains occurred. A completely different scenario was ascertained for epoxidized SIS block copolymer, which conducted to nonspherical nanodomains due to the uncontrolled epoxidized poly(isoprene) demixing process during the curing reaction. These results demonstrate the importance of the epoxy soluble block being reactive toward the epoxy precursors to control the morphology of the obtained nanostructure.
Cellulose and starch nanoparticles: Function and surface modifications for biomedical application
Polysaccharide Nanoparticles
ChemInform Abstract: Synthesis and Characterization of Some Heterocyclic Derivatives by Cyclization of Carbohydrate Thiosemicarbazone. Part 2
ChemInform, Jan 9, 2001
Magnetic materials in oil applications
Fundamentals and Industrial Applications of Magnetic Nanoparticles, 2022
Polybenzimidazole membrane for efficient copper removal from aqueous solutions
Polymer International, 2022
Polymer with tetrazolic pendant groups. Interaction between the heterocyclic groups and heavy metals
Fil: Grassi, Diego. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Est... more Fil: Grassi, Diego. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Estudios Transdisciplinarios del Agua; Argentina;
Cuantificacion del principio activo utilizando su absorcion UV. A partir del aislamiento de una b... more Cuantificacion del principio activo utilizando su absorcion UV. A partir del aislamiento de una benzodiazepina a partir de un producto comercial (realizado segun el procedimiento descripto en la PARTE I) se procedera a la verificacion de la dosis del producto activo por cuantificacion del mismo utilizando metodos espectrofotometricos. Para ello es necesario la utilizacion de un espectrometro de UV, realizandose una curva de calibracion apropiada.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this p... more The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Thiolated biopolymers in drug delivery and biomedical applications
Tailor-Made and Functionalized Biopolymer Systems, 2021
Abstract In medicine, the applications of biopolymers are of great interest because of their easy... more Abstract In medicine, the applications of biopolymers are of great interest because of their easy accessibility, low cost, and high functionality. In this context, collagen, albumin, alginate, gelatin, cyclodextrins (CDs), chitosan (CS), dextran, starch, agarose, cellulose, hyaluronic acid, etc. are the most attractive for their several biomedical uses. The incorporation of thiol groups into these biopolymers leads to the production of thiomers, which show an improved possibility to interact with the glycoproteins on the mucosal surfaces. These mucoadhesive properties of thiomers eventually make them ideal substrates for drug delivery and biomedical applications. In this chapter, recent advances in the synthesis of thiolated biopolymers based on CS, starch, gelatin, β-CD, hyaluronic acid, whey protein, pullulan, and alginate are reported.
In this work, from an endemic and non-significant value-added bamboo argentine, nanofibrils (CNFs... more In this work, from an endemic and non-significant value-added bamboo argentine, nanofibrils (CNFs) of 20 nm in width were obtained. These nanofibrils were chemical modified in surface with three simple steps using a noncommercial low molecular weight polylactic acid. The success of modification was confirmed by FTIR, TGA, DSC and XRD analysis. The modified nanofibrils were taken up for changing surface properties in films based on commercial PLA. The results show that dispersive (γ D/S) component of films increase of 34.7 mN/m to 36.1 mN/m after the addition of modified nanofibrils from 2 to 5% in formulation of the films, comparing with a physical blend. Interesting others result in physical, mechanical, and thermal properties of the nanocomposites, were reported.
Chemically modified chitosan for biomolecule delivery
Chitosan in Drug Delivery, 2022
Antiviral activity against Zika virus of a new formulation of curcumin in poly lactic-co-glycolic acid nanoparticles
Journal of Pharmacy and Pharmacology, 2021
Objectives In the search of an effective antiviral formulation, the natural product curcumin (CUR... more Objectives In the search of an effective antiviral formulation, the natural product curcumin (CUR) was encapsulated into poly(lactic-co-glycolic acid) nanoparticles, a non-toxic bioresorbable and biocompatible copolymer. The resulting CUR containing particles (PLGA-CUR NPs) were characterized and analysed for antiviral activity against Zika virus (ZIKV) infection. Methods The PLGA-CUR NPs were characterized by Fourier transform infrared, differential scanning calorimetry, dynamic light scattering, scanning electron microscopy and thermogravimetric analysis and release profile. Cytotoxicity of PLGA-CUR and the antiviral activity against ZIKV were determined in Vero cells. The effect of PLGA-CUR NPs on viral RNA synthesis and protein expression was analysed by RT–qPCR and immunofluorescence staining, respectively. Key findings The PLGA-CUR NPs showed an appropriate in vitro drug release profile. Our studies of the antiviral activity of PLGA-CUR NPs and CUR against ZIKV by virus yield ...
Industrial Applications of Renewable Biomass Products, 2017
Journal of Petroleum Science and Engineering, 2020
A one-step procedure is presented for developing novel superhydrophobic oil-water separation memb... more A one-step procedure is presented for developing novel superhydrophobic oil-water separation membranes, based on composites of nanoparticles and polymers. The combination of hydrophilic particles with hydrophobic polymers allows obtaining superhydrophobic coatings on metal meshes, with chemical and physical stability. The methodology consists of coating SiO 2 hydrophilic nanoparticles with two hydrophobic polymers (polydimethylsiloxane and polyvinylidene fluoride, PDMS and PVDF, respectively) on metal meshes. The nanoparticles generate roughness in the nanoscale, while the combination of PVDF and PDMS provides hydrophobicity, chemical resistance, and reinforce of mechanical properties. Membranes were characterized by XPS, SEM, TEM, FTIR, TGA, water-contact-angles (WCA) measurements, and elongation tests. The membranes present oil flux in the order of 10 2 Lm-2 s-1 , with stable performance during several months for water/oil separation tests when using saline (Na + , Cl-) and hard water (Ca +2 , Mg +2) solutions. The synergetic mixture of three components, PDMS-PVDF-SiO 2 , provides superhydrophobic behaviour while coatings formed by any combination of only two components do not show the targeted properties.
Polyvinyl alcohol nanofibers reinforced with polybenzimidazole: Facile preparation and properties of an anion exchange membrane
Polymers for Advanced Technologies, 2021
The search of novel materials for anion exchange membranes (AEMs) is a key factor in addressing c... more The search of novel materials for anion exchange membranes (AEMs) is a key factor in addressing challenges of electrochemical energy conversion and storage devices in terms of cost, durability, efficiency, and up‐scalability; and composite materials based in electrospun nanofibers have a great potential in this regard. We report a facile preparation method of an AEM composed by polyvinyl alcohol (PVA) nanofibers crosslinked with glutaraldehyde (GA) and reinforced with poly[2‐2′‐(m‐phenylene)‐5‐5′‐bibenzimidazole] (ABPBI) polymer, characterizing it as an AEM in a liquid alkaline water electrolyzer (LAWE) device. Homogeneous and flexible membranes were obtained, with a good chemical stability in the doping solution (15 wt.% KOH), and better swelling resistance than pure ABPBI membranes. The membranes also showed a specific ionic conductivity of 36 mS·cm−1 at 60°C and 41 mS·cm−1 at 80°C, with an activation energy value of 3.5 kJ·mol−1. Regarding LAWE performances, it attained current d...
Carbohydrate Research, 2019
Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-r... more Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The pchlorophenyl derivatives showed antiviral activity in a range of micromolar concentration.
Bioorganic & Medicinal Chemistry Letters, 2019
D-ribofuranosyl azide was synthesized by deacetylation from 5-Oacetyl-2,3-isopropylidene-β-D-ribo... more D-ribofuranosyl azide was synthesized by deacetylation from 5-Oacetyl-2,3-isopropylidene-β-D-ribofuranosyl azide. 10 6-O-Propargyl-Dgalactopyranose was synthesized in two steps from 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose by treatment with NaH, propargyl bromide 11 and subsequent deprotection in acidic media. 12 The reduction of 6-O-propargyl-D-galactopyranose with NaBH 4 yielded the 1-Opropargyl-L-galactitol. All novel compounds (1-17) were obtained by CuAAC reaction under microwave irradiation at 80°C during 40 min with overall satisfactory yields. In addition, 1,2,3-triazole-ribose conjugates 18-20 previously reported 13,14 were also synthesized to test their antiviral activity for comparative purposes.
Abstract 4717: Clinical implications for m-tyrosine, an isomer of p-tyrosine, for the treatment of aggressive prostate tumors
Cancer Research, 2016
Clinical and experimental evidence suggest that primary tumors may exert a controlling action on ... more Clinical and experimental evidence suggest that primary tumors may exert a controlling action on its metastases. The phenomenon, by which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis, is known as concomitant tumor resistance (CR). We have previously showed in murine T-lymphoma (LB) tumors, that meta-tyrosine (m-Tyr) an isomer of tyrosine not present in normal proteins, is the main serum anti-tumoral factor responsible for CR. In this work, we assess for the first time the CR phenomenon in human prostate cancer (PCa). Athymic nude mice were inoculated with PC3 cells (primary implant) and after 14 days the animals received a second inoculation (secondary implant). Strikingly, the growth of the secondary implant was significantly reduced after 27 days, in animals carrying the primary xenograft. When phenylalanine (Phe), a protective amino acid highly present in primary tumors, and precursor of p-tyrosine, was periodically inoculated at the ...
Miscibility, Phase Separation, and Mechanism of Phase Separation of Epoxy/Block-Copolymer Blends
Handbook of Epoxy Blends, 2015
Materials Science and Engineering: C, 2016
A new biomedical material to be used as part of acrylic bone cement formulations is described. Th... more A new biomedical material to be used as part of acrylic bone cement formulations is described. This new material is tough, its Young's Modulus is similar to the one of poly (methylmethacrylate) and the contrast agent, usually employed in acrylic bone cements, is homogeneously distributed among the polymeric matrix. Additionally, its wear coefficient is 66% lower than the one measured in poly(methyl methacrylate). The developed material is a branched polymer with polyisoprene backbone and poly(methyl methacrylate) side chains, which are capable of retaining barium sulphate nanoparticles thus avoiding their aggregation. The grafting reaction was carried out in presence of the nanoparticles, using methyl methacrylate as solvent. From the 1 H-NMR spectra it was possible to determine the average number of MMA units per unit of isoprene (3.75:1). The ability to retain nanoparticles (about 8 wt.%), attributed to their interaction with the polymer branches, was determined by thermogravimetric analysis and confirmed by FTIR and microscopy techniques. By SEM microscopy it was also possible to determine the homogeneous spatial distribution of the barium sulphate nanoparticles along the polymer matrix.
Macromolecules, 2014
Controlling nanodomain morphology of nanostructured epoxy thermosets is critical to modulate the ... more Controlling nanodomain morphology of nanostructured epoxy thermosets is critical to modulate the mechanical properties of the cross-linked matrix. In this contribution, we demonstrate that this can be achieved by using a suitable block copolymer containing an epoxy soluble block with the ability to react toward the epoxy system during curing. For this purpose we designed an epoxidized poly-(styrene-b-isoprene-b-styrene) block copolymer incorporating amine-reactive functionalities (eSIS-AEP) in the epoxidized block as modifier for an epoxy system, which allowed the formation of nanostructured thermosets with controlled spherelike nanodomain morphology. The eSIS-AEP was obtained in two steps from poly(styrene-b-isoprene-b-styrene) (SIS) block copolymer by controlled epoxidation of the olefinic block followed by partial oxirane ring-opening reaction using 1-(2-aminoethyl)piperazine as nucleophile. Before the curing reaction it was observed that poly(styrene) blocks self-assembled to form ordered spherelike nanostructures in blends of eSIS-AEP with epoxy precursors. Since the amine-reactive moiety was incorporated to the block copolymer so that it could react toward diglicidyl ether of bisphenol A (DGEBA) at a similar temperature than the DGEBA/hardener reaction, the epoxy miscible block of eSIS-AEP (ePI-AEP) was able to react with DGEBA during curing. Once the cross-linked network was formed, the initially obtained spherelike nanodomains were preserved, indicating that no reaction-induced microphase separation of ePI-AEP subchains occurred. A completely different scenario was ascertained for epoxidized SIS block copolymer, which conducted to nonspherical nanodomains due to the uncontrolled epoxidized poly(isoprene) demixing process during the curing reaction. These results demonstrate the importance of the epoxy soluble block being reactive toward the epoxy precursors to control the morphology of the obtained nanostructure.