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Papers by Nur Dokuzeylül Güngör

PubMed, 2023

Objective: To investigate the effects of body mass index (BMI) values and 25(OH) vitamin D levels... more Objective: To investigate the effects of body mass index (BMI) values and 25(OH) vitamin D levels determined by Endocrine Society on serum Anti Mullerian Hormone (AMH) and antral follicle count (AFC) in women with polycystic ovary syndrome (PCOS). Patients and methods: Sixty infertile women with PCOS and 30 age-matched women with unexplained infertility (UEI), were included. Patients in PCOS and control groups were divided into three subgroups according to their BMI values as normal, overweight and obese. Each BMI group was divided into three subgroups according to vitamin D levels. While AMH and vitamin D levels were determined at first admission, AFC was measured on the third day of cycle. Results: BMI, AFC, and AMH levels of women with PCOS were significantly higher than the UEI group. AMH values of women with PCOS with normal BMI were found to be significantly higher than UEI controls with normal BMI. AMH values of overweight and obese PCOS patients and controls were similar. As BMI values of the PCOS group increased, vitamin D levels decreased significantly. Vitamin D levels of the patients in the PCOS group were found to be significantly lower than the control group. When evaluated according to BMI, the vitamin D levels of normal, overweight and obese women with PCOS were significantly lower than the UEI. Conclusions: Rising BMI in PCOS leads to a significant decrease in vitamin D and AMH. Deficiency, insufficiency or normality of vitamin D do not affect the main markers of ovarian reserve.

International Journal of Environmental Research and Public Health

Background: Homeobox genes A10 (HOXA10) and A11 (HOXA11), members of the abdominal B gene family,... more Background: Homeobox genes A10 (HOXA10) and A11 (HOXA11), members of the abdominal B gene family, are responsible for embryonic survival and implantation. This study was planned to investigate whether endometrial injury alters the expression of both transcripts in women with implantation failure. Methods: A total of 54 women with implantation failure were divided into two equal groups as experimental (scratching) and sham (no scratching). Participants in the scratching group were exposed to endometrial injury in the mid-luteal phase, and those in the sham group were exposed to endometrial flushing. The scratching group, but not the sham group, underwent prior endometrial sampling. A second endometrial sampling was performed on the scratching group in the mid-luteal phase of the following cycle. The mRNA and protein levels of the HOXA10 and 11 transcripts were determined in endometrial samples collected before and after injury/flushing. Participants in each group underwent IVF/ET in ...

Gynecology & Reproductive Health

Objective: The biological mechanism of the fertility-enhancing effect of hysterosalpingography (H... more Objective: The biological mechanism of the fertility-enhancing effect of hysterosalpingography (HSG) is not fully known. Leukemia inhibitory factor (LIF) is an important cytokine involved in implantation. This study was planned to investigate the effect of HSG on LIF mRNA expression in endometrial flushing samples. Methods: Forty infertile patients scheduled for HSG were included in the study. Before HSG, endometrial flushing was performed in the mid-luteal phase, followed by contrast-medium infusion into the cavity. Second flushing was done in the mid-luteal phase of the next cycle. Ten patients who underwent diagnostic hysteroscopy were taken as the second control group. LIF mRNA levels were measured by RT-PCR in endometrial flushing samples collected from each group. Results: The pre-HSG LIF mRNA levels of the infertile group were significantly lower than those of the fertile group. In infertile patients, LIF mRNA expression increased 3.2 times after HSG compared to baseline leve...

European review for medical and pharmacological sciences, 2022

OBJECTIVE The aim of the study was to investigate the relationship between serum level of vitamin... more OBJECTIVE The aim of the study was to investigate the relationship between serum level of vitamin D, semen analysis parameters and sperm DNA damage in men with unexplained subfertility. PATIENTS AND METHODS Fifty-eight men diagnosed with unexplained infertility and 50 age and BMI matched fertile men were included in the study. A participant whose semen parameter is normal but pregnancy is not achieved was accepted as unexplained male infertility. Blood samples were taken from all participants following three-day abstinence for measurement of vitamin D. Sperm DNA damage was assessed by Aniline Blue staining of the collected samples. RESULTS Compared with the fertile men, male patients with unexplained infertility had significantly lower vit D levels (27.00 ng/mL (12.63-39.30) vs. 23.66 ng/mL (7.50-55.00), p<0.004). While the number of patients with vitamin D levels lower than 20 ng/mL was 26 (44.8%) in the infertile group, it was recorded as 5 (10.0%) in the fertile group (p<0....

THE ULUTAS MEDICAL JOURNAL, 2022

Annals of Clinical and Analytical Medicine, 2021

Journal of Controversies in Obstetrics & Gynecology and Pediatrics

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive a... more Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by a combination of hormonal imbalances, ovarian dysfunction, and metabolic disturbances. PCOS has significant implications for women's health, fertility, and overall well-being. This comprehensive review aims to provide an overview of PCOS, including its etiology, clinical manifestations, diagnosis, and management strategies.

THE ULUTAS MEDICAL JOURNAL, 2021

Introduction: Individuals with polycystic ovary syndrome (PCOS) tend to exhibit insulin resistanc... more Introduction: Individuals with polycystic ovary syndrome (PCOS) tend to exhibit insulin resistance and circulating levels of insulin higher than controls matched to obesity levels. The present study aimed to evaluate the hormonal alterations through body mass index (BMI) on the relationship between insulin, insulin resistance (IR), and thyroid hormone levels in PCOS. Materials and Methods: This study is a retrospective clinical analysis study conducted at the department of gynecology and obstetrics between January 2019 and April 2020. PCOS participants were divided into two groups: 59 obese PCOS patients whose BMI value is equal and higher than 27kg/m2; 51 normal or overweight PCOS with BMI less than 27kg/m2. Results: Age factor did not differ between groups (29.8±6 vs 31±7.2; p=0.345). In hormone tests, insulin (14.2±6.8 vs 14.8±8; p=0.688), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (3.1±1.4 vs 3.4±1.8; p=0.344), thyroxine (T4)(1.2±0.5 vs 1.2±0.4) and thyroid-stimulating hormone (TSH)(1.9±1.2 vs 1.8±0.9; p=0.848) levels did not differ for BMI groups (p>0.05). Because there was no difference in laboratory comparison for any parameter we analyzed, we could not perform multivariate analysis for further investigations in terms of BMI factor. In the hematological analysis, we did not see any significant alteration for groups. Conclusion: We did not observe any difference between thyroid and IR in the patients who were grouped according to the BMI. PCOS and obesity may be directly related to hormonal interaction rather than adipose tissue.

Human Reproduction, Jun 29, 2022

The World Journal of Men's Health

Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health... more Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant professional society guideline recommendations, and provide expert recommendations. Materials and Methods: Materials and Methods: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus. Results: Results: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing. Conclusions: Conclusions: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians.

The World Journal of Men's Health

Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assi... more Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods: Materials and Methods: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method.

Anatolian Current Medical Journal

Aim: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequen... more Aim: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequential estradiol valerate (EV) administration for frozen embryo transfer (FET) cycles.Material and Method: In this cross-sectional case-control study, 1272 cycles of FET were analyzed retrospectively from computer records between January 2015 to August 2020. EV was administrated in 795 patients with a fixed dose and in 477 patients with a sequential dose. P4 values were measured on the day when the endometrial thickness reached 8 mm in the patients.Results: There were 795 patients in the fixed EV administration group with a mean age of 30.75±3.39 and 477 patients in the sequential EV administration with a mean age of 30.75±3.39. P4 of the sequential-dose group (1.05±0.31) was significantly higher than the fixed-dose group (1.01±0.33). The Pairwise Z-Tests found that the abort rate was significantly higher in the sequential-dose group (p=0.04).Conclusion: Our results showed a higher P4 and ...

Istanbul University - DergiPark, Jul 16, 2022

In this study, we compared the effects of sperm parameters and sperm DNA damage on pregnancy outc... more In this study, we compared the effects of sperm parameters and sperm DNA damage on pregnancy outcomes of women undergoing intrauterine insemination (IUI) because of an ovulatory dysfunction (OD) and unexplained infertility (UEI). This study was retrospective, and semen samples were collected from records of 88 infertile couples referred to private clinic for infertility treatment from December 2019 to March 2020. The study has two groups: Groups 1: couples with UEI, and Group 2: fertile males with their partners having OD. The participants' age and body mass index (BMI) were 28.20 ± 3.08 and 25.45±2.25, respectively. In the control group, the pregnancy rate was 9/41 (%21.9), and one out of nine patients had a miscarriage. The pregnancy rate in the study group (UEI) was 8/47 (17%), and half of the pregnancies ended as miscarriage. Our results showed that sperm DNA damage increases the abortion rate but has not influenced the pregnancy rate in IUI.

Istanbul University - DergiPark, May 5, 2022

Chorioangioma is the most common benign tumor of the placenta which results from vascular malform... more Chorioangioma is the most common benign tumor of the placenta which results from vascular malformations. Their clinical significance changes according to their associated complications such as preeclampsia, premature placenta release, polyhydramnios, intrauterine growth restriction, fetal anemia, fetal cardiomegaly and fetomaternal hemorrhage. This case is about a 32-year-old patient whose pregnancy was complicated by a large placental chorioangioma in the third trimester.

Journal of Experimental and Clinical Medicine

The case was a 32-year-old, nulliparous pregnant woman, after in-vitro fertilization (IVF) pregna... more The case was a 32-year-old, nulliparous pregnant woman, after in-vitro fertilization (IVF) pregnancy. Her contractions started, and the amniotic fluid membrane ruptured at 38 gestational ages. The patient developed shortness of breath and lower oxygen saturation which started suddenly at the 8th hour after the cesarean section procedure under general anesthesia. Thrombotic conditions that may appear during the postpartum period should be diagnosed early and immediate treatment should be started to resolve the actual cause.

Journal of Experimental and Clinical Medicine

The purpose of this study was to determine whether changes in lipid profile in pregnant women mig... more The purpose of this study was to determine whether changes in lipid profile in pregnant women might have any effect on the perinatal outcomes. This retrospective study was conducted between January 2020 and December 2020 by evaluating data drawn from the hospital database. The total serum cholesterol(C), HDL-C, LDL-C, VLDL-C and triglycerides levels were measured in 587 women during the first trimester of pregnancy and confounding factors were analyzed. The mean age was 27 years. The mean gravida and parity were 2 and 1 respectively. The mean birth weight of newborn was 3280 g. The mean Apgar score was 9 at 0 and 5 minutes respectively. The vaginal delivery rate was 68.3% whereas caeserian delivery rate was 31.7%. Neonatal intensive care unit (NICU) was needed in 0.5% of newborns. There was no significant statistical difference between the rates of caeserian section and vaginal delivery in patients with respect to lipid profile levels. The total serum cholesterol(C), triglycerides, ...

Journal of Experimental and Clinical Medicine

Autoimmune thyroid diseases are multifaceted conditions in which the thyroid gland is infiltrated... more Autoimmune thyroid diseases are multifaceted conditions in which the thyroid gland is infiltrated by lymphocytes, resulting in the production of thyroid-specific auto-antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb). Iron deficiency is a common nutritional deficiency and has multiple adverse effects on thyroid metabolism. The association between iron status and thyroid autoimmunity has not been well-evaluated. This retrospective study aimed to determine whether the frequency of iron deficiency was higher in patients with thyroid autoimmunity than in healthy individuals with negative thyroid autoantibodies. One-hundred-and-eighty female patients with positive thyroid auto-antibodies and 81 healthy controls were involved in the study. Hemoglobin, hematocrit, mean corpuscular volume (MCV), iron, thyrotropin (TSH), TPOAb, TGAb, free-T4, vitamin B12, ferritin and transferrin saturation (TS) were recorded. TSH, TPOAb and TGAb levels were significantly higher, while h...

Archives of Gynecology and Obstetrics

Objective: The aim of this study was to determine the ratio of CRP/albumin (CRP/Alb) and the mono... more Objective: The aim of this study was to determine the ratio of CRP/albumin (CRP/Alb) and the monocyte/HDL ratio (MHR), new inflammatory markers, in women with gestational diabetes mellitus (GDM) and normal glucose tolerance test (NGT). Methods: Thirty pregnant women who underwent 50 gram glucose challenge test (GCT) between 24-28 gestational weeks were included the study. If the serum glucose level was above 140 mg/dl on the 50 gram GCT, 100 gram oral glucose tolerance test (OGTT) was applied. Diagnosis of GDM in 20 patients was confirmed if two of the blood glucose test results were above the following levels: fasting serum glucose ≥92 mg/dL and/or 1hour glycemia ≥180 mg/dL and/or 2 hour glycemia ≥153 mg/dL. Ten patients with a result below this value were accepted as NGT. The CRP/Alb and MHR were determined. Correlation between biochemical, demographic parameters, CRP/Alb ratio and MHR in GDM and NGT groups were analyzed. Results: No significant difference was found between GDM an...

PubMed, 2023

Objective: To investigate the effects of body mass index (BMI) values and 25(OH) vitamin D levels... more Objective: To investigate the effects of body mass index (BMI) values and 25(OH) vitamin D levels determined by Endocrine Society on serum Anti Mullerian Hormone (AMH) and antral follicle count (AFC) in women with polycystic ovary syndrome (PCOS). Patients and methods: Sixty infertile women with PCOS and 30 age-matched women with unexplained infertility (UEI), were included. Patients in PCOS and control groups were divided into three subgroups according to their BMI values as normal, overweight and obese. Each BMI group was divided into three subgroups according to vitamin D levels. While AMH and vitamin D levels were determined at first admission, AFC was measured on the third day of cycle. Results: BMI, AFC, and AMH levels of women with PCOS were significantly higher than the UEI group. AMH values of women with PCOS with normal BMI were found to be significantly higher than UEI controls with normal BMI. AMH values of overweight and obese PCOS patients and controls were similar. As BMI values of the PCOS group increased, vitamin D levels decreased significantly. Vitamin D levels of the patients in the PCOS group were found to be significantly lower than the control group. When evaluated according to BMI, the vitamin D levels of normal, overweight and obese women with PCOS were significantly lower than the UEI. Conclusions: Rising BMI in PCOS leads to a significant decrease in vitamin D and AMH. Deficiency, insufficiency or normality of vitamin D do not affect the main markers of ovarian reserve.

International Journal of Environmental Research and Public Health

Background: Homeobox genes A10 (HOXA10) and A11 (HOXA11), members of the abdominal B gene family,... more Background: Homeobox genes A10 (HOXA10) and A11 (HOXA11), members of the abdominal B gene family, are responsible for embryonic survival and implantation. This study was planned to investigate whether endometrial injury alters the expression of both transcripts in women with implantation failure. Methods: A total of 54 women with implantation failure were divided into two equal groups as experimental (scratching) and sham (no scratching). Participants in the scratching group were exposed to endometrial injury in the mid-luteal phase, and those in the sham group were exposed to endometrial flushing. The scratching group, but not the sham group, underwent prior endometrial sampling. A second endometrial sampling was performed on the scratching group in the mid-luteal phase of the following cycle. The mRNA and protein levels of the HOXA10 and 11 transcripts were determined in endometrial samples collected before and after injury/flushing. Participants in each group underwent IVF/ET in ...

Gynecology & Reproductive Health

Objective: The biological mechanism of the fertility-enhancing effect of hysterosalpingography (H... more Objective: The biological mechanism of the fertility-enhancing effect of hysterosalpingography (HSG) is not fully known. Leukemia inhibitory factor (LIF) is an important cytokine involved in implantation. This study was planned to investigate the effect of HSG on LIF mRNA expression in endometrial flushing samples. Methods: Forty infertile patients scheduled for HSG were included in the study. Before HSG, endometrial flushing was performed in the mid-luteal phase, followed by contrast-medium infusion into the cavity. Second flushing was done in the mid-luteal phase of the next cycle. Ten patients who underwent diagnostic hysteroscopy were taken as the second control group. LIF mRNA levels were measured by RT-PCR in endometrial flushing samples collected from each group. Results: The pre-HSG LIF mRNA levels of the infertile group were significantly lower than those of the fertile group. In infertile patients, LIF mRNA expression increased 3.2 times after HSG compared to baseline leve...

European review for medical and pharmacological sciences, 2022

OBJECTIVE The aim of the study was to investigate the relationship between serum level of vitamin... more OBJECTIVE The aim of the study was to investigate the relationship between serum level of vitamin D, semen analysis parameters and sperm DNA damage in men with unexplained subfertility. PATIENTS AND METHODS Fifty-eight men diagnosed with unexplained infertility and 50 age and BMI matched fertile men were included in the study. A participant whose semen parameter is normal but pregnancy is not achieved was accepted as unexplained male infertility. Blood samples were taken from all participants following three-day abstinence for measurement of vitamin D. Sperm DNA damage was assessed by Aniline Blue staining of the collected samples. RESULTS Compared with the fertile men, male patients with unexplained infertility had significantly lower vit D levels (27.00 ng/mL (12.63-39.30) vs. 23.66 ng/mL (7.50-55.00), p<0.004). While the number of patients with vitamin D levels lower than 20 ng/mL was 26 (44.8%) in the infertile group, it was recorded as 5 (10.0%) in the fertile group (p<0....

THE ULUTAS MEDICAL JOURNAL, 2022

Annals of Clinical and Analytical Medicine, 2021

Journal of Controversies in Obstetrics & Gynecology and Pediatrics

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive a... more Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by a combination of hormonal imbalances, ovarian dysfunction, and metabolic disturbances. PCOS has significant implications for women's health, fertility, and overall well-being. This comprehensive review aims to provide an overview of PCOS, including its etiology, clinical manifestations, diagnosis, and management strategies.

THE ULUTAS MEDICAL JOURNAL, 2021

Introduction: Individuals with polycystic ovary syndrome (PCOS) tend to exhibit insulin resistanc... more Introduction: Individuals with polycystic ovary syndrome (PCOS) tend to exhibit insulin resistance and circulating levels of insulin higher than controls matched to obesity levels. The present study aimed to evaluate the hormonal alterations through body mass index (BMI) on the relationship between insulin, insulin resistance (IR), and thyroid hormone levels in PCOS. Materials and Methods: This study is a retrospective clinical analysis study conducted at the department of gynecology and obstetrics between January 2019 and April 2020. PCOS participants were divided into two groups: 59 obese PCOS patients whose BMI value is equal and higher than 27kg/m2; 51 normal or overweight PCOS with BMI less than 27kg/m2. Results: Age factor did not differ between groups (29.8±6 vs 31±7.2; p=0.345). In hormone tests, insulin (14.2±6.8 vs 14.8±8; p=0.688), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (3.1±1.4 vs 3.4±1.8; p=0.344), thyroxine (T4)(1.2±0.5 vs 1.2±0.4) and thyroid-stimulating hormone (TSH)(1.9±1.2 vs 1.8±0.9; p=0.848) levels did not differ for BMI groups (p>0.05). Because there was no difference in laboratory comparison for any parameter we analyzed, we could not perform multivariate analysis for further investigations in terms of BMI factor. In the hematological analysis, we did not see any significant alteration for groups. Conclusion: We did not observe any difference between thyroid and IR in the patients who were grouped according to the BMI. PCOS and obesity may be directly related to hormonal interaction rather than adipose tissue.

Human Reproduction, Jun 29, 2022

The World Journal of Men's Health

Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health... more Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant professional society guideline recommendations, and provide expert recommendations. Materials and Methods: Materials and Methods: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus. Results: Results: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing. Conclusions: Conclusions: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians.

The World Journal of Men's Health

Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assi... more Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods: Materials and Methods: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method.

Anatolian Current Medical Journal

Aim: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequen... more Aim: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequential estradiol valerate (EV) administration for frozen embryo transfer (FET) cycles.Material and Method: In this cross-sectional case-control study, 1272 cycles of FET were analyzed retrospectively from computer records between January 2015 to August 2020. EV was administrated in 795 patients with a fixed dose and in 477 patients with a sequential dose. P4 values were measured on the day when the endometrial thickness reached 8 mm in the patients.Results: There were 795 patients in the fixed EV administration group with a mean age of 30.75±3.39 and 477 patients in the sequential EV administration with a mean age of 30.75±3.39. P4 of the sequential-dose group (1.05±0.31) was significantly higher than the fixed-dose group (1.01±0.33). The Pairwise Z-Tests found that the abort rate was significantly higher in the sequential-dose group (p=0.04).Conclusion: Our results showed a higher P4 and ...

Istanbul University - DergiPark, Jul 16, 2022

In this study, we compared the effects of sperm parameters and sperm DNA damage on pregnancy outc... more In this study, we compared the effects of sperm parameters and sperm DNA damage on pregnancy outcomes of women undergoing intrauterine insemination (IUI) because of an ovulatory dysfunction (OD) and unexplained infertility (UEI). This study was retrospective, and semen samples were collected from records of 88 infertile couples referred to private clinic for infertility treatment from December 2019 to March 2020. The study has two groups: Groups 1: couples with UEI, and Group 2: fertile males with their partners having OD. The participants' age and body mass index (BMI) were 28.20 ± 3.08 and 25.45±2.25, respectively. In the control group, the pregnancy rate was 9/41 (%21.9), and one out of nine patients had a miscarriage. The pregnancy rate in the study group (UEI) was 8/47 (17%), and half of the pregnancies ended as miscarriage. Our results showed that sperm DNA damage increases the abortion rate but has not influenced the pregnancy rate in IUI.

Istanbul University - DergiPark, May 5, 2022

Chorioangioma is the most common benign tumor of the placenta which results from vascular malform... more Chorioangioma is the most common benign tumor of the placenta which results from vascular malformations. Their clinical significance changes according to their associated complications such as preeclampsia, premature placenta release, polyhydramnios, intrauterine growth restriction, fetal anemia, fetal cardiomegaly and fetomaternal hemorrhage. This case is about a 32-year-old patient whose pregnancy was complicated by a large placental chorioangioma in the third trimester.

Journal of Experimental and Clinical Medicine

The case was a 32-year-old, nulliparous pregnant woman, after in-vitro fertilization (IVF) pregna... more The case was a 32-year-old, nulliparous pregnant woman, after in-vitro fertilization (IVF) pregnancy. Her contractions started, and the amniotic fluid membrane ruptured at 38 gestational ages. The patient developed shortness of breath and lower oxygen saturation which started suddenly at the 8th hour after the cesarean section procedure under general anesthesia. Thrombotic conditions that may appear during the postpartum period should be diagnosed early and immediate treatment should be started to resolve the actual cause.

Journal of Experimental and Clinical Medicine

The purpose of this study was to determine whether changes in lipid profile in pregnant women mig... more The purpose of this study was to determine whether changes in lipid profile in pregnant women might have any effect on the perinatal outcomes. This retrospective study was conducted between January 2020 and December 2020 by evaluating data drawn from the hospital database. The total serum cholesterol(C), HDL-C, LDL-C, VLDL-C and triglycerides levels were measured in 587 women during the first trimester of pregnancy and confounding factors were analyzed. The mean age was 27 years. The mean gravida and parity were 2 and 1 respectively. The mean birth weight of newborn was 3280 g. The mean Apgar score was 9 at 0 and 5 minutes respectively. The vaginal delivery rate was 68.3% whereas caeserian delivery rate was 31.7%. Neonatal intensive care unit (NICU) was needed in 0.5% of newborns. There was no significant statistical difference between the rates of caeserian section and vaginal delivery in patients with respect to lipid profile levels. The total serum cholesterol(C), triglycerides, ...

Journal of Experimental and Clinical Medicine

Autoimmune thyroid diseases are multifaceted conditions in which the thyroid gland is infiltrated... more Autoimmune thyroid diseases are multifaceted conditions in which the thyroid gland is infiltrated by lymphocytes, resulting in the production of thyroid-specific auto-antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb). Iron deficiency is a common nutritional deficiency and has multiple adverse effects on thyroid metabolism. The association between iron status and thyroid autoimmunity has not been well-evaluated. This retrospective study aimed to determine whether the frequency of iron deficiency was higher in patients with thyroid autoimmunity than in healthy individuals with negative thyroid autoantibodies. One-hundred-and-eighty female patients with positive thyroid auto-antibodies and 81 healthy controls were involved in the study. Hemoglobin, hematocrit, mean corpuscular volume (MCV), iron, thyrotropin (TSH), TPOAb, TGAb, free-T4, vitamin B12, ferritin and transferrin saturation (TS) were recorded. TSH, TPOAb and TGAb levels were significantly higher, while h...

Archives of Gynecology and Obstetrics

Objective: The aim of this study was to determine the ratio of CRP/albumin (CRP/Alb) and the mono... more Objective: The aim of this study was to determine the ratio of CRP/albumin (CRP/Alb) and the monocyte/HDL ratio (MHR), new inflammatory markers, in women with gestational diabetes mellitus (GDM) and normal glucose tolerance test (NGT). Methods: Thirty pregnant women who underwent 50 gram glucose challenge test (GCT) between 24-28 gestational weeks were included the study. If the serum glucose level was above 140 mg/dl on the 50 gram GCT, 100 gram oral glucose tolerance test (OGTT) was applied. Diagnosis of GDM in 20 patients was confirmed if two of the blood glucose test results were above the following levels: fasting serum glucose ≥92 mg/dL and/or 1hour glycemia ≥180 mg/dL and/or 2 hour glycemia ≥153 mg/dL. Ten patients with a result below this value were accepted as NGT. The CRP/Alb and MHR were determined. Correlation between biochemical, demographic parameters, CRP/Alb ratio and MHR in GDM and NGT groups were analyzed. Results: No significant difference was found between GDM an...