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Papers by Nuri Senguleroglu

Journal of contemporary medicine, Jan 15, 2022

In this research, we aimed to analyze the factors affecting the control of blood pressure and soc... more In this research, we aimed to analyze the factors affecting the control of blood pressure and social adaptation in hypertensive patients. Material and Method: Our study was conducted with 100 hypertensive patients in Ankara Training and Research Hospital Family Medicine Polyclinics between December 2015 and March 2016. Five-day blood pressure follow-up, socio-demographic characteristics and "Fatih Social Tendencies Scale" questionnaire data of the patients were recorded. 5-day blood pressure follow-up of the patients was performed. Results: A total of 100 individuals including 48 (48%) male and 52 (52%) female patients were included in the study. In our research, physical activity, regular exercise, being on diet, smoking, regular doctor check, medication compliance, marital status, years of education, regular book reading, working status and monthly income were found to be effective in blood pressure control. "Social Adaptation", "Avoidance of Substance", "Avoidance of Violence", "Family Status" and "Economic Status" among social tendency factors were found to be better in patients with blood pressure under control. Conclusion: In blood pressure follow-up, the lifestyle characteristics of the patient should be questioned and taken into consideration. Questioning psychological factors such as social adaptation and providing support through the provision of necessary information and education to the patient will make a great contribution to the patients in terms of blood pressure control.

DOAJ (DOAJ: Directory of Open Access Journals), Dec 1, 2020

Amaç: Çalışmamızda aile hekimliği polikliniklerine gelen hastaların kullandığı geleneksel ve tama... more Amaç: Çalışmamızda aile hekimliği polikliniklerine gelen hastaların kullandığı geleneksel ve tamamlayıcı tıp tedavileri, bu tedavilere başlama şekilleri, tedavileri kullanma sebepleri, görülen etkiler ve alternatif tıp hakkındaki genel görüşlerinin kaynaklarının değerlendirilmesi amaçlanmıştır.

Pharmacological Reports, Feb 1, 2015

Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic p... more Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice. Methods: We used tail flick, tail clip and hot plate tests to investigate the central antinociceptive effects and acetic acid-induced writhing test to assess peripheral antinociceptive effects of pregabalin (10, 30, 100 mg/kg). We also combined pregabalin (100 mg/kg) with, a nonspecific nitric oxide synthase inhibitor L-NAME (100 mg/kg), a serotonin receptor antagonist cyproheptadine (50 mg/kg), and an opioid receptor antagonist naloxone (1 mg/kg). Results: Pregabalin 30 mg/kg enhanced the percentage of maximal possible effect (% MPE) in tail flick test. Pregabalin 100 mg/kg significantly increased % MPE in tail clip and tail flick tests and decreased the number of writhings. Pregabalin made no significant alteration in hot plate test at all doses. The combined use of pregabalin 100 mg/kg with L-NAME, cyproheptadine, and naloxone showed that % MPE was reduced only in the combination of pregabalin with naloxone and solely in tail clip test while no significant difference was observed in writhing test. Conclusions: We suggest that pregabalin (30 and 100 mg/kg) presents central spinal but not central supraspinal antinociceptive effect and pregabalin 100 mg/kg shows peripheral antinociceptive effect. The opioidergic pathway seems to mediate the central spinal antinociceptive effect of pregabalin while nitrergic and serotonergic pathways are not involved.