O. Imventarza - Academia.edu (original) (raw)
Papers by O. Imventarza
HPB, 2017
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Medicina
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Clinical Chemistry and Laboratory Medicine, 2001
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Transplantation
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Intensive Care Medicine, 1996
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Acta Bioquim Clin Latinoam, Dec 1, 2002
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Medicina, 2005
Orthotopic liver transplantation is the only definitive mode of therapy for children with end-sta... more Orthotopic liver transplantation is the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the necessity to prevent long-term complications. The aim of this study was to analyze the evolution of transplanted patients with more than one year of follow up. Between November 1992 and November 2001, 238 patients underwent 264 liver transplantations. A total of 143 patients with more than one year of follow up were included. The median age of patients +/- SD was 5.41 years +/- 5.26 (r: 0.58-21.7 years). All children received primary immunosuppression with cyclosporine. The indications for liver replacement were: fulminant hepatic failure (n: 50), biliary atresia (n: 38), cirrhosis (n: 37), chronic cholestasis (n: 13) and miscellaneous (n: 5). The indications for liver re-transplantation were: biliary cirrhosis (n: 7), hepatic artery thrombosis (n: 4) and chronic rejection (n: 3). Reduced-size liver allografts were used in ...
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Breast Cancer, 1999
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Liver Transplantation, 2020
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Transplantation, 1991
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Surgery, 1989
FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native ne... more FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 +/- 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 +/- 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial.
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Transplantation proceedings, 1994
... IMVENTARZA O. ; BIANCO G. ; CERVIO G. ; CIOCCA M. ; DAVILA M. ; ROJAS L. ; GONZALEZ S. ; QUES... more ... IMVENTARZA O. ; BIANCO G. ; CERVIO G. ; CIOCCA M. ; DAVILA M. ; ROJAS L. ; GONZALEZ S. ; QUESTA H. ; SASBON J. ; WACHOLDER V. ; WILLIAMS E. ; DEBBAG R. ; ACERENZA ... INIST-CNRS, Cote INIST : 14765, 35400002522416.0950. Nº notice refdoc (ud4) : 3960505. ...
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Transplantation proceedings, 1989
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Transplantation, 1989
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Transplantation Journal, 2010
L. McCormack1, E. de Santibañes2, J. Lendoire1, O. Imventarza3, O. Gil4, L. Toselli5, O. Andriani... more L. McCormack1, E. de Santibañes2, J. Lendoire1, O. Imventarza3, O. Gil4, L. Toselli5, O. Andriani6, L. Bisigniano7, A.C. Gadano8 1General Surgery, Hospital Aleman of Buenos Aires, Buenos Aires/ARGENTINA, 2, Liver Transplantation Unit, Buenos Aires/ ARGENTINA, 3, Hospital Argerich, Buenos Aires/ARGENTINA, 4, Sanatorio Allende, Cordoba/ARGENTINA, 5, CRAI Norte, Buenos Aires/ARGENTINA, 6, Hospital Universitario Austral, Pilar/ ARGENTINA, 7, INCUCAI, Buenos Aires/ARGENTINA, 8Liver Transplantation Unit, Hospital Italiano, Buenos Aires/ARGENTINA
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Liver Transplantation, 2000
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Gastroenterology, 1998
ABSTRACT Over a period of 11 years a total of 140 liver resections for non-colorectal, non-neuroe... more ABSTRACT Over a period of 11 years a total of 140 liver resections for non-colorectal, non-neuroendocrine hepatic metastases were performed in 127 patients (73 women, 54 men; median age 53 years). There were 120 first, 14 second and 6 third liver resections. Primary tumors were: breast cancer (n = 34), leiomyosarcoma (n = 20), pancreatic cancer (n = 16), renal cell carcinoma (n = 13), melanoma (n = 9), gastric cancer (n = 9), lung cancer (n = 6) and adrenal cancer (n = 6) and miscellaneous tumors (n = 14). Extrahepatic tumor manifestation (including synchronous primary tumors) was found in 69/140 cases (49%); 61 of 120 patients with a first liver resection had extrahepatic tumor (51%). In the 120 first liver resections, 82 (68%) R0, 13 (11%) R1 and 25 (21%) R2 excisions were possible. Median survival after first liver resection was 20 months; after R0 resection a median survival of 28 months and after R1/2 resection of 8 months was achieved. The 5-year survival rate was 16% for the total group, 24% in patients with R0 resection and 0% for R1/2 resections. After a second liver resection (n = 14) there was a median survival of 28 months (5-year-survival-rate of 21%) for all patients and of 41 months (5-year survival rate 38%) after R0 resection. Morbidity and mortality after the first liver resection were 32.5% and 5.8%, respectively. In patients without extrahepatic tumor at the time of the first liver resection a median survival of 32 months (5-year survival rate 25%) and 7 months was achieved after R0 resection and R1/2 resection, respectively. In case of extrahepatic tumor the median survival was 24 months (5-year survival rate 23%) for R0 resection compared to 8 months after R1/2 resection. These data suggest that not the presence of extrahepatic tumor but rather the possibility of a R0 resection is most decisive for the prognosis after liver resection. We conclude that patients with liver metastases of non-colorectal, non-neuroendocrine tumors may benefit from liver resection. Similar to colorectal metastases, a second or third liver resection can be worthwhile in selected cases. Even in more unfavorable tumor entities, several cases of long-term survival were observed after surgical therapy. Therefore, the indication for liver resection should be considered carefully in every single case.
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Transplantation, 1992
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Cirugía pediátrica, 2011
The need to measure the level of surgical risk arises from its direct relationship with the devel... more The need to measure the level of surgical risk arises from its direct relationship with the development of postoperative complications and the use of hospital resources. The construction of a surgical risk scale (ERQ) for pediatric surgery should be based on a common language, by using a small number of easy to collect and reproduce variables. The objectives of this study were to construct an ERQ for pediatric patients and to analyze the surgical performance. We retrospectively analyzed 105 primary surgical procedures under general anesthesia performed by liver transplantation service at Hospital Garrahan, between 29/6/08 and 25/3/10. Newborn patients were not considered. The ERQ was built by adding patient risk factors (PRL): weight (< o > 10 kg), co-morbidities (coagulopathy-obesity-diabetes) and life support; and the magnitude level of the surgical procedure (SPL): surgical time and requirement of blood transfusions. The surgical performance was considered as a relation bet...
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HPB, 2017
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Medicina
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Clinical Chemistry and Laboratory Medicine, 2001
Bookmarks Related papers MentionsView impact
Transplantation
Bookmarks Related papers MentionsView impact
Intensive Care Medicine, 1996
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Acta Bioquim Clin Latinoam, Dec 1, 2002
Bookmarks Related papers MentionsView impact
Medicina, 2005
Orthotopic liver transplantation is the only definitive mode of therapy for children with end-sta... more Orthotopic liver transplantation is the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the necessity to prevent long-term complications. The aim of this study was to analyze the evolution of transplanted patients with more than one year of follow up. Between November 1992 and November 2001, 238 patients underwent 264 liver transplantations. A total of 143 patients with more than one year of follow up were included. The median age of patients +/- SD was 5.41 years +/- 5.26 (r: 0.58-21.7 years). All children received primary immunosuppression with cyclosporine. The indications for liver replacement were: fulminant hepatic failure (n: 50), biliary atresia (n: 38), cirrhosis (n: 37), chronic cholestasis (n: 13) and miscellaneous (n: 5). The indications for liver re-transplantation were: biliary cirrhosis (n: 7), hepatic artery thrombosis (n: 4) and chronic rejection (n: 3). Reduced-size liver allografts were used in ...
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Breast Cancer, 1999
Bookmarks Related papers MentionsView impact
Liver Transplantation, 2020
Bookmarks Related papers MentionsView impact
Transplantation, 1991
Bookmarks Related papers MentionsView impact
Surgery, 1989
FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native ne... more FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 +/- 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 +/- 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial.
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Transplantation proceedings, 1994
... IMVENTARZA O. ; BIANCO G. ; CERVIO G. ; CIOCCA M. ; DAVILA M. ; ROJAS L. ; GONZALEZ S. ; QUES... more ... IMVENTARZA O. ; BIANCO G. ; CERVIO G. ; CIOCCA M. ; DAVILA M. ; ROJAS L. ; GONZALEZ S. ; QUESTA H. ; SASBON J. ; WACHOLDER V. ; WILLIAMS E. ; DEBBAG R. ; ACERENZA ... INIST-CNRS, Cote INIST : 14765, 35400002522416.0950. Nº notice refdoc (ud4) : 3960505. ...
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Transplantation proceedings, 1989
Bookmarks Related papers MentionsView impact
Transplantation, 1989
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Transplantation Journal, 2010
L. McCormack1, E. de Santibañes2, J. Lendoire1, O. Imventarza3, O. Gil4, L. Toselli5, O. Andriani... more L. McCormack1, E. de Santibañes2, J. Lendoire1, O. Imventarza3, O. Gil4, L. Toselli5, O. Andriani6, L. Bisigniano7, A.C. Gadano8 1General Surgery, Hospital Aleman of Buenos Aires, Buenos Aires/ARGENTINA, 2, Liver Transplantation Unit, Buenos Aires/ ARGENTINA, 3, Hospital Argerich, Buenos Aires/ARGENTINA, 4, Sanatorio Allende, Cordoba/ARGENTINA, 5, CRAI Norte, Buenos Aires/ARGENTINA, 6, Hospital Universitario Austral, Pilar/ ARGENTINA, 7, INCUCAI, Buenos Aires/ARGENTINA, 8Liver Transplantation Unit, Hospital Italiano, Buenos Aires/ARGENTINA
Bookmarks Related papers MentionsView impact
Liver Transplantation, 2000
Bookmarks Related papers MentionsView impact
Gastroenterology, 1998
ABSTRACT Over a period of 11 years a total of 140 liver resections for non-colorectal, non-neuroe... more ABSTRACT Over a period of 11 years a total of 140 liver resections for non-colorectal, non-neuroendocrine hepatic metastases were performed in 127 patients (73 women, 54 men; median age 53 years). There were 120 first, 14 second and 6 third liver resections. Primary tumors were: breast cancer (n = 34), leiomyosarcoma (n = 20), pancreatic cancer (n = 16), renal cell carcinoma (n = 13), melanoma (n = 9), gastric cancer (n = 9), lung cancer (n = 6) and adrenal cancer (n = 6) and miscellaneous tumors (n = 14). Extrahepatic tumor manifestation (including synchronous primary tumors) was found in 69/140 cases (49%); 61 of 120 patients with a first liver resection had extrahepatic tumor (51%). In the 120 first liver resections, 82 (68%) R0, 13 (11%) R1 and 25 (21%) R2 excisions were possible. Median survival after first liver resection was 20 months; after R0 resection a median survival of 28 months and after R1/2 resection of 8 months was achieved. The 5-year survival rate was 16% for the total group, 24% in patients with R0 resection and 0% for R1/2 resections. After a second liver resection (n = 14) there was a median survival of 28 months (5-year-survival-rate of 21%) for all patients and of 41 months (5-year survival rate 38%) after R0 resection. Morbidity and mortality after the first liver resection were 32.5% and 5.8%, respectively. In patients without extrahepatic tumor at the time of the first liver resection a median survival of 32 months (5-year survival rate 25%) and 7 months was achieved after R0 resection and R1/2 resection, respectively. In case of extrahepatic tumor the median survival was 24 months (5-year survival rate 23%) for R0 resection compared to 8 months after R1/2 resection. These data suggest that not the presence of extrahepatic tumor but rather the possibility of a R0 resection is most decisive for the prognosis after liver resection. We conclude that patients with liver metastases of non-colorectal, non-neuroendocrine tumors may benefit from liver resection. Similar to colorectal metastases, a second or third liver resection can be worthwhile in selected cases. Even in more unfavorable tumor entities, several cases of long-term survival were observed after surgical therapy. Therefore, the indication for liver resection should be considered carefully in every single case.
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Transplantation, 1992
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Cirugía pediátrica, 2011
The need to measure the level of surgical risk arises from its direct relationship with the devel... more The need to measure the level of surgical risk arises from its direct relationship with the development of postoperative complications and the use of hospital resources. The construction of a surgical risk scale (ERQ) for pediatric surgery should be based on a common language, by using a small number of easy to collect and reproduce variables. The objectives of this study were to construct an ERQ for pediatric patients and to analyze the surgical performance. We retrospectively analyzed 105 primary surgical procedures under general anesthesia performed by liver transplantation service at Hospital Garrahan, between 29/6/08 and 25/3/10. Newborn patients were not considered. The ERQ was built by adding patient risk factors (PRL): weight (< o > 10 kg), co-morbidities (coagulopathy-obesity-diabetes) and life support; and the magnitude level of the surgical procedure (SPL): surgical time and requirement of blood transfusions. The surgical performance was considered as a relation bet...
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