O. Imventarza - Profile on Academia.edu (original) (raw)

Papers by O. Imventarza

HPB, 2017

Objective: Technical tips in laparoscopic distal pancreatectomy using 3D camera. Methods: 43 year... more Objective: Technical tips in laparoscopic distal pancreatectomy using 3D camera. Methods: 43 years old lady presented with upper abdominal pain, ultrasound showed 12X10 cm distal pancreatic mass. EUS biopsy suggested mucinous cystadenoma of the pancreases. Results: Laparoscopic distal pancreatectomy using olympus 3D camera used to do total laproscopic distal pancreatectomy & splenectomy. Conclusion: The use of 3D camera improves the feasibility of completing laparoscopic distal pancreatectomy.

Medicina

Resumen La polineuropatía amiloidótica familiar (PAF) es un tipo de amiloidosis hereditaria. Cons... more Resumen La polineuropatía amiloidótica familiar (PAF) es un tipo de amiloidosis hereditaria. Constituye un desorden autosómico dominante caracterizado por el depósito sistémico de material amiloide en tejidos especialmente en nervios periféricos. El principal componente del amiloide es una variante mutada de la transtiretina (TTR), proteína transportadora de tiroxina y retinol. Han sido descriptas numerosas mutaciones en el gen TTR que causan alteración de la secuencia primaria de la proteína. La PAF portuguesa o PAF Tipo I se origina por la variante TTR Val30Met en la cual una valina en posición 30 es reemplazada por una metionina. Es fundamental la identificación temprana de portadores de la mutación porque una vez declarada la enfermedad el único tratamiento efectivo es el trasplante hepático, órgano de síntesis de la TTR. La PAF Tipo I ha sido muy estudiada en la Argentina debido al hallazgo de un área endémica donde habitan familias descendientes de inmigrantes portugueses. El presente trabajo ha sido enfocado a resolver la necesidad diagnóstica de la comunidad, ya que la ausencia de una metodología apropiada en nuestro país ha impedido, hasta ahora, que individuos con antecedentes familiares de PAF puedan tener un diagnóstico precoz y acceder al trasplante hepático temprano. En consecuencia, nuestro objetivo fue optimizar una metodología para detectar la mutación Val30Met adaptando técnicas previamente descriptas. La fiabilidad, sencillez y rapidez en la obtención de los resultados, así como el requerimiento de pequeño volumen de muestra, hacen que la técnica desarrollada en este trabajo sea una herramienta apropiada para procedimientos de screening, permitiendo contar con un marcador preclínico de la enfermedad.

Clinical Chemistry and Laboratory Medicine, 2001

Liver transplantation is the only therapeutic option for patients with end-stage liver disease. N... more Liver transplantation is the only therapeutic option for patients with end-stage liver disease. Nitric oxide, a free radical produced from L-arginine, a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. The inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. We analyzed the relationships between the levels of nitric oxide, hepatic enzymes and other clinical parameters (glucose, total proteins, total bilirubin, creatinine, albumin) obtained in serum samples before liver transplantation and every 48 h till day 15 in 15 patients aged 40 ± 13 years. Aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study, cholinesterase levels remained decreased throughout the study and nitric oxide remained high, never reaching normal values.

P13.01: Pediatric Liver Transplantation for Inborn Errors of Metabolism at the Hospital Juan P Garrahan, Argentina

Transplantation

Intensive Care Medicine, 1996

f the Working Groups 2000Working Group on Liver and Intestinal Transplantation in Children

El óxido nítrico y las enzimas en trasplante hepático: perfiles evolutivos

Acta Bioquim Clin Latinoam, Dec 1, 2002

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[Evolution of children one year post liver transplant]

Medicina, 2005

Orthotopic liver transplantation is the only definitive mode of therapy for children with end-sta... more Orthotopic liver transplantation is the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the necessity to prevent long-term complications. The aim of this study was to analyze the evolution of transplanted patients with more than one year of follow up. Between November 1992 and November 2001, 238 patients underwent 264 liver transplantations. A total of 143 patients with more than one year of follow up were included. The median age of patients +/- SD was 5.41 years +/- 5.26 (r: 0.58-21.7 years). All children received primary immunosuppression with cyclosporine. The indications for liver replacement were: fulminant hepatic failure (n: 50), biliary atresia (n: 38), cirrhosis (n: 37), chronic cholestasis (n: 13) and miscellaneous (n: 5). The indications for liver re-transplantation were: biliary cirrhosis (n: 7), hepatic artery thrombosis (n: 4) and chronic rejection (n: 3). Reduced-size liver allografts were used in ...

Breast Cancer, 1999

The sentinel lymphadenectomy (SLND) technique using blue dye alone, developed over the last eight... more The sentinel lymphadenectomy (SLND) technique using blue dye alone, developed over the last eight years at the John Wayne Cancer Institute and tested for its accuracy, has been proven to precisely predict the status of the axillary lymph nodes. Techniques using radioguided surgery to detect the sentinel node have also been employed with similar results. The procedure is well tolerated, and axillary staging can be achieved with minimal morbidity. Tissue is obtained for the pathologist that represents the site most likely to harbor metastases with a minimally invasive procedure. Surgeons should validate the technique at their own institutions to ensure accuracy; mastery in removing the true sentinel node will not help if the pathologists cannot detect metastases with proficiency. Future investigation is required on patients who have only had an SLND, and whose sentinel nodes are free of metastases. These patients will require prolonged follow-up to garner recurrence and survival information that is still unavailable. With upcoming planned multicenter clinical trials, we hopefully will be able to determine the outcome of patients who have metastases in the sentinel node but have not had a completion axillary lymphadenectomy (ALND). We are enthusiastic about these trials, which will also help to define the role of SLND in the management of all patients with early breast cancer.

Liver Transplantation, 2020

Background The most common indications for early liver retransplantation(eRe-LT) are vascular com... more Background The most common indications for early liver retransplantation(eRe-LT) are vascular complications and primary non-function(PNF). These patients are usually in a critical clinical condition that can affect their chances of survival. In fact, the survival of these patients is usually lower compared to the first transplant. To the best of our knowledge, to date no specific series of pediatric patients undergoing eRe-LT have been published.

Transplantation, 1991

Five hundred ninety-three cadaveric livers were used for primary liver transplantation between Oc... more Five hundred ninety-three cadaveric livers were used for primary liver transplantation between October 24, 1987, and May 19, 1989. The grafts were procured with a combined method, using in situ cooling with cold electrolyte solution and backtable flushing with UW solution. The mean cold-ischemia time was 12.8 (range 2.4-34.7) hr. The cases were divided into 5 groups according to the cold-ischemia time: group 1: <10 hr (n=223); group 2: 10-14 hr (n=188): group 3: 15-19 hr (n=101);

Surgery, 1989

FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native ne... more FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 +/- 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 +/- 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial.

Liver transplant program in Argentina: development and preliminary results

Transplantation proceedings, 1994

... IMVENTARZA O. ; BIANCO G. ; CERVIO G. ; CIOCCA M. ; DAVILA M. ; ROJAS L. ; GONZALEZ S. ; QUES... more ... IMVENTARZA O. ; BIANCO G. ; CERVIO G. ; CIOCCA M. ; DAVILA M. ; ROJAS L. ; GONZALEZ S. ; QUESTA H. ; SASBON J. ; WACHOLDER V. ; WILLIAMS E. ; DEBBAG R. ; ACERENZA ... INIST-CNRS, Cote INIST : 14765, 35400002522416.0950. Nº notice refdoc (ud4) : 3960505. ...

Transplantation proceedings, 1989

First National Report After the Implementation of the Meld-Based Allocation System for Liver Transplantation in Argentina

Transplantation Journal, 2010

L. McCormack1, E. de Santibañes2, J. Lendoire1, O. Imventarza3, O. Gil4, L. Toselli5, O. Andriani... more L. McCormack1, E. de Santibañes2, J. Lendoire1, O. Imventarza3, O. Gil4, L. Toselli5, O. Andriani6, L. Bisigniano7, A.C. Gadano8 1General Surgery, Hospital Aleman of Buenos Aires, Buenos Aires/ARGENTINA, 2, Liver Transplantation Unit, Buenos Aires/ ARGENTINA, 3, Hospital Argerich, Buenos Aires/ARGENTINA, 4, Sanatorio Allende, Cordoba/ARGENTINA, 5, CRAI Norte, Buenos Aires/ARGENTINA, 6, Hospital Universitario Austral, Pilar/ ARGENTINA, 7, INCUCAI, Buenos Aires/ARGENTINA, 8Liver Transplantation Unit, Hospital Italiano, Buenos Aires/ARGENTINA

Liver Transplantation, 2000

Invasive fungal infections (IFI), due to their high morbidity and mortality, are recognized as se... more Invasive fungal infections (IFI), due to their high morbidity and mortality, are recognized as severe infectious complications in patients undergoing orthctopic liver transplantation (OLT). The purpose of the Study was to analyze risk factors of moo.silty of IFI in patients who have

Liver resection for noncolorectal nonneuro-endocrine hepatic metastases

Gastroenterology, 1998

ABSTRACT Over a period of 11 years a total of 140 liver resections for non-colorectal, non-neuroe... more ABSTRACT Over a period of 11 years a total of 140 liver resections for non-colorectal, non-neuroendocrine hepatic metastases were performed in 127 patients (73 women, 54 men; median age 53 years). There were 120 first, 14 second and 6 third liver resections. Primary tumors were: breast cancer (n = 34), leiomyosarcoma (n = 20), pancreatic cancer (n = 16), renal cell carcinoma (n = 13), melanoma (n = 9), gastric cancer (n = 9), lung cancer (n = 6) and adrenal cancer (n = 6) and miscellaneous tumors (n = 14). Extrahepatic tumor manifestation (including synchronous primary tumors) was found in 69/140 cases (49%); 61 of 120 patients with a first liver resection had extrahepatic tumor (51%). In the 120 first liver resections, 82 (68%) R0, 13 (11%) R1 and 25 (21%) R2 excisions were possible. Median survival after first liver resection was 20 months; after R0 resection a median survival of 28 months and after R1/2 resection of 8 months was achieved. The 5-year survival rate was 16% for the total group, 24% in patients with R0 resection and 0% for R1/2 resections. After a second liver resection (n = 14) there was a median survival of 28 months (5-year-survival-rate of 21%) for all patients and of 41 months (5-year survival rate 38%) after R0 resection. Morbidity and mortality after the first liver resection were 32.5% and 5.8%, respectively. In patients without extrahepatic tumor at the time of the first liver resection a median survival of 32 months (5-year survival rate 25%) and 7 months was achieved after R0 resection and R1/2 resection, respectively. In case of extrahepatic tumor the median survival was 24 months (5-year survival rate 23%) for R0 resection compared to 8 months after R1/2 resection. These data suggest that not the presence of extrahepatic tumor but rather the possibility of a R0 resection is most decisive for the prognosis after liver resection. We conclude that patients with liver metastases of non-colorectal, non-neuroendocrine tumors may benefit from liver resection. Similar to colorectal metastases, a second or third liver resection can be worthwhile in selected cases. Even in more unfavorable tumor entities, several cases of long-term survival were observed after surgical therapy. Therefore, the indication for liver resection should be considered carefully in every single case.

Transplantation, 1992

The roles of host and donor cells in the rejection of skin allograft by T cell-deprived rats inje... more The roles of host and donor cells in the rejection of skin allograft by T cell-deprived rats injected with syngeneic T cells_ Eur J Immunol1982; 12: 511. 8. Dalchau R. Fabre JW. The purification of antigens and other studies using monoclonal antibody affinity columns: the complementary new dimension of monoclonal antibodies. In: Mc-Michael AJ. Fabre JW, eds. Monoclonal antibodies in clinical medicine. New York: Academic, 1982: 519. 9. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 277: 680. 10. Lear PA, Cunningham AJ, Crane PW, Wood RFM. Lymphocyte migration patterns in small bowel transplants. Transplant Proc 1989; 21: 2881. 11. Milton AD. Fabre JW. Musive induction of donor type clus I and class II MHC antigens in rejecting cardiac allografts in the rat.

Surgical risk scale in pediatric surgery

Cirugía pediátrica, 2011

The need to measure the level of surgical risk arises from its direct relationship with the devel... more The need to measure the level of surgical risk arises from its direct relationship with the development of postoperative complications and the use of hospital resources. The construction of a surgical risk scale (ERQ) for pediatric surgery should be based on a common language, by using a small number of easy to collect and reproduce variables. The objectives of this study were to construct an ERQ for pediatric patients and to analyze the surgical performance. We retrospectively analyzed 105 primary surgical procedures under general anesthesia performed by liver transplantation service at Hospital Garrahan, between 29/6/08 and 25/3/10. Newborn patients were not considered. The ERQ was built by adding patient risk factors (PRL): weight (< o > 10 kg), co-morbidities (coagulopathy-obesity-diabetes) and life support; and the magnitude level of the surgical procedure (SPL): surgical time and requirement of blood transfusions. The surgical performance was considered as a relation bet...

Liver transplantation in adult patients with portal vein thrombosis: risk factors, management and outcome

Background. Portal vein thrombosis (PVT) is a well recognized complication of patients with end-s... more Background. Portal vein thrombosis (PVT) is a well recognized complication of patients with end-stage cirrhosis and its incidence ranges from 2 to 26%. The aim of this study was to analyze the results and long-term follow-up of a consecutive series of liver transplants performed in patients with PVT and compare them with patients transplanted without PVT. Patients and methods. Between July 1995 and June 2006, 26 liver transplants were performed in patients with PVT (8.7%). Risk factors and variables associated with the transplant and the post-transplant period were analyzed. A comparative analysis with 273 patients transplanted without PVT was performed. Results. The patients comprised 53.8% males, average age 40, 7 years. PVTwas detected during surgery in 65%. Indications for transplantation were: post-necrotic cirrhosis 73%, cholestatic liver diseases 23%, and congenital liver fibrosis 4%. Child-Pugh C: 61.5%. Techniques were trombectomy in 21 patients with PVT grades I, II, IV, a...