O. Lidegaard - Academia.edu (original) (raw)
Papers by O. Lidegaard
BJOG: An International Journal of Obstetrics & Gynaecology, 2021
Many clinicians are of the opinion that observational studies may provide only "statistical ... more Many clinicians are of the opinion that observational studies may provide only "statistical associations", but not "causal inference". And further, that only randomized designs ensure causal interpretation. For the same reason, many medical journals have made rules for all observational studies finding significant statistical associations to be presented as just "associations" often emphasizing that a causal inference is not possible.
Contraception, Mar 1, 2002
The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk ... more The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk of venous thromboembolism (VTE) in young women. A 5-year case-control study including all Danish hospitals was conducted. All women 15-44 years old, suffering a first ever deep venous thrombosis or a first pulmonary embolism (PE)
Lancet, Jan 12, 2015
Half the epidemiological studies with information about menopausal hormone therapy and ovarian ca... more Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with <5 years of use (RR 1·43, 95% CI 1·31-1·56; p<0·0001). Combining current-or-recent use (any duration, but stopped <5 years ...
Human reproduction (Oxford, England), 2014
With interest we read the article of Henningsen et al., who compared pregnancy outcomes in single... more With interest we read the article of Henningsen et al., who compared pregnancy outcomes in singleton pregnancies after ART to singleton pregnancies that were conceived naturally. The authors report a significantly increased risk of stillbirth after ART before a gestational age of 28 weeks. They conclude that in view of the fact that the increased stillbirth risk was observed before 28 weeks only, prevention of stillbirth in the third trimester might be sufficient. We have two comments. First, the authors have acknowledged that a proportion of the cohort of women with ART singleton pregnancies (estimating background rate 1 in 10 (Henningsen et al., 2014)) initially might have had a vanishing twin. They have also acknowledged the subsequent possible implications for early stillbirths in this group. It would be crucial to know what proportion of the singletons after ART would be the result from single embryo transfer (SET) or from double embryo transfer (DET). This information is not provided, but may be available to the authors. Moreover, as SET in Scandinavia was introduced well before the end of the study period, the authors might be able to look at trends over this time. Secondly, when the increased perinatal mortality rate before 28 weeks indeed can be linked to the use of ART, we would like to challenge the opinion of the authors on the liberal use of ART in Nordic countries, where .3% of the babies are conceived after ART, with Denmark leading the way with 4.5% of infants born through ART (Ferraretti et al., 2013). Considering the fact that many couples would conceived naturally when allowed a longer expectant management period we could imagine stricter guidelines around use of ART in Scandinavia to prevent unnecessary stillbirth and preterm delivery.
The European Journal of Contraception & Reproductive Health Care, 1996
The survey was designed to study the attitudes of gynecologists from 11 European centers providin... more The survey was designed to study the attitudes of gynecologists from 11 European centers providing guidance in contraception to women at high risk and women with cardiovascular disease. Attitudes were registered by means of a standard questionnaire. Most contributors reported that, in women with venous thrombosis (10/11), deep venous thrombosis (10/11), coagulation disorders (11/11) and stroke (8/11), they prefer to prescribe methods other than combined oral contraceptives (COCs). A history of myocardial infarction was considered a relative contraindication and some experts suggested that, in some cases, the use of third-generation COCs may be possible. COCs were not recommended in women with severe cardiovascular disease and in those over 35 years of age with light or moderate cardiovascular disease, heavy smokers (over 20 cigarettes per day), or those presenting with severe hyperlipidemia. The pill is not considered appropriate for women with clinically established cardiovascular diseases or in cases where more than two coronary risk factors exist. COCs may safely be given to women with elevated blood pressure as long as it is lower than 160/100 mmHg, in cases of light and moderate cardiovascular disease as long as the patient is less than 35 years of age, in women who are not heavy smokers, in the presence of a light or moderate degree of hyperlipidemia, and in uncomplicated diabetes mellitus provided that there are no additional risk factors. In these cases, third-generation COCs are preferred. The co-operation of the cardiologist is desirable in order to classify cardiovascular disease and for patient follow-up.
Acta Neurologica Scandinavica, 1987
The mortality of cerebrovascular diseases in Denmark was analysed for men and women 15-44 years o... more The mortality of cerebrovascular diseases in Denmark was analysed for men and women 15-44 years of age, in a 14-year period before and after the appearance of oral contraceptives (OC) in 1966. 1,670 deaths were registered over 28 years, during which the female incidence of cerebrovascular deaths increased by 19% (P<0.025), while the male mortality was unchanged. Women showed a percentage increase in deaths from cerebral thromboembolic attacks (CTA) of 33%, men a fall of 14%. The increase of female CTA deaths was most pronounced in the young fertile group, the age group with a high OC use. A relative risk of CTA of 3.3-4.5 for OC users compared with non-users could explain the CTA trend difference between women and men. No other single risk factor responsible for the observed trends could be identified. Both women and men had a significant increase in the mortality of subarachnoidal hemorrhages, and a significant fall in the mortality of intracere-bra1 hemorrhages.
Archives of General Psychiatry, 2012
Context: Mental health problems are associated with women's reproductive decisions and predict po... more Context: Mental health problems are associated with women's reproductive decisions and predict poor mental health outcomes after abortion and childbirth. Objectives: To study whether having a first-trimester induced abortion influenced the risk of psychiatric readmission and compare findings with readmission risk in women with mental disorders giving birth. Design: Survival analyses were performed in a population-based cohort study merging data from the Danish Civil Registration System, the Danish Psychiatric Cen
Stroke, 1986
In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thr... more In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this material we found an average age-adjusted incidence rate of cerebral thromboembolism of 14.4/100.000 among men and 15.5/100.000 among women. The incidence rates rose rapidly with increasing age. Women aged 15-34 had significantly higher incidence rates of brain infarction and TIA compared to those of men of the same age. This was reversed in the age group 35-44. The magnitude of the ratio between the female and the male mean incidence rates by increasing age corresponded exactly to the age distribution of the use of oral contraceptives in Denmark. The relative risk for developing cerebral thromboembolism among users of oral contraceptives was estimated to be 3.2-6.5. The mo...
Acta Neurologica Scandinavica, 1983
In 5 patients with definite or highly probable MS, unusually large hypodense plaques are seen by ... more In 5 patients with definite or highly probable MS, unusually large hypodense plaques are seen by computerized tomography (CT scan). The active plaques all show enhancement after i.v. contrast medium injection, suggestive of blood-brain-barrier-damage, and differ from the well-known CT findings in chronic MS patients, causing diagnostic difficulties between glioma and infarction.
Ugeskrift for læger, Nov 1, 1993
A retrospective case control study was carried out in order to assess the risk of developing cere... more A retrospective case control study was carried out in order to assess the risk of developing cerebral thromboembolism by use of low dose oral contraceptives (OC). The subjects were all the 794 women in Denmark aged 15-44 who had suffered a cerebral thromboembolic attack (CTA) during the period 1985-1989, and an age-matched randomly selected control population of 1588 women. CTA included occlusion of precerebral arteria (ICD 432), cerebral thrombosis (ICD 433), cerebral embolism (ICD 434), transitory cerebral ischaemia (TCI; ICD 435) and the unspecified group apoplexia cerebri (ICD 436). Of 692/1584 case/control questionnaires sent out, 590/1396 (85.1/88.1%) were returned. Among the cases, 15 refused to participate, 69 had a revised or unreliable diagnosis, 40 had previously had thromboembolic disease, 13 were pregnant, and 152 had a disease predisposing them for CTA, leaving 323 without known predisposition, of whom 320 reported use/non-use of OC. Among 1396 controls, eight either r...
Ugeskrift for læger, Oct 14, 1996
The aim of this study was to analyze age specific incidence rates (IRs) of cerebral thromboemboli... more The aim of this study was to analyze age specific incidence rates (IRs) of cerebral thromboembolic attacks (CTA) among women and men 15-44 years of age in Denmark from 1980 through 1993 and quantify possible influences from oral contraceptives (OC) on the incidence figures. The discharge diagnoses ICD 432-436 from all Danish neurological, neurosurgical and medical departments during the period 1980-1993 were identified in a central diagnosis register. The use of OC was achieved from complete sale statistics during the study period and cross-sectional studies assessing the type-specific use of OC at different ages. During the 14-year study period, 2100 female and 2552 male attacks were registered. Men had an exponentially increasing IR with increasing age. Compared with men in the period 1980-1986, women had more attacks in the 20-35-year age group and fewer attacks above the age of 35. After 1987 the sex differences below the age of 35 were not significant. From the first half (1980...
Ugeskrift for læger, Nov 14, 1983
Ugeskrift for læger, May 31, 1999
Early medical abortion was introduced in Denmark in 1998. In countries in which this practice has... more Early medical abortion was introduced in Denmark in 1998. In countries in which this practice has been in use for several years, clinical studies have identified an effective and at the same time gentle regimen. For the time being, this regimen is a combination of the antiprogestogen "mifepristone" and a prostaglandin E1 analogue. Among women with pregnancies up to eight weeks of gestation, 95% will have a complete abortion on a regimen of 600 mg oral mifepristone combined 24 hours later with 1 mg vaginal gemeprost. About five percent will undergo evacuation due to incomplete abortion or heavy bleeding. Although many women experience moderate or severe pain, nausea or vomiting, the tolerability is generally good. Complications wuch as infection or excessive bleeding occur in less than one percent. It is concluded that medical abortion is a good alternative to surgical abortion, and that women who wish an abortion have to be referred to hospital as early as possible in orde...
Ugeskrift for læger, Nov 28, 1994
The objective of this analysis was to assess the incidence rate of cervical incompetence diagnose... more The objective of this analysis was to assess the incidence rate of cervical incompetence diagnoses in Denmark 1980-1990 according to maternal age, to analyze regional variations, to investigate how often cervical cerclage is applied, and finally to estimate abortion rates among women with cervical incompetence with and without cervical cerclage. The design was a register-based retrospective cross sectional study, including all Danish gynaecological departments. Since 1977, all hospitalized patients in Denmark have been centrally recorded by diagnosis according to the ICD classification and by operation codes in The National Patient Register. From this database, all women with cervical incompetence (CI) and cerclage in the period 1980-1990 were identified. From the same database all cases of spontaneous abortions were registered. A total of 2756 cases of cervical incompetence were registered in the period 1980-1990, corresponding to an incidence rate of 4.6/1000 births. The risk of c...
Ugeskrift for læger, Apr 9, 1984
Ugeskrift for laeger, 1984
An article for Larsen & Hauge which claimed that no increase of cerebrovascular mortality of wome... more An article for Larsen & Hauge which claimed that no increase of cerebrovascular mortality of women occurred after 1966 is being disputed. The author cites Danish vital statistics data to prove that there is a correlation between higher mortality and oral contraceptive use. After 1966 there was an 85% increase of thromboembolic cerebral mortality (primarily cerebral hemorrhages) in women aged 15-34 vs. a decrease of 30% in men. This conclusion was criticized by Larsen & Hauge who claimed that only 8 cases of death were due to cerebral thromboembolic attacks vs. the 17 cases in women and 13 in men listed by the author. This discrepancy is due to the different classification or cerebrovascular diseases after 1969; occlusio arteriae precerebralis is included in this class thus yielding the 2 figures cited by the author. The charge of Larsen & Hauge concerning no distinction between cerebral hemorrhage and cerebral embolism prior to 1961 is refuted by citing 4 distinct categories of vita...
Ugeskrift for laeger, 1992
The mortality from ovarian cancer is responsible for 450-500 cancer deaths annually in Denmark. T... more The mortality from ovarian cancer is responsible for 450-500 cancer deaths annually in Denmark. This high mortality rate has remained unchanged for decades. No effective screening method is available. Oophorectomy per occasionem may reduce the incidence of ovarian cancer. The literature suggests a reduction in the incidence of ovarian cancer of 5.7% which corresponds to approximately 30 women annually in Denmark when OPO is performed at the age of forty or later. OPO also avoids reoperation due to the Residual Ovarian Syndrome, which is detected in approximately 2% of women after pelvic surgery.
Ugeskrift for laeger, 1997
Ugeskrift for laeger, 1998
Oestrogen replacement therapy in women with a history of breast cancer has long been considered c... more Oestrogen replacement therapy in women with a history of breast cancer has long been considered contraindicated. However, the literature does not indicate an increased risk of recurrent breast cancer in postmenopausal women receiving oestrogen replacement therapy. We advocate that women with a history of breast cancer without nodal involvement could be offered oestrogen replacement therapy and thereby benefit from prevention of cardiovascular disease and osteoporosis. But the patients must accept a potentially increased risk of recurrence. We emphasize the need for randomized prospective studies.
BJOG: An International Journal of Obstetrics & Gynaecology, 2021
Many clinicians are of the opinion that observational studies may provide only "statistical ... more Many clinicians are of the opinion that observational studies may provide only "statistical associations", but not "causal inference". And further, that only randomized designs ensure causal interpretation. For the same reason, many medical journals have made rules for all observational studies finding significant statistical associations to be presented as just "associations" often emphasizing that a causal inference is not possible.
Contraception, Mar 1, 2002
The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk ... more The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk of venous thromboembolism (VTE) in young women. A 5-year case-control study including all Danish hospitals was conducted. All women 15-44 years old, suffering a first ever deep venous thrombosis or a first pulmonary embolism (PE)
Lancet, Jan 12, 2015
Half the epidemiological studies with information about menopausal hormone therapy and ovarian ca... more Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with <5 years of use (RR 1·43, 95% CI 1·31-1·56; p<0·0001). Combining current-or-recent use (any duration, but stopped <5 years ...
Human reproduction (Oxford, England), 2014
With interest we read the article of Henningsen et al., who compared pregnancy outcomes in single... more With interest we read the article of Henningsen et al., who compared pregnancy outcomes in singleton pregnancies after ART to singleton pregnancies that were conceived naturally. The authors report a significantly increased risk of stillbirth after ART before a gestational age of 28 weeks. They conclude that in view of the fact that the increased stillbirth risk was observed before 28 weeks only, prevention of stillbirth in the third trimester might be sufficient. We have two comments. First, the authors have acknowledged that a proportion of the cohort of women with ART singleton pregnancies (estimating background rate 1 in 10 (Henningsen et al., 2014)) initially might have had a vanishing twin. They have also acknowledged the subsequent possible implications for early stillbirths in this group. It would be crucial to know what proportion of the singletons after ART would be the result from single embryo transfer (SET) or from double embryo transfer (DET). This information is not provided, but may be available to the authors. Moreover, as SET in Scandinavia was introduced well before the end of the study period, the authors might be able to look at trends over this time. Secondly, when the increased perinatal mortality rate before 28 weeks indeed can be linked to the use of ART, we would like to challenge the opinion of the authors on the liberal use of ART in Nordic countries, where .3% of the babies are conceived after ART, with Denmark leading the way with 4.5% of infants born through ART (Ferraretti et al., 2013). Considering the fact that many couples would conceived naturally when allowed a longer expectant management period we could imagine stricter guidelines around use of ART in Scandinavia to prevent unnecessary stillbirth and preterm delivery.
The European Journal of Contraception & Reproductive Health Care, 1996
The survey was designed to study the attitudes of gynecologists from 11 European centers providin... more The survey was designed to study the attitudes of gynecologists from 11 European centers providing guidance in contraception to women at high risk and women with cardiovascular disease. Attitudes were registered by means of a standard questionnaire. Most contributors reported that, in women with venous thrombosis (10/11), deep venous thrombosis (10/11), coagulation disorders (11/11) and stroke (8/11), they prefer to prescribe methods other than combined oral contraceptives (COCs). A history of myocardial infarction was considered a relative contraindication and some experts suggested that, in some cases, the use of third-generation COCs may be possible. COCs were not recommended in women with severe cardiovascular disease and in those over 35 years of age with light or moderate cardiovascular disease, heavy smokers (over 20 cigarettes per day), or those presenting with severe hyperlipidemia. The pill is not considered appropriate for women with clinically established cardiovascular diseases or in cases where more than two coronary risk factors exist. COCs may safely be given to women with elevated blood pressure as long as it is lower than 160/100 mmHg, in cases of light and moderate cardiovascular disease as long as the patient is less than 35 years of age, in women who are not heavy smokers, in the presence of a light or moderate degree of hyperlipidemia, and in uncomplicated diabetes mellitus provided that there are no additional risk factors. In these cases, third-generation COCs are preferred. The co-operation of the cardiologist is desirable in order to classify cardiovascular disease and for patient follow-up.
Acta Neurologica Scandinavica, 1987
The mortality of cerebrovascular diseases in Denmark was analysed for men and women 15-44 years o... more The mortality of cerebrovascular diseases in Denmark was analysed for men and women 15-44 years of age, in a 14-year period before and after the appearance of oral contraceptives (OC) in 1966. 1,670 deaths were registered over 28 years, during which the female incidence of cerebrovascular deaths increased by 19% (P<0.025), while the male mortality was unchanged. Women showed a percentage increase in deaths from cerebral thromboembolic attacks (CTA) of 33%, men a fall of 14%. The increase of female CTA deaths was most pronounced in the young fertile group, the age group with a high OC use. A relative risk of CTA of 3.3-4.5 for OC users compared with non-users could explain the CTA trend difference between women and men. No other single risk factor responsible for the observed trends could be identified. Both women and men had a significant increase in the mortality of subarachnoidal hemorrhages, and a significant fall in the mortality of intracere-bra1 hemorrhages.
Archives of General Psychiatry, 2012
Context: Mental health problems are associated with women's reproductive decisions and predict po... more Context: Mental health problems are associated with women's reproductive decisions and predict poor mental health outcomes after abortion and childbirth. Objectives: To study whether having a first-trimester induced abortion influenced the risk of psychiatric readmission and compare findings with readmission risk in women with mental disorders giving birth. Design: Survival analyses were performed in a population-based cohort study merging data from the Danish Civil Registration System, the Danish Psychiatric Cen
Stroke, 1986
In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thr... more In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this material we found an average age-adjusted incidence rate of cerebral thromboembolism of 14.4/100.000 among men and 15.5/100.000 among women. The incidence rates rose rapidly with increasing age. Women aged 15-34 had significantly higher incidence rates of brain infarction and TIA compared to those of men of the same age. This was reversed in the age group 35-44. The magnitude of the ratio between the female and the male mean incidence rates by increasing age corresponded exactly to the age distribution of the use of oral contraceptives in Denmark. The relative risk for developing cerebral thromboembolism among users of oral contraceptives was estimated to be 3.2-6.5. The mo...
Acta Neurologica Scandinavica, 1983
In 5 patients with definite or highly probable MS, unusually large hypodense plaques are seen by ... more In 5 patients with definite or highly probable MS, unusually large hypodense plaques are seen by computerized tomography (CT scan). The active plaques all show enhancement after i.v. contrast medium injection, suggestive of blood-brain-barrier-damage, and differ from the well-known CT findings in chronic MS patients, causing diagnostic difficulties between glioma and infarction.
Ugeskrift for læger, Nov 1, 1993
A retrospective case control study was carried out in order to assess the risk of developing cere... more A retrospective case control study was carried out in order to assess the risk of developing cerebral thromboembolism by use of low dose oral contraceptives (OC). The subjects were all the 794 women in Denmark aged 15-44 who had suffered a cerebral thromboembolic attack (CTA) during the period 1985-1989, and an age-matched randomly selected control population of 1588 women. CTA included occlusion of precerebral arteria (ICD 432), cerebral thrombosis (ICD 433), cerebral embolism (ICD 434), transitory cerebral ischaemia (TCI; ICD 435) and the unspecified group apoplexia cerebri (ICD 436). Of 692/1584 case/control questionnaires sent out, 590/1396 (85.1/88.1%) were returned. Among the cases, 15 refused to participate, 69 had a revised or unreliable diagnosis, 40 had previously had thromboembolic disease, 13 were pregnant, and 152 had a disease predisposing them for CTA, leaving 323 without known predisposition, of whom 320 reported use/non-use of OC. Among 1396 controls, eight either r...
Ugeskrift for læger, Oct 14, 1996
The aim of this study was to analyze age specific incidence rates (IRs) of cerebral thromboemboli... more The aim of this study was to analyze age specific incidence rates (IRs) of cerebral thromboembolic attacks (CTA) among women and men 15-44 years of age in Denmark from 1980 through 1993 and quantify possible influences from oral contraceptives (OC) on the incidence figures. The discharge diagnoses ICD 432-436 from all Danish neurological, neurosurgical and medical departments during the period 1980-1993 were identified in a central diagnosis register. The use of OC was achieved from complete sale statistics during the study period and cross-sectional studies assessing the type-specific use of OC at different ages. During the 14-year study period, 2100 female and 2552 male attacks were registered. Men had an exponentially increasing IR with increasing age. Compared with men in the period 1980-1986, women had more attacks in the 20-35-year age group and fewer attacks above the age of 35. After 1987 the sex differences below the age of 35 were not significant. From the first half (1980...
Ugeskrift for læger, Nov 14, 1983
Ugeskrift for læger, May 31, 1999
Early medical abortion was introduced in Denmark in 1998. In countries in which this practice has... more Early medical abortion was introduced in Denmark in 1998. In countries in which this practice has been in use for several years, clinical studies have identified an effective and at the same time gentle regimen. For the time being, this regimen is a combination of the antiprogestogen "mifepristone" and a prostaglandin E1 analogue. Among women with pregnancies up to eight weeks of gestation, 95% will have a complete abortion on a regimen of 600 mg oral mifepristone combined 24 hours later with 1 mg vaginal gemeprost. About five percent will undergo evacuation due to incomplete abortion or heavy bleeding. Although many women experience moderate or severe pain, nausea or vomiting, the tolerability is generally good. Complications wuch as infection or excessive bleeding occur in less than one percent. It is concluded that medical abortion is a good alternative to surgical abortion, and that women who wish an abortion have to be referred to hospital as early as possible in orde...
Ugeskrift for læger, Nov 28, 1994
The objective of this analysis was to assess the incidence rate of cervical incompetence diagnose... more The objective of this analysis was to assess the incidence rate of cervical incompetence diagnoses in Denmark 1980-1990 according to maternal age, to analyze regional variations, to investigate how often cervical cerclage is applied, and finally to estimate abortion rates among women with cervical incompetence with and without cervical cerclage. The design was a register-based retrospective cross sectional study, including all Danish gynaecological departments. Since 1977, all hospitalized patients in Denmark have been centrally recorded by diagnosis according to the ICD classification and by operation codes in The National Patient Register. From this database, all women with cervical incompetence (CI) and cerclage in the period 1980-1990 were identified. From the same database all cases of spontaneous abortions were registered. A total of 2756 cases of cervical incompetence were registered in the period 1980-1990, corresponding to an incidence rate of 4.6/1000 births. The risk of c...
Ugeskrift for læger, Apr 9, 1984
Ugeskrift for laeger, 1984
An article for Larsen & Hauge which claimed that no increase of cerebrovascular mortality of wome... more An article for Larsen & Hauge which claimed that no increase of cerebrovascular mortality of women occurred after 1966 is being disputed. The author cites Danish vital statistics data to prove that there is a correlation between higher mortality and oral contraceptive use. After 1966 there was an 85% increase of thromboembolic cerebral mortality (primarily cerebral hemorrhages) in women aged 15-34 vs. a decrease of 30% in men. This conclusion was criticized by Larsen & Hauge who claimed that only 8 cases of death were due to cerebral thromboembolic attacks vs. the 17 cases in women and 13 in men listed by the author. This discrepancy is due to the different classification or cerebrovascular diseases after 1969; occlusio arteriae precerebralis is included in this class thus yielding the 2 figures cited by the author. The charge of Larsen & Hauge concerning no distinction between cerebral hemorrhage and cerebral embolism prior to 1961 is refuted by citing 4 distinct categories of vita...
Ugeskrift for laeger, 1992
The mortality from ovarian cancer is responsible for 450-500 cancer deaths annually in Denmark. T... more The mortality from ovarian cancer is responsible for 450-500 cancer deaths annually in Denmark. This high mortality rate has remained unchanged for decades. No effective screening method is available. Oophorectomy per occasionem may reduce the incidence of ovarian cancer. The literature suggests a reduction in the incidence of ovarian cancer of 5.7% which corresponds to approximately 30 women annually in Denmark when OPO is performed at the age of forty or later. OPO also avoids reoperation due to the Residual Ovarian Syndrome, which is detected in approximately 2% of women after pelvic surgery.
Ugeskrift for laeger, 1997
Ugeskrift for laeger, 1998
Oestrogen replacement therapy in women with a history of breast cancer has long been considered c... more Oestrogen replacement therapy in women with a history of breast cancer has long been considered contraindicated. However, the literature does not indicate an increased risk of recurrent breast cancer in postmenopausal women receiving oestrogen replacement therapy. We advocate that women with a history of breast cancer without nodal involvement could be offered oestrogen replacement therapy and thereby benefit from prevention of cardiovascular disease and osteoporosis. But the patients must accept a potentially increased risk of recurrence. We emphasize the need for randomized prospective studies.