GONUL Yucel - Academia.edu (original) (raw)

Papers by GONUL Yucel

South African journal of psychiatry, Oct 8, 2014

The corpus callosum (CC) is known to be the largest white-matter fibre tract in the brain. It con... more The corpus callosum (CC) is known to be the largest white-matter fibre tract in the brain. It connects the two cerebral hemispheres and facilitates interhemispheric communication. [1,2] The CC has been strongly implicated as an anatomical mediator of dysfunctional interhemispheric transfer in schizophrenia [3] and a number of psychiatric disorders, including bipolar affective disorder, depression, [4] antisocial personality disorder, [5] post-traumatic stress disorder, [6] autism [7] and attention deficit hyperactivity disorder. [8] Rosenthal and Bigelow [9] first drew attention to an increased thickness of the CC in postmortem brains of schizophrenia patients. Later, in neuroimaging studies, CC size was found to be increased, [10] decreased [11] or unaltered [12] compared with healthy controls. In a meta-analysis of 28 magnetic resonance imaging (MRI) studies carried out by Arnone et al., [13] they found that schizophrenia patients seem to show a reduction in CC area. [13] The inconsistent findings may be a consequence of possible confounding factors, including age, [14] handedness, [15] gender, [16] chronicity of illness [17,18] and differences in CC partitioning schemes employed by the different studies. [19,20] In addition, it was suggested that it may also be owing to the heterogeneity in symptom profiles. [12,18] Schizophrenia is characterised by large heterogeneity, [12,18] and subtypes of schizophrenia may differ in neuroimaging-based measures of brain morphology. [21] Therefore, we planned to examine CC size on the basis of clinical subtype in schizophrenia, and we recruited the four subtypes of schizophrenia patients (paranoid, disorganised, undifferentiated and residual) who had different illness durations but were matched in age, sex and handedness. We hypothesised that the size of the CC may be different in the different subtypes of schizophrenia. Objective The objective of the current MRI study was to determine whether there were any differences in length and area of the CC among schizophrenia subtype patients and healthy subjects. Examining the association between schizophrenia subtypes and the size of the CC is likely to deepen our understanding of the pathophysiology of schizophrenia.

Pankreas, hem endokrin hem ekzokrin salgı yapan bir bezdir. Salgıları metabolik düzenin devamlılı... more Pankreas, hem endokrin hem ekzokrin salgı yapan bir bezdir. Salgıları metabolik düzenin devamlılığının sağlanmasında önemli bir yere sahiptir. Ayrıca lokalizasyonu itibari ile birçok organ ve anatomik yapı ile sıkı bir ilişki içerisindedir. Bu nedenle komşu organ ve yapıların cerrahisinde pankreas anatomisi ve varyasyonlarının bilinmesi cerrahi açısından önemlidir. Biz derlememizde pankreas ile ilgili temel anatomik bilgilerin, bu bölge cerrahisi ile ilgilenen hekimler için yardımcı bir kaynak olacağını ümit ediyoruz.

OncoTargets and Therapy, Feb 1, 2016

Background: In the literature, some articles report that the incidence of numerous diseases incre... more Background: In the literature, some articles report that the incidence of numerous diseases increases among the individuals who live around high-voltage electric transmission lines (HVETL) or are exposed vocationally. However, it was not investigated whether HVETL affect bone metabolism, oxidative stress, and the prevalence of thyroid nodule. Methods: Dual-energy X-ray absorptiometry (DEXA) bone density measurements, serum free triiodothyronine (FT3), free thyroxine (FT4), RANK, RANKL, osteoprotegerin (OPG), alkaline phosphatase (ALP), phosphor, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels were analyzed to investigate this effect. Results: Bone mineral density levels of L1-L4 vertebrae and femur were observed significantly lower in the electrical workers. ALP, phosphor, RANK, RANKL, TOS, OSI, and anteroposterior diameter of the left thyroid lobe levels were significantly higher, and OPG, TAS, and FT4 levels were detected significantly lower in the study group when compared with the control group. Conclusion: Consequently, it was observed that the balance between construction and destruction in the bone metabolism of the electrical workers who were employed in HVETL replaced toward destruction and led to a decrease in OPG levels and an increase in RANK and RANKL levels. In line with the previous studies, long-term exposure to an electromagnetic field causes disorders in many organs and systems. Thus, it is considered that long-term exposure to an electromagnetic field affects bone and thyroid metabolism and also increases OSI by increasing the TOS and decreasing the antioxidant status.

Elsevier Masson, Sep 9, 2016

Turkish Journal of Bioethics, 2015

Bir grup tıp fakültesi öğrencisinin kadavrayı nasıl algıladıklarını ve tıp eğitiminde kadavra kul... more Bir grup tıp fakültesi öğrencisinin kadavrayı nasıl algıladıklarını ve tıp eğitiminde kadavra kullanıma yönelik ne tür bir yaklaşım benimsediklerini belirlemektir. Yöntem: Öğrencilerin kadavra algısını ve eğitimde kadavra kullanımı hakkındaki yaklaşımlarını belirleme amacıyla, Ögenler ve Ark. tarafından oluşturulan veri toplama formu revize edilerek Ege Bölgesi'ndeki sekiz farklı tıp fakültesindeki 511 ikinci sınıf öğrencisine uygulanmıştır. Formda her birine benimseme derecesine göre bir-beş arası puan verilmesi istenen 19 ifade yer almaktadır. Derlenen veriler ortalama ve standart sapma üzerinden değerlendirilmiş, alt grup karşılaştırmalarında t test ve ki kare testleri kullanılmıştır. Çalışma için etik kurul onayı alınmıştır. 1 Yazarlardan Bilir'in Erbay yönetiminde yürüttüğü yüksek lisans tezinin bir ön ürünü olan bu çalışma, 1-9 Kasım 2014'te Japonya'da yapılan 15. Asya Biyoetik Konferansı'nda, sözlü bildiri olarak sunulmuştur. Makaleye eleştirileri ve önerileri ile katkıda bulunan Çukurova Üniversitesi öğretim üyesi Doç. Dr. Selim Kadıoğlu'na teşekkür ederiz.

Genel tıp dergisi, 2015

Yapay zeka yöntemleri insanların zekice olarak tasvir edilen davranışlarının akıllı cihazlar tara... more Yapay zeka yöntemleri insanların zekice olarak tasvir edilen davranışlarının akıllı cihazlar tarafından modellenmesidir. Yapay sinir ağları (YSA) ile sinir sisteminin çalışma şekli benzerdir. Stimüle edilen sinir hücreleri çeşitli şekillerde birbirlerine bağlanarak bir YSA oluştururlar. YSA' dan istenen ise, insanların düşünme yeteneğini bilgisayarlar aracılığı ile kopyalamak ve belirli ölçüde bilgisayarlara öğrenme yeteneği kazandırabilmektir. YSA'ların çok boyutlu, karmaşık, kesin olmayan, eksik, hata olasılığı yüksek sensör verileri olduğu ve problemleri çözmek için matematiksel modellerin ve algoritmaların bulunmadığı durumlarda yaygın olarak kullanıldıkları görülmektedir. Bu amaçla geliştirilmiş ağlar; muhtemel fonksiyon kestirimleri, sınıflandırma, ilişkilendirme veya örüntü eşleştirme, örüntü tanıma ve optimizasyon gibi fonksiyonları gerçekleştirmektedirler. YSA tıbbi araştırma verileri içinden daha önce fark edilmemiş desenleri saptama, sınıflama, tıbbi aygıtların kontrolü, tıbbi görüntülerin karakteristiklerinin tespit edilmesi gibi pek çok uygulamada aktif olarak kullanılmaktadır. Yapay zeka yöntemlerinin yeterliliği tıbbın neredeyse her alanında araştırılmıştır ve uygulanma potansiyeline sahiptir. Bu çalışmalara örnek olarak; akut apandisit, ateroskleroz ve koroner arter hastalıkları için tanı koyma, apical foramen lokalizasyonu, artritte el ve bilek radyografisi kullanılarak lokalizasyon değerlendirme, osteoporoz riski değerlendirme, yürüme bozukluğu ve baş ağrılarının sınıflandırılması, oral veya orofarenjiyal kanser tedavisinde hastalardaki hipernazalitenin değerlendirilmesi ve analizi, farenjiyal yüksek çözünürlük manometresinin sınıflandırılması gösterilebilir. Hatalı teşhis riski olan kompleks hastalıkların tanısında faydalı bir araç olduğu gösterilmiştir. Bu nedenle YSA tekniğinin gereksiz araştırmaları, olumsuz ameliyat oranlarını ve potansiyel olarak ortaya çıkabilecek maliyeti azaltabileceği söylenebilir. YSA araştırmalarının getirileri ve başarıları göz önüne alındığında tıp alanında yeni bir çağ açacağı ve daha gelişmiş tanı ve tedavi yöntemleri için ışık tutacağı kaçınılmaz bir gerçektir. Anahtar sözcükler: Yapay sinir ağları, yapay zeka, klinik Artificial neural networks and the use in clinical researchs Artificial intelligence methods are modeling of humans' behaviors which described as "intelligently" by smart devices. The operating mode of nervous system is imitated by Artificial neural networks (ANN). Stimulated nerve cells constitute ANN by connecting to each other in various forms. Desired from ANN is to copy peoples' thinking ability through computers and to be gained learning ability by computers. It is observed that ANNs are widely used in some situations such as sensor data which is multi-dimensional, complex, imprecise, incomplete and have high error probability and the absence of mathematical models and algorithms to solve these problems. Developed networks for this purpose actualize some functions such as estimation of possible functions, classification, association, pattern matching, pattern recognition and optimization. ANN is actively used in many applications such as detecting patterns which were previously unrecognized from medical research data, classification, medical devices, control and determining characteristics of medical images. The adequacy of artificial intelligence methods were investigated almost in all fields of medicine. The diagnosis of acute appendicitis, atherosclerosis and coroner artery disease, localization of the apical foramen, arthritis, localization assessment using the hand and wrist radiographs, osteoporosis risk assessment, gait disturbances and the classification of headache, analysis to assess hypernasality in patients treated for oral or oropharyngeal cancer, classification of pharyngeal high-resolution manometry can be shown as examples. ANN was shown to be a useful tool to diagnose complex diseases which have misdiagnosis risk. Therefore it can be said that, ANN technique can reduce unnecessary investigations, negative surgery rates and cost which may arise potentially. Considering the benefits and achievements of ANN research, it is an unavoidable fact that, ANN will open a new era in medicine and will shed light on more advanced diagnosis and treatment method.

Amaç: Bu çalışmanın amacı yaygın anksiyete bozukluğu (YAB)’nun patogenezinde nesfatin-1’in olası ... more Amaç: Bu çalışmanın amacı yaygın anksiyete bozukluğu (YAB)’nun patogenezinde nesfatin-1’in olası rolünü araştırmaktır. Yöntem: Bu çalışmada 40 YAB’lu hasta ile yaş ve BMI ile eşleştirilmiş 42 sağlıklı kontrol’un plasma nesfatin-1 düzeyleri ölçüldü. Anksiyete şiddeti Hamilton Anksiyete Derecelendirme Ölçeği (HAM-A) ile değerlendirildi. Bulgular: Hasta ve kontrol grupları arasında nesfatin-1 düzeyinde anlamlı bir farklılık yoktur. Ortalama serum nesfatin-1 düzeyi yaş, hastalık süresi, BMI ve HAM-A skoru ile korelasyon göstermiyordu. Sonuç: Sonuçlarımız YAB‘nun nesfatin-1 ile ilişkili olduğunu desteklemiyor.Objective: The aim of the present study was to find out the possible role of nesfatin-1 in the pathogenesis of generalized anxiety disorder (GAD). Methods: In this study, we measured plasma nesfatin-1 levels in 40 GAD patients and 42 controls that were matched by age and BMI. The severity of anxiety was evaluated with the Hamilton Anxiety Rating Scale (HAM-A). Results: There was no ...

Diagnostic and Interventional Imaging, 2016

OBJECTIVE The goal of this study was to investigate the possible variations in morphology of naso... more OBJECTIVE The goal of this study was to investigate the possible variations in morphology of nasopalatine canal (NPC) morphometry depending on age, gender and absence of anterior incisors using multidetector row computed tomography (MDCT). MATERIALS AND METHODS A total of 100 patients (50 men, 50 women) with a mean age of 43.29±18.81 (SD) years (range: 18-90 years) who have undergone head MDTC were included into the study. Foramen nasalis diameter (P1), foramen incisivum diameter (P2), NPC length (P3), distance between buccal wall of incisive foramen and facial side of the buccal bone (P4), distances between buccal bone wall of NPC and facial side of buccal bone (P5), distance between mid-NPC buccal wall and facial side of buccal bone (P6), distance between buccal wall of NPC and the apex of anterior central incisors (P7) and NPC angle (P8) were measured. Formal variations in NPC were searched for. Differences in morphometric data were searched using Student t-test or Mann-Whitney test. Gender-based analysis of the variations was done with the χ2 test. Pearson's test was used to search for correlation between morphometric data and age. RESULTS P1 was larger in men (3.72±1.41mm) than in women (3.07±1.34mm) (P<0.001). Similarly, P3 was larger in men (13.68±2.73mm) than in women (11.43±2.78mm) (P<0.001). No differences in the other NPC measurements (P2, P4, P5, P6, P7, P8) were found between men and women. Morphological variations in NPC (cylindrical, hourglass, banana shape, funnel shape, single canal, Y-type canal, parallel canal and others) were detected with frequencies ranging from 8 to 65.3%. A significant negative correlation was found between NCP measurements and patient age for P3 (r=-0.311; P=0.002), P4 (r=-0.267; P=0.007) and P8 (r=-0.318; P<0.001). New NPC variations, which were not reported before were found in 19% of our patients. CONCLUSION NPC shows myriad potential variations that have various prevalences. It is assumed that familiarity with these variations may help decrease the incidence of complications during facial or dental surgery.

IJCR, Aug 17, 2014

Pankreas, hem endokrin hem ekzokrin salgi yapan bir bezdir. Salgilari metabolik duzenin devamlili... more Pankreas, hem endokrin hem ekzokrin salgi yapan bir bezdir. Salgilari metabolik duzenin devamliliginin saglanmasinda onemli bir yere sahiptir. Ayrica lokalizasyonu itibari ile bircok organ ve anatomik yapi ile siki bir iliski icerisindedir. Bu nedenle komsu organ ve yapilarin cerrahisinde pankreas anatomisi ve varyasyonlarinin bilinmesi cerrahi acisindan onemlidir. Biz derlememizde pankreas ile ilgili temel anatomik bilgilerin, bu bolge cerrahisi ile ilgilenen hekimler icin yardimci bir kaynak olacagini umit ediyoruz. Anahtar kelimeler: Pankreas, anatomi, pankreas kanallari, varyasyon. Abstract Pancreas is a digestive gland which has both endocrin and exocrin functions. Pancreatic secretions play an important role in the normal functioning of the metabolism. Pancreas is closely related to many organs and anatomic structures. Thus, knowledge of normal and variational anatomy of these organs is essental for surgical operations. We hope our review will be a source of basic anatomical knowledge for surgeons dealing with pancreatic problems. Key words: Pancreas, anatomy, ductus pancreaticus, variation.

Background: Theaimofthisstudywastoinvestigatethepossibleprotectiveeffectofinterleukin 18ebinding ... more Background: Theaimofthisstudywastoinvestigatethepossibleprotectiveeffectofinterleukin 18ebinding protein (IL-18BP) on ischemiaereperfusion (I/R)einduced liver injury in experimental rat models. Liver is one of the most affected organs from I/R process. IL-18 is an important proinflammatory cytokine, which may induce some events such as production of reactive oxygen substances and release of various cytokines. IL-18BP acts as an inhibitor of IL18.TherelationshipbetweenIL-18andIL-18BPhasanimportantplaceininflammatoryprocess. Materials and methods: Rats were equally divided into three groups as follows: sham: Hepatic pedicle dissection was done, but hepatic pedicle clamping was not used. I/R: Sixty minutes of ischemia and 2 h of reperfusion were applied. IR þ IL-18BP: Recombinant human IL-18BP (100 mg/kg) was administered 30 min before the surgery. Hepatic pedicle was clamped during 60 min of ischemia and 2 h of reperfusion was achieved. Results: Liver enzyme levels were significantly ...

1136 students participated, from which 52.4% (n=594) had already received training. The average n... more 1136 students participated, from which 52.4% (n=594) had already received training. The average number of correct answers was higher in the group that had already received training (7.73 in 9) in comparison to the other group (5.25 in 9). By the end of the school year 2016/2017, the Project had visited 68 schools, covering 12,183 students (+523 [4.49%] when compared with 2014/2015) and 648 teachers (+34 [5.54%]).

Bratislava Medical Journal, 2019

AIM: The objective of this study was to determine the neuroprotective effects of 2-aminoethyl dip... more AIM: The objective of this study was to determine the neuroprotective effects of 2-aminoethyl diphenyl-borinate (2-APB) on the brains of rats with experimentally-induced severe acute pancreatitis. MATERIALS AND METHODS: Thirty Spraque-Dawley male rats with an average weight of 200-250 grams were randomly divided into three groups. Group 1: Sham group, Group 2: Severe acute pancreatitis group, Group 3: Treatment group with severe acute pancreatitis, given 2 mg/kg 2-APB before pancreatitis onset. In Groups 2 and 3, severe acute pancreatitis was induced by intraperitoneal administration of 1.5 g/kg L-arginine with a 1-hour interval. Tumor necrosis factor-α, interleukin 6, pancreatic amylase were all measured. Brain tissue samples were evaluated histopathologically. TUNEL staining method was used to visualize apoptotic cells. RESULTS: In Group 3, it was determined that the density of TUNEL-positive cells in the cerebral cortex has decreased, while the number of Bcl-2-positive cells had increased. In Group 3, it was observed that glial aggregation areas were diminished and histopathological changes were decreased as compared to Group 2. In Group 2, on the other hand, it was observed that in areas with glial cell aggregation, the density of TUNELpositive glial cells had increased, while Bcl-2-positive cell reaction has been feeble. CONCLUSIONS: It was observed that 2-APB decreases neuronal apoptosis and glial cell aggregation (Tab. 2, Fig. 3, Ref.

Journal of Surgical Arts, Jun 1, 2009

Duzce Medical Journal, Mar 1, 2013

Vaskuler lezyonlar, bebek ve cocukluk doneminin en sik gorulen konjenital anomalisidir. Bu lezyon... more Vaskuler lezyonlar, bebek ve cocukluk doneminin en sik gorulen konjenital anomalisidir. Bu lezyonlarin yaridan fazlasi bas-boyun bolgesinde gorulup, ciddi estetik ve fonksiyonel bozukluklara neden olabilir. Yakin zamana kadar vaskuler lezyonlarin evrensel olarak kabul edilen bir siniflamasi mevcut degildi. Gunumuzde ise tedavi yaklasimlari acisindan tartismalar devam etmektedir. Baslica iki ana baslikta; hucre hiperplazisiyle karakterize vaskuler tumorler ve damarlarin gelisimi sirasinda ortaya cikan lokalize defektlerden kaynaklanan vaskuler malformasyonlar olmak uzere incelenebilir. Her bir anomalinin kendine ozgu fizyopatolojisi, klinigi, goruntuleme ozellikleri ve tedavi secenekleri vardir. Bu biyolojik siniflama ilk olarak 1982’de Mulliken ve Glowacki tarafindan onerilmistir ve vaskuler anomaliler arasindaki klinik, histokimyasal ve hucresel farkliliklara dayanmaktadir. Bu makalede, daha siklikla gorulen vaskuler lezyonlar fizyopatoloji, tani ve tedavileri acisindan literatur b...

Journal of Surgical Research, 2015

Renal injury is an important complication of infrarenal aortic occlusion (IAO), which is mainly e... more Renal injury is an important complication of infrarenal aortic occlusion (IAO), which is mainly encountered during the postoperative period. Aortic clamping procedure may lead to turbulent blood flow and eventually vasoconstriction at renal arterial level of the abdominal aorta. IL-18BP has well-known antioxidant and anti-inflammatory properties. In this study, we aimed to determine whether IL-18BP has anti-inflammatory, antiapoptotic, antioxidant, and protective effects on acute kidney damage induced by IAO rat model. A total of 30 adult male Wistar-Albino rats were equally and randomly separated to three groups as follows: SHAM laparotomy, ischemia-reperfusion (IR), and IR + IL-18BP. We applied 30-min IAO and 2-h reperfusion. Inflammatory cytokine levels (TNF-α, IL-1β, IL-18, IL-6, and IFN-γ) and oxidative stress parameters (TAS, TOS, and OSI) were measured. In addition to this, urea and creatinine levels, histopathology of kidney, mRNA expression levels of inflammatory cytokines, and apoptotic genes were investigated. Urea and creatinine, tissue and serum levels of TNF-α, IL-6, IL-18, IFN-γ, and TOS, and oxidative stress index (OSI) were found significantly lower in IR + IL-18BP group, when compared to the IR group. Moreover, mRNA expression levels of inflammatory cytokines and apoptotic genes were prominently depressed in IR + IL-18BP pre-treatment group in histopathologic examination, there was a significant difference between the IR and other three groups (P &amp;amp;amp;amp;amp;amp;amp;lt; 0.001). These improvements were demonstrated with a total score of histopathologic damage. In our previous studies, we have demonstrated that IL-18BP has antioxidant, inflammatory, and protective effects on liver and spinal cord IR injury. Data established from the present study suggest that IL-18BP may exert anti-inflammatory, antiapoptotic, antioxidant, and protective effects on IAO-induced acute kidney injury in rats, and this would be the first study to be conducted in this field. Data established from the present study suggest that IL-18BP may exert anti-inflammatory, antiapoptotic, antioxidant, and protective effects on IAO-induced acute kidney injury in rats.