Oliver Haase - Academia.edu (original) (raw)

Papers by Oliver Haase

Medicina

Background and Objectives: After liver transplantation (LT), long-term immunosuppression (IS) is ... more Background and Objectives: After liver transplantation (LT), long-term immunosuppression (IS) is essential. IS is associated with de novo malignancies, and the incidence of colorectal cancer (CRC) is increased in LT patients. We assessed course of disease in patients with de novo CRC after LT with focus of IS and impact on survival in a retrospective, single-center study. Materials and Methods: All patients diagnosed with CRC after LT between 1988 and 2019 were included. The management of IS regimen following diagnosis and the oncological treatment approach were analyzed: Kaplan–Meier analysis as well as univariate and multivariate analysis were performed. Results: A total of 33 out of 2744 patients were diagnosed with CRC after LT. Two groups were identified: patients with restrictive IS management undergoing dose reduction (RIM group, n = 20) and those with unaltered regimen (maintenance group, n = 13). The groups did not differ in clinical and oncological characteristics. Statist...

Chirurgisches Forum 2006, 2006

Pulmonary disorders are the most important general complications after esophagectomy. A restricti... more Pulmonary disorders are the most important general complications after esophagectomy. A restrictive fluid therapy may reduce fluid storage and could improve the postoperative pulmonary function. Methods: In a controlled randomized trial with 22 patients the effect of fluid restriction guided by intrathoracic blood volume index (ITBVI) on pulmonary and cardiac function was studied in two groups. Results: There were no differences in patient characteristics, morbidity and mortality. The resulting amount of infusions and the cumulative fluid intake were reduced in the restricted group. In 5 patients of the restricted group infusions could not be reduced in the complete postoperative course because of impaired cardiac function. Pulmonary function was significantly improved in the restricted group. Conclusion: A restricted fluid therapy leads to improved pulmonary function but can impair cardiac function in the postoperative course.

Cancer Medicine, 2016

Psychological interventions can improve Quality of Life (QoL). Object of interest was if differen... more Psychological interventions can improve Quality of Life (QoL). Object of interest was if different psychological interventions influence short-term QoL after colonic resection for carcinoma. Furthermore, we wanted to see if there is a correlation between patients` preoperative affect and postoperative QoL. Sixty patients that underwent colorectal surgery were divided into three groups. Group one (n = 20) received Guided Imagery and group 2 (n = 22) Progressive Muscle Relaxation. The third group (Control, n = 18) had no intervention. Quality of Life (QoL) was measured using the EORTC QLQ-C30 and the Gastrointestinal Quality of life Index (GIQLI). Patients' affect was measured by the PANAS questionnaire. The higher the preoperative Negative Affect was, the lower were the scores for QoL on the 30th postoperative day. Patients' QoL was highest preoperatively and lowest on the third postoperative day. On the 30th postoperative day scores for QoL were almost as high as preoperative without difference between the three groups. Neither Guided Imagery nor Progressive Relaxation was influencing short-term QoL measured by the EORTC QLQ-C30 and the GIQLI questionnaire after colorectal surgery for cancer. Screening patients' with the PANAS questionnaire might help to identify individuals that are more likely to have a worse QoL postoperatively.

Journal of Clinical Medicine

Introduction: The laparoscopic approach for TME is proven to be non-inferior in oncological outco... more Introduction: The laparoscopic approach for TME is proven to be non-inferior in oncological outcome compared to open surgery. Anatomical limitations in the male and obese pelvis with resulting pathological shortcomings and high conversion rates were stimuli for alternative approaches. The transanal approach for TME (TaTME) was introduced to overcome these limitations. The aim of this study was to evaluate the outcomes of TaTME for mid and low rectal cancer at our center. Methods: TaTME is a hybrid procedure of simultaneously laparoscopic and transanal mesorectal excision. A retrospective analysis of all consecutive TaTME procedures performed at our center for mid and low rectal cancer between December 2014 and January 2020 was conducted. Results: A total of 157 patients underwent TaTME, with 72.6% receiving neoadjuvant chemoradiation. Mean tumor height was 6.1 ± 2.3 cm from the anal verge, 72.6% of patients had undergone neoadjuvant chemoradiotherapy, and 34.2% of patients presented...

Acta Anaesthesiologica Scandinavica, 2008

Background: Perioperative fluid therapy is controversially debated in surgery. In malnourished an... more Background: Perioperative fluid therapy is controversially debated in surgery. In malnourished and hypovolaemic patients, a restrictive fluid regimen may lead to hypoperfusion and increased incidence of complications. The present prospective cohort study was performed to assess whether pre-operative i.v. fluid administration improves intraoperative cardiac preload in patients undergoing oesophageal resection. Methods: Intraoperatively, the intrathoracic blood volume index (ITBVI) was monitored in 44 consecutive patients undergoing elective oesophagectomies with the transthoracic thermodilution technique. Twenty-two of these patients received a pre-operative i.v. fluid loading with a balanced crystalloid solution (1 ml/kg/h over 48 h). Results: After induction of anaesthesia ITBVI was low but not different between the groups [767 (512-1314) vs. 775 (531-1200) ml/m 2 , P 5 0.81]. In the intervention group, the extravascular lung water increased above normal levels during the operation. The groups did not differ in cardiac output, blood pressure, heart rate and central venous pressure. Post-operative morbidity was not different between the cohorts. Conclusion: Pre-operative i.v. fluid loading with crystalloid solutions could not be shown to improve the intraoperative volume status and cardiac function in this study. Randomised trials with other volume replacement techniques are recommended.

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie

Journal of Clinical Oncology

Zentralblatt für Chirurgie

Zentralblatt für Chirurgie

Acta Chirurgica Belgica

Lymphatic fistulas are common complications after lymph node dissections in melanoma patients. We... more Lymphatic fistulas are common complications after lymph node dissections in melanoma patients. We investigated whether drain management could improve the patient's outcome. Patients who underwent axillary or inguinal lymph node dissection (RALND or RILND) for malignant melanoma were recorded in a prospective database. Two different methods of drain management were compared. Either the drain was removed no later than the eighth postoperative day (period I, 2003-2007) or it was left in place until fluid flow was below 50 ml in 24 h for two consecutive days (period II, 2008-2011). The main outcome criterion was the incidence of seroma punctures after drain removal. 374 patients were analysed. The incidence of seroma punctures significantly decreased in period II. The number of patients with elevated lymphatic secretions rose by 41.3% (RALND) and 38.1% (RILND). With the exception of lymphatic fistulas, we observed significantly more local complications with need for treatment in period I (n = 104, 52%) than in period II (n = 31, 18%). In period II, the hospital stays after both procedures were significantly reduced. We conclude that quantity-guided drain management leads to a prolonged interval of drainage but is associated with a lower incidence of seroma formation and shorter hospital stay.

PloS one, 2016

5-year survival rate in patients with early adenocarcinoma of the gastro-esophageal junction or s... more 5-year survival rate in patients with early adenocarcinoma of the gastro-esophageal junction or stomach (AGE/S) in Caucasian patients is reported to be 60-80%. We aimed to identify prognostic markers for patients with UICC-I without lymph-node involvement (N0). Clinical data and tissue specimen from patients with AGE/S stage UICC-I-N0, treated by surgery only, were collected retrospectively. Tumor size, lymphatic vessel or vein invasion, grading, classification systems (WHO, Lauren, Ming), expression of BAX, BCL-2, CDX2, Cyclin E, E-cadherin, Ki-67, TP53, TP21, SHH, Survivin, HIF1A, TROP2 and mismatch repair deficiency were analyzed using tissue microarrays and correlated with overall and tumor related survival. 129 patients (48 female) with a mean follow-up of 129.1 months were identified. 5-year overall survival was 83.9%, 5-year tumor related survival was 95.1%. Poorly differentiated medullary cancer subtypes (p<0.001) and positive vein invasion (p<0.001) were identified as...

Fast Track in der operativen Medizin, 2009

Fast Track in der operativen Medizin, 2009

ABSTRACT Am Anfang einer effektiven postoperativen Rehabilitation steht die optimale Operationsvo... more ABSTRACT Am Anfang einer effektiven postoperativen Rehabilitation steht die optimale Operationsvorbereitung. Die Prinzipien der Indikationsstellung, forensischen Operationsaufklärung sowie der Diagnostik und Therapie relevanter Begleiterkrankungen bestehen in der Fast-track-Rehabilitation ebenso, wie in der »traditionellen« perioperativen Behandlung. Allerdings existieren auch bei der Operationsvorbereitung tradierte Vorgehensweisen, die den perioperativen Verlauf des Patienten beeinträchtigen können. Diese Traditionen können nicht nur den Patientenkomfort mindern, sie können auch schon präoperativ die Kompensationsreserven der Patienten angreifen und deren Homöostase beeinträchtigen.

Deutsche Gesellschaft für Chirurgie, 2000

Fast Track in der operativen Medizin, 2009

Colo-Proctology, 2001

Zusammenfassung Hintergrund: Bevor ein neuartiges onkologisches Operationsverfahren zur Anwendung... more Zusammenfassung Hintergrund: Bevor ein neuartiges onkologisches Operationsverfahren zur Anwendung im klinischen Alltag empfohlen wird, sollte es analog zu den Zulassungsverfahren neuer Pharmaka eine phasenweise wissenschaftliche Evaluation durchlaufen haben, die für die laparoskopische kolorektale Resektion von Karzinomen exemplarisch vorgestellt wird. Studienergebnisse: In tierexperimentellen und chirurgisch-anatomischen Phase-I-Studien wurde belegt, dass das anatomische Ausmaß der laparoskopischen und konventionellen Resektion vergleichbar sein kann. Klinische

Medicina

Background and Objectives: After liver transplantation (LT), long-term immunosuppression (IS) is ... more Background and Objectives: After liver transplantation (LT), long-term immunosuppression (IS) is essential. IS is associated with de novo malignancies, and the incidence of colorectal cancer (CRC) is increased in LT patients. We assessed course of disease in patients with de novo CRC after LT with focus of IS and impact on survival in a retrospective, single-center study. Materials and Methods: All patients diagnosed with CRC after LT between 1988 and 2019 were included. The management of IS regimen following diagnosis and the oncological treatment approach were analyzed: Kaplan–Meier analysis as well as univariate and multivariate analysis were performed. Results: A total of 33 out of 2744 patients were diagnosed with CRC after LT. Two groups were identified: patients with restrictive IS management undergoing dose reduction (RIM group, n = 20) and those with unaltered regimen (maintenance group, n = 13). The groups did not differ in clinical and oncological characteristics. Statist...

Chirurgisches Forum 2006, 2006

Pulmonary disorders are the most important general complications after esophagectomy. A restricti... more Pulmonary disorders are the most important general complications after esophagectomy. A restrictive fluid therapy may reduce fluid storage and could improve the postoperative pulmonary function. Methods: In a controlled randomized trial with 22 patients the effect of fluid restriction guided by intrathoracic blood volume index (ITBVI) on pulmonary and cardiac function was studied in two groups. Results: There were no differences in patient characteristics, morbidity and mortality. The resulting amount of infusions and the cumulative fluid intake were reduced in the restricted group. In 5 patients of the restricted group infusions could not be reduced in the complete postoperative course because of impaired cardiac function. Pulmonary function was significantly improved in the restricted group. Conclusion: A restricted fluid therapy leads to improved pulmonary function but can impair cardiac function in the postoperative course.

Cancer Medicine, 2016

Psychological interventions can improve Quality of Life (QoL). Object of interest was if differen... more Psychological interventions can improve Quality of Life (QoL). Object of interest was if different psychological interventions influence short-term QoL after colonic resection for carcinoma. Furthermore, we wanted to see if there is a correlation between patients` preoperative affect and postoperative QoL. Sixty patients that underwent colorectal surgery were divided into three groups. Group one (n = 20) received Guided Imagery and group 2 (n = 22) Progressive Muscle Relaxation. The third group (Control, n = 18) had no intervention. Quality of Life (QoL) was measured using the EORTC QLQ-C30 and the Gastrointestinal Quality of life Index (GIQLI). Patients' affect was measured by the PANAS questionnaire. The higher the preoperative Negative Affect was, the lower were the scores for QoL on the 30th postoperative day. Patients' QoL was highest preoperatively and lowest on the third postoperative day. On the 30th postoperative day scores for QoL were almost as high as preoperative without difference between the three groups. Neither Guided Imagery nor Progressive Relaxation was influencing short-term QoL measured by the EORTC QLQ-C30 and the GIQLI questionnaire after colorectal surgery for cancer. Screening patients' with the PANAS questionnaire might help to identify individuals that are more likely to have a worse QoL postoperatively.

Journal of Clinical Medicine

Introduction: The laparoscopic approach for TME is proven to be non-inferior in oncological outco... more Introduction: The laparoscopic approach for TME is proven to be non-inferior in oncological outcome compared to open surgery. Anatomical limitations in the male and obese pelvis with resulting pathological shortcomings and high conversion rates were stimuli for alternative approaches. The transanal approach for TME (TaTME) was introduced to overcome these limitations. The aim of this study was to evaluate the outcomes of TaTME for mid and low rectal cancer at our center. Methods: TaTME is a hybrid procedure of simultaneously laparoscopic and transanal mesorectal excision. A retrospective analysis of all consecutive TaTME procedures performed at our center for mid and low rectal cancer between December 2014 and January 2020 was conducted. Results: A total of 157 patients underwent TaTME, with 72.6% receiving neoadjuvant chemoradiation. Mean tumor height was 6.1 ± 2.3 cm from the anal verge, 72.6% of patients had undergone neoadjuvant chemoradiotherapy, and 34.2% of patients presented...

Acta Anaesthesiologica Scandinavica, 2008

Background: Perioperative fluid therapy is controversially debated in surgery. In malnourished an... more Background: Perioperative fluid therapy is controversially debated in surgery. In malnourished and hypovolaemic patients, a restrictive fluid regimen may lead to hypoperfusion and increased incidence of complications. The present prospective cohort study was performed to assess whether pre-operative i.v. fluid administration improves intraoperative cardiac preload in patients undergoing oesophageal resection. Methods: Intraoperatively, the intrathoracic blood volume index (ITBVI) was monitored in 44 consecutive patients undergoing elective oesophagectomies with the transthoracic thermodilution technique. Twenty-two of these patients received a pre-operative i.v. fluid loading with a balanced crystalloid solution (1 ml/kg/h over 48 h). Results: After induction of anaesthesia ITBVI was low but not different between the groups [767 (512-1314) vs. 775 (531-1200) ml/m 2 , P 5 0.81]. In the intervention group, the extravascular lung water increased above normal levels during the operation. The groups did not differ in cardiac output, blood pressure, heart rate and central venous pressure. Post-operative morbidity was not different between the cohorts. Conclusion: Pre-operative i.v. fluid loading with crystalloid solutions could not be shown to improve the intraoperative volume status and cardiac function in this study. Randomised trials with other volume replacement techniques are recommended.

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie

Journal of Clinical Oncology

Zentralblatt für Chirurgie

Zentralblatt für Chirurgie

Acta Chirurgica Belgica

Lymphatic fistulas are common complications after lymph node dissections in melanoma patients. We... more Lymphatic fistulas are common complications after lymph node dissections in melanoma patients. We investigated whether drain management could improve the patient&amp;amp;amp;amp;#39;s outcome. Patients who underwent axillary or inguinal lymph node dissection (RALND or RILND) for malignant melanoma were recorded in a prospective database. Two different methods of drain management were compared. Either the drain was removed no later than the eighth postoperative day (period I, 2003-2007) or it was left in place until fluid flow was below 50 ml in 24 h for two consecutive days (period II, 2008-2011). The main outcome criterion was the incidence of seroma punctures after drain removal. 374 patients were analysed. The incidence of seroma punctures significantly decreased in period II. The number of patients with elevated lymphatic secretions rose by 41.3% (RALND) and 38.1% (RILND). With the exception of lymphatic fistulas, we observed significantly more local complications with need for treatment in period I (n = 104, 52%) than in period II (n = 31, 18%). In period II, the hospital stays after both procedures were significantly reduced. We conclude that quantity-guided drain management leads to a prolonged interval of drainage but is associated with a lower incidence of seroma formation and shorter hospital stay.

PloS one, 2016

5-year survival rate in patients with early adenocarcinoma of the gastro-esophageal junction or s... more 5-year survival rate in patients with early adenocarcinoma of the gastro-esophageal junction or stomach (AGE/S) in Caucasian patients is reported to be 60-80%. We aimed to identify prognostic markers for patients with UICC-I without lymph-node involvement (N0). Clinical data and tissue specimen from patients with AGE/S stage UICC-I-N0, treated by surgery only, were collected retrospectively. Tumor size, lymphatic vessel or vein invasion, grading, classification systems (WHO, Lauren, Ming), expression of BAX, BCL-2, CDX2, Cyclin E, E-cadherin, Ki-67, TP53, TP21, SHH, Survivin, HIF1A, TROP2 and mismatch repair deficiency were analyzed using tissue microarrays and correlated with overall and tumor related survival. 129 patients (48 female) with a mean follow-up of 129.1 months were identified. 5-year overall survival was 83.9%, 5-year tumor related survival was 95.1%. Poorly differentiated medullary cancer subtypes (p<0.001) and positive vein invasion (p<0.001) were identified as...

Fast Track in der operativen Medizin, 2009

Fast Track in der operativen Medizin, 2009

ABSTRACT Am Anfang einer effektiven postoperativen Rehabilitation steht die optimale Operationsvo... more ABSTRACT Am Anfang einer effektiven postoperativen Rehabilitation steht die optimale Operationsvorbereitung. Die Prinzipien der Indikationsstellung, forensischen Operationsaufklärung sowie der Diagnostik und Therapie relevanter Begleiterkrankungen bestehen in der Fast-track-Rehabilitation ebenso, wie in der »traditionellen« perioperativen Behandlung. Allerdings existieren auch bei der Operationsvorbereitung tradierte Vorgehensweisen, die den perioperativen Verlauf des Patienten beeinträchtigen können. Diese Traditionen können nicht nur den Patientenkomfort mindern, sie können auch schon präoperativ die Kompensationsreserven der Patienten angreifen und deren Homöostase beeinträchtigen.

Deutsche Gesellschaft für Chirurgie, 2000

Fast Track in der operativen Medizin, 2009

Colo-Proctology, 2001

Zusammenfassung Hintergrund: Bevor ein neuartiges onkologisches Operationsverfahren zur Anwendung... more Zusammenfassung Hintergrund: Bevor ein neuartiges onkologisches Operationsverfahren zur Anwendung im klinischen Alltag empfohlen wird, sollte es analog zu den Zulassungsverfahren neuer Pharmaka eine phasenweise wissenschaftliche Evaluation durchlaufen haben, die für die laparoskopische kolorektale Resektion von Karzinomen exemplarisch vorgestellt wird. Studienergebnisse: In tierexperimentellen und chirurgisch-anatomischen Phase-I-Studien wurde belegt, dass das anatomische Ausmaß der laparoskopischen und konventionellen Resektion vergleichbar sein kann. Klinische