Olivier Adam - Academia.edu (original) (raw)
Papers by Olivier Adam
Journal of Marine Science and Engineering
Visual observations of the marine biodiversity can be difficult in specific areas for different r... more Visual observations of the marine biodiversity can be difficult in specific areas for different reasons, including weather conditions or a lack of observers. In such conditions, passive acoustics represents a potential alternative approach. The objective of this work is to demonstrate how information about marine biodiversity can be obtained via detailed analysis of the underwater acoustic environment. This paper presents the first analysis of the Saint-Pierre-and-Miquelon (SPM) archipelago underwater acoustic environment. In order to have a better knowledge about the marine biodiversity of SPM, acoustic recordings were sampled at different time periods to highlight seasonal variations over several years. To extract information from these acoustic recordings, standard soundscape and ecoacoustic analysis workflow was used to compute acoustic metrics such as power spectral density, third-octave levels, acoustic complexity index, and sound pressure levels. The SPM marine acoustic envir...
Journal of Thermal Science, 2008
Clinical Infectious Diseases, 2004
S irIn their letter, Penack et al.[1] question the reliability of the association between false-... more S irIn their letter, Penack et al.[1] question the reliability of the association between false-positive galactomannan (GM) antigenemia results obtained with use of the Platelia Aspergillus ELISA (Bio-Rad) and piperacillin-tazobactam treatment. To date, outbreaks of ...
- La mesure automatique de latence des potentiels évoqués s'apparente à un problème de détect... more - La mesure automatique de latence des potentiels évoqués s'apparente à un problème de détection-estimation. Nous proposons une approche de reconnaissance des formes supervisée. Nous analysons l'ensemble des potentiels recueillis pour une oreille, en tenant compte de propriétés physiologiques et optimisons l'estimation de latence par régression non linéaire selon les moindres carrés. Nous obtenons une précision moyenne inférieure à 0.1 ms. Nous envisageons ensuite l'application à la recherche objective de seuil.
The paper shows an efficient detection and tracking al-gorithm that is based on the adaptive opti... more The paper shows an efficient detection and tracking al-gorithm that is based on the adaptive optimal orthogonal parameterisation. The model parameters, being a solution to second-order signal prediction, are updated at every time-instant, thus making this approach well adapted to detection and tracking problems. The proposed approach is robust in the sense of resistance to the continuously present noise. The innovations filter proposed as the transient signal detector is a lattice structure optimal orthogonal filter that is character-ized by an extremely fast start-up performance and excellent convergence behaviour. At every sample the proposed method calculates recursively a set of reflection coefficients, which we propose to use in detection and second-order signal description. We demonstrate performances of the proposed approach by introducing the Receiver-Operating Characteris-tics curves in different algorithm aspects and for different SNR. The algorithm is well suited to the r...
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jan 15, 2004
We report the occurrence of a high rate of false-positive test results during the surveillance of... more We report the occurrence of a high rate of false-positive test results during the surveillance of hematology patients for galactomannan (GM) antigenemia. Among 218 patients surveyed from June 2002 through June 2003, 42 (19.3%) had > or =1 serum sample positive for GM (optical density index, >1.5). Of these patients, 38 had no additional evidence of invasive aspergillosis, and, therefore, their test results were considered to be false-positives. Case-control analysis showed that treatment with piperacillin-tazobactam was the only risk factor significantly associated with receiving false-positive test results. When tested for GM antigen, 3 of 4 piperacillin-tazobactam batches had positive results. Physicians should be aware of the possible interference of treatment with piperacillin-tazobactam when interpreting the results of the GM assay.
Vaccine, 2015
Recently, several virus studies have shown that protein glycosylation play a fundamental role in ... more Recently, several virus studies have shown that protein glycosylation play a fundamental role in the virus-host cell interaction. Glycosylation characterization of the envelope proteins in both insect and mammalian cell-derived dengue virus (DENV) has established that two potential glycosylation residues, the asparagine 67 and 153 can potentially be glycosylated. Moreover, it appears that the glycosylation of these two residues can influence dramatically the virus production and the infection spreading in either mosquito or mammalian cells. The Sanofi Pasteur tetravalent dengue vaccine (CYD) consists of four chimeric viruses produced in mammalian vero cells. As DENV, the CYDs are able to infect human monocyte-derived dendritic cells in vitro via C-type lectins cell-surface molecules. Despite the importance of this interaction, the specific glycosylation pattern of the DENV has not been clearly documented so far. In this paper, we investigated the structure of the N-linked glycans in the four CYD serotypes. Using MALDI-TOF analysis, the N-linked glycans of CYDs were found to be a mix of high-mannose, hybrid and complex glycans. Site-specific N-glycosylation analysis of CYDs using nanoLC-ESI-MS/MS demonstrates that both asparagine residues 67 and 153 are glycosylated. Predominant glycoforms at asparagine 67 are high mannose-type structures while mainly complex- and hybrid-type structures are detected at asparagine 153. In vitro studies have shown that the immunological consequences of infection by the CYD dengue viruses 1-4 versus the wild type parents are comparable in human monocyte-derived dendritic cells. Our E-protein glycan characterizations of CYD are consistent with those observations from the wild type parents and thus support in vitro studies. In addition, these data provide new insights for the role of glycans in the dengue virus-host cell interactions.
European journal of biochemistry / FEBS, Jan 15, 1996
The capsular polysaccharide (CPS) produced by the non-pathogenic Klebsiella strain I-714, selecte... more The capsular polysaccharide (CPS) produced by the non-pathogenic Klebsiella strain I-714, selected for its immunomodulating activity, has been purified and almost completely detoxified in a previous study [Adam, O., Vercellone, A., Paul, F., Monsan, P. F. & Puzo, G. (1995) Anal. Biochem. 225, 321-327]. The present report concerns the structural elucidation of this CPS by several one-dimensional and two-dimensional 1H-NMR and 13C-NMR experiments performed on the native molecule. It was found to be a high molecular-mass branched polymer constituted by a hexasaccharide repeating unit of following structure: 4)-alpha-L-Rhap-(1-->3)-beta-D-Galp-(1-->2)-alpha-L-Rhap-(1- ->4)-beta-D- GlcpA-(1-->3)-¿alpha-L-Rhap-(1-->2)-¿-alpha-D-Galp-(1. The presence of two glycosidic substitutions on the Galp residue resulted in a strong overlapping of its proton signals, preventing direct assignment of both proton and carbon resonances. However, assignment could be achieved using the two-b...
Combustion Diagnostics, 1997
ABSTRACT
2008 New Trends for Environmental Monitoring Using Passive Systems, 2008
Journal of Structural Biology, 2011
Lecture Notes in Computer Science, 1999
Since about twenty years, the otoneurology functional exploration possesses experimental techniqu... more Since about twenty years, the otoneurology functional exploration possesses experimental techniques to analyze objectively the state of the nervous conduction of auditive pathway. It conerns brainstem evoked response auditory. In this paper we present a new classification approach based on a hybrid neural network technique focusing this biomedical application for developing a diagnostic tool. We have used two models of
Separation and Purification Technology, 2005
Physical Review A, 1993
Diffraction is shown to play a dramatic role in the frequency characteristics of ring-laser gyros... more Diffraction is shown to play a dramatic role in the frequency characteristics of ring-laser gyroscopes. It is proved theoretically and experimentally that a small misalignment of the cavity leads to a nonreciprocity of the resonant diffraction mechanism. The resonant diffraction losses of the two counterpropagating modes being then different, the asymmetries of their output-power versus cavity-frequency profiles are different. This
The Journal of the Acoustical Society of America, 2008
ABSTRACT Analysis of one year of acoustic signal recordings from the five permanent autonomous hy... more ABSTRACT Analysis of one year of acoustic signal recordings from the five permanent autonomous hydrophones of the International Monitoring System in the South-West Indian Ocean reveals low frequency with high intensity calls produced by two blue whale subspecies. The "Antarctic" or "true" blue whale (B. m. intermedia) calls and the "Madagascar-type" Pygmy blue whale calls (B. m. brevicauda) were automatically detected through the matched filtering method. The potential movements were investigated by using the time difference of arrival (TDOA) of calls to assess the bearing of the sound source. The fully range dependent parabolic equation code (RAM - range-dependent acoustic model) and the PMCC code (progressive multi-channel correlation) are applied to estimate the range between our system and the vocalising animals. Our results show that (1) the variation of call number revealed two distinct patterns of seasonal whale occurrences and (2) the distances from the hydrophones to the blue whales reached up to 50 km. Tracking whales is possible when whales are concentrated of the hydrophone array.
The Journal of the Acoustical Society of America, 2006
The common use of the bent-horn model of the sperm whale sound generator describes sperm whale cl... more The common use of the bent-horn model of the sperm whale sound generator describes sperm whale clicks as the pulse series {p0, p1, p2, p3,...}. Clicks, however, deviate from this standard when recorded using off-axis hydrophones. The existence of additional pulses within the {p0, p1, p2, p3, ...} series can be explained still using the bent-horn model. Multiple reflections on the whale's frontal and distal sacs of the p0 pulse lead to additional sets of pulses detectable using a farfield, off-axis hydrophone. The travel times of some of these additional pulses depend on the whale's orientation. The authors propose a method to estimate the off-axis angle of sperm whale clicks. They also propose a method to determine the nature of the movement (if it is pitch, yaw, or roll) of phonating sperm whales. The application of both methods requires the measurement of the travel time differences between pulses composing a sperm whale click. They lead, using a simple apparatus consisting of a single hydrophone at an unknown depth, to new measurements of the underwater movements of sperm whales. Using these methods shows that sperm whales would methodically scan seawater while searching for prey, by making periodic pitch and yaw movements in sync with their acoustic activity.
The Journal of the Acoustical Society of America, 2005
ABSTRACT The algorithm proposed by Lee and Morf [IEEE Transactions on Circuits and Systems 28(6) ... more ABSTRACT The algorithm proposed by Lee and Morf [IEEE Transactions on Circuits and Systems 28(6) (1981)] which stems from the method defined by Schur [Operator Theory: Advances & Application, Vol. 18 (Birk-Verlag, 1986)] has acquired a new significance [Zarzycki, Journal of Multidimensional Systems & Signal Processing (Kluwer Academic, 2004)], due to its performances and particularly due to its applications in real time, made possible by the speed of processors available nowadays. Based on the innovations filter principle, Schur's proposal models the signal by calculating reflection coefficients, describing entirely the second-order signal. The reflection coefficients can be simply transformed to the AR coefficients, from which one derives the time-frequency representation. We compare performances of this approach with other time-frequency representations commonly used in the signal processing (spectrogram, AR, wavelet transform); we subsequently present the results obtained for transitory underwater acoustic signals, which our laboratory is investigating. The Lee and Morf algorithm offers an excellent tracking of the signal's characteristics and allows us to systematically detect transitory signals. This is particularly pertinent to segmentation problems relating to the application of underwater acoustics. The robustness of the Schur detector and a resolution of the Schur time-frequency representation support the resurgence of the Schur algorithm.
The Journal of the Acoustical Society of America, 2010
Journal of Marine Science and Engineering
Visual observations of the marine biodiversity can be difficult in specific areas for different r... more Visual observations of the marine biodiversity can be difficult in specific areas for different reasons, including weather conditions or a lack of observers. In such conditions, passive acoustics represents a potential alternative approach. The objective of this work is to demonstrate how information about marine biodiversity can be obtained via detailed analysis of the underwater acoustic environment. This paper presents the first analysis of the Saint-Pierre-and-Miquelon (SPM) archipelago underwater acoustic environment. In order to have a better knowledge about the marine biodiversity of SPM, acoustic recordings were sampled at different time periods to highlight seasonal variations over several years. To extract information from these acoustic recordings, standard soundscape and ecoacoustic analysis workflow was used to compute acoustic metrics such as power spectral density, third-octave levels, acoustic complexity index, and sound pressure levels. The SPM marine acoustic envir...
Journal of Thermal Science, 2008
Clinical Infectious Diseases, 2004
S irIn their letter, Penack et al.[1] question the reliability of the association between false-... more S irIn their letter, Penack et al.[1] question the reliability of the association between false-positive galactomannan (GM) antigenemia results obtained with use of the Platelia Aspergillus ELISA (Bio-Rad) and piperacillin-tazobactam treatment. To date, outbreaks of ...
- La mesure automatique de latence des potentiels évoqués s'apparente à un problème de détect... more - La mesure automatique de latence des potentiels évoqués s'apparente à un problème de détection-estimation. Nous proposons une approche de reconnaissance des formes supervisée. Nous analysons l'ensemble des potentiels recueillis pour une oreille, en tenant compte de propriétés physiologiques et optimisons l'estimation de latence par régression non linéaire selon les moindres carrés. Nous obtenons une précision moyenne inférieure à 0.1 ms. Nous envisageons ensuite l'application à la recherche objective de seuil.
The paper shows an efficient detection and tracking al-gorithm that is based on the adaptive opti... more The paper shows an efficient detection and tracking al-gorithm that is based on the adaptive optimal orthogonal parameterisation. The model parameters, being a solution to second-order signal prediction, are updated at every time-instant, thus making this approach well adapted to detection and tracking problems. The proposed approach is robust in the sense of resistance to the continuously present noise. The innovations filter proposed as the transient signal detector is a lattice structure optimal orthogonal filter that is character-ized by an extremely fast start-up performance and excellent convergence behaviour. At every sample the proposed method calculates recursively a set of reflection coefficients, which we propose to use in detection and second-order signal description. We demonstrate performances of the proposed approach by introducing the Receiver-Operating Characteris-tics curves in different algorithm aspects and for different SNR. The algorithm is well suited to the r...
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jan 15, 2004
We report the occurrence of a high rate of false-positive test results during the surveillance of... more We report the occurrence of a high rate of false-positive test results during the surveillance of hematology patients for galactomannan (GM) antigenemia. Among 218 patients surveyed from June 2002 through June 2003, 42 (19.3%) had > or =1 serum sample positive for GM (optical density index, >1.5). Of these patients, 38 had no additional evidence of invasive aspergillosis, and, therefore, their test results were considered to be false-positives. Case-control analysis showed that treatment with piperacillin-tazobactam was the only risk factor significantly associated with receiving false-positive test results. When tested for GM antigen, 3 of 4 piperacillin-tazobactam batches had positive results. Physicians should be aware of the possible interference of treatment with piperacillin-tazobactam when interpreting the results of the GM assay.
Vaccine, 2015
Recently, several virus studies have shown that protein glycosylation play a fundamental role in ... more Recently, several virus studies have shown that protein glycosylation play a fundamental role in the virus-host cell interaction. Glycosylation characterization of the envelope proteins in both insect and mammalian cell-derived dengue virus (DENV) has established that two potential glycosylation residues, the asparagine 67 and 153 can potentially be glycosylated. Moreover, it appears that the glycosylation of these two residues can influence dramatically the virus production and the infection spreading in either mosquito or mammalian cells. The Sanofi Pasteur tetravalent dengue vaccine (CYD) consists of four chimeric viruses produced in mammalian vero cells. As DENV, the CYDs are able to infect human monocyte-derived dendritic cells in vitro via C-type lectins cell-surface molecules. Despite the importance of this interaction, the specific glycosylation pattern of the DENV has not been clearly documented so far. In this paper, we investigated the structure of the N-linked glycans in the four CYD serotypes. Using MALDI-TOF analysis, the N-linked glycans of CYDs were found to be a mix of high-mannose, hybrid and complex glycans. Site-specific N-glycosylation analysis of CYDs using nanoLC-ESI-MS/MS demonstrates that both asparagine residues 67 and 153 are glycosylated. Predominant glycoforms at asparagine 67 are high mannose-type structures while mainly complex- and hybrid-type structures are detected at asparagine 153. In vitro studies have shown that the immunological consequences of infection by the CYD dengue viruses 1-4 versus the wild type parents are comparable in human monocyte-derived dendritic cells. Our E-protein glycan characterizations of CYD are consistent with those observations from the wild type parents and thus support in vitro studies. In addition, these data provide new insights for the role of glycans in the dengue virus-host cell interactions.
European journal of biochemistry / FEBS, Jan 15, 1996
The capsular polysaccharide (CPS) produced by the non-pathogenic Klebsiella strain I-714, selecte... more The capsular polysaccharide (CPS) produced by the non-pathogenic Klebsiella strain I-714, selected for its immunomodulating activity, has been purified and almost completely detoxified in a previous study [Adam, O., Vercellone, A., Paul, F., Monsan, P. F. & Puzo, G. (1995) Anal. Biochem. 225, 321-327]. The present report concerns the structural elucidation of this CPS by several one-dimensional and two-dimensional 1H-NMR and 13C-NMR experiments performed on the native molecule. It was found to be a high molecular-mass branched polymer constituted by a hexasaccharide repeating unit of following structure: 4)-alpha-L-Rhap-(1-->3)-beta-D-Galp-(1-->2)-alpha-L-Rhap-(1- ->4)-beta-D- GlcpA-(1-->3)-¿alpha-L-Rhap-(1-->2)-¿-alpha-D-Galp-(1. The presence of two glycosidic substitutions on the Galp residue resulted in a strong overlapping of its proton signals, preventing direct assignment of both proton and carbon resonances. However, assignment could be achieved using the two-b...
Combustion Diagnostics, 1997
ABSTRACT
2008 New Trends for Environmental Monitoring Using Passive Systems, 2008
Journal of Structural Biology, 2011
Lecture Notes in Computer Science, 1999
Since about twenty years, the otoneurology functional exploration possesses experimental techniqu... more Since about twenty years, the otoneurology functional exploration possesses experimental techniques to analyze objectively the state of the nervous conduction of auditive pathway. It conerns brainstem evoked response auditory. In this paper we present a new classification approach based on a hybrid neural network technique focusing this biomedical application for developing a diagnostic tool. We have used two models of
Separation and Purification Technology, 2005
Physical Review A, 1993
Diffraction is shown to play a dramatic role in the frequency characteristics of ring-laser gyros... more Diffraction is shown to play a dramatic role in the frequency characteristics of ring-laser gyroscopes. It is proved theoretically and experimentally that a small misalignment of the cavity leads to a nonreciprocity of the resonant diffraction mechanism. The resonant diffraction losses of the two counterpropagating modes being then different, the asymmetries of their output-power versus cavity-frequency profiles are different. This
The Journal of the Acoustical Society of America, 2008
ABSTRACT Analysis of one year of acoustic signal recordings from the five permanent autonomous hy... more ABSTRACT Analysis of one year of acoustic signal recordings from the five permanent autonomous hydrophones of the International Monitoring System in the South-West Indian Ocean reveals low frequency with high intensity calls produced by two blue whale subspecies. The "Antarctic" or "true" blue whale (B. m. intermedia) calls and the "Madagascar-type" Pygmy blue whale calls (B. m. brevicauda) were automatically detected through the matched filtering method. The potential movements were investigated by using the time difference of arrival (TDOA) of calls to assess the bearing of the sound source. The fully range dependent parabolic equation code (RAM - range-dependent acoustic model) and the PMCC code (progressive multi-channel correlation) are applied to estimate the range between our system and the vocalising animals. Our results show that (1) the variation of call number revealed two distinct patterns of seasonal whale occurrences and (2) the distances from the hydrophones to the blue whales reached up to 50 km. Tracking whales is possible when whales are concentrated of the hydrophone array.
The Journal of the Acoustical Society of America, 2006
The common use of the bent-horn model of the sperm whale sound generator describes sperm whale cl... more The common use of the bent-horn model of the sperm whale sound generator describes sperm whale clicks as the pulse series {p0, p1, p2, p3,...}. Clicks, however, deviate from this standard when recorded using off-axis hydrophones. The existence of additional pulses within the {p0, p1, p2, p3, ...} series can be explained still using the bent-horn model. Multiple reflections on the whale's frontal and distal sacs of the p0 pulse lead to additional sets of pulses detectable using a farfield, off-axis hydrophone. The travel times of some of these additional pulses depend on the whale's orientation. The authors propose a method to estimate the off-axis angle of sperm whale clicks. They also propose a method to determine the nature of the movement (if it is pitch, yaw, or roll) of phonating sperm whales. The application of both methods requires the measurement of the travel time differences between pulses composing a sperm whale click. They lead, using a simple apparatus consisting of a single hydrophone at an unknown depth, to new measurements of the underwater movements of sperm whales. Using these methods shows that sperm whales would methodically scan seawater while searching for prey, by making periodic pitch and yaw movements in sync with their acoustic activity.
The Journal of the Acoustical Society of America, 2005
ABSTRACT The algorithm proposed by Lee and Morf [IEEE Transactions on Circuits and Systems 28(6) ... more ABSTRACT The algorithm proposed by Lee and Morf [IEEE Transactions on Circuits and Systems 28(6) (1981)] which stems from the method defined by Schur [Operator Theory: Advances & Application, Vol. 18 (Birk-Verlag, 1986)] has acquired a new significance [Zarzycki, Journal of Multidimensional Systems & Signal Processing (Kluwer Academic, 2004)], due to its performances and particularly due to its applications in real time, made possible by the speed of processors available nowadays. Based on the innovations filter principle, Schur's proposal models the signal by calculating reflection coefficients, describing entirely the second-order signal. The reflection coefficients can be simply transformed to the AR coefficients, from which one derives the time-frequency representation. We compare performances of this approach with other time-frequency representations commonly used in the signal processing (spectrogram, AR, wavelet transform); we subsequently present the results obtained for transitory underwater acoustic signals, which our laboratory is investigating. The Lee and Morf algorithm offers an excellent tracking of the signal's characteristics and allows us to systematically detect transitory signals. This is particularly pertinent to segmentation problems relating to the application of underwater acoustics. The robustness of the Schur detector and a resolution of the Schur time-frequency representation support the resurgence of the Schur algorithm.
The Journal of the Acoustical Society of America, 2010