Olivier Halfon - Academia.edu (original) (raw)
Papers by Olivier Halfon
International Perspectives on Child and Adolescent Mental Health, 2002
... Clinic for Children and Adolescents Jacques Laget Psychiatric University Clinic for Children ... more ... Clinic for Children and Adolescents Jacques Laget Psychiatric University Clinic for Children and Adolescents Olivier Halfon Psychiatric ... relations, and psychiatric status); the POSIT (Problem Oriented Screening Instrument for Teenagers, Hall, Richardson, Spears, & Rembert ...
Substance Use Amp Misuse, 2003
Adolescence corresponds to a transition period that requires adaptation and change capacities and... more Adolescence corresponds to a transition period that requires adaptation and change capacities and skills. Most young people succeed with this challenge, whereas a minority fail. In order to identify with the teenage culture, become autonomous, and differentiate from their parents, some adolescents choose to use drugs, beginning with the use of cigarettes, alcohol, cannabis, followed by other illicit drugs such as opiates and stimulants. A high proportion of these adolescents attempt suicide, which is the primary cause of death during adolescence in many European countries. Who are the "vulnerable" adolescents? What are the mechanisms that can explain the varieties of drug-use initiation or suicide attempts? Can "protective factors" be identified? What kind of strategies might be developed at a social and political level in order to prevent or to minimize drug abuse and suicide attempts, among other harmful behaviors? These issues will be discussed on the basis of the recent literature and in the light of a recent study carried out in the French-speaking part of Switzerland on large cohorts of adolescent drug users. Unresolved critical issues are noted and future needed research is suggested.
During the past twenty years, various instruments have been developed for the assessment of subst... more During the past twenty years, various instruments have been developed for the assessment of substance use in adolescents, mainly in the United States. However, few of them have been adapted to, and validated in, French-speaking populations. Consequently, although increasing alcohol and drug use among teenagers has become a major concern, the various health and social programs developed in response to this specific problem have received little attention with regard to follow-up and outcome assessment. A standardized multidimensional assessment instrument adapted for adolescents is needed to assess the individual needs of adolescents and assign them to the most appropriate treatment setting, to provide a single measurement within and across health and social systems, and to conduct treatment outcome evaluations. Moreover, having an available instrument makes it possible to develop longitudinal and trans-cultural research studies. For this reason, a French version of the Adolescent Drug Abuse Diagnosis (ADAD) was developed and validated at the University Child and Adolescent Psychiatric Clinic in Lausanne, Switzerland. This paper aims to discuss the methodological issues that we faced when using the ADAD instrument in a 4-year longitudinal study including adolescent substance users. Methodological aspects relating to the content and format of the instrument, the assessment administration and the statistical analyses are discussed.
During the past twenty years, various instruments have been developed for the assessment of subst... more During the past twenty years, various instruments have been developed for the assessment of substance use in adolescents, mainly in the United States. However, few of them have been adapted to, and validated in, French-speaking populations. Consequently, although increasing alcohol and drug use among teenagers has become a major concern, the various health and social programs developed in response to this specific problem have received little attention with regard to follow-up and outcome assessment. A standardized multidimensional assessment instrument adapted for adolescents is needed to assess the individual needs of adolescents and assign them to the most appropriate treatment setting, to provide a single measurement within and across health and social systems, and to conduct treatment outcome evaluations. Moreover, having an available instrument makes it possible to develop longitudinal and trans-cultural research studies. For this reason, a French version of the Adolescent Drug Abuse Diagnosis (ADAD) was developed and validated at the University Child and Adolescent Psychiatric Clinic in Lausanne, Switzerland. This paper aims to discuss the methodological issues that we faced when using the ADAD instrument in a 4-year longitudinal study including adolescent substance users. Methodological aspects relating to the content and format of the instrument, the assessment administration and the statistical analyses are discussed.
Journal of Drug Education, Feb 1, 2005
Journal of Drug Education, Feb 1, 2005
American Journal of Psychiatry, Oct 8, 2014
... Clin Neuropharmacol 2000; 23:9097 LAURENT HOLZER, MD GINA PAIVA, MD OLIVIER HALFON, MD Lausa... more ... Clin Neuropharmacol 2000; 23:9097 LAURENT HOLZER, MD GINA PAIVA, MD OLIVIER HALFON, MD Lausanne, Switzerland ... PH.D. HÉLOISE LIPSKI, MD DEPHINE GASTAL, MD KHALID KALALOU, MD CLAIRE-MARIE VERDON, MD DOMINIQUE JANUEL, MD, PH.D. Saint ...
Revue Medicale De La Suisse Romande, Oct 1, 2003
Substance user adolescents were asked to report on each contact they had had with any type of car... more Substance user adolescents were asked to report on each contact they had had with any type of care providers since they had begun to use alcohol or illegal drugs regularly. Primary care doctors and social workers represent the main access to the care network. In one out of two contacts substance use was not discussed.
Biological Psychiatry, 2014
Biological Psychiatry, 2014
Http Dx Doi Org 10 1080 14616734 2012 706394, Aug 2, 2012
La Psychiatrie De L Enfant, 1985
Medecine Et Hygiene, 1999
Behavioural and cognitive psychotherapy, 2014
Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cogn... more Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cognitive deficits in adults with psychosis. However, scarce studies explored the outcome of CACR in adolescents with psychosis or at high risk. To investigate the effectiveness of a computer-assisted cognitive remediation (CACR) program in adolescents with psychosis or at high risk. Intention to treat analyses included 32 adolescents who participated in a blinded 8-week randomized controlled trial of CACR treatment compared to computer games (CG). Cognitive abilities, symptoms and psychosocial functioning were assessed at baseline and posttreatment. Improvement in visuospatial abilities was significantly greater in the CACR group than in CG. Other cognitive functions, psychotic symptoms and psychosocial functioning improved significantly, but at similar rates, in the two groups. CACR can be successfully administered in this population; it proved to be effective over and above CG for the mos...
Annales Medico Psychologiques, 2000
Cellular Signalling, 2015
CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biologi... more CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biological processes that affect cell growth, transformation, differentiation, and development. In this study, we provide evidence of the involvement of homeodomain-interacting protein kinase 2 (HIPK2) in the regulation of CBP activity. We show that HIPK2 interacts with and phosphorylates several regions of CBP. We demonstrate that serines 2361, 2363, 2371, 2376, and 2381 are responsible for the HIPK2-induced mobility shift of CBP C-terminal activation domain. Moreover, we show that HIPK2 strongly potentiates the transcriptional activity of CBP. However, our data suggest that HIPK2 activates CBP mainly by counteracting the repressive action of cell cycle regulatory domain 1 (CRD1), located between amino acids 977 and 1076, independently of CBP phosphorylation. Our findings thus highlight a complex regulation of CBP activity by HIPK2, which might be relevant for the control of specific sets of target genes involved in cellular proliferation, differentiation and apoptosis.
International Perspectives on Child and Adolescent Mental Health, 2002
... Clinic for Children and Adolescents Jacques Laget Psychiatric University Clinic for Children ... more ... Clinic for Children and Adolescents Jacques Laget Psychiatric University Clinic for Children and Adolescents Olivier Halfon Psychiatric ... relations, and psychiatric status); the POSIT (Problem Oriented Screening Instrument for Teenagers, Hall, Richardson, Spears, & Rembert ...
Substance Use Amp Misuse, 2003
Adolescence corresponds to a transition period that requires adaptation and change capacities and... more Adolescence corresponds to a transition period that requires adaptation and change capacities and skills. Most young people succeed with this challenge, whereas a minority fail. In order to identify with the teenage culture, become autonomous, and differentiate from their parents, some adolescents choose to use drugs, beginning with the use of cigarettes, alcohol, cannabis, followed by other illicit drugs such as opiates and stimulants. A high proportion of these adolescents attempt suicide, which is the primary cause of death during adolescence in many European countries. Who are the "vulnerable" adolescents? What are the mechanisms that can explain the varieties of drug-use initiation or suicide attempts? Can "protective factors" be identified? What kind of strategies might be developed at a social and political level in order to prevent or to minimize drug abuse and suicide attempts, among other harmful behaviors? These issues will be discussed on the basis of the recent literature and in the light of a recent study carried out in the French-speaking part of Switzerland on large cohorts of adolescent drug users. Unresolved critical issues are noted and future needed research is suggested.
During the past twenty years, various instruments have been developed for the assessment of subst... more During the past twenty years, various instruments have been developed for the assessment of substance use in adolescents, mainly in the United States. However, few of them have been adapted to, and validated in, French-speaking populations. Consequently, although increasing alcohol and drug use among teenagers has become a major concern, the various health and social programs developed in response to this specific problem have received little attention with regard to follow-up and outcome assessment. A standardized multidimensional assessment instrument adapted for adolescents is needed to assess the individual needs of adolescents and assign them to the most appropriate treatment setting, to provide a single measurement within and across health and social systems, and to conduct treatment outcome evaluations. Moreover, having an available instrument makes it possible to develop longitudinal and trans-cultural research studies. For this reason, a French version of the Adolescent Drug Abuse Diagnosis (ADAD) was developed and validated at the University Child and Adolescent Psychiatric Clinic in Lausanne, Switzerland. This paper aims to discuss the methodological issues that we faced when using the ADAD instrument in a 4-year longitudinal study including adolescent substance users. Methodological aspects relating to the content and format of the instrument, the assessment administration and the statistical analyses are discussed.
During the past twenty years, various instruments have been developed for the assessment of subst... more During the past twenty years, various instruments have been developed for the assessment of substance use in adolescents, mainly in the United States. However, few of them have been adapted to, and validated in, French-speaking populations. Consequently, although increasing alcohol and drug use among teenagers has become a major concern, the various health and social programs developed in response to this specific problem have received little attention with regard to follow-up and outcome assessment. A standardized multidimensional assessment instrument adapted for adolescents is needed to assess the individual needs of adolescents and assign them to the most appropriate treatment setting, to provide a single measurement within and across health and social systems, and to conduct treatment outcome evaluations. Moreover, having an available instrument makes it possible to develop longitudinal and trans-cultural research studies. For this reason, a French version of the Adolescent Drug Abuse Diagnosis (ADAD) was developed and validated at the University Child and Adolescent Psychiatric Clinic in Lausanne, Switzerland. This paper aims to discuss the methodological issues that we faced when using the ADAD instrument in a 4-year longitudinal study including adolescent substance users. Methodological aspects relating to the content and format of the instrument, the assessment administration and the statistical analyses are discussed.
Journal of Drug Education, Feb 1, 2005
Journal of Drug Education, Feb 1, 2005
American Journal of Psychiatry, Oct 8, 2014
... Clin Neuropharmacol 2000; 23:9097 LAURENT HOLZER, MD GINA PAIVA, MD OLIVIER HALFON, MD Lausa... more ... Clin Neuropharmacol 2000; 23:9097 LAURENT HOLZER, MD GINA PAIVA, MD OLIVIER HALFON, MD Lausanne, Switzerland ... PH.D. HÉLOISE LIPSKI, MD DEPHINE GASTAL, MD KHALID KALALOU, MD CLAIRE-MARIE VERDON, MD DOMINIQUE JANUEL, MD, PH.D. Saint ...
Revue Medicale De La Suisse Romande, Oct 1, 2003
Substance user adolescents were asked to report on each contact they had had with any type of car... more Substance user adolescents were asked to report on each contact they had had with any type of care providers since they had begun to use alcohol or illegal drugs regularly. Primary care doctors and social workers represent the main access to the care network. In one out of two contacts substance use was not discussed.
Biological Psychiatry, 2014
Biological Psychiatry, 2014
Http Dx Doi Org 10 1080 14616734 2012 706394, Aug 2, 2012
La Psychiatrie De L Enfant, 1985
Medecine Et Hygiene, 1999
Behavioural and cognitive psychotherapy, 2014
Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cogn... more Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cognitive deficits in adults with psychosis. However, scarce studies explored the outcome of CACR in adolescents with psychosis or at high risk. To investigate the effectiveness of a computer-assisted cognitive remediation (CACR) program in adolescents with psychosis or at high risk. Intention to treat analyses included 32 adolescents who participated in a blinded 8-week randomized controlled trial of CACR treatment compared to computer games (CG). Cognitive abilities, symptoms and psychosocial functioning were assessed at baseline and posttreatment. Improvement in visuospatial abilities was significantly greater in the CACR group than in CG. Other cognitive functions, psychotic symptoms and psychosocial functioning improved significantly, but at similar rates, in the two groups. CACR can be successfully administered in this population; it proved to be effective over and above CG for the mos...
Annales Medico Psychologiques, 2000
Cellular Signalling, 2015
CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biologi... more CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biological processes that affect cell growth, transformation, differentiation, and development. In this study, we provide evidence of the involvement of homeodomain-interacting protein kinase 2 (HIPK2) in the regulation of CBP activity. We show that HIPK2 interacts with and phosphorylates several regions of CBP. We demonstrate that serines 2361, 2363, 2371, 2376, and 2381 are responsible for the HIPK2-induced mobility shift of CBP C-terminal activation domain. Moreover, we show that HIPK2 strongly potentiates the transcriptional activity of CBP. However, our data suggest that HIPK2 activates CBP mainly by counteracting the repressive action of cell cycle regulatory domain 1 (CRD1), located between amino acids 977 and 1076, independently of CBP phosphorylation. Our findings thus highlight a complex regulation of CBP activity by HIPK2, which might be relevant for the control of specific sets of target genes involved in cellular proliferation, differentiation and apoptosis.