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Papers by Oluseguna Babaniyi

Research paper thumbnail of Characterization of Rubella Seronegative Females in the Zambian Blood Donor Community

Frontiers in Public Health, 2015

Research paper thumbnail of Intussusception incidence rates in 9 Zambian hospitals, 2007-2011: prerotavirus vaccine introduction

The Pediatric infectious disease journal, 2014

Intussusception, a rare adverse event associated with rotavirus vaccines in some settings, is a c... more Intussusception, a rare adverse event associated with rotavirus vaccines in some settings, is a common cause of intestinal obstruction in infants and toddlers globally with a peak age of 4-6 months. This age group may overlap with the extended age of administering rotavirus vaccine. A retrospective (January 2007 to June 2009) and prospective (July 2009 to June 2012) survey was conducted in 9 Zambian hospitals. Children between 0 and 24 months who were operated on for intestinal obstruction/intussusception were identified in theatre log books. In the latter part of the survey, patients were recruited prospectively. Demographic, clinical and surgical data from hospital files were collected for each patient. One-hundred and five children were identified to have undergone surgery for intussusceptions. Many were boys 57.6% (57/99). Of those with complete data, intussusception was common in infants 86.9% (86/99) and many children (68.0%) were between 3 and 8 months of age with a peak age ...

Research paper thumbnail of Genetic characterization and progression of B3 measles genotype in Ethiopia: a study of five measles outbreak cases

Ethiopian medical journal, 2008

One of the countries where measles remains endemic is Ethiopia. Previously, sequence data from Me... more One of the countries where measles remains endemic is Ethiopia. Previously, sequence data from Measles Viruses (MV) circulating in Ethiopia were obtained from clinical specimens. Now the Ethiopian Health and Nutrition Research Institute (ENHRI) has implemented cell culture techniques to isolate measles virus and molecular epidemiologic studies can be generated more easily. To characterize the strains of Measles Virus circulating in Ethiopia during measles outbreaks in 2006 using viral isolates, and compare the results to previously identified Ethiopian strains. A case study and convenience sampling method were conducted on five measles outbreak cases tb identify the circulating measles virus genotype in Addis Ababa and Amhara regions of Ethiopia in 2006. Three isolates were obtained from five specimens collected in two regions (1 from Amhara: Bahir Dar, and 2 from Addis Ababa: Addis Ketema and Kolefe Keranio subcities) in Ethiopia during 2006. The viral isolates were analyzed using ...

Research paper thumbnail of Risk assessment for yellow fever in western and North-Western provinces of Zambia

Journal of Global Infectious Diseases, 2015

reported cases because mild cases can go undetected as the signs and symptoms of YF are similar t... more reported cases because mild cases can go undetected as the signs and symptoms of YF are similar to those of viral hepatitis, malaria, leptospirosis, typhus, Ebola and other viral hemorrhagic fevers.

Research paper thumbnail of Characterization of Rubella Seronegative Females in the Zambian Blood Donor Community

Frontiers in Public Health, 2015

Rubella is an acute, contagious viral infection caused by a teratogenic enveloped singlestranded ... more Rubella is an acute, contagious viral infection caused by a teratogenic enveloped singlestranded RNA virus, rubella virus, a member of the togaviridae family. Though causing generally mild infections in children and adults, it is a disease of public health importance in pregnant women causing major problems including abortions, miscarriages, and congenital rubella syndrome in more than 20% of the susceptible population. This study was carried out to determine the characteristics associated with rubella seronegativity among female blood donors in Zambia. Rubella-specific IgG antibody levels were measured in the blood serum. Proportions were compared using the Chi-squared test at the 5% significance level, and magnitudes of associations were determined using the odds ratio and its 95% confidence interval. Of the 124 female blood donors tested for rubella IgG 46.0% were aged <20 years. Overall, 66.7% of the participants had never been married. More than half (62.1%) of the participants resided in rural areas of the country. Of the 114 participants with recorded level of education, 50.1% had at least completed secondary school. Out of 43 participants with recorded current employment status, 44.2% were not working for pay. A total of 10 (8.1%) participants were seronegative to rubella IgG antibodies. No factors were associated with seronegativity. Protection against rubella through natural infection appears inadequate to protect the population, increasing the risk of CRS.

Research paper thumbnail of Characterization of Rubella Seronegative Females in the Zambian Blood Donor Community

Frontiers in Public Health, 2015

Research paper thumbnail of Intussusception incidence rates in 9 Zambian hospitals, 2007-2011: prerotavirus vaccine introduction

The Pediatric infectious disease journal, 2014

Intussusception, a rare adverse event associated with rotavirus vaccines in some settings, is a c... more Intussusception, a rare adverse event associated with rotavirus vaccines in some settings, is a common cause of intestinal obstruction in infants and toddlers globally with a peak age of 4-6 months. This age group may overlap with the extended age of administering rotavirus vaccine. A retrospective (January 2007 to June 2009) and prospective (July 2009 to June 2012) survey was conducted in 9 Zambian hospitals. Children between 0 and 24 months who were operated on for intestinal obstruction/intussusception were identified in theatre log books. In the latter part of the survey, patients were recruited prospectively. Demographic, clinical and surgical data from hospital files were collected for each patient. One-hundred and five children were identified to have undergone surgery for intussusceptions. Many were boys 57.6% (57/99). Of those with complete data, intussusception was common in infants 86.9% (86/99) and many children (68.0%) were between 3 and 8 months of age with a peak age ...

Research paper thumbnail of Genetic characterization and progression of B3 measles genotype in Ethiopia: a study of five measles outbreak cases

Ethiopian medical journal, 2008

One of the countries where measles remains endemic is Ethiopia. Previously, sequence data from Me... more One of the countries where measles remains endemic is Ethiopia. Previously, sequence data from Measles Viruses (MV) circulating in Ethiopia were obtained from clinical specimens. Now the Ethiopian Health and Nutrition Research Institute (ENHRI) has implemented cell culture techniques to isolate measles virus and molecular epidemiologic studies can be generated more easily. To characterize the strains of Measles Virus circulating in Ethiopia during measles outbreaks in 2006 using viral isolates, and compare the results to previously identified Ethiopian strains. A case study and convenience sampling method were conducted on five measles outbreak cases tb identify the circulating measles virus genotype in Addis Ababa and Amhara regions of Ethiopia in 2006. Three isolates were obtained from five specimens collected in two regions (1 from Amhara: Bahir Dar, and 2 from Addis Ababa: Addis Ketema and Kolefe Keranio subcities) in Ethiopia during 2006. The viral isolates were analyzed using ...

Research paper thumbnail of Risk assessment for yellow fever in western and North-Western provinces of Zambia

Journal of Global Infectious Diseases, 2015

reported cases because mild cases can go undetected as the signs and symptoms of YF are similar t... more reported cases because mild cases can go undetected as the signs and symptoms of YF are similar to those of viral hepatitis, malaria, leptospirosis, typhus, Ebola and other viral hemorrhagic fevers.

Research paper thumbnail of Characterization of Rubella Seronegative Females in the Zambian Blood Donor Community

Frontiers in Public Health, 2015

Rubella is an acute, contagious viral infection caused by a teratogenic enveloped singlestranded ... more Rubella is an acute, contagious viral infection caused by a teratogenic enveloped singlestranded RNA virus, rubella virus, a member of the togaviridae family. Though causing generally mild infections in children and adults, it is a disease of public health importance in pregnant women causing major problems including abortions, miscarriages, and congenital rubella syndrome in more than 20% of the susceptible population. This study was carried out to determine the characteristics associated with rubella seronegativity among female blood donors in Zambia. Rubella-specific IgG antibody levels were measured in the blood serum. Proportions were compared using the Chi-squared test at the 5% significance level, and magnitudes of associations were determined using the odds ratio and its 95% confidence interval. Of the 124 female blood donors tested for rubella IgG 46.0% were aged <20 years. Overall, 66.7% of the participants had never been married. More than half (62.1%) of the participants resided in rural areas of the country. Of the 114 participants with recorded level of education, 50.1% had at least completed secondary school. Out of 43 participants with recorded current employment status, 44.2% were not working for pay. A total of 10 (8.1%) participants were seronegative to rubella IgG antibodies. No factors were associated with seronegativity. Protection against rubella through natural infection appears inadequate to protect the population, increasing the risk of CRS.