Omar Ozgur - Academia.edu (original) (raw)

Papers by Omar Ozgur

Investigative Ophthalmology & Visual Science, Jun 16, 2013

Investigative Ophthalmology & Visual Science, Apr 30, 2014

PubMed, May 1, 2012

Dry eye syndrome is a potential complication of botulinum toxin type-A injection (BTX-A) into the... more Dry eye syndrome is a potential complication of botulinum toxin type-A injection (BTX-A) into the lateral canthal rhytids (crow's feet). The early manifestations of this syndrome are subtle and are rarely reported to the treating physician. A guideline for early detection of dry-eye state is proposed, in order to avoid more troublesome adverse effects that may develop with repeated injections of BTX-A into the crow's feet region. If suspected early, clinical manifestations remain minor and are reversible. However, delayed diagnosis may lead to troublesome and persistent symptoms. A novel and practical grading scale of lower eyelid snap-back and distraction tests is offered that helps in documenting patient's clinical progress and in deciding when BTX-A injections should be delayed or discontinued.

American Journal of Ophthalmology, Aug 1, 2015

To review our experience treating patients with the hedgehog pathway inhibitor, vismodegib, in pa... more To review our experience treating patients with the hedgehog pathway inhibitor, vismodegib, in patients with orbital or periocular locally advanced or metastatic basal cell carcinoma (BCC) or basal cell nevus syndrome. Design: Retrospective interventional case series. Methods: We reviewed all patients with locally advanced or metastatic orbital or periocular BCC or basal cell nevus syndrome treated with the hedgehog pathway inhibitor, vismodegib, at a comprehensive cancer center from 2009 through 2015. Reviewed data included age; gender; American Joint Commission on Cancer tumor, node, metastasis staging system designation; type and grade of drug-related side effects; response to treatment; duration of follow-up, and status at last follow-up. Results: The study included 10 white men and 2 white women; the median age was 64.5 years. Ten patients had locally advanced BCC; 2 had basal cell nevus syndrome. Among the patients with locally advanced BCC, 5 had T3bN0M0 disease at presentation; 1 each had T3aN0M0, T3bN1M0, T2N1M1, T4N1M1, and T4N2cM1 disease. Overall, 3 patients had a complete response, 6 had a partial response, and 3 had stable disease at last follow-up. Two patients developed progressive disease after a complete response for 38 months and stable disease for 16 months respectively. All patients developed grade I drug-related adverse effects, most commonly muscle spasms (12 patients), weight loss (10), dysgeusia (9), alopecia (9), decreased appetite (5), and fatigue (4). Five patients developed grade II adverse effects. At last follow-up, none of the 5 patients presenting with T3bN0M0, or the patient with T3bN1M0 disease had required orbital exenteration. Conclusion: Hedgehog pathway inhibition produces a significant clinical response in most patients with locally advanced or metastatic orbital or periocular BCC or basal cell nevus syndrome and can obviate orbital exenteration in some patients. Drug-related adverse effects are manageable in most patients. Hedgehog pathway inhibition for locally advanced periocular basal cell carcinoma and basal cell nevus syndrome Short title: Vismodegib for periocular basal cell carcinoma

The Journal of Urology, Apr 1, 2008

DVC loose knot/inaccurate plane (n=9), bladder neck too large (n=10), posterior bladder neck plan... more DVC loose knot/inaccurate plane (n=9), bladder neck too large (n=10), posterior bladder neck plane inaccurate (n=2), sewing error: broken needle/stitch (n=7), and prostate capsule violation (n=1).

Acta Ophthalmologica, Oct 24, 2016

International Ophthalmology, Nov 10, 2016

Purpose To evaluate the accuracy of clinicians in evaluating the growth of eyelid lesions and to ... more Purpose To evaluate the accuracy of clinicians in evaluating the growth of eyelid lesions and to compare the measurements of experienced ophthalmologists to a novel computerized measurement method. Design Prospective, single center, observational study. Methods Six experienced ophthalmologists were asked to measure 3 simulated eyelid lesions using a slit lamp. These lesions were then enlarged, and the same examiners were asked to measure the enlarged lesions without prompting that the lesions had changed. Slit lamp photography of the original lesions and enlarged lesions were analyzed using freely available software from the National Institutes of Health. The results of clinician measurements were compared to the software-generated data. Results Clinician data regarding the growth of the lesions were as follows:-40.9 to ?76.8% for lesion 1, ?29.3 to ?134.4% for lesion 2, and ?148.5 to ?1169.2% for lesion 3. Software-based measurements were as follows: ?53.6, ?100.7, and ?182.2% for lesions 1, 2, and 3, respectively. Conclusions Monitoring growth of eyelid lesions in clinical practice can be challenging. We propose that using computerized software to analyze surface area of concerning eyelid lesions may provide a significant advantage over current clinical practices.

Ophthalmic Plastic and Reconstructive Surgery, May 1, 2018

To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local contro... more To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local control following therapy. The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried to identify patients diagnosed with orbital plasmacytoma. These patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; records were reviewed for demographic characteristics, clinical and radiologic findings, treatments, and outcomes. Thirty patients from 4 institutions (24 from MD Anderson Cancer Center, 3 from SUNY Downstate Medical Center, 2 from University of California, Los Angeles, and 1 from Oregon Health and Science University) were identified. Eighteen patients (60%) were diagnosed with multiple myeloma (MM) before and 11 (37%) were diagnosed with MM immediately after orbital plasmacytoma. Based on imaging, 4 distinct anatomical patterns were identified: 1) bony plasmacytoma affecting the superotemporal orbit, epidural space, and temporal fossa (15 patients; 50%); 2) discrete orbital plasmacytoma (7 patients; 23%); 3) infiltrative plasmacytoma either originating from a sinus (4 patients; 13%); or 4) originating from the orbital floor and infiltrating facial soft tissue (4 patients; 13%). Of the 29 patients with available treatment data, 2 had radiation only, 3 had chemotherapy only, 6 had chemoradiation, and 18 had stem cell transplant following chemoradiation (n = 17) or only chemotherapy (n = 1). Following treatment, 10 patients achieved complete and 11 achieved partial responses. Orbital plasmacytomas were found exclusively in patients with MM diagnosed before or immediately after orbital plasmacytoma. Plasmacytomas can have 4 distinct anatomical patterns of origin. Following treatment, all patients had good to excellent local control of their orbital lesions.

Georg Thieme Verlag eBooks, 2020

Ophthalmic Plastic and Reconstructive Surgery, Sep 1, 2010

Angiosarcoma is a rare malignancy with only 8 previous reports of eyelid involvement. The authors... more Angiosarcoma is a rare malignancy with only 8 previous reports of eyelid involvement. The authors report 2 further cases, one as a primary lesion and the other as a recurrence from a contiguous area. In both cases, the lesions appeared relatively inconspicuous, and their extent during micrographic excision was considerably larger than anticipated. Although wide surgical margins were obtained and adjuvant radiotherapy and chemotherapy was undertaken, one patient had died from distant metastasis, while the second had distant cutaneous recurrences within 1 year. A ngiosarcomas (AS) are uncommon, highly malignant, vascular endothelial tumors that typically arise in the skin or subcutaneous tissue. 1 The cutaneous variant may be solitary or multifocal and most commonly involves the scalp and upper face in elderly whites. 2,3 They may present as flat or nodular lesions, may have surrounding edema, and their color may range from bluish-red to skin tones. They are frequently misdiagnosed as benign lesions, and their extent is often underestimated. Chronic lymphedema and previous radiotherapy are predisposing factors for cutaneous AS, but only 10% of tumors have this association. No underlying genetic abnormality has been reported for cutaneous AS. AS involving the eyelid is rare, and we could identify only 8 cases in the literature. 2,4,5 We report 2 additional cases of AS involving the eyelid. CASE 1 An 82-year-old white woman presented with a painless, erythematous, slightly elevated lesion in the left, medial upper eyelid, increasing in size over the previous 6 weeks. Also noted were small, irregular, poorly defined violaceous papules on the left nasal bridge and lower eyelid and cheek (Fig. 1A). An incisional biopsy of the upper eyelid showed oddly shaped vascular channels lined by malignant endothelial cells (Fig. 1B). A systemic workup found no metastases. She was treated by Mohs excision with wide free margins involving all the multifocal areas with a defect much larger than anticipated (Fig. 1C). Reconstruction with a cheek rotation flap, midline forehead flap, and skin grafts was followed 6 weeks later by focal radiotherapy (Fig. 1D). Although no apparent recurrence developed in the face, within 1 year, she developed a right pleural effusion from a pulmonary metastasis, followed by liver metastases. She died 6 months later. CASE 2 A 71-year-old white male was referred with a violaceous, painless maculo-papular lesion at the left medial upper eyelid (Fig. 2A). He had been diagnosed with angiosarcoma of the nasal bridge 4 years previously and treated with complete excision of the nose, reconstruction, and adjuvant radiotherapy. An incisional biopsy confirmed recurrent angiosarcoma (Fig. 2B). A systemic workup was negative, and the eyelid lesion was treated with wide excision using frozen section control (Fig. 2C), reconstruction with a modified Tenzel flap, and adjuvant radio

Journal of ophthalmic and vision research, 2016

Ocular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incid... more Ocular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incidence in African countries (3.4 and 3.0 cases/year/100,000). Despite its potential for vision loss and death, OSSN remains largely neglected by both eye and HIV care programs in Africa. The purpose of this review is to identify the barriers to timely diagnosis and early interventions for OSSN in Africa. PubMed searches were conducted targeting previous use of topical chemotherapy (interferon alpha 2b, Mitomycin-C, 5-Fluorouracil) and Human papillomavirus (HPV) vaccination in Africa. We found that OSSN is a significant vision and life-threatening health problem in Africa leading to significant loss of vision, as well as facial disfigurement and social stigma. We did not find any reports on the use of topical interferon, Mitomycin-C or HPV vaccination for OSSN in Africa. One report on the use of topical 5-FU for OSSN in Africa was found. Common barriers to early detection and management of OSSN in Africa include lack of sufficient laboratory infrastructure, lack of trained healthcare personnel, lack of compliance with follow-up visits, cost of topical chemotherapies, and cultural preferences for traditional medicines. In conclusion, OSSN is a significant vision and life-threatening health problem in Africa. There is not much literature on prevention or treatment options for early stages of OSSN in Africa. The use of topical chemotherapy as early interventions and judicious use of smart phone Apps to help with remote diagnosis of early OSSN should be further explored.

Journal of Ophthalmic and Vision Research, 2016

Seminars in Diagnostic Pathology, 2016

Ocular surface tumors are commonly encountered by ophthalmologists and ophthalmic pathologists. T... more Ocular surface tumors are commonly encountered by ophthalmologists and ophthalmic pathologists. These tumors have varied clinical manifestations. In this article, we discuss the most commonly encountered non-melanocytic and melanocytic ocular surface tumors, with emphasis on their common clinical features, morphologic patterns, and prognostic factors.

The Annual ASCRS and ASOA Symposium and Congress, 2014

Investigative Ophthalmology & Visual Science, 2014