Omer Lodi - Academia.edu (original) (raw)
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Papers by Omer Lodi
Anaesthesia, Mar 21, 2007
Anaesthesia & Intensive Care Medicine, 2009
Skin or tissue defects that cannot be closed primarily with simple suturing may need skin grafts,... more Skin or tissue defects that cannot be closed primarily with simple suturing may need skin grafts, tissue expanders or flaps to maintain skin integrity and prevent infection. Flaps may be local, pedicled or free and may involve skin, muscle, bone, bowel or a combination. Local and pedicled flaps keep their primary vascular supply while free flaps have their circulation detached
Experimental cell research, Jun 15, 2017
Galectins are multifunctional β-galactoside-binding proteins that are involved in the regulation ... more Galectins are multifunctional β-galactoside-binding proteins that are involved in the regulation of cellular stress responses and differentiation. The relationship between these processes is unclear and we report here that galectins display oxidative-stress specific expression patterns in neutrophil-like differentiated HL-60 cells. Three galectins (-1, -3, and -10) are upregulated in response to either menadione or DMSO exposure whereas galectins -9 and -12 exhibited a stimulus-dependent downregulation. Changes in galectin expression are oxidant dependent based on the observations that 1) oxidative stress biomarkers HMOX1 (heme oxygenase-1) and NCF1 (neutrophil cytosolic factor 1, which is also a biomarker of neutrophil differentiation) are elevated in both cases, and 2) the antioxidant N-acetyl-L-cysteine restores basal expression of galectin-3 following oxidant exposure. In addition, our results suggest that the regulation of oxidative stress-sensitive galectins involves DNA hypom...
Anaesthesia & Intensive Care Medicine, 2012
Anesthesia & Analgesia, 2008
BACKGROUND: During regional anesthesia for carotid endarterectomy (CEA), 10% to 15% of patients d... more BACKGROUND: During regional anesthesia for carotid endarterectomy (CEA), 10% to 15% of patients develop signs of cerebral hypoxia after cross-clamping, manifested as changes in speech, cerebration or contralateral motor power. Reversal of such neurological deficits using administration of 100% O 2 has been described. We used near-infrared cerebral oximetry to assess whether 100% O 2 reliably improves regional cerebral oxygenation (rSO 2 ) during carotid cross-clamping. METHODS: Sixteen patients undergoing awake CEA were studied. Bilateral rSO 2 optodes were applied before the initiation of sedation and the conduct of the regional blockade. Patients received 28% oxygen by Venturi facemask. Perioperative blood pressure was maintained at or within 10% above the patient's normal limits during carotid cross-clamping. After cross-clamping, 100% O 2 was administered for 5 min by a close-fitting anesthetic facemask. The O 2 mask was then removed and the patient breathed room air. The effects on rSO 2 readings and arterial blood gases were observed after each intervention. RESULTS: Data were analyzed for 15 patients. Ipsilateral rSO 2 values decreased by 7.4% Ϯ 5% after carotid cross-clamping. Administration of 100% O 2 resulted in an increase in ipsilateral rSO 2 in all patients of 6.9% Ϯ 3.3% (range, 1%-12%) (paired t-test, P Ͻ 0.001) over the cross-clamped value while receiving 28% O 2 . Hemodynamic variables and arterial Paco 2 values were unaltered. CONCLUSION: With the carotid cross-clamped, ipsilateral rSO 2 was reliably increased by the administration of 100% O 2 compared with 28% O 2 . The etiology of this increase is unclear, but may relate to the associated increase in O 2 content of the blood or to an improvement in cerebral blood flow. Thus administration of 100% O 2 during carotid cross-clamping may be beneficial for all patients undergoing CEA.
Anaesthesia & Intensive Care Medicine, 2012
ABSTRACT
Anaesthesia, Mar 21, 2007
Anaesthesia & Intensive Care Medicine, 2009
Skin or tissue defects that cannot be closed primarily with simple suturing may need skin grafts,... more Skin or tissue defects that cannot be closed primarily with simple suturing may need skin grafts, tissue expanders or flaps to maintain skin integrity and prevent infection. Flaps may be local, pedicled or free and may involve skin, muscle, bone, bowel or a combination. Local and pedicled flaps keep their primary vascular supply while free flaps have their circulation detached
Experimental cell research, Jun 15, 2017
Galectins are multifunctional β-galactoside-binding proteins that are involved in the regulation ... more Galectins are multifunctional β-galactoside-binding proteins that are involved in the regulation of cellular stress responses and differentiation. The relationship between these processes is unclear and we report here that galectins display oxidative-stress specific expression patterns in neutrophil-like differentiated HL-60 cells. Three galectins (-1, -3, and -10) are upregulated in response to either menadione or DMSO exposure whereas galectins -9 and -12 exhibited a stimulus-dependent downregulation. Changes in galectin expression are oxidant dependent based on the observations that 1) oxidative stress biomarkers HMOX1 (heme oxygenase-1) and NCF1 (neutrophil cytosolic factor 1, which is also a biomarker of neutrophil differentiation) are elevated in both cases, and 2) the antioxidant N-acetyl-L-cysteine restores basal expression of galectin-3 following oxidant exposure. In addition, our results suggest that the regulation of oxidative stress-sensitive galectins involves DNA hypom...
Anaesthesia & Intensive Care Medicine, 2012
Anesthesia & Analgesia, 2008
BACKGROUND: During regional anesthesia for carotid endarterectomy (CEA), 10% to 15% of patients d... more BACKGROUND: During regional anesthesia for carotid endarterectomy (CEA), 10% to 15% of patients develop signs of cerebral hypoxia after cross-clamping, manifested as changes in speech, cerebration or contralateral motor power. Reversal of such neurological deficits using administration of 100% O 2 has been described. We used near-infrared cerebral oximetry to assess whether 100% O 2 reliably improves regional cerebral oxygenation (rSO 2 ) during carotid cross-clamping. METHODS: Sixteen patients undergoing awake CEA were studied. Bilateral rSO 2 optodes were applied before the initiation of sedation and the conduct of the regional blockade. Patients received 28% oxygen by Venturi facemask. Perioperative blood pressure was maintained at or within 10% above the patient's normal limits during carotid cross-clamping. After cross-clamping, 100% O 2 was administered for 5 min by a close-fitting anesthetic facemask. The O 2 mask was then removed and the patient breathed room air. The effects on rSO 2 readings and arterial blood gases were observed after each intervention. RESULTS: Data were analyzed for 15 patients. Ipsilateral rSO 2 values decreased by 7.4% Ϯ 5% after carotid cross-clamping. Administration of 100% O 2 resulted in an increase in ipsilateral rSO 2 in all patients of 6.9% Ϯ 3.3% (range, 1%-12%) (paired t-test, P Ͻ 0.001) over the cross-clamped value while receiving 28% O 2 . Hemodynamic variables and arterial Paco 2 values were unaltered. CONCLUSION: With the carotid cross-clamped, ipsilateral rSO 2 was reliably increased by the administration of 100% O 2 compared with 28% O 2 . The etiology of this increase is unclear, but may relate to the associated increase in O 2 content of the blood or to an improvement in cerebral blood flow. Thus administration of 100% O 2 during carotid cross-clamping may be beneficial for all patients undergoing CEA.
Anaesthesia & Intensive Care Medicine, 2012
ABSTRACT