Omur Ataoglu - Academia.edu (original) (raw)
Papers by Omur Ataoglu
ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018
Oral lichen planus (OLP) is a chronic immune-mediated dermatosis of unknown origin. Considered as... more Oral lichen planus (OLP) is a chronic immune-mediated dermatosis of unknown origin. Considered as one of the most common diseases of the oral mucosa, OLP has been subject of intense interest since its first identification as a premalignant condition. Oral lichenoid contact reactions (OLCRs) are distinct analogs of OLP lesions, in that they are nearly indistinguishable from OLP both clinically and histologically. There is an ongoing debate about whether the underlying condition causing OLP-induced malignant oral squamous cell carcinoma is OLP or OLCR. Even currently, a considerable number of patients with OLCR are diagnosed and managed as OLP without searching for specific causative agents. Dental restorative materials are one of the most common inducers of OLCR. Here, we describe a case with dental material-induced OLCR, who had previously undergone marginal mandibulectomy and neck dissection with a diagnosis of invasive well differentiated squamous cell carcinoma associated with OLP. We emphasize the need for investigation of possible etiological factors in every case of OLP or OLCR, as a basal patch test may completely change the course of the disease.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, Jan 9, 2017
International Journal of Dermatology, 1992
Behget's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clini... more Behget's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clinical criteria in the establishment of diagnosis is of great importance. We present the case of a 27-year-old man with BD, who had a surgical operation during the active period of his disease and experienced subsequent complications. Cutaneous hyper-reactivity response to minor cutaneous trauma-the pathergy phenomenon-is found in most patients with BD. Theoretically, major traumas may lead to major reactions in the skin or any of the organs. In practice, we observed that while there was a severe Inflammatory reaction-histopathologically a superficial perivascular dermatitis-which developed at the incision site, the systemic symptoms of the disease increased in spite of intensive treatment of the condition. Beh^et's Disease (liD) is a complex multisystemic disease, which, due to the absence of any pathognomonic laboratory test., must be diagnosed using clinical criteria. The recognized clinical criteria consist of recurrent oral aphthosis, recurrent genital ulcers, uveitis, synovitis., pathergy phenomenon, fever, etc.'"-' The pathergy phenomenon, the most important of the clinical criteria, is a strong response to nonspecific minor traumas such as simple cutaneous injections.''''' A more serious response should be expected in the case of major traumas, and with this in view, doctors are reluctant to perform major operations on patients with liD. We present an acute appendicitis case in a 27year-old male with BD. Postoperatively, severe erythema and induration developed at the appendectomy incision site, and concurrently, the patient's BD symptoms were aggravated. Case Report A 27-year-old man was referred to our department, in January 1990, with oral and genital aphthous lesions and painful nodosities of the lower extremities. The medical history included BD of 7-years duration, involving the oral and genital mucocutaneous areas and the eye. He had been treated with colchicine (3 x 0.5 mg/day orally) for a period of 5 years. The family history of the patient was noncontributory.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, Jan 9, 2009
Şakir Arslan, M. Emin Kalkan, Yekta Gürlertop Cardiology Department, Faculty of Medicine, Ataturk... more Şakir Arslan, M. Emin Kalkan, Yekta Gürlertop Cardiology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey ... Cem Köz, İnanç Güvenç*, Oben Baysan, Mehmet Yokuşoğlu, Haldun Karagöz1, Ömür Ataoğlu2 From Departments of Cardiology and *Radiology ...
Frontiers in Oncology, 2015
Neuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers... more Neuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers, including prostate cancer (PCa), whereby the malignant tissue contains a significant proportion of cells displaying neuronal, endocrine, or mixed features. NED cells produce, and can secrete, a cocktail of mediators commonly encountered in the nervous system, which may stimulate and coordinate cancer growth. In PCa, NED appears during advanced stages, subsequent to treatment, and accompanies treatment resistance and poor prognosis. However, the term "neuroendocrine" in this context is intrinsically vague. This article seeks to provide a framework on which a unified view of NED might emerge. First, we review the mutually beneficial interplay between PCa and neural structures, mainly supported by cell biology experiments and neurological conditions. Next, we address the correlations between PCa and neural functions, as described in the literature. Based upon the integration of clinical and basic observations, we suggest that it is legitimate to seek for true neural differentiation, or neuromimicry, in cancer progression, most notably in PCa cells exhibiting what is commonly described as NED.
International Urology and Nephrology, 2001
We report a case of large renal hemangioma that completely filled the collecting system in a 43-y... more We report a case of large renal hemangioma that completely filled the collecting system in a 43-year-old man. Most of the renal hemangiomas are small in size and this situation is extremely rare. The diagnosis and treatment of the case is discussed.
Plastic and Reconstructive Surgery, 1999
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2003
In a rabbit model of squamous cell carcinoma of the tongue, we monitored histopathologic changes ... more In a rabbit model of squamous cell carcinoma of the tongue, we monitored histopathologic changes and assessed the effect of selenium against carcinogenesis. The study included 36 male albino New Zealand rabbits. To induce squamous cell carcinoma of the tongue, 9,10-dimethyl-1,2-benzanthracene (DMBA)-acetone solution was applied three times a week for a duration of 20 weeks under anesthesia with xylazine hydrochloride and ketamine. The rabbits were randomly assigned to receive either pure tap water (24 rabbits) or tap water supplemented with 4 ppm sodium selenite (12 rabbits). One rabbit in each group was sacrificed at the end of 4, 8, 12 and 16 weeks, and the remaining rabbits at the end of 20 weeks for macroscopic and microscopic examination of the tongue. By week 20, two rabbits in the selenium group, and nine rabbits receiving tap water died from acute necrotizing bronchopneumonia due to pasteurellosis. Dysplasia was significantly less in selenium-receiving rabbits (16.7% vs 66.7...
Dermatologic Surgery, 2002
yavuzer et al.: microcystic adnexal carcinoma 1093 and she was kept under close clinical follow-u... more yavuzer et al.: microcystic adnexal carcinoma 1093 and she was kept under close clinical follow-up. It has She is now been more than 1 year without any local recurrences.
Obstetrical & Gynecological Survey, 2007
Primary pure ovarian leiomyosarcomas constitute a malignant subgroup of ovarian smooth muscle tum... more Primary pure ovarian leiomyosarcomas constitute a malignant subgroup of ovarian smooth muscle tumors which comprise only 1% of ovarian tumors. Their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure. Malignant behavior is almost always associated with any 2 of coagulative necrosis, cellular atypia, and mitotic index greater than 10. Immunohistochemical and electron microscopic evaluations may improve diagnostic accuracy. Traditionally, International Federation of Gynecology and Obstetrics (FIGO) staging and treatment of ovarian sarcomas have been the same as for epithelial ovarian carcinomas. Although surgery was performed for all cases, the extent of surgery is debatable. Benefit and modality of adjuvant therapy is controversial. The prognosis of primary pure ovarian leiomyosarcomas is extremely poor depending on tumor stage, tumor size, grade, and mitotic index and mostly recurs in abdomen and pelvis. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this article, the reader should be able to state how rare primary ovarian leiomyosarcoma (POLMS) is, explain that because of its rarity the best diagnostic and treatment modalities are not conclusive, and recall that the authors reviewed the literature to bring the readership current on POLMS. Contrary to their uterine counterparts, ovarian smooth muscle tumors (SMT) are extremely rare comprising only 1% of ovarian tumors (1). Primary pure ovarian leiomyosarcomas (POLMS) constitute a malignant subgroup of ovarian SMT, and, to our knowledge, 61 cases have been reported. Therefore, their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure. ETIOLOGY Primary ovarian sarcoma represents a heterogeneous group of ovarian tumors and is classified as teratoid, mesenchymal, and mullerian type according The authors have disclosed that they have no financial relationships with or interests in any commercial companies pertaining to this educational activity. Lippincott Continuing Medical Education Institute, Inc. has identified and resolved all faculty conflicts of interest regarding this educational activity.
Tuberkuloz ve Toraks, 2011
Inflammatory bowel disease (IBD) is a chronic and relatively common disorder of uncertain etiolog... more Inflammatory bowel disease (IBD) is a chronic and relatively common disorder of uncertain etiology (1). IBD can be associated with a variety of respiratory disorders (2). A link between pulmonary disease and IBD was suggested nearly 40 years ago (3). Both screening studies and the cumulative volume of case reports suggest that respiratory system may be involved in IBD more frequently than it is generally appreciated (4). The colonic and respiratory epithelia both share embryonic origin from the primitive foregut (5). Although, many of the reported pulmonary diseases associated with IBD have cryptic etiologies, the causes or mechanisms of respiratory tract involvement in IBD remain poorly understood (2). A 51 years old female patient was admitted to our clinic with the complaints of cough, fever and sputum production for 10 days and abdominal pain, bloody stool and diarrhea for two days. The patient was a lifelong non-smoker and had no history of occupational or environmental exposure relevant to lung disease. Despite empirical antibiotic treatment, there was no clinical improvement. Chest X-ray revealed infiltration at the right lower zone. Pulmonary function test was normal. Connective tissue markers including ANA, anti-dsDNA, RF were negative. Erytrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were high. Contrast-enhanced computed tomography revealed segmental atelectasis on the right lower lobe and infiltration around atelectasis (Figure 1). A bronchoscopy was performed; there was endobronchial polypoid lesion on the posterior wall of the posterior segment of right lower lobe. Bronchoscopic biopsy revealed subepithelial fibrosis and under the 312
Southern Medical Journal, 2009
The coexistence of multiple and synchronous primary neoplasms in the genitourinary system has rar... more The coexistence of multiple and synchronous primary neoplasms in the genitourinary system has rarely been described in the literature. To our knowledge, this is the first report of a very rare tumor, a "tubulocystic carcinoma," simultaneously occurring with micropapillary urothelial carcinoma in the bladder and clear cell type renal cell carcinoma in the same kidney. Tubulocystic carcinoma is a recently entitled tumor. It had been thought to arise from the distal collecting duct for a period of time and was therefore named as a low-grade collecting duct carcinoma. Microscopically, the tumor is defined as being tubulocystic or having tubulopapillary architecture and a low nuclear grade with hobnail morphology. Its progression and treatment protocol are uncertain.
Plastic and Reconstructive Surgery, 2002
Medical and Pediatric Oncology, 1997
Osteoblastoma is a rare primary bone tumor that is curable by complete excision. There are few da... more Osteoblastoma is a rare primary bone tumor that is curable by complete excision. There are few data about the effectiveness of chemotherapy or radiotherapy in the treatment of recurrent osteoblastoma. We report a 13-year-old girl wit recurrent osteoblastoma who, after in complete surgical excision, responded to treatment with radiotherapy and later with chemotherapy. Surgery remains the treatment of choice for osteoblastoma. Radiotherapy and chemotherapy either alone or together may be useful in selected patients with recurrent, aggressive tumor or in patients with surgically unresectable disease.
International Urology and Nephrology, 1998
A case of solitary sacral soft tissue metastasis from renal cell carcinoma in a 62-year-old man i... more A case of solitary sacral soft tissue metastasis from renal cell carcinoma in a 62-year-old man is presented.
International Urology and Nephrology, 1997
Forty-four pathologic specimens of 39 bladder cancer patients were analyzed immunohistochemically... more Forty-four pathologic specimens of 39 bladder cancer patients were analyzed immunohistochemically with D07 monoclonal antibody to detect over-expression of mutant p53 gene. The findings were interpreted by correlating with patient age, sex, cigarette smoking, number and macroscopic appearance of tumour, histological tumour grade, muscular invasion, vascular invasion, necrosis and urothelial atypia or dysplasia. Mutant p53 gene was over-expressed in 8 (18.2%) specimens. Statistically significant correlation with grade, vascular invasion, necrosis and patient sex was found with p53 over-expression. Available follow-up data were insufficient to draw a conclusion about the prognostic role of p53 over-expression. Prospective studies with larger number of patients are needed to define the exact place of nuclear p53 over-expression in transitional cell bladder cancer.
Gynecologic Oncology, 2002
INTRODUCTION: Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the M... more INTRODUCTION: Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the MPN-STs occur in patients with neurofibromatosis type-1 (NF-1), while the rest are sporadic. Here, we present a 52-year-old woman with MPNST of the vulva without NF-1. We will discuss basics of the disease, treatment options and follow-up strategies. PRESENTATION OF CASE: 52-year-old female admitted to our hospital with complaint of abnormal uterine bleeding and rapidly growing vulvar mass. Excisional biopsy of the mass showed MPNST of the vulva. Afterwards, the patient underwent radical vulvectomy with inguinofemoral lymph node dissection. Short after the surgery, multiple lung metastasis were shown and responded to chemotherapy, but rapid local recurrence occurred short after the completion of the chemotherapy. DISCUSSION: The primary treatment option in MPNSTs is surgical excision with or without adjuvant therapy. There is not enough data about the role of systemic chemotherapy in the management of MPNSTs and it still remains controversial. CONCLUSION: In general, radiation therapy has not been demonstrated to improve overall survival. Complete surgical resection of the primary tumor is the mainstay of the treatment.
Gynecologic Oncology, 2002
It is difficult to recognize epithelioid trophoblastic tumor (ETT) as a trophoblastic disease bec... more It is difficult to recognize epithelioid trophoblastic tumor (ETT) as a trophoblastic disease because of its rarity and growth pattern simulating a carcinoma. A 36-year-old woman with stage IB(1) squamous cell carcinoma of the uterine cervix and a high serum beta-human chorionic gonadotropin (beta-hCG) level underwent radical hysterectomy with pelvic and para-aortic lymphadenectomy. However, light microscopic findings and immunohistochemical studies with pan-cytokeratin, epithelial membrane antigen, inhibin-alpha, beta-hCG, and human placental lactogen revealed ETT of the endocervix. The patient is alive with no evidence of disease 12 months after surgery. Before the patient is resorted to radical surgical interventions for assumed cervical carcinoma, ETT should be ruled out in women of reproductive age with endocervical tumors and elevated serum beta-hCG levels.
Gynecologic and Obstetric Investigation, 2003
ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018
Oral lichen planus (OLP) is a chronic immune-mediated dermatosis of unknown origin. Considered as... more Oral lichen planus (OLP) is a chronic immune-mediated dermatosis of unknown origin. Considered as one of the most common diseases of the oral mucosa, OLP has been subject of intense interest since its first identification as a premalignant condition. Oral lichenoid contact reactions (OLCRs) are distinct analogs of OLP lesions, in that they are nearly indistinguishable from OLP both clinically and histologically. There is an ongoing debate about whether the underlying condition causing OLP-induced malignant oral squamous cell carcinoma is OLP or OLCR. Even currently, a considerable number of patients with OLCR are diagnosed and managed as OLP without searching for specific causative agents. Dental restorative materials are one of the most common inducers of OLCR. Here, we describe a case with dental material-induced OLCR, who had previously undergone marginal mandibulectomy and neck dissection with a diagnosis of invasive well differentiated squamous cell carcinoma associated with OLP. We emphasize the need for investigation of possible etiological factors in every case of OLP or OLCR, as a basal patch test may completely change the course of the disease.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, Jan 9, 2017
International Journal of Dermatology, 1992
Behget's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clini... more Behget's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clinical criteria in the establishment of diagnosis is of great importance. We present the case of a 27-year-old man with BD, who had a surgical operation during the active period of his disease and experienced subsequent complications. Cutaneous hyper-reactivity response to minor cutaneous trauma-the pathergy phenomenon-is found in most patients with BD. Theoretically, major traumas may lead to major reactions in the skin or any of the organs. In practice, we observed that while there was a severe Inflammatory reaction-histopathologically a superficial perivascular dermatitis-which developed at the incision site, the systemic symptoms of the disease increased in spite of intensive treatment of the condition. Beh^et's Disease (liD) is a complex multisystemic disease, which, due to the absence of any pathognomonic laboratory test., must be diagnosed using clinical criteria. The recognized clinical criteria consist of recurrent oral aphthosis, recurrent genital ulcers, uveitis, synovitis., pathergy phenomenon, fever, etc.'"-' The pathergy phenomenon, the most important of the clinical criteria, is a strong response to nonspecific minor traumas such as simple cutaneous injections.''''' A more serious response should be expected in the case of major traumas, and with this in view, doctors are reluctant to perform major operations on patients with liD. We present an acute appendicitis case in a 27year-old male with BD. Postoperatively, severe erythema and induration developed at the appendectomy incision site, and concurrently, the patient's BD symptoms were aggravated. Case Report A 27-year-old man was referred to our department, in January 1990, with oral and genital aphthous lesions and painful nodosities of the lower extremities. The medical history included BD of 7-years duration, involving the oral and genital mucocutaneous areas and the eye. He had been treated with colchicine (3 x 0.5 mg/day orally) for a period of 5 years. The family history of the patient was noncontributory.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, Jan 9, 2009
Şakir Arslan, M. Emin Kalkan, Yekta Gürlertop Cardiology Department, Faculty of Medicine, Ataturk... more Şakir Arslan, M. Emin Kalkan, Yekta Gürlertop Cardiology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey ... Cem Köz, İnanç Güvenç*, Oben Baysan, Mehmet Yokuşoğlu, Haldun Karagöz1, Ömür Ataoğlu2 From Departments of Cardiology and *Radiology ...
Frontiers in Oncology, 2015
Neuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers... more Neuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers, including prostate cancer (PCa), whereby the malignant tissue contains a significant proportion of cells displaying neuronal, endocrine, or mixed features. NED cells produce, and can secrete, a cocktail of mediators commonly encountered in the nervous system, which may stimulate and coordinate cancer growth. In PCa, NED appears during advanced stages, subsequent to treatment, and accompanies treatment resistance and poor prognosis. However, the term "neuroendocrine" in this context is intrinsically vague. This article seeks to provide a framework on which a unified view of NED might emerge. First, we review the mutually beneficial interplay between PCa and neural structures, mainly supported by cell biology experiments and neurological conditions. Next, we address the correlations between PCa and neural functions, as described in the literature. Based upon the integration of clinical and basic observations, we suggest that it is legitimate to seek for true neural differentiation, or neuromimicry, in cancer progression, most notably in PCa cells exhibiting what is commonly described as NED.
International Urology and Nephrology, 2001
We report a case of large renal hemangioma that completely filled the collecting system in a 43-y... more We report a case of large renal hemangioma that completely filled the collecting system in a 43-year-old man. Most of the renal hemangiomas are small in size and this situation is extremely rare. The diagnosis and treatment of the case is discussed.
Plastic and Reconstructive Surgery, 1999
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2003
In a rabbit model of squamous cell carcinoma of the tongue, we monitored histopathologic changes ... more In a rabbit model of squamous cell carcinoma of the tongue, we monitored histopathologic changes and assessed the effect of selenium against carcinogenesis. The study included 36 male albino New Zealand rabbits. To induce squamous cell carcinoma of the tongue, 9,10-dimethyl-1,2-benzanthracene (DMBA)-acetone solution was applied three times a week for a duration of 20 weeks under anesthesia with xylazine hydrochloride and ketamine. The rabbits were randomly assigned to receive either pure tap water (24 rabbits) or tap water supplemented with 4 ppm sodium selenite (12 rabbits). One rabbit in each group was sacrificed at the end of 4, 8, 12 and 16 weeks, and the remaining rabbits at the end of 20 weeks for macroscopic and microscopic examination of the tongue. By week 20, two rabbits in the selenium group, and nine rabbits receiving tap water died from acute necrotizing bronchopneumonia due to pasteurellosis. Dysplasia was significantly less in selenium-receiving rabbits (16.7% vs 66.7...
Dermatologic Surgery, 2002
yavuzer et al.: microcystic adnexal carcinoma 1093 and she was kept under close clinical follow-u... more yavuzer et al.: microcystic adnexal carcinoma 1093 and she was kept under close clinical follow-up. It has She is now been more than 1 year without any local recurrences.
Obstetrical & Gynecological Survey, 2007
Primary pure ovarian leiomyosarcomas constitute a malignant subgroup of ovarian smooth muscle tum... more Primary pure ovarian leiomyosarcomas constitute a malignant subgroup of ovarian smooth muscle tumors which comprise only 1% of ovarian tumors. Their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure. Malignant behavior is almost always associated with any 2 of coagulative necrosis, cellular atypia, and mitotic index greater than 10. Immunohistochemical and electron microscopic evaluations may improve diagnostic accuracy. Traditionally, International Federation of Gynecology and Obstetrics (FIGO) staging and treatment of ovarian sarcomas have been the same as for epithelial ovarian carcinomas. Although surgery was performed for all cases, the extent of surgery is debatable. Benefit and modality of adjuvant therapy is controversial. The prognosis of primary pure ovarian leiomyosarcomas is extremely poor depending on tumor stage, tumor size, grade, and mitotic index and mostly recurs in abdomen and pelvis. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this article, the reader should be able to state how rare primary ovarian leiomyosarcoma (POLMS) is, explain that because of its rarity the best diagnostic and treatment modalities are not conclusive, and recall that the authors reviewed the literature to bring the readership current on POLMS. Contrary to their uterine counterparts, ovarian smooth muscle tumors (SMT) are extremely rare comprising only 1% of ovarian tumors (1). Primary pure ovarian leiomyosarcomas (POLMS) constitute a malignant subgroup of ovarian SMT, and, to our knowledge, 61 cases have been reported. Therefore, their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure. ETIOLOGY Primary ovarian sarcoma represents a heterogeneous group of ovarian tumors and is classified as teratoid, mesenchymal, and mullerian type according The authors have disclosed that they have no financial relationships with or interests in any commercial companies pertaining to this educational activity. Lippincott Continuing Medical Education Institute, Inc. has identified and resolved all faculty conflicts of interest regarding this educational activity.
Tuberkuloz ve Toraks, 2011
Inflammatory bowel disease (IBD) is a chronic and relatively common disorder of uncertain etiolog... more Inflammatory bowel disease (IBD) is a chronic and relatively common disorder of uncertain etiology (1). IBD can be associated with a variety of respiratory disorders (2). A link between pulmonary disease and IBD was suggested nearly 40 years ago (3). Both screening studies and the cumulative volume of case reports suggest that respiratory system may be involved in IBD more frequently than it is generally appreciated (4). The colonic and respiratory epithelia both share embryonic origin from the primitive foregut (5). Although, many of the reported pulmonary diseases associated with IBD have cryptic etiologies, the causes or mechanisms of respiratory tract involvement in IBD remain poorly understood (2). A 51 years old female patient was admitted to our clinic with the complaints of cough, fever and sputum production for 10 days and abdominal pain, bloody stool and diarrhea for two days. The patient was a lifelong non-smoker and had no history of occupational or environmental exposure relevant to lung disease. Despite empirical antibiotic treatment, there was no clinical improvement. Chest X-ray revealed infiltration at the right lower zone. Pulmonary function test was normal. Connective tissue markers including ANA, anti-dsDNA, RF were negative. Erytrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were high. Contrast-enhanced computed tomography revealed segmental atelectasis on the right lower lobe and infiltration around atelectasis (Figure 1). A bronchoscopy was performed; there was endobronchial polypoid lesion on the posterior wall of the posterior segment of right lower lobe. Bronchoscopic biopsy revealed subepithelial fibrosis and under the 312
Southern Medical Journal, 2009
The coexistence of multiple and synchronous primary neoplasms in the genitourinary system has rar... more The coexistence of multiple and synchronous primary neoplasms in the genitourinary system has rarely been described in the literature. To our knowledge, this is the first report of a very rare tumor, a "tubulocystic carcinoma," simultaneously occurring with micropapillary urothelial carcinoma in the bladder and clear cell type renal cell carcinoma in the same kidney. Tubulocystic carcinoma is a recently entitled tumor. It had been thought to arise from the distal collecting duct for a period of time and was therefore named as a low-grade collecting duct carcinoma. Microscopically, the tumor is defined as being tubulocystic or having tubulopapillary architecture and a low nuclear grade with hobnail morphology. Its progression and treatment protocol are uncertain.
Plastic and Reconstructive Surgery, 2002
Medical and Pediatric Oncology, 1997
Osteoblastoma is a rare primary bone tumor that is curable by complete excision. There are few da... more Osteoblastoma is a rare primary bone tumor that is curable by complete excision. There are few data about the effectiveness of chemotherapy or radiotherapy in the treatment of recurrent osteoblastoma. We report a 13-year-old girl wit recurrent osteoblastoma who, after in complete surgical excision, responded to treatment with radiotherapy and later with chemotherapy. Surgery remains the treatment of choice for osteoblastoma. Radiotherapy and chemotherapy either alone or together may be useful in selected patients with recurrent, aggressive tumor or in patients with surgically unresectable disease.
International Urology and Nephrology, 1998
A case of solitary sacral soft tissue metastasis from renal cell carcinoma in a 62-year-old man i... more A case of solitary sacral soft tissue metastasis from renal cell carcinoma in a 62-year-old man is presented.
International Urology and Nephrology, 1997
Forty-four pathologic specimens of 39 bladder cancer patients were analyzed immunohistochemically... more Forty-four pathologic specimens of 39 bladder cancer patients were analyzed immunohistochemically with D07 monoclonal antibody to detect over-expression of mutant p53 gene. The findings were interpreted by correlating with patient age, sex, cigarette smoking, number and macroscopic appearance of tumour, histological tumour grade, muscular invasion, vascular invasion, necrosis and urothelial atypia or dysplasia. Mutant p53 gene was over-expressed in 8 (18.2%) specimens. Statistically significant correlation with grade, vascular invasion, necrosis and patient sex was found with p53 over-expression. Available follow-up data were insufficient to draw a conclusion about the prognostic role of p53 over-expression. Prospective studies with larger number of patients are needed to define the exact place of nuclear p53 over-expression in transitional cell bladder cancer.
Gynecologic Oncology, 2002
INTRODUCTION: Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the M... more INTRODUCTION: Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the MPN-STs occur in patients with neurofibromatosis type-1 (NF-1), while the rest are sporadic. Here, we present a 52-year-old woman with MPNST of the vulva without NF-1. We will discuss basics of the disease, treatment options and follow-up strategies. PRESENTATION OF CASE: 52-year-old female admitted to our hospital with complaint of abnormal uterine bleeding and rapidly growing vulvar mass. Excisional biopsy of the mass showed MPNST of the vulva. Afterwards, the patient underwent radical vulvectomy with inguinofemoral lymph node dissection. Short after the surgery, multiple lung metastasis were shown and responded to chemotherapy, but rapid local recurrence occurred short after the completion of the chemotherapy. DISCUSSION: The primary treatment option in MPNSTs is surgical excision with or without adjuvant therapy. There is not enough data about the role of systemic chemotherapy in the management of MPNSTs and it still remains controversial. CONCLUSION: In general, radiation therapy has not been demonstrated to improve overall survival. Complete surgical resection of the primary tumor is the mainstay of the treatment.
Gynecologic Oncology, 2002
It is difficult to recognize epithelioid trophoblastic tumor (ETT) as a trophoblastic disease bec... more It is difficult to recognize epithelioid trophoblastic tumor (ETT) as a trophoblastic disease because of its rarity and growth pattern simulating a carcinoma. A 36-year-old woman with stage IB(1) squamous cell carcinoma of the uterine cervix and a high serum beta-human chorionic gonadotropin (beta-hCG) level underwent radical hysterectomy with pelvic and para-aortic lymphadenectomy. However, light microscopic findings and immunohistochemical studies with pan-cytokeratin, epithelial membrane antigen, inhibin-alpha, beta-hCG, and human placental lactogen revealed ETT of the endocervix. The patient is alive with no evidence of disease 12 months after surgery. Before the patient is resorted to radical surgical interventions for assumed cervical carcinoma, ETT should be ruled out in women of reproductive age with endocervical tumors and elevated serum beta-hCG levels.
Gynecologic and Obstetric Investigation, 2003