Opeyemi Adeloye - Academia.edu (original) (raw)

Papers by Opeyemi Adeloye

Social Science Research Network, Oct 19, 2020

Covid-19

Social Science Research Network, Jun 9, 2019

This abstract discussed preamble of effects of therapeutic exercise on motor symptoms of Parkinso... more This abstract discussed preamble of effects of therapeutic exercise on motor symptoms of Parkinson’s disease. By definition, Parkinson disease (PD) is a progressive chronic nervous system disease resulted from decrease in amount of dopamine production in substantia nigra. This is characterized by tremor at rest, abnormal gait pattern (Shuffling gait), bradykinesia and rigidity. Motor complication accompanied by motor symptom due to the loss of straiatal dopaminergic neuron. There are symptoms of motor complication of PD (Parkinson’s disease) which includes postural instability, rigidity, bradykinesia and shuffling gait pattern. The manifestation of the symptom affects quality of life and social interaction. PD has negative influence on patients and the caregiver. However, research has suggested that people suffering from motor complication of Parkinson disease are managed through therapeutic exercise intervention. Geriatrics categories have been found more with PD. Available studies in the literature indicate that therapeutic protocol has to focus on: cueing strategies, balance, cognitive movement strategies and improved physical capacity. Therapeutic motor training exercise for PD patients have been designed and evaluated but only specific training strategies tailored for each patient, may produce improvements in gait speed and stride length, decrease motor and balance symptoms and improve quality of life. Furthermore, therapeutic exercise such as balance and coordination training may improve muscle trophism and postural balance and strength. It seems reasonable to state that tailored therapeutic exercise is the physical activities that is structure, planned and repetitive and condition for any part of the body which is a valid tool to be included in the therapeutic program of PD patients, considering that this therapeutic exercise may alieviate the symptoms as well as the overall physical incapacity, reduce the risk of falls and injuries, and ultimately improve quality of life and social interaction

Synaptic plasticity is a biological system of specific pattern of synaptic activity result in cha... more Synaptic plasticity is a biological system of specific pattern of synaptic activity result in changes in synaptic strength. This influence puberty, pregnancy hormones, sensory experiences, and brain disorders. Long-term synaptic plasticity is accompanied by protein synthesis and trafficking, leading to structural changes of the synapse. Increasing evidence connects the terminal synaptic changes with potential propagation in adolescent and pregnancy. We investigate on the synaptic structural plasticity, which has mainly been studied with in vivo twophoton laser scanning microscopy. We also discuss how a different type of synapses, the multicontact synapses associated with pregnancy.

Journal of Dermatology Research Reviews & Reports, 2020

Alzheimer disease (AD) is the most common neurodegenerative disease and form of dementia. The pep... more Alzheimer disease (AD) is the most common neurodegenerative disease and form of dementia. The peptide amyloid-β (Aβ) is a most therapeutic target in AD on the basis of pathological and genetic suffices that supports a role for this molecule in the disease process. Studies show that Aβ immunotherapies (Active and passive) have been revealed to alleviate cerebral Aβ levels and improve cognition in animal models of AD. In humans, clinical trial phase 2 AN1792 conducted by Elan et al stated that Aβ vaccine was stopped when ~6% of the immunized patients developed meningoencephalitis. However, some plaque clearance and modest clinical improvements were observed in patients following immunization. In this study, Aβ immunotherapies will be discussed. Passive and active method of treatment in human and non-human primate with AD will also be review. Preclinical studies and the limited data from clinical trials and non-human primates’ evidence suggest Aβ immunotherapy as the most effective in ...

Journal of Neurology and Neuroscience, 2020

Transcranial magnetic stimulation is a painless noninvasive brain stimulation technique that used... more Transcranial magnetic stimulation is a painless noninvasive brain stimulation technique that used in cortical function in healthy individuals and inter alia, the pathophysiology of movement disorders. Many years, its use has evolved from primarily research purposes to treatment of a large variety of neurological and psychiatric diseases. In this article, we describe the theoretical background to TMS techniques and discuss the uses of TMS as a potential diagnostic tool in movement disorders. We also illustrate the basic principles on which the therapeutic use of transcranial magnetic stimulation is based and review the clinical trials that have been performed in patients with movement disorders.

The National Program for Food Security (NPFS) is designed to contribute to a sustainable improvem... more The National Program for Food Security (NPFS) is designed to contribute to a sustainable improvement in national food security. The main implementation strategy of the programme is to empower small farmer communities with a timely provision of credit, agricultural input, and technical support services to increase farmers’ output and income on a sustainable basis. The present study was designed to examine factors influencing a farmer’s participation in the NPFS as well as the resource productivity of farmers within and outside the NPFS activities in Nigeria. We employed an endogenous switching regression with a sample selection model on a total of 176 farmers (89 within and 87 outside) for the econometrics analysis. The empirical evidence from the Probit model indicates that variables such as education, age, extension, farm size and hired labour significantly increased the probability of a farmer’s participation in the NPFS. The estimates of the endogenous switching regression model ...

Background:The lack of awareness of several health conditions among people of the community has b... more Background:The lack of awareness of several health conditions among people of the community has been on the rise. This study however is aimed at the youths of the society specifically corps members as there is dearth in the evidence on the level of awareness and knowledge in our youth particularly corps members. Methodology: This study is a cross sectional survey among serving corps members within in Nnewi north local government. Information on knowledge and perception on HIV/AIDS, Tuberculosis and Hepatitis was sort through a structure questionnaire. Descriptive analysis was used in analysing the data obtained. Result: One hundred questionnaire were distributed but 76 questionnaire were with complete information and analysed, representing 76% response rate, comprising 27(35.5%) male and 49(64.5) female, with a M : F ratio of 1:1.8.Fifteen CDS group participated in the survey, out of which Health and Drug free CDS Group had the highest respondent, health 10(13.2%) and Drug free 9(11...

Journal of metabolic syndrome, 2020

We are grateful for editors and reviewers of the Journal of Neurological Disorders, and we also v... more We are grateful for editors and reviewers of the Journal of Neurological Disorders, and we also very much appreciate your suggestions, which have been very helpful in improving the manuscript. We also thank the reviewers for their careful reading of our text.

International Journal of Clinical Case Reports and Reviews, 2021

Objective To compare group supervised exercise (GE) and individual exercise (IE) in a hospital se... more Objective To compare group supervised exercise (GE) and individual exercise (IE) in a hospital setting, in terms of improvement in quality of life, gait and balance and social interaction. Study Design and Setting This was a prospective cohort study in Jos (Plateau State) Participants Sixty seven patients completed the outcome data. Measures Daily activities were measured by the bartel index, tinetti scale (balance and gait), short form SF-36 health survey to compare quality of life. Results No statically significant differences were found between the two groups regarding the symptoms of PD. After exercise supervised by physiotherapist both group showed significant improvement from each measurement. These improvements were better in individual than group supervised exercise patient with all functionality scales with a smaller margin. Conclusion Individual supervised exercise is more effective than group supervised exercise in term of improvement in quality of life, activities of dai...

Online Journal of Neurology and Brain Disorders, 2020

that glutamate receptor-mediated synaptic plasticity, in particular long-term depression (LTD), i... more that glutamate receptor-mediated synaptic plasticity, in particular long-term depression (LTD), is important for elimination of synaptic contacts in brain synaptic changes during pregnancy. Synaptic changes influenced differently by development, sensory

Asian Journal of Basic Science & Research, 2020

Parkinson disease (PD) is a progressive chronic nervous system disease resulted from decrease in ... more Parkinson disease (PD) is a progressive chronic nervous system disease resulted from decrease in amount of dopamine production in substantia nigra. Studies shows that human being evolved a symbiotic relationship with their gut microbiome, a complex microbial community composed of bacteria, archaea, protists, and viruses. The enteric nervous system (ENS) is a gateway for the bidirectional communication between the brain and the gut, mostly through the vagus nerve (VN). Environmental exposure plays a vital role in both the composition and functionality of the gut microbiome and may contribute to susceptibility to neurodegenerative disorders, such as Parkinson's disease (PD). The neuropathological hallmark of PD is the widespread appearance of alpha-synuclein aggregates in both the central and peripheral nervous systems, including the ENS. Studies suggest that gut toxins can induce the formation of α-syn aggregates in the ENS, which may then be transmitted in a prion-like manner to the CNS through the vagus nerve. PD is strongly associated with aging and its negative effects on homeostatic mechanisms protecting from inflammation, oxidative stress, and protein malfunction. In this mini-review we attempt to concisely summarize the papers in the field of the gut-brain axis and Parkinson's disease. We focus on evidence showing gut-association and related microbial-derived components of PD. Therefore, the gut microbiome emerges as a potential target for protective measures aiming to prevent PD onset.

Technology and health care : official journal of the European Society for Engineering and Medicine, 2014

There is a paucity of data on effects of motor-level stimulation using Transcutaneous Electrical ... more There is a paucity of data on effects of motor-level stimulation using Transcutaneous Electrical Nerve Stimulator (TENS) on ipsilateral quadriceps femoris group of muscles. The effect is also unknown on the untrained contralateral quadriceps femoris. The primary purpose of this study was to determine the effect of TENS on quadriceps muscle strength at the stimulated ipsilateral and un-stimulated contra-lateral extremities. Participants were 50 apparently healthy undergraduate. They were recruited using sample of convenience. The right quadriceps group of muscles were stimulated for 15 minutes twice a week for 8 weeks using motor-level stimulation parameters (frequency of 85 Hz and pulse width of 100 microseconds) while the left lower limbs (control) were not stimulated. The right and left quadriceps muscle strengths were quantified using tensiometer; at onset and after 8 weeks. The data were analysed using the descriptive and inferential statistics (paired t-test and ANOVA). Alpha l...

Annals of Indian Academy of Neurology, 2013

and less sensitive for early diagnosis. [5] In the default mode networking of the brain, motor pa... more and less sensitive for early diagnosis. [5] In the default mode networking of the brain, motor pathways are harbored in the frontal circuits and parietal lobes are concerned with inhibition. Transcranial Magnetic Stimulation (TMS) being a non-invasive test the presence of specific features if found will improve the anti-mortem diagnostic accuracy greatly without the use of invasive tools. Studies in TMS in dementia are not there from India to our knowledge and the aim of this study was to find out whether considerable differences in TMS parameters are there between FTD and AD in early stages. If present it will serve as a diagnostic bio-marker. Paired pulse was not used as the aim of this pilot study was not to analyze the pathophysiological mechanisms of alteration in these parameters. There is conflicting reports regarding the basis of alteration in the TMS parameters in patients with AD and FTD when studied using single pulse and paired pulse paradigms. TMS serves as a simple method of evaluating the excitatory and inhibitory properties of the motor cortex. [6] The threshold of motor response is an index of excitability of the corticospinal motor neurons and the amplitude of the motor response and duration of silent period (SP) is related to cortical inhibition mediated through gamma-aminobutyric acid (GABA)-B receptors. Using a study performed in fifteen patients with a single pulse stimulation the authors found the following changes in Alzheimer's disease using the short-latency afferent inhibition (SAI), which is produced by inhibitory interactions

Brain and Neurological Disorders

The purpose of this article is to highlight the main evaluation techniques used in body balance. ... more The purpose of this article is to highlight the main evaluation techniques used in body balance. We discussed movement regulation, biomechanical, metric characteristics, validity, objectivity, repeatability, sensitivity for the practical use of every assessment. We also identify critical research-based reviews, Pros and cons of the body balance tests. The techniques are widely used in rehabilitation, sports medicine, and laboratory. The article closes with a summary of human balance and proposals for future research work.