Opher Globus - Academia.edu (original) (raw)
Papers by Opher Globus
Journal of Clinical Oncology, 2019
9103 Background: Millions of dollars invested in improving outcomes for metastatic lung cancer pa... more 9103 Background: Millions of dollars invested in improving outcomes for metastatic lung cancer patients are essentially aimed at extending long term survival, with significant benefits being achieved over the last decade. However, little is known about lung cancer patients who die rapidly after diagnosis, potentially being deprived of these advances. We analyzed population-based data to describe real-world outcomes in metastatic lung cancer patients focusing on patients with early mortality. Methods: Using the Survival, Epidemiology and End Results (SEER) Database we analyzed adult metastatic lung cancers diagnosed between 1994-2014. This period was divided into 3 equal time periods: 1994-2000 (TP1), 2001-2007 (TP2) and 2008-2014 (TP3). Early mortality was defined as death within 2 months of diagnosis. Correlations between categorical variables were analyzed with chi squared tests and survival was analyzed using the Kaplan-Meier method. Results: Of 276,527 patients diagnosed with me...
Annals of breast surgery, Dec 1, 2023
Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the ris... more Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the rise. Neoadjuvant treatment is equally effective as adjuvant treatment in preventing disease recurrence and death. The role of neoadjuvant treatment is unique for each breast cancer subtype. Neoadjuvant systemic therapy can improve surgical outcomes, provide valuable prognostic information and the response can guide post operative systemic treatment decisions. There is a growing need for all disciplines involved in the treatment of early breast cancer to discuss with patients the potential role of neoadjuvant treatment for their tumor subtype. To better guide the use of neoadjuvant systemic treatment we aim to detail its unique role in the three breast cancer subtypes with a focus on patient selection, surgical and oncological benefits, and future directions. Methods: We performed a search of the PubMed, Cochrane Review, and Clinical Trials.gov databases. We used the search terms "neoadjuvant chemotherapy" AND "breast cancer" and then conducted a thorough manual review of all bibliographies and relevant studies to identify additional potentially eligible studies.
Foot & Ankle International, Sep 11, 2014
Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cr... more Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cross-sectional area, in response to endurance training exercise remains in question. We investigated the hypothesis that transition from civilian life through 6 months of elite infantry training would induce adaptive Achilles tendon hypertrophy. Seventy-two new elite infantry recruits had the cross-sectional area of their Achilles tendons measured at a point 2.5 cm proximal to the Achilles insertion by ultrasound before beginning elite infantry training. Measurements were repeated by the same ultrasonographer for those recruits who were still in the training program at 6 months. Prior to beginning the study the intraobserver reliability of the ultrasonographer's Achilles tendon measurements was calculated (intraclass correlation coefficient = .96). Fifty-five recruits completed 6 months of training. The mean cross-sectional area of their right Achilles tendon increased from 47.0 ± 11.2 to 50.2 ± 9.6 mm(2) (P = .037) and the left Achilles tendon from 47.2 ± 8.9 to 51.1 ± 8.3 mm(2) (P = .013). The change in cross-sectional area did not correlate with subject height, weight, prior sport history, or jumping and running abilities. An abrupt stimulus of 6 months of elite infantry training was adequate to induce hypertrophic changes in the Achilles tendon. This is the first human prospective study showing an increase in the Achilles tendon cross-sectional area in response to rigorous endurance type training. The finding supports the hypothesis that the Achilles tendon in response to sufficiently high and sustained loading can remodel its morphological properties and thereby strengthen itself. Level II, etiology study.
Cancer Research, Mar 1, 2023
Cancer Research, 2022
Background. Neoadjuvant chemotherapy (NACT) is increasingly administered for high-risk breast can... more Background. Neoadjuvant chemotherapy (NACT) is increasingly administered for high-risk breast cancer patients. Yet, oncologists lack an effective method for assessing response to treatment beyond clinicpathological features. Organ tissue slices freshly obtained from the tumor and incubated in appropriate media, recapitulate the tumor’s heterogeneity and may provide a superior ex-vivo model for predicting response/resistance to treatment. While these models were tested in metastatic tumors, no studies up to date have been reported in early breast cancer or for NACT. These tests have short turnaround time (7-9 days), critical for the neoadjuvant setting. Here we aimed to prove the feasibility of performing cResponse assay, an ex vivo organ culture (EVOC), on freshly derived pre-treatment core needle biopsies and to evaluate it as a tool for predicting response to NACT in breast cancer. Methods. Pre-treatment tumor biopsies were obtained from breast cancer patients about to undergo NAC...
Whether the cross-sectional area (CSA) and mechanical properties of the human Achilles tendon cha... more Whether the cross-sectional area (CSA) and mechanical properties of the human Achilles tendon change in response to habitual exercise remains largely unexplored. The present study evaluated the CSA and contraction-induced displacement of the aponeurosis-tendon complex of the triceps surae in 11 untrained subjects before (tests 1 and 2) and after (test 3) ϳ9 mo of regular running (ϳ78 training sessions). Displacement of the tendon-aponeurosis complex obtained by ultrasonography; electromyography of the gastrocnemius, soleus, and dorsiflexor muscles; and joint angular rotation were recorded during graded isometric plantarflexion ramps. Tendon CSA and moment arm were measured by using MRI, and tendon force was calculated from joint moments and tendon moment arm. A treadmill test was used to determine submaximal oxygen consumption (V O2) at a given speed and maximal V O2. The total running duration was ϳ43 h, distributed over 34 wk. Maximal V O2 increased 8.6% (P Ͻ 0.01), and submaximal V O2 decreased 6.2% (P Ͻ 0.05). Tendon-aponeurosis displacement during maximal voluntary contraction was unchanged (tests 1-3, 5.2 Ϯ 0.6, 5.2 Ϯ 0.5, and 5.3 Ϯ 0.4 mm, respectively) and yielded a structural stiffness of 365 Ϯ 50, 358 Ϯ 40, and 384 Ϯ 52 N/mm for tests 1-3, respectively (P Ͼ 0.05). Tendon CSA also remained unchanged (tests 1-3, 34.2 Ϯ 2.2, 33.9 Ϯ 2.2, and 33.8 Ϯ 2.1 mm 2 , respectively). In conclusion, a total training stimulus of ϳ9 mo of running in previously untrained subjects was adequate to induce significant cardiovascular improvements, although it did not result in any changes in the mechanical properties of the triceps surea tendon-aponeurosis complex or in the dimensions of Achilles tendon.
Foot & ankle international, 2014
Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cr... more Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cross-sectional area, in response to endurance training exercise remains in question. We investigated the hypothesis that transition from civilian life through 6 months of elite infantry training would induce adaptive Achilles tendon hypertrophy. Seventy-two new elite infantry recruits had the cross-sectional area of their Achilles tendons measured at a point 2.5 cm proximal to the Achilles insertion by ultrasound before beginning elite infantry training. Measurements were repeated by the same ultrasonographer for those recruits who were still in the training program at 6 months. Prior to beginning the study the intraobserver reliability of the ultrasonographer's Achilles tendon measurements was calculated (intraclass correlation coefficient = .96). Fifty-five recruits completed 6 months of training. The mean cross-sectional area of their right Achilles tendon increased from 47.0 ± 11....
Annals of Breast Surgery
Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the ris... more Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the rise. Neoadjuvant treatment is equally effective as adjuvant treatment in preventing disease recurrence and death. The role of neoadjuvant treatment is unique for each breast cancer subtype. Neoadjuvant systemic therapy can improve surgical outcomes, provide valuable prognostic information and the response can guide post operative systemic treatment decisions. There is a growing need for all disciplines involved in the treatment of early breast cancer to discuss with patients the potential role of neoadjuvant treatment for their tumor subtype. To better guide the use of neoadjuvant systemic treatment we aim to detail its unique role in the three breast cancer subtypes with a focus on patient selection, surgical and oncological benefits, and future directions. Methods: We performed a search of the PubMed, Cochrane Review, and Clinical Trials.gov databases. We used the search terms "neoadjuvant chemotherapy" AND "breast cancer" and then conducted a thorough manual review of all bibliographies and relevant studies to identify additional potentially eligible studies.
Archives of Medicine, 2017
Cerebrospinal fluid pleocytosis has rarely been described as a possible transient finding followi... more Cerebrospinal fluid pleocytosis has rarely been described as a possible transient finding following epileptic activity. We report a 68-year-old woman who presented with acute confusion and Cerebrospinal fluid pleocytosis. No evidence of an inflammatory, infectious or neoplastic cause explaining the pleocytosis was found. We presume that the pleocytosis in this patient was a result of epileptic convulsions. The mechanism for this finding is not fully understood.
Cancer Research, Mar 1, 2023
Journal of Clinical Oncology, 2019
9103 Background: Millions of dollars invested in improving outcomes for metastatic lung cancer pa... more 9103 Background: Millions of dollars invested in improving outcomes for metastatic lung cancer patients are essentially aimed at extending long term survival, with significant benefits being achieved over the last decade. However, little is known about lung cancer patients who die rapidly after diagnosis, potentially being deprived of these advances. We analyzed population-based data to describe real-world outcomes in metastatic lung cancer patients focusing on patients with early mortality. Methods: Using the Survival, Epidemiology and End Results (SEER) Database we analyzed adult metastatic lung cancers diagnosed between 1994-2014. This period was divided into 3 equal time periods: 1994-2000 (TP1), 2001-2007 (TP2) and 2008-2014 (TP3). Early mortality was defined as death within 2 months of diagnosis. Correlations between categorical variables were analyzed with chi squared tests and survival was analyzed using the Kaplan-Meier method. Results: Of 276,527 patients diagnosed with me...
Annals of breast surgery, Dec 1, 2023
Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the ris... more Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the rise. Neoadjuvant treatment is equally effective as adjuvant treatment in preventing disease recurrence and death. The role of neoadjuvant treatment is unique for each breast cancer subtype. Neoadjuvant systemic therapy can improve surgical outcomes, provide valuable prognostic information and the response can guide post operative systemic treatment decisions. There is a growing need for all disciplines involved in the treatment of early breast cancer to discuss with patients the potential role of neoadjuvant treatment for their tumor subtype. To better guide the use of neoadjuvant systemic treatment we aim to detail its unique role in the three breast cancer subtypes with a focus on patient selection, surgical and oncological benefits, and future directions. Methods: We performed a search of the PubMed, Cochrane Review, and Clinical Trials.gov databases. We used the search terms "neoadjuvant chemotherapy" AND "breast cancer" and then conducted a thorough manual review of all bibliographies and relevant studies to identify additional potentially eligible studies.
Foot & Ankle International, Sep 11, 2014
Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cr... more Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cross-sectional area, in response to endurance training exercise remains in question. We investigated the hypothesis that transition from civilian life through 6 months of elite infantry training would induce adaptive Achilles tendon hypertrophy. Seventy-two new elite infantry recruits had the cross-sectional area of their Achilles tendons measured at a point 2.5 cm proximal to the Achilles insertion by ultrasound before beginning elite infantry training. Measurements were repeated by the same ultrasonographer for those recruits who were still in the training program at 6 months. Prior to beginning the study the intraobserver reliability of the ultrasonographer's Achilles tendon measurements was calculated (intraclass correlation coefficient = .96). Fifty-five recruits completed 6 months of training. The mean cross-sectional area of their right Achilles tendon increased from 47.0 ± 11.2 to 50.2 ± 9.6 mm(2) (P = .037) and the left Achilles tendon from 47.2 ± 8.9 to 51.1 ± 8.3 mm(2) (P = .013). The change in cross-sectional area did not correlate with subject height, weight, prior sport history, or jumping and running abilities. An abrupt stimulus of 6 months of elite infantry training was adequate to induce hypertrophic changes in the Achilles tendon. This is the first human prospective study showing an increase in the Achilles tendon cross-sectional area in response to rigorous endurance type training. The finding supports the hypothesis that the Achilles tendon in response to sufficiently high and sustained loading can remodel its morphological properties and thereby strengthen itself. Level II, etiology study.
Cancer Research, Mar 1, 2023
Cancer Research, 2022
Background. Neoadjuvant chemotherapy (NACT) is increasingly administered for high-risk breast can... more Background. Neoadjuvant chemotherapy (NACT) is increasingly administered for high-risk breast cancer patients. Yet, oncologists lack an effective method for assessing response to treatment beyond clinicpathological features. Organ tissue slices freshly obtained from the tumor and incubated in appropriate media, recapitulate the tumor’s heterogeneity and may provide a superior ex-vivo model for predicting response/resistance to treatment. While these models were tested in metastatic tumors, no studies up to date have been reported in early breast cancer or for NACT. These tests have short turnaround time (7-9 days), critical for the neoadjuvant setting. Here we aimed to prove the feasibility of performing cResponse assay, an ex vivo organ culture (EVOC), on freshly derived pre-treatment core needle biopsies and to evaluate it as a tool for predicting response to NACT in breast cancer. Methods. Pre-treatment tumor biopsies were obtained from breast cancer patients about to undergo NAC...
Whether the cross-sectional area (CSA) and mechanical properties of the human Achilles tendon cha... more Whether the cross-sectional area (CSA) and mechanical properties of the human Achilles tendon change in response to habitual exercise remains largely unexplored. The present study evaluated the CSA and contraction-induced displacement of the aponeurosis-tendon complex of the triceps surae in 11 untrained subjects before (tests 1 and 2) and after (test 3) ϳ9 mo of regular running (ϳ78 training sessions). Displacement of the tendon-aponeurosis complex obtained by ultrasonography; electromyography of the gastrocnemius, soleus, and dorsiflexor muscles; and joint angular rotation were recorded during graded isometric plantarflexion ramps. Tendon CSA and moment arm were measured by using MRI, and tendon force was calculated from joint moments and tendon moment arm. A treadmill test was used to determine submaximal oxygen consumption (V O2) at a given speed and maximal V O2. The total running duration was ϳ43 h, distributed over 34 wk. Maximal V O2 increased 8.6% (P Ͻ 0.01), and submaximal V O2 decreased 6.2% (P Ͻ 0.05). Tendon-aponeurosis displacement during maximal voluntary contraction was unchanged (tests 1-3, 5.2 Ϯ 0.6, 5.2 Ϯ 0.5, and 5.3 Ϯ 0.4 mm, respectively) and yielded a structural stiffness of 365 Ϯ 50, 358 Ϯ 40, and 384 Ϯ 52 N/mm for tests 1-3, respectively (P Ͼ 0.05). Tendon CSA also remained unchanged (tests 1-3, 34.2 Ϯ 2.2, 33.9 Ϯ 2.2, and 33.8 Ϯ 2.1 mm 2 , respectively). In conclusion, a total training stimulus of ϳ9 mo of running in previously untrained subjects was adequate to induce significant cardiovascular improvements, although it did not result in any changes in the mechanical properties of the triceps surea tendon-aponeurosis complex or in the dimensions of Achilles tendon.
Foot & ankle international, 2014
Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cr... more Whether the human Achilles tendon undergoes hypertrophic changes as measured by an increase in cross-sectional area, in response to endurance training exercise remains in question. We investigated the hypothesis that transition from civilian life through 6 months of elite infantry training would induce adaptive Achilles tendon hypertrophy. Seventy-two new elite infantry recruits had the cross-sectional area of their Achilles tendons measured at a point 2.5 cm proximal to the Achilles insertion by ultrasound before beginning elite infantry training. Measurements were repeated by the same ultrasonographer for those recruits who were still in the training program at 6 months. Prior to beginning the study the intraobserver reliability of the ultrasonographer's Achilles tendon measurements was calculated (intraclass correlation coefficient = .96). Fifty-five recruits completed 6 months of training. The mean cross-sectional area of their right Achilles tendon increased from 47.0 ± 11....
Annals of Breast Surgery
Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the ris... more Background and Objective: The use of neoadjuvant systemic therapy for breast cancer is on the rise. Neoadjuvant treatment is equally effective as adjuvant treatment in preventing disease recurrence and death. The role of neoadjuvant treatment is unique for each breast cancer subtype. Neoadjuvant systemic therapy can improve surgical outcomes, provide valuable prognostic information and the response can guide post operative systemic treatment decisions. There is a growing need for all disciplines involved in the treatment of early breast cancer to discuss with patients the potential role of neoadjuvant treatment for their tumor subtype. To better guide the use of neoadjuvant systemic treatment we aim to detail its unique role in the three breast cancer subtypes with a focus on patient selection, surgical and oncological benefits, and future directions. Methods: We performed a search of the PubMed, Cochrane Review, and Clinical Trials.gov databases. We used the search terms "neoadjuvant chemotherapy" AND "breast cancer" and then conducted a thorough manual review of all bibliographies and relevant studies to identify additional potentially eligible studies.
Archives of Medicine, 2017
Cerebrospinal fluid pleocytosis has rarely been described as a possible transient finding followi... more Cerebrospinal fluid pleocytosis has rarely been described as a possible transient finding following epileptic activity. We report a 68-year-old woman who presented with acute confusion and Cerebrospinal fluid pleocytosis. No evidence of an inflammatory, infectious or neoplastic cause explaining the pleocytosis was found. We presume that the pleocytosis in this patient was a result of epileptic convulsions. The mechanism for this finding is not fully understood.
Cancer Research, Mar 1, 2023