Orhan Unal - Academia.edu (original) (raw)
Papers by Orhan Unal
trsgo.dergisi.org
Amaç: Bu çalışmada erken evre serviks kanseri tanısı alan ve Hastanemiz Kadın Hastalıkları ve Doğ... more Amaç: Bu çalışmada erken evre serviks kanseri tanısı alan ve Hastanemiz Kadın Hastalıkları ve Doğum Kliniğinde tip 3 radikal histerektomi yapılan hastalarda operasyon sonrası oluşan komplikasyonları, patolojik sonuçlarını, prognozu etkileyen parametreleri ve sağkalımları ...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1999
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Amaç: Doğal ve cerrahi yol ile menopoza giren hastalara] hormon replasman tedavisine verdikleri c... more Amaç: Doğal ve cerrahi yol ile menopoza giren hastalara] hormon replasman tedavisine verdikleri cevabın monitorizasvonıında Kupperman indeksi, hipoöstrojenemik in
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Amaç: 7 hcı/ıa ıv üstü gebelik lerıııiıtasvoıımıda oral misoprostal 'iiıı, servikal Dihuasyoiı iç... more Amaç: 7 hcı/ıa ıv üstü gebelik lerıııiıtasvoıımıda oral misoprostal 'iiıı, servikal Dihuasyoiı için etkinliğini, güve nilirliğini ve vatı etkisinin gösterilmesi ıımaçhımlı. Çalışmalım yapıldığı yer: Sağlık Hakanlığı. Kartal Eğitim ve i ray tı rina IhıstaneCı Kadın Hastalıkları ve Poğııııı Kliniği Materyal ve M et od: Hu prospı-ki i/' çalışmada ınıssed ahoriııs. /etol ölüm ıvıvv medi/uil nedenli gebelik terminasyoıııı yapılacak ii başlaya pcroral, misoprosıol, i satıl artıy la 40Ö ııg dazda, verildi.4S sual içimle ahoriııs veya doğum gerçekleştnı î'e hislıup skorunun o ve üstümle olan vakalarda uygulamayı başarılı kahııl ettik. Ilulgular: Hastaların "•'> l >(>. " sinde 4<S saat içinde ahoriııs veva doğum gerçekleşti. Yan etki olarak en \ık görülen ateş hastaların ":,'). 6 sinde görüldü. Sonuç: 7 haftanın üstündeki gebelik ternıinasyoıuı için. miso prasıol güvenli ve etkin bir afandtr.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Amaç: Ovaryen musinöz kistadenom nedeniyle öpere edilen bir hastada ilk operasyondan 3.5 yıl sonr... more Amaç: Ovaryen musinöz kistadenom nedeniyle öpere edilen bir hastada ilk operasyondan 3.5 yıl sonra pseudomyxoma peritonei saptanması nedeniyle literatür gözden geçirildi.
Amaç: Overin malign mikst mezodermal tümörleri nadir görülür. Bu nedenle tedavileri konusunda fik... more Amaç: Overin malign mikst mezodermal tümörleri nadir görülür. Bu nedenle tedavileri konusunda fikir birliði yoktur. Olgumuz eþliðinde, malign mikst mezodermal tümörlerin taný, patoloji, tedavi ve prognozunu tartýþtýk.
Iranian journal of pediatrics, 2010
Prevalence of low birth weight deliveries may vary across different environments. The necessity o... more Prevalence of low birth weight deliveries may vary across different environments. The necessity of determination of regional data prompted this study. Information of all deliveries from January 2004 to December 2008 was obtained from delivery registry records retrospectively. Initial data including birth weight, vital status, sex, maternal age and mode of delivery were recorded using medical files. The frequency of low birth weight, very low birth weight, extremely low birth weight and stillbirth deliveries were determined. Among 19,533 total births, there were 450 (23.04 per 1000) stillbirths. Low birth weight rate was 10.61%. A significant increase in yearly distribution of low birth weight deliveries was observed (P<0.001). Very low birth weight and extremely low birth weight delivery rates were 3.14% and 1.58% respectively. Among 2073 low birth weight infants, 333 (16.06%) were stillbirths. The stillbirth delivery rate and the birth of a female infant among low birth weight d...
JPMA. The Journal of the Pakistan Medical Association, 2010
To investigate the relationship between adverse pregnancy outcomes and unexplained elevations of ... more To investigate the relationship between adverse pregnancy outcomes and unexplained elevations of second trimester maternal serum human chorionic gonadotropin (hCG), alpha fetoprotein (AFP) levels and uterine artery Doppler measurements. A total of 144 women between 16-20 weeks of gestation that applied to our clinic for triple test were enrolled into the study. Study group consisted of 84 pregnant women with hCG and/or AFP levels > or =2 MoM. Control group comprised of 60 pregnant women with hCG and AFP levels <2 MoM. Study group was further subdivided into 3 subgroups: Subgroup I; only AFP> or =2 MoM (n=30), subgroup II; only hCG > or =2 MoM (n=64) and subgroup III; both AFP and hCG > or =2 MoM (n=10). Operative delivery rate (p = 0.0017), overall complication rate (p=0.0002), bilateral early diastolic notch presence rate (p = 0.015) were high and mean birth weight was low (p=0.045) in the study group. In subgroup I patients, low birth weight [LBW] (p = 0.0008), pret...
Journal of Pelvic Medicine and Surgery, 2006
... Pelvic Tuberculosis Simulating Advanced Ovarian Malignancy. Karsidag, A Yasemin Karageyim MD;... more ... Pelvic Tuberculosis Simulating Advanced Ovarian Malignancy. Karsidag, A Yasemin Karageyim MD; Api, Olus MD; Dansuk, Ramazan MD; Kotil, Gonul MD; Kars, Bulent MD; Unal, Orhan MD;Turan, M Cem MD. Article Outline. Collapse Box Author Information. ...
Ultrasound in Obstetrics and Gynecology, 2006
We report a case of cervical ectopic pregnancy successfully treated with systemic methotrexate. C... more We report a case of cervical ectopic pregnancy successfully treated with systemic methotrexate. Conservative management with single-dose methotrexate was undertaken, but owing to the failure of human chorionic gonadotropin (hCG) levels to fall by 15% by day 7 and the persistence of fetal cardiac activity, two further doses of methotrexate were required. The patient's hCG levels were monitored, and repeat transvaginal ultrasonography was performed until complete resolution of the pregnancy by spontaneous miscarriage. We describe the ultrasonographic findings, which showed that the sac size increased despite treatment.
Journal of Maternal-Fetal and Neonatal Medicine, 2010
... 2010 Sep;23(9):1069-71. Fetal retroperitoneal lipoblastoma: ultrasonographic appearance of a ... more ... 2010 Sep;23(9):1069-71. Fetal retroperitoneal lipoblastoma: ultrasonographic appearance of a rare embryonal soft tissue tumor. Api O, Akil A, Uzun MG, Acioglu HC, Yalcin O, Api M, Unal O. PMID: 20718582 [PubMed - indexed for MEDLINE]. Publication Types: ...
Gynecological Endocrinology, 2004
Using an ultrasensitive assay, prostate-specific antigen (PSA) has been detected in female serum ... more Using an ultrasensitive assay, prostate-specific antigen (PSA) has been detected in female serum and has been proposed as a potential marker of androgen excess in hirsute women. Measurement of PSA levels in serum may play a role in monitoring hirsutism during antiandrogen therapy. We investigated the role of PSA as a marker of androgen activity in hirsute patients taking spironolactone together with oral contraceptive pills containing ethinyl estradiol and gestodene. Twenty-eight hirsute patients were included in the study. Clinical and biochemical variables including serum levels of PSA (using an ultrasensitive chemiluminscent immunoassay), dehydroepiandrosterone sulfate, total testosterone, free testosterone and 17-hydroxyprogesterone concentrations were recorded at baseline and after six cycles of treatment. Fifteen healthy women were included in the study as controls. Serum PSA levels in hirsute women were clearly higher than in the control group (0.023 +/- 0.004 vs. 0.006 +/- 0.003 ng/ml, p < 0.001) and correlated with baseline serum free testosterone concentrations (r = 0.518, p = 0.005). After 6 months, serum PSA concentrations as compared with baseline values did not change significantly in patients who were given spironolactone plus contraceptive pills (p = 0.4) despite a marked decrease in total testosterone, free testosterone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate and hirsutism score (p < 0.05). Thus, serum PSA levels in hirsute women were higher than in non-hirsute healthy controls. A 6-month course of treatment with spironolactone combined with contraceptive pills containing ethinylestradiol and gestodene did not reduce high serum PSA levels in these subjects. In conclusion, the serum PSA level is not a convenient biochemical marker with the available assays for the management of hirsute women treated with the combination of spironolactone and oral contraceptives.
Gynecological Endocrinology, 2005
The objective of the present study was to compare the effects of various gestagens on insulin sen... more The objective of the present study was to compare the effects of various gestagens on insulin sensitivity in postmenopausal women on hormone replacement therapy (HRT). This prospective study enrolled 156 postmenopausal women who had menopausal status for at least 6 months. Group 1 was treated with 17b-estradiol (E 2 ; 2 mg) plus norethisterone acetate (NETA; 1 mg); Group 2 was given E 2 (2 mg) plus medroxyprogesterone acetate (MPA; 2.5 mg); Group 3 was given E 2 (2 mg) plus dydrogesterone (DG; 10 mg); and Group 4 was given E 2 (2 mg) plus micronized progesterone (MP; 100 mg). Group 5 was the surgical menopausal group and was given only E 2 (2 mg) continuously. All 156 subjects completed the 3month follow-up on the trial. The patients were analyzed by using homeostatic model assessment (HOMA) for insulin sensitivity before treatment and 3 months after treatment, comparing the effects of various HRT regimens on insulin sensitivity. No significant differences were found in the baseline characteristics of the patients (p 4 0.05). There were no significant differences in mean values of HOMA before HRT among the five groups (p 4 0.05). There were statistically significant differences in mean values of HOMA only in Group 1 (E 2 + NETA) and Group 3 (E 2 + DG) after HRT (p 4 0.05). E 2 + NETA and E 2 + DG were found to improve insulin sensitivity in postmenopausal women after 3 months of treatment, whereas E 2 + MPA, E 2 + MP and E 2 only did not show such an effect in postmenopausal women.
Gynecological Endocrinology, 2007
Women with polycystic ovary syndrome (PCOS) are insulin-resistant and have increased risk for typ... more Women with polycystic ovary syndrome (PCOS) are insulin-resistant and have increased risk for type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). But it is controversial whether the increased risk of CHD and T2DM is associated with endocrine abnormalities occurring as a consequence of PCOS or whether it is related to obesity or metabolic changes frequently seen in women with PCOS. Since both homocysteine (Hcy) and C-reactive protein (CRP) are supposed to predict T2DM and CHD, we investigated their possible relationship with insulin resistance, obesity, hyperandrogenemia and metabolic alterations in 44 PCOS women and 26 healthy controls matched by age and body mass index (BMI). Hcy and CRP levels were significantly elevated in PCOS women compared with controls (13.30 +/- 4.81 vs. 9.02 +/- 3.36 micromol/l, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05 and 4.22 +/- 2.95 vs. 2.66 +/- 2.49 mg/l, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There was no correlation between Hcy and CRP (r = 0.171, p = 0.05) as two risk markers. While plasma Hcy levels were correlated with BMI, ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH), total testosterone, free testosterone, triglyceride and insulin levels and homeostatic model assessment-insulin resistance index (HOMA-IR) (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05), CRP was correlated with BMI, total cholesterol, triglyceride, low-density lipoprotein cholesterol and insulin levels and HOMA-IR (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There was no correlation of CRP with parameters of PCOS such as testosterone and LH/FSH ratio (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Multiple regression analysis revealed BMI as the major factor examined that influenced both Hcy and CRP levels. In PCOS women, plasma levels of Hcy and CRP were significantly elevated compared with age- and BMI-matched controls. Although most of the PCOS-related endocrine and metabolic changes are related to elevated plasma Hcy and CRP levels in PCOS women, BMI seems to be the major factor determining CHD and T2DM in women with PCOS.
Fetal Diagnosis and Therapy, 2005
Single fetal death in a twin pregnancy in the late second or early third trimester is associated ... more Single fetal death in a twin pregnancy in the late second or early third trimester is associated with significant morbidity and mortality rate in the surviving co-twin, especially in monochorionic twin pregnancies. The common causes are twin-to-twin transfusion syndrome, chromosomal abnormalities, and congenital anomalies of the fetus or anomalies of the umbilical cord-placenta. Here we report a case of monochorionic twin pregnancy in which one fetus had a single umbilical artery (SUA) while the co-twin had two umbilical arteries. The twin with SUA died in utero at the 30th week of gestation and the other fetus was delivered by cesarean section immediately due to fetal distress diagnosed by cardiotocography. Disseminated intravascular coagulation and multicystic encephalomalacia have been observed in the surviving neonate. This case and review of the literature suggest that neurologic complication rates are also increased in monochorionic twin pregnancies with single fetal demise de...
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of c... more Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of complex cyst resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen which resolved by administering monthly depot GnRHagonist (GnRH-a) without abandoning the tamoxifen treatment.
… Klinikleri Journal of …, 2010
Kamptomelik displazi (KD) uzun kemiklerde öne doğru eğrilik ile karakterize nadir görülen bir isk... more Kamptomelik displazi (KD) uzun kemiklerde öne doğru eğrilik ile karakterize nadir görülen bir iskelet displazisidir. XY karyotipine sahip hastaların çoğunluğunda kuşkulu dış genitalya mevcuttur. SRY ilişkili gendeki mutasyon, SOX9, bu hastalığın sorumlusudur. İskelet ...
trsgo.dergisi.org
Amaç: Bu çalışmada erken evre serviks kanseri tanısı alan ve Hastanemiz Kadın Hastalıkları ve Doğ... more Amaç: Bu çalışmada erken evre serviks kanseri tanısı alan ve Hastanemiz Kadın Hastalıkları ve Doğum Kliniğinde tip 3 radikal histerektomi yapılan hastalarda operasyon sonrası oluşan komplikasyonları, patolojik sonuçlarını, prognozu etkileyen parametreleri ve sağkalımları ...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1999
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Amaç: Doğal ve cerrahi yol ile menopoza giren hastalara] hormon replasman tedavisine verdikleri c... more Amaç: Doğal ve cerrahi yol ile menopoza giren hastalara] hormon replasman tedavisine verdikleri cevabın monitorizasvonıında Kupperman indeksi, hipoöstrojenemik in
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Amaç: 7 hcı/ıa ıv üstü gebelik lerıııiıtasvoıımıda oral misoprostal 'iiıı, servikal Dihuasyoiı iç... more Amaç: 7 hcı/ıa ıv üstü gebelik lerıııiıtasvoıımıda oral misoprostal 'iiıı, servikal Dihuasyoiı için etkinliğini, güve nilirliğini ve vatı etkisinin gösterilmesi ıımaçhımlı. Çalışmalım yapıldığı yer: Sağlık Hakanlığı. Kartal Eğitim ve i ray tı rina IhıstaneCı Kadın Hastalıkları ve Poğııııı Kliniği Materyal ve M et od: Hu prospı-ki i/' çalışmada ınıssed ahoriııs. /etol ölüm ıvıvv medi/uil nedenli gebelik terminasyoıııı yapılacak ii başlaya pcroral, misoprosıol, i satıl artıy la 40Ö ııg dazda, verildi.4S sual içimle ahoriııs veya doğum gerçekleştnı î'e hislıup skorunun o ve üstümle olan vakalarda uygulamayı başarılı kahııl ettik. Ilulgular: Hastaların "•'> l >(>. " sinde 4<S saat içinde ahoriııs veva doğum gerçekleşti. Yan etki olarak en \ık görülen ateş hastaların ":,'). 6 sinde görüldü. Sonuç: 7 haftanın üstündeki gebelik ternıinasyoıuı için. miso prasıol güvenli ve etkin bir afandtr.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Amaç: Ovaryen musinöz kistadenom nedeniyle öpere edilen bir hastada ilk operasyondan 3.5 yıl sonr... more Amaç: Ovaryen musinöz kistadenom nedeniyle öpere edilen bir hastada ilk operasyondan 3.5 yıl sonra pseudomyxoma peritonei saptanması nedeniyle literatür gözden geçirildi.
Amaç: Overin malign mikst mezodermal tümörleri nadir görülür. Bu nedenle tedavileri konusunda fik... more Amaç: Overin malign mikst mezodermal tümörleri nadir görülür. Bu nedenle tedavileri konusunda fikir birliði yoktur. Olgumuz eþliðinde, malign mikst mezodermal tümörlerin taný, patoloji, tedavi ve prognozunu tartýþtýk.
Iranian journal of pediatrics, 2010
Prevalence of low birth weight deliveries may vary across different environments. The necessity o... more Prevalence of low birth weight deliveries may vary across different environments. The necessity of determination of regional data prompted this study. Information of all deliveries from January 2004 to December 2008 was obtained from delivery registry records retrospectively. Initial data including birth weight, vital status, sex, maternal age and mode of delivery were recorded using medical files. The frequency of low birth weight, very low birth weight, extremely low birth weight and stillbirth deliveries were determined. Among 19,533 total births, there were 450 (23.04 per 1000) stillbirths. Low birth weight rate was 10.61%. A significant increase in yearly distribution of low birth weight deliveries was observed (P<0.001). Very low birth weight and extremely low birth weight delivery rates were 3.14% and 1.58% respectively. Among 2073 low birth weight infants, 333 (16.06%) were stillbirths. The stillbirth delivery rate and the birth of a female infant among low birth weight d...
JPMA. The Journal of the Pakistan Medical Association, 2010
To investigate the relationship between adverse pregnancy outcomes and unexplained elevations of ... more To investigate the relationship between adverse pregnancy outcomes and unexplained elevations of second trimester maternal serum human chorionic gonadotropin (hCG), alpha fetoprotein (AFP) levels and uterine artery Doppler measurements. A total of 144 women between 16-20 weeks of gestation that applied to our clinic for triple test were enrolled into the study. Study group consisted of 84 pregnant women with hCG and/or AFP levels > or =2 MoM. Control group comprised of 60 pregnant women with hCG and AFP levels <2 MoM. Study group was further subdivided into 3 subgroups: Subgroup I; only AFP> or =2 MoM (n=30), subgroup II; only hCG > or =2 MoM (n=64) and subgroup III; both AFP and hCG > or =2 MoM (n=10). Operative delivery rate (p = 0.0017), overall complication rate (p=0.0002), bilateral early diastolic notch presence rate (p = 0.015) were high and mean birth weight was low (p=0.045) in the study group. In subgroup I patients, low birth weight [LBW] (p = 0.0008), pret...
Journal of Pelvic Medicine and Surgery, 2006
... Pelvic Tuberculosis Simulating Advanced Ovarian Malignancy. Karsidag, A Yasemin Karageyim MD;... more ... Pelvic Tuberculosis Simulating Advanced Ovarian Malignancy. Karsidag, A Yasemin Karageyim MD; Api, Olus MD; Dansuk, Ramazan MD; Kotil, Gonul MD; Kars, Bulent MD; Unal, Orhan MD;Turan, M Cem MD. Article Outline. Collapse Box Author Information. ...
Ultrasound in Obstetrics and Gynecology, 2006
We report a case of cervical ectopic pregnancy successfully treated with systemic methotrexate. C... more We report a case of cervical ectopic pregnancy successfully treated with systemic methotrexate. Conservative management with single-dose methotrexate was undertaken, but owing to the failure of human chorionic gonadotropin (hCG) levels to fall by 15% by day 7 and the persistence of fetal cardiac activity, two further doses of methotrexate were required. The patient's hCG levels were monitored, and repeat transvaginal ultrasonography was performed until complete resolution of the pregnancy by spontaneous miscarriage. We describe the ultrasonographic findings, which showed that the sac size increased despite treatment.
Journal of Maternal-Fetal and Neonatal Medicine, 2010
... 2010 Sep;23(9):1069-71. Fetal retroperitoneal lipoblastoma: ultrasonographic appearance of a ... more ... 2010 Sep;23(9):1069-71. Fetal retroperitoneal lipoblastoma: ultrasonographic appearance of a rare embryonal soft tissue tumor. Api O, Akil A, Uzun MG, Acioglu HC, Yalcin O, Api M, Unal O. PMID: 20718582 [PubMed - indexed for MEDLINE]. Publication Types: ...
Gynecological Endocrinology, 2004
Using an ultrasensitive assay, prostate-specific antigen (PSA) has been detected in female serum ... more Using an ultrasensitive assay, prostate-specific antigen (PSA) has been detected in female serum and has been proposed as a potential marker of androgen excess in hirsute women. Measurement of PSA levels in serum may play a role in monitoring hirsutism during antiandrogen therapy. We investigated the role of PSA as a marker of androgen activity in hirsute patients taking spironolactone together with oral contraceptive pills containing ethinyl estradiol and gestodene. Twenty-eight hirsute patients were included in the study. Clinical and biochemical variables including serum levels of PSA (using an ultrasensitive chemiluminscent immunoassay), dehydroepiandrosterone sulfate, total testosterone, free testosterone and 17-hydroxyprogesterone concentrations were recorded at baseline and after six cycles of treatment. Fifteen healthy women were included in the study as controls. Serum PSA levels in hirsute women were clearly higher than in the control group (0.023 +/- 0.004 vs. 0.006 +/- 0.003 ng/ml, p < 0.001) and correlated with baseline serum free testosterone concentrations (r = 0.518, p = 0.005). After 6 months, serum PSA concentrations as compared with baseline values did not change significantly in patients who were given spironolactone plus contraceptive pills (p = 0.4) despite a marked decrease in total testosterone, free testosterone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate and hirsutism score (p < 0.05). Thus, serum PSA levels in hirsute women were higher than in non-hirsute healthy controls. A 6-month course of treatment with spironolactone combined with contraceptive pills containing ethinylestradiol and gestodene did not reduce high serum PSA levels in these subjects. In conclusion, the serum PSA level is not a convenient biochemical marker with the available assays for the management of hirsute women treated with the combination of spironolactone and oral contraceptives.
Gynecological Endocrinology, 2005
The objective of the present study was to compare the effects of various gestagens on insulin sen... more The objective of the present study was to compare the effects of various gestagens on insulin sensitivity in postmenopausal women on hormone replacement therapy (HRT). This prospective study enrolled 156 postmenopausal women who had menopausal status for at least 6 months. Group 1 was treated with 17b-estradiol (E 2 ; 2 mg) plus norethisterone acetate (NETA; 1 mg); Group 2 was given E 2 (2 mg) plus medroxyprogesterone acetate (MPA; 2.5 mg); Group 3 was given E 2 (2 mg) plus dydrogesterone (DG; 10 mg); and Group 4 was given E 2 (2 mg) plus micronized progesterone (MP; 100 mg). Group 5 was the surgical menopausal group and was given only E 2 (2 mg) continuously. All 156 subjects completed the 3month follow-up on the trial. The patients were analyzed by using homeostatic model assessment (HOMA) for insulin sensitivity before treatment and 3 months after treatment, comparing the effects of various HRT regimens on insulin sensitivity. No significant differences were found in the baseline characteristics of the patients (p 4 0.05). There were no significant differences in mean values of HOMA before HRT among the five groups (p 4 0.05). There were statistically significant differences in mean values of HOMA only in Group 1 (E 2 + NETA) and Group 3 (E 2 + DG) after HRT (p 4 0.05). E 2 + NETA and E 2 + DG were found to improve insulin sensitivity in postmenopausal women after 3 months of treatment, whereas E 2 + MPA, E 2 + MP and E 2 only did not show such an effect in postmenopausal women.
Gynecological Endocrinology, 2007
Women with polycystic ovary syndrome (PCOS) are insulin-resistant and have increased risk for typ... more Women with polycystic ovary syndrome (PCOS) are insulin-resistant and have increased risk for type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). But it is controversial whether the increased risk of CHD and T2DM is associated with endocrine abnormalities occurring as a consequence of PCOS or whether it is related to obesity or metabolic changes frequently seen in women with PCOS. Since both homocysteine (Hcy) and C-reactive protein (CRP) are supposed to predict T2DM and CHD, we investigated their possible relationship with insulin resistance, obesity, hyperandrogenemia and metabolic alterations in 44 PCOS women and 26 healthy controls matched by age and body mass index (BMI). Hcy and CRP levels were significantly elevated in PCOS women compared with controls (13.30 +/- 4.81 vs. 9.02 +/- 3.36 micromol/l, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05 and 4.22 +/- 2.95 vs. 2.66 +/- 2.49 mg/l, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There was no correlation between Hcy and CRP (r = 0.171, p = 0.05) as two risk markers. While plasma Hcy levels were correlated with BMI, ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH), total testosterone, free testosterone, triglyceride and insulin levels and homeostatic model assessment-insulin resistance index (HOMA-IR) (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05), CRP was correlated with BMI, total cholesterol, triglyceride, low-density lipoprotein cholesterol and insulin levels and HOMA-IR (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There was no correlation of CRP with parameters of PCOS such as testosterone and LH/FSH ratio (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Multiple regression analysis revealed BMI as the major factor examined that influenced both Hcy and CRP levels. In PCOS women, plasma levels of Hcy and CRP were significantly elevated compared with age- and BMI-matched controls. Although most of the PCOS-related endocrine and metabolic changes are related to elevated plasma Hcy and CRP levels in PCOS women, BMI seems to be the major factor determining CHD and T2DM in women with PCOS.
Fetal Diagnosis and Therapy, 2005
Single fetal death in a twin pregnancy in the late second or early third trimester is associated ... more Single fetal death in a twin pregnancy in the late second or early third trimester is associated with significant morbidity and mortality rate in the surviving co-twin, especially in monochorionic twin pregnancies. The common causes are twin-to-twin transfusion syndrome, chromosomal abnormalities, and congenital anomalies of the fetus or anomalies of the umbilical cord-placenta. Here we report a case of monochorionic twin pregnancy in which one fetus had a single umbilical artery (SUA) while the co-twin had two umbilical arteries. The twin with SUA died in utero at the 30th week of gestation and the other fetus was delivered by cesarean section immediately due to fetal distress diagnosed by cardiotocography. Disseminated intravascular coagulation and multicystic encephalomalacia have been observed in the surviving neonate. This case and review of the literature suggest that neurologic complication rates are also increased in monochorionic twin pregnancies with single fetal demise de...
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of c... more Tamoxifen use in breast cancer patients may cause ovarian cysts. This report presents a case of complex cyst resembling ovarian hyperstimulation in a premenopausal breast cancer patient receiving tamoxifen which resolved by administering monthly depot GnRHagonist (GnRH-a) without abandoning the tamoxifen treatment.
… Klinikleri Journal of …, 2010
Kamptomelik displazi (KD) uzun kemiklerde öne doğru eğrilik ile karakterize nadir görülen bir isk... more Kamptomelik displazi (KD) uzun kemiklerde öne doğru eğrilik ile karakterize nadir görülen bir iskelet displazisidir. XY karyotipine sahip hastaların çoğunluğunda kuşkulu dış genitalya mevcuttur. SRY ilişkili gendeki mutasyon, SOX9, bu hastalığın sorumlusudur. İskelet ...