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Papers by Osman Goni

Many human diseases with a high disease burden worldwide such as for example different forms of c... more Many human diseases with a high disease burden worldwide such as for example different forms of cancer, infectious diseases and autoimmune diseases are affected by the polysaccharide Heparan Sulfate (HS). The actions of HS largely depend on the structure of its polysaccharide chains that provide specific binding sites for proteins. The aim of this master project was to gain more understanding of how the biosynthesis of HS is regulated, focusing on the HS biosynthesis enzymes, exostosin (EXT)1 and EXT2. The EXTproteins have a key role in generating the HS polysaccharide backbone composed of alternating glucuronic acid (GlcA) and N-acetylglucosamine (GlcNAc) units. It is suggested that the biologically functional unit in HS chain elongation is a Golgi-complex containing EXT1 and EXT2. Due to the low enzyme activities of EXT2 it has been speculated that EXT2 is not involved in the actual elongation of the HS backbone but serves as a transport protein to transport EXT1 from the endoplasmic reticulum to the Golgi apparatus where HS elongation takes place. This will mean that EXT1 alone is elongating HS. Still, there are some indications that EXT2 may have some, but low, elongating enzyme activity. However, this has been difficult to study as the EXT proteins tend to associate with each other and to remain associated also after purification. In this thesis, to be able to in detail study of individual enzyme activities of the EXT proteins, human cells lacking either EXT1 or EXT2 were transiently transfected with the full-length EXT2 plasmid and EXT1plasmid DNA in EXT1 and EXT2 deficient cells, respectively. In this study we found that when the EXT2 protein was expressed in mouse cells lacking EXT1, the expressed EXT2 transferred glucuronic acid to an acceptor oligosaccharide, indication that EXT2 has HS elongating activity. However, this result was not repeated when similar experiments were done in a human cell line lacking EXT1. Further studies are needed to determine the role of EXT2 on HS elongation.

Volume 1, Issue 3, 2021

Cardiopulmonary resuscitation (CPR) is a critical, life-saving skill for healthcare professionals... more Cardiopulmonary resuscitation (CPR) is a critical, life-saving skill for healthcare professionals (HCPs) in emergency departments (EDs) and other health care settings and are expected to have a profound knowledge of the CPR guidelines. A cross-sectional study was carried out among 160 health care providers to assess the level of knowledge and attitude towards cardiopulmonary resuscitation. Data analysis were done by SPSS software version-20. Total respondents in the study were 160 health care providers (HCP) and among them 80 respondents were doctors and 80 respondents were nurses. Among the respondents, 69% were female and 31% were male. Regarding the CPR training, 51% doctors and 49% had trained in CPR. Regarding performing the CPR, 58% doctors performed CPR and 66.2% nurses had performed CPR in clinical practice. Regarding meaning of the CPR, majority (92%) respondents knew correctly as ventilation and chest compression. More than half 58% respondents correctly knew about cardiac...

Undergraduate Topics in Computer Science, 2021

Journal of Dhaka Medical College, 2021

Background: Esophageal cancer is one of the most serious gastrointestinal cancer worldwide, owing... more Background: Esophageal cancer is one of the most serious gastrointestinal cancer worldwide, owing to its rapid development and fatal prognoses in most cases. There is a paucity of published data regarding esophageal cancer the study area in particular. This study was conducted to describe the endoscopic and clinicopathological patterns of esophageal cancer in this part of the world. The study provides baseline local data for future comparison. Objectives: The present study is done to highlight the increasing incidence of oesophageal cancer in the population. Methods: Detailed informations were obtained in each cases according to protocol. Complete history was taken either from patient or accompanying attendants. Thorough clinical examination was done. Relevant investigation reports were collected. All the informations were recorded according to fixed protocol. Collected data were classified, edited, coded and entered into the computer for statistical analysis by using SPSS version 1...

Background: Proper patient selection for most appropriate treatment option for hepatic hydatid is... more Background: Proper patient selection for most appropriate treatment option for hepatic hydatid is crucial to ensure successful treatment outcome. Chemotherapy, newer approaches, like PAIR procedure, (puncture, aspiration, injection and reaspiration) laparoscopy are available. As the indications for these approaches are restricted, surgery remains the key treatment strategy with hope for complete cure. Radical surgical excision coupled with chemotherapy and long-term aggressive chemotherapy for partially resected ensures lowest morbidity and mortality. Methods: This cross sectional observational study of 15-year single-institution experience, intended to further validate different surgical procedures in management of hydatid disease of liver and its outcome. Patients were randomly selected irrespective of their age, sex and mode of presentation. Different preferred surgical treatment modalities, perioperative complications, recurrences, and length of hospital stay were retrospectivel...

2021 International Applied Computational Electromagnetics Society Symposium (ACES), 2021

New Surface-Volume-Surface Electric Field Integral Equation (SVS-EFIE) based on magnetic current ... more New Surface-Volume-Surface Electric Field Integral Equation (SVS-EFIE) based on magnetic current single source field representation (SVS-EFIE-M) is proposed for the problems of scattering on homogeneous non-magnetic dielectric objects. It's analytic MoM solution for a dielectric sphere is compared against the Mie series expansion to validate the exact nature of this new magnetic current based SVS-EFIE formulation. This analytic solution also allows to rigorously study spectral properties of the SVS-EFIE- M operators and to determine proper functional spaces in which MoM solutions of it should be sought in order to maintain bounded condition number of the pertinent matrix equation.

International Journal of Electronics Engineering and Applications, 2021

We live in age of modern science. Computer Network is the best innovation of Modern science. A lo... more We live in age of modern science. Computer Network is the best innovation of Modern science. A local area network (LAN) is a computer network within a small geographical area such as a home, school, computer laboratory, office building or group of buildings. A LAN is composed of interconnected workstations and personal computers which are each capable of accessing and sharing data and devices, such as printers, scanners and data storage devices, anywhere on the LAN. LANs are characterized by higher communication and data transfer rates and the lack of any need for leased communication lines. A high-quality and correctly dimensioned network infrastructure is essential for all well-functional IT system. A Local Area Network based network can ensure high speed as well as high quality network. To fulfill the current requirements of AERE (Atomic Energy Research Establishment) considering its smooth operation of high-speed internet service, LAN based network is the state-of-the-art network solution. A LAN network design refers to the specialized processes leading to a successful installation and operation of a network which includes determining the type of communication system(s) which will be carried over the network, the geographic layout, the transmission equipment required and the fiber network over which it will operate. The purpose of this Network is to design a Local Area Network (LAN) for AERE (Atomic Energy Research Establishment) and implement security measures to protect network resources and system services. To do so, I will deal with the physical and logical design of a LAN. The goal of this Network is to examine of the Local Area Network set up for AERE and build a secure LAN system.

Electroporation or electropermeabilization (EP) is a non-viral physical process of inducing and/o... more Electroporation or electropermeabilization (EP) is a non-viral physical process of inducing and/or increasing permeability of biological membranes by the application of high intensity and short duration electrical pulses. The resulting high field strength in the membrane can lead to the formation of regions of increased permeability, often called pores that allow transmembrane transport of macromolecules, such as DNA and chemo drugs. The efficacy of EP depends on a number of parameters, such as electric field strength, duration, number of pulses, size of target cell, and type of drug or DNA to be fed, to mention a few parameters. While electric field strength, duration, and number of pulses are the dominant parameters for the electroporation effect, the electric field distribution also depends on the shape, the size, and the material of electrodes used. The various electrodes used in practice are the parallel plate electrodes, the needle electrodes, the needle array electrodes, and ...

International Journal of Computer Science and Mobile Computing, 2021

A local area network (LAN) is a computer network within a small geographical area such as a home,... more A local area network (LAN) is a computer network within a small geographical area such as a home, school, computer laboratory, office building or group of buildings. A LAN is composed of interconnected workstations and personal computers which are each capable of accessing and sharing data and devices, such as printers, scanners and data storage devices, anywhere on the LAN. LANs are characterized by higher communication and data transfer rates and the lack of any need for leased communication lines. Communication between remote parties can be achieved through a process called Networking, involving the connection of computers, media and networking devices. When we talk about networks, we need to keep in mind three concepts, distributed processing, network criteria and network structure. The purpose of this Network is to design a Local Area Network (LAN) for a BAEC (Bangladesh Atomic Energy Commission) Head Quarter and implement security measures to protect network resources and syst...

Journal of Ethnopharmacology, 2021

ETHNOPHARMACOLOGICAL RELEVANCE Aglaonema hookerianum Schott is an ethnomedicinally important plan... more ETHNOPHARMACOLOGICAL RELEVANCE Aglaonema hookerianum Schott is an ethnomedicinally important plant used to treat a variety of diseases, including sexual and depression-like disorders. However, the scientific basis underlying the aforesaid properties have not been well justified. AIM OF THE STUDY The present investigation aimed to investigate the anxiolytic, antidepressant and aphrodisiac potentials of methanol leaves extract of A. hookerianum (MEAH) in Swiss albino mice. MATERIALS & METHODS Swiss albino mice (20-30 g) were orally administrated with MEAH at the doses ranging from 100 to 400 mg/kg, b.w. The elevated plus maze (EPM) and hole board test (HBT) were performed to determine the anxiolytic activity and the forced swimming test (FST) and tail suspension test (TST) were performed to determine the antidepressant activity of MEAH. Besides, the aphrodisiac activity of MEAH was conducted through the mounting behaviour and orientation behaviour analysis. Diazepam (1 mg/kg, b.w., i.p.) for EPM and HBT; fluoxetine HCl (20 mg/kg, b.w., p.o.) for FST and TST, and sildenafil (5 mg/kg, b.w., p.o.) for the mounting behaviour analysis and orientation behaviour analysis were used as reference drugs. RESULTS The administration of the MEAH produced a strong (p<0.001) dose-dependent anxiolytic effects in both HBT and EPM tests. Likewise, the extract revealed a significant (p<0.001) reduction in the immobility time in both FST and TST as compared to the control group. Besides, the MEAH also found to possess marked aphrodisiac activity complying several facets such as an increase in the sexual performance at the highest dose (400 mg/kg, p.o.) as well as the orientation toward female mice (p<0.001) at all tested doses. CONCLUSION Taken together, MEAH can be recommended as a potent source of neuroprotective and a libido-boosting drug candidate for the management of neurological and sexual disorders.

IEEE Transactions on Antennas and Propagation, 2021

Exact solution of the Surface-Volume-Surface Electric Field Integral Equation (SVS-EFIE) is prese... more Exact solution of the Surface-Volume-Surface Electric Field Integral Equation (SVS-EFIE) is presented for the problem of radiation in the vicinity of homogeneous dielectric sphere. The solution is obtained via Galerkin Method of Moments (MoM) utilizing rotational and irrotational complete sets of orthogonal vector spherical harmonics as basis and test functions according to the Helmholtz decomposition. In the case of radial or tangential electric dipole radiation the electric field throughout the sphere evaluated via analytic MoM solution of the SVS-EFIE is compared against the exact classical Mie series solution. The two are shown to agree to 12 digits of accuracy upon sufficient number of basis/test functions taken in the MoM solution and the Mie series expansion. The exact solution confirms and validates the rigorous nature of the SVS-EFIE formulation. It also reveals the spectral properties of its individual operators, their products and their linear combination, as well as the spectrum of the MoM impedance matrix. It is shown that upon choosing basis and test functions in Sobolev space Hdiv1/2(S) and performing testing inner products evaluation in the space Hdiv-1/2(S), S being the surface of the sphere, the MoM impedance matrix features bounded condition number with increasing order of discretization similar with analogous exact MoM solution of the surface EFIE on perfectly electrically conducting (PEC) sphere.

Differential Equations, 2020

Abstract A numerical method based on the nonsmooth contact dynamics method is proposed for calcul... more Abstract A numerical method based on the nonsmooth contact dynamics method is proposed for calculating the dynamics of an underwater solid body with positive buoyancy, which is attached to the operational surface (bottom of the reservoir) by flexible cables. A hemisphere-shaped body with three cables is considered as an example. The results of numerical calculations confirming the efficiency of the method are presented.

Dhaka University Journal of Biological Sciences, Jan 18, 2019

The present study intends to investigate the medium-term effect of early life weather shock on no... more The present study intends to investigate the medium-term effect of early life weather shock on non-verbal intelligence of SIDR affected children. The hypothesis was, the nonverbal IQ of SIDR affected children would be lower than the non-verbal IQ of SIDR non-affected children. For this purpose, 60 students of grade 4-5 were selected as respondents. Among them half of the respondents were from SIDR affected area and remaining were from non-affected area. In order to measure non-verbal intelligence, Test of Non-verbal Intelligence-2 (TONI-2) was administered which was developed by Brown et al. (1990). Independent-sample t-test was employed to compare the non-verbal intelligence of the participants in SIDR affected and SIDR non-affected conditions. The result shown that there is a significant difference on non-verbal intelligence between affected and non-affected samples and the nonverbal intelligence (IQ) of SIDR affected children is significantly lower than the non-verbal intelligence (IQ) of non-affected participants.

Microbiology Research Journal International, 2020

Thai Pangas (Pangasiaus hypophthalmus) has been emerging as an economically very important specie... more Thai Pangas (Pangasiaus hypophthalmus) has been emerging as an economically very important species due their faster growth, year round production and high productivity in South-East Asian aquaculture. It has good market value as a food fish due to its good taste and deliciousness with high protein, minerals and fat content. It is also popular as a game fish. Aims: The present study was conducted to identify bacterial pathogens in diseased P. hypophthalmus and evaluate their sensitivity to antibiotics. Methodology: To identify the causativeagent of diseased fish pure culture of bacteria using slant and streak plate techniques and different biochemical tests such as Gram’s Staining, Motility Test, Sugar Fermentation Test, MR-VP test, Indole Test etc. were performed. To assess the sensitivity of the isolated bacteria to antibiotics five antibiotics disks i.e. Ciprofloxacin (5μg), Azithromycin (15μg), Ampicillin/Sulbactam (20μg), Tetracycline (30μg) and Erythromycin (15μg) were used. Re...

2015 2nd International Conference on Electrical Information and Communication Technologies (EICT), 2015

Nanotechnology has enabled the use of Nanosized devices for various purposes i.e. biological, ind... more Nanotechnology has enabled the use of Nanosized devices for various purposes i.e. biological, industrial, and military and especially in communication field.By using graphene the antennas can be implemented in nano scale. And the miniature antennas would work more efficiently than the conventional antennas. The miniature device can transmit data in terabyte scale. Conventional antennas would require very high frequency which is quite unfeasible. But the slower movement of electrons in graphene would enable the grapheme nano antennas to operate at a feasible frequency.[1][2]. In this paper we designed, Graphene nano ribbon based antenna that would operate in terahertz band and investigatedits radiation characteristics in the 2.45-2.98 THz band. The proposed antennas are also compared with the conventional antennas operating in terahertz band. The antenna is simulated by using the finite element method based simulator -CST (computer simulation technology).

Materials Science Forum, 1997

ABSTRACT We present results from Raman-scattering experiments on GaN layers grown on GaAs and sap... more ABSTRACT We present results from Raman-scattering experiments on GaN layers grown on GaAs and sapphire. In the low-energy region between 95 cm-1 and 250 cm-1 a series of sharp lines appear which decreases exponentially in intensity with increasing temperature. The lines disappear when reaching room temperature. Wavelength-dependent measurements reveal that they are strongest under excitation at around 514.5 nm. Raman-scattering experiments at high pressures up to 6 GPa show that neither their energies nor their resonance profile vary remarkably with pressure indicating that they are not connected to the bandgap. Comparitive measurements on different substrates show that these lines are exclusively present in GaN layers grown on GaAs.

Journal of Dhaka Medical College, 2015

Background: Hydatid disease is a zoonotic disease caused by Echinococcus granulosus. In humans, l... more Background: Hydatid disease is a zoonotic disease caused by Echinococcus granulosus. In humans, lungs are the second common organ involved after liver. Surgical treatment is considered gold standard. Different surgical techniques has developed. However, head to head comparison of these has not yet been done in our country. Methods: A prospective randomized study was done in the Department of Thoracic Surgery, National Institute of Diseases of the Chest and Hospital between July 2004 and June 2006. Patients with pulmonary hydatid disease were offered two surgical techniques, enucleation with or without capitonnage. Group I was offered enucleation of cyst with closure of bronchial opening. Group II was offered enucleation of cyst with capitonnage. Results: 43 patients (age range 7 45 years, mean 25 years) having hydatid disease of the lung were enrolled in the study. Group I involved 23 patients, Group II involved 20 patients. There were 15 males and 28 females. Presenting complaint...