Ozlem Su - Academia.edu (original) (raw)
Papers by Ozlem Su
Annals of Plastic Surgery, 2004
Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling... more Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling. Priming the tissue to be incised with proinflammatory cytokines offers a new approach to wound healing. This has been studied mostly in incisional wounds till now. This study was designed to investigate the role of granulocyte macrophage colony stimulating factor (GM-CSF) priming of planned incision lines in random flaps in rats with impaired wound healing due to glucocorticoid administration, and immune profiles of rats were also evaluated. GM-CSF priming of incision lines in immunosuppressed rats was shown to improve the wound healing parameters, hydroxyproline levels, breaking strength, flap survival, and immune profile, although all of the parameters were somewhat lower than those of control group. The findings of this study suggest that wound healing can be accelerated and thus morbidity lowered by making use of the immunomodulator effects of GM-CSF in cases where wound healing is impaired due to systemic disease or drug use and flap reconstruction is necessary.
The Journal of dermatology, 2011
Türkderm-Deri Hastalıkları ve Frengi Arşivi, 2014
Giornale italiano di dermatologia e venereologia, Jun 1, 2019
Indian Journal of Dermatology, 2016
There is limited data about the relationship between psoriasis and melanocytic lesions and melano... more There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi. To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. We performed a prospective study in 100 psoriatic patients and 100 controls. Clinical data were recorded for all participants. As compared with controls, patients had overall fewer nevi congenital nevi. Among psoriatic patients, biologic agents and disease severity did not correlate with the number of nevi. Psoriatic patients have fewer nevi than controls. Frequency of nevi in psoriatic patients is not related to treatment and disease severity.
Indian Journal of Dermatology, 2011
Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its preva... more Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its prevalence is however probably underestimated in dermatological literature. Early recognition of the signs can prevent misdiagnosis. We describe a Turkish patient who presented with palmoplantar pustulosis and involvement of the sternoclavicular joint and peripheral oligoarthritis.
Dermatology Practical & Conceptual, 2015
Background: In vivo confocal microscopy is an imaging technique that has been applied to the stud... more Background: In vivo confocal microscopy is an imaging technique that has been applied to the study of the ocular surface. However, confocal microscopes dedicated to eye examination are routinely adopted only in ophthalmology reference centres and do not allow an examination of periocular tissue, nor a fluorescence examination. Methods: We applied for the first time the two in vivo confocal microscopes commonly used in dermatology (VivaScope ® 1500 and 3000, CALIBER, distributed in Europe by Mavig GmbH, Munich, Germany) to observe the cornea, the bulbar and tarsal conjunctiva, the eyelid margin, the lacrimal punctum and the palpebral skin of healthy volunteers. Tumoral, inflammatory and infectious diseases of the ocular mucosa and periocular skin from more than 200 patients were observed under the same microscopes. Both microscopes have a reflectance mode. VivaScope ® 1500 allows an additional fluorescent examination and its placement on the ocular surface was made possible by the creation of a special interface between the microscope and the ocular apparatus. Results: Thanks to its compact and flexible configuration, the handheld camera VivaScope ® 3000 allowed to access more easily to the ocular and periocular tissues. Diagnosis of benign and malignant tumors (melanoma, squamous cell carcinoma and basal cell carcinoma), as well as infectious and genetic disease (storage diseases), could be evocated. The detection of parasites (Demodex folliculorum) on eyelids was possible. Confocal images correlated well with conventional histopathology. The fluorescence examination of corneal squamous cell carcinoma by VivaScope 1500 was characterized by extravasation of fluorescein after intravenous injection. Conclusions: Confocal microscopes dedicated to the skin offer new perspectives for the diagnosis, optimization of treatments, and follow-up of the ocular diseases. They will allow dermatologists to examine conjunctival and eyelid tumors, as it is for skin or genital mucosa. In addition, thanks to some adaptations of the dermatological device VivaScope ® 1500, it is possible for the first time to perform a fluorsecnte examination of the ocular and peri-ocular tissue, opening a new era in the clinical imaging of the ocular surface. A new semiology remains to be learned.
Bezmialem Science, 2020
There is no standard practice for the sustainability of medical education in epidemics such as Co... more There is no standard practice for the sustainability of medical education in epidemics such as Covid-19 and disasters affecting society. Synchronous or asynchronous trainings have been carried out in some of universities and colleges that have distance education technical infrastructure, during the Covid-19 pandemic. If every student has access to information technologies and the skills of the instructors who will prepare and deliver the training increase their ability to use information technologies, there is no problem in the implementation and maintenance of theoretical lessons. During the Covid-19 pandemic, we had to go to distance education, which we had not yet implemented at Bezmialem Vakıf University Faculty of Medicine. During this period, we applied asynchronous and synchronous education models (mixed model) for theoretical lessons. However, the fact that practical and internship applications were carried out by distance education-although videos about skills and practices were shot and uploaded to the system-it was not possible to replace the formal education. Distance education is inevitable for the continuity of education in epidemic and disaster situations. However, after the epidemic and disaster situations have passed, practical and internship practices should be carried out as much as possible in addition to distance education in medical education. In normal times, distance education can only be used to support formal education in medical education. As a result of all these evaluations and experiences we gained in the Covid 19 pandemic, we think that synchronous/synchronous distance education applications will improve over time and contribute to medical education.
Turkiye Klinikleri Journal of Dermatology, 2016
Türkderm-Deri Hastalıkları ve Frengi Arşivi, 2014
Çal›flmam›z›n amac› alerjik kontakt dermatit (AKD)/ mukozit(M) düflünülen hastalarda pozitif yama... more Çal›flmam›z›n amac› alerjik kontakt dermatit (AKD)/ mukozit(M) düflünülen hastalarda pozitif yama testi reaksiyon-lar›n›n s›kl›¤›n› ve en s›k reaksiyon veren alerjenleri belirlemek, "Thin-layer Rapid-Use Epicutaneous" (T.R.U.E.) testle birlikte ek serilerin kullan›lmas›n›n yama testi sonuçlar› üzerine etkisini de¤erlendirmek idi. Gereç ve Yöntem: Yüz altm›fl bir AKD, 5 AKM ve 1 AKD ve AKM birlikteli¤i olan toplam 167 hasta çal›flmaya al›nd›. Hastalar›n 139' una yaln›z T.R.U.E. test; 28' ine meslek ve klinik tabloya göre seçilen (9 hastaya tekstil, 9 hastaya plastik yap›flt›r›c›lar, 6 hastaya dental, 2 hastaya f›r›nc›l›k, 1 hastaya kozmetik, 1 hastaya dental ve plastik yap›flt›r›c›lar) ek seri alerjenleri ile birlikte T.R.U.E. test uyguland›. Tüm sonuçlar yüzdelik olarak analiz edildi.Atopi, kontakt duyarl›l›k iliflkisi Yate's düzeltmeli x 2 yöntemi ile de¤erlendirildi. Bulgular: Çal›flmaya al›nan hastalar›n 86's› erkek, 81'i kad›n, yafl ortalamas› 36.5 (2-88) idi.Yaln›z T.RU.E. test uygulanan 139 hastan›n %25.9'u; T.R.U.E. test ile birlikte ek seri uygulanan 28 hastan›n ise %46.4'ü en az bir alerjene pozitif yama testi reaksiyonu gösterdi.En s›k yama testi pozitifli¤i gösteren alerjenler nikel sülfat (%14.4), potasyum dikromat (%4.8), koku kar›fl›m› (%2.9) ve kolofoni (%2.9) idi. En s›k pozitif reaksiyon veren ek seri alerjenleri ise f›r›nc›l›k serisinden oktil galat (%50) ve dental seriden bak›r sülfat (%42.8) ile alt›nsodyumtiyosülfat (%42.8) oldu. AKM'i olan 6 hastan›n %83.3'ünde pozitif yama testi reaksiyonu saptand›. Bu reaksiyonlar›n %80'i dental seri alerjenlerine karfl› geliflmiflti. Atopik olanlarla olmayanlar aras›nda kontakt duyarl›l›k yönünden fark saptanmad›. (p>0.05). Sonuç: Özellikle kontakt mukozit ya da mesleki kontakt dermatit durumunda sorumlu alerjen veya alerjenlerin a盤a ç›kar›lmas›nda T.R.U.E. testle birlikte ek serilerin kullanmas›n›n daha yararl› olaca¤›na inan›yoruz.
Amaç: Klasik Kaposi sarkomu (KKS) yafll›lar aras›nda özellikle Yahudi, ‹talyan ve Yunan toplumlar... more Amaç: Klasik Kaposi sarkomu (KKS) yafll›lar aras›nda özellikle Yahudi, ‹talyan ve Yunan toplumlar›nda görülmektedir. Türkiye'de epidemiyolojik veriler olmasa da s›k görüldü¤ü düflünülmektedir. Çal›flmam›zda 18 KKS'lu hastada demografik, klinik özellikler, insan herpesvirüs 8'in (HHV-8) etyopatolojideki rolü ve tedavi sonuçlar›n›n de¤erlendirilmesi amaçland›. Gereç ve Yöntem: Ocak 2001-A¤ustos 2008 y›llar› aras›nda dermatoloji klini¤imize baflvuran klinik ve histopatolojik olarak KKS tan›s› alm›fl 18 olgu çal›flmaya al›nd›. Demografik, klinik özellikler ve tedavi sonuçlar› retrospektif olarak de¤erlendirildi. Yedi hastan›n lezyonlu derisinde HHV-8 araflt›r›ld›. Bulgular: Erkek/kad›n oran› 2/1 olup ortalama yafl 67.2 y›l (37-94 y›l) idi. Bilateral alt ekstremite tutulumu 15 olguda (%83.3), gö¤üs tutulumu ise 3 olguda (%16.81) mevcuttu. Plak ve nodüller en s›k görülen lezyon tipleriydi (%66.6 ve %55.5). Dokuz olguda hiçbir yak›nma yoktu. Ödem en s›k görülen bulgu idi (%44.4...
Indian journal of dermatology, venereology and leprology, Jan 8, 2015
European journal of dermatology : EJD
The aims of this study were to determine the prevalence of H. pylori seropositivity in patients w... more The aims of this study were to determine the prevalence of H. pylori seropositivity in patients with psoriasis, to evaluate the relationship between PASI (Psoriasis Area and Severity Index) scores and H. pylori infection, and to assess the impact of H. pylori infection on the response to treatment. A total of 300 patients with psoriasis and 150 non-psoriatic healthy controls were enrolled in the study. Patient PASI scores were recorded and H. pylori stool antigen tests performed in both patients and controls. Fifty patients with H. pylori infections were randomly assigned to one of two groups, one of which received acitretin with H. pylori treatment and the other acitretin alone. Statistical analyses were performed using chi-square and logistic regression tests. PASI scores were significantly higher in patients with H. pylori infections. Treatment aimed at eradicating H. pylori infection enhanced the effectiveness of acitretin therapy and shortened response times. Our results sugges...
The Breast, 2009
Objective: To assess whether body mass index (BMI), waist circumference (WC) and waist to hip rat... more Objective: To assess whether body mass index (BMI), waist circumference (WC) and waist to hip ratio (WRH) are associated to the steroid receptor status in breast carcinomas. Methods: Four hundred and seventy three women with breast malignancies stage I-III were included. Weight, height, the waist and hip circumferences (WC), body mass index (BMI), and the waist to hip ratio (WHR) were determined. The expression of estrogen (ER) and progesterone (PR) receptors was determined with immunohistochemistry. Results: Most women had central obesity (WC ! 88 and WHR ! 0.85 in 64.3 and 73.4%, respectively). The majority (78.1%) of the women had tumors that expressed at least one of the HR. BMI, WC and WHP were not related to the HR status in neither the pre-or postmenopausal women. Multivariate analysis confirmed these findings. Conclusions: BMI, WC or WHR may not be good predictors of HR status in breast malignancies in either pre-or postmenopausal women.
Our Dermatology Online, 2017
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 2020
Introduction Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma.... more Introduction Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma. Prognostic factors may help to evaluate the course of the disease and may also be useful in selecting appropriate treatment plans for patients. Aim To investigate the potential prognostic factors of MF and their correlations with MF stage. Material and methods We evaluated the records of patients with MF who were followed in our lymphoma clinic between 1998 and 2015. Age, sex, disease stage, peripheral blood eosinophilia, eosinophil cationic protein, serum total IgE, lactate dehydrogenase (LDH), and β2-microglobulin levels were investigated and recorded at the time of diagnosis. Results There was a statistically significant positive correlation between high β2-microglobulin levels and the advanced stage of disease (p < 0.001). The older group of patients had statistically significantly higher levels of β2-microglobulin compared to the younger group (p = 0.001). We found strong, signi...
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2016
Annals of Plastic Surgery, 2004
Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling... more Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling. Priming the tissue to be incised with proinflammatory cytokines offers a new approach to wound healing. This has been studied mostly in incisional wounds till now. This study was designed to investigate the role of granulocyte macrophage colony stimulating factor (GM-CSF) priming of planned incision lines in random flaps in rats with impaired wound healing due to glucocorticoid administration, and immune profiles of rats were also evaluated. GM-CSF priming of incision lines in immunosuppressed rats was shown to improve the wound healing parameters, hydroxyproline levels, breaking strength, flap survival, and immune profile, although all of the parameters were somewhat lower than those of control group. The findings of this study suggest that wound healing can be accelerated and thus morbidity lowered by making use of the immunomodulator effects of GM-CSF in cases where wound healing is impaired due to systemic disease or drug use and flap reconstruction is necessary.
The Journal of dermatology, 2011
Türkderm-Deri Hastalıkları ve Frengi Arşivi, 2014
Giornale italiano di dermatologia e venereologia, Jun 1, 2019
Indian Journal of Dermatology, 2016
There is limited data about the relationship between psoriasis and melanocytic lesions and melano... more There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi. To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. We performed a prospective study in 100 psoriatic patients and 100 controls. Clinical data were recorded for all participants. As compared with controls, patients had overall fewer nevi congenital nevi. Among psoriatic patients, biologic agents and disease severity did not correlate with the number of nevi. Psoriatic patients have fewer nevi than controls. Frequency of nevi in psoriatic patients is not related to treatment and disease severity.
Indian Journal of Dermatology, 2011
Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its preva... more Pustulotic arthro-osteitis, first described by Sonozaki, is a relatively rare disorder. Its prevalence is however probably underestimated in dermatological literature. Early recognition of the signs can prevent misdiagnosis. We describe a Turkish patient who presented with palmoplantar pustulosis and involvement of the sternoclavicular joint and peripheral oligoarthritis.
Dermatology Practical & Conceptual, 2015
Background: In vivo confocal microscopy is an imaging technique that has been applied to the stud... more Background: In vivo confocal microscopy is an imaging technique that has been applied to the study of the ocular surface. However, confocal microscopes dedicated to eye examination are routinely adopted only in ophthalmology reference centres and do not allow an examination of periocular tissue, nor a fluorescence examination. Methods: We applied for the first time the two in vivo confocal microscopes commonly used in dermatology (VivaScope ® 1500 and 3000, CALIBER, distributed in Europe by Mavig GmbH, Munich, Germany) to observe the cornea, the bulbar and tarsal conjunctiva, the eyelid margin, the lacrimal punctum and the palpebral skin of healthy volunteers. Tumoral, inflammatory and infectious diseases of the ocular mucosa and periocular skin from more than 200 patients were observed under the same microscopes. Both microscopes have a reflectance mode. VivaScope ® 1500 allows an additional fluorescent examination and its placement on the ocular surface was made possible by the creation of a special interface between the microscope and the ocular apparatus. Results: Thanks to its compact and flexible configuration, the handheld camera VivaScope ® 3000 allowed to access more easily to the ocular and periocular tissues. Diagnosis of benign and malignant tumors (melanoma, squamous cell carcinoma and basal cell carcinoma), as well as infectious and genetic disease (storage diseases), could be evocated. The detection of parasites (Demodex folliculorum) on eyelids was possible. Confocal images correlated well with conventional histopathology. The fluorescence examination of corneal squamous cell carcinoma by VivaScope 1500 was characterized by extravasation of fluorescein after intravenous injection. Conclusions: Confocal microscopes dedicated to the skin offer new perspectives for the diagnosis, optimization of treatments, and follow-up of the ocular diseases. They will allow dermatologists to examine conjunctival and eyelid tumors, as it is for skin or genital mucosa. In addition, thanks to some adaptations of the dermatological device VivaScope ® 1500, it is possible for the first time to perform a fluorsecnte examination of the ocular and peri-ocular tissue, opening a new era in the clinical imaging of the ocular surface. A new semiology remains to be learned.
Bezmialem Science, 2020
There is no standard practice for the sustainability of medical education in epidemics such as Co... more There is no standard practice for the sustainability of medical education in epidemics such as Covid-19 and disasters affecting society. Synchronous or asynchronous trainings have been carried out in some of universities and colleges that have distance education technical infrastructure, during the Covid-19 pandemic. If every student has access to information technologies and the skills of the instructors who will prepare and deliver the training increase their ability to use information technologies, there is no problem in the implementation and maintenance of theoretical lessons. During the Covid-19 pandemic, we had to go to distance education, which we had not yet implemented at Bezmialem Vakıf University Faculty of Medicine. During this period, we applied asynchronous and synchronous education models (mixed model) for theoretical lessons. However, the fact that practical and internship applications were carried out by distance education-although videos about skills and practices were shot and uploaded to the system-it was not possible to replace the formal education. Distance education is inevitable for the continuity of education in epidemic and disaster situations. However, after the epidemic and disaster situations have passed, practical and internship practices should be carried out as much as possible in addition to distance education in medical education. In normal times, distance education can only be used to support formal education in medical education. As a result of all these evaluations and experiences we gained in the Covid 19 pandemic, we think that synchronous/synchronous distance education applications will improve over time and contribute to medical education.
Turkiye Klinikleri Journal of Dermatology, 2016
Türkderm-Deri Hastalıkları ve Frengi Arşivi, 2014
Çal›flmam›z›n amac› alerjik kontakt dermatit (AKD)/ mukozit(M) düflünülen hastalarda pozitif yama... more Çal›flmam›z›n amac› alerjik kontakt dermatit (AKD)/ mukozit(M) düflünülen hastalarda pozitif yama testi reaksiyon-lar›n›n s›kl›¤›n› ve en s›k reaksiyon veren alerjenleri belirlemek, "Thin-layer Rapid-Use Epicutaneous" (T.R.U.E.) testle birlikte ek serilerin kullan›lmas›n›n yama testi sonuçlar› üzerine etkisini de¤erlendirmek idi. Gereç ve Yöntem: Yüz altm›fl bir AKD, 5 AKM ve 1 AKD ve AKM birlikteli¤i olan toplam 167 hasta çal›flmaya al›nd›. Hastalar›n 139' una yaln›z T.R.U.E. test; 28' ine meslek ve klinik tabloya göre seçilen (9 hastaya tekstil, 9 hastaya plastik yap›flt›r›c›lar, 6 hastaya dental, 2 hastaya f›r›nc›l›k, 1 hastaya kozmetik, 1 hastaya dental ve plastik yap›flt›r›c›lar) ek seri alerjenleri ile birlikte T.R.U.E. test uyguland›. Tüm sonuçlar yüzdelik olarak analiz edildi.Atopi, kontakt duyarl›l›k iliflkisi Yate's düzeltmeli x 2 yöntemi ile de¤erlendirildi. Bulgular: Çal›flmaya al›nan hastalar›n 86's› erkek, 81'i kad›n, yafl ortalamas› 36.5 (2-88) idi.Yaln›z T.RU.E. test uygulanan 139 hastan›n %25.9'u; T.R.U.E. test ile birlikte ek seri uygulanan 28 hastan›n ise %46.4'ü en az bir alerjene pozitif yama testi reaksiyonu gösterdi.En s›k yama testi pozitifli¤i gösteren alerjenler nikel sülfat (%14.4), potasyum dikromat (%4.8), koku kar›fl›m› (%2.9) ve kolofoni (%2.9) idi. En s›k pozitif reaksiyon veren ek seri alerjenleri ise f›r›nc›l›k serisinden oktil galat (%50) ve dental seriden bak›r sülfat (%42.8) ile alt›nsodyumtiyosülfat (%42.8) oldu. AKM'i olan 6 hastan›n %83.3'ünde pozitif yama testi reaksiyonu saptand›. Bu reaksiyonlar›n %80'i dental seri alerjenlerine karfl› geliflmiflti. Atopik olanlarla olmayanlar aras›nda kontakt duyarl›l›k yönünden fark saptanmad›. (p>0.05). Sonuç: Özellikle kontakt mukozit ya da mesleki kontakt dermatit durumunda sorumlu alerjen veya alerjenlerin a盤a ç›kar›lmas›nda T.R.U.E. testle birlikte ek serilerin kullanmas›n›n daha yararl› olaca¤›na inan›yoruz.
Amaç: Klasik Kaposi sarkomu (KKS) yafll›lar aras›nda özellikle Yahudi, ‹talyan ve Yunan toplumlar... more Amaç: Klasik Kaposi sarkomu (KKS) yafll›lar aras›nda özellikle Yahudi, ‹talyan ve Yunan toplumlar›nda görülmektedir. Türkiye'de epidemiyolojik veriler olmasa da s›k görüldü¤ü düflünülmektedir. Çal›flmam›zda 18 KKS'lu hastada demografik, klinik özellikler, insan herpesvirüs 8'in (HHV-8) etyopatolojideki rolü ve tedavi sonuçlar›n›n de¤erlendirilmesi amaçland›. Gereç ve Yöntem: Ocak 2001-A¤ustos 2008 y›llar› aras›nda dermatoloji klini¤imize baflvuran klinik ve histopatolojik olarak KKS tan›s› alm›fl 18 olgu çal›flmaya al›nd›. Demografik, klinik özellikler ve tedavi sonuçlar› retrospektif olarak de¤erlendirildi. Yedi hastan›n lezyonlu derisinde HHV-8 araflt›r›ld›. Bulgular: Erkek/kad›n oran› 2/1 olup ortalama yafl 67.2 y›l (37-94 y›l) idi. Bilateral alt ekstremite tutulumu 15 olguda (%83.3), gö¤üs tutulumu ise 3 olguda (%16.81) mevcuttu. Plak ve nodüller en s›k görülen lezyon tipleriydi (%66.6 ve %55.5). Dokuz olguda hiçbir yak›nma yoktu. Ödem en s›k görülen bulgu idi (%44.4...
Indian journal of dermatology, venereology and leprology, Jan 8, 2015
European journal of dermatology : EJD
The aims of this study were to determine the prevalence of H. pylori seropositivity in patients w... more The aims of this study were to determine the prevalence of H. pylori seropositivity in patients with psoriasis, to evaluate the relationship between PASI (Psoriasis Area and Severity Index) scores and H. pylori infection, and to assess the impact of H. pylori infection on the response to treatment. A total of 300 patients with psoriasis and 150 non-psoriatic healthy controls were enrolled in the study. Patient PASI scores were recorded and H. pylori stool antigen tests performed in both patients and controls. Fifty patients with H. pylori infections were randomly assigned to one of two groups, one of which received acitretin with H. pylori treatment and the other acitretin alone. Statistical analyses were performed using chi-square and logistic regression tests. PASI scores were significantly higher in patients with H. pylori infections. Treatment aimed at eradicating H. pylori infection enhanced the effectiveness of acitretin therapy and shortened response times. Our results sugges...
The Breast, 2009
Objective: To assess whether body mass index (BMI), waist circumference (WC) and waist to hip rat... more Objective: To assess whether body mass index (BMI), waist circumference (WC) and waist to hip ratio (WRH) are associated to the steroid receptor status in breast carcinomas. Methods: Four hundred and seventy three women with breast malignancies stage I-III were included. Weight, height, the waist and hip circumferences (WC), body mass index (BMI), and the waist to hip ratio (WHR) were determined. The expression of estrogen (ER) and progesterone (PR) receptors was determined with immunohistochemistry. Results: Most women had central obesity (WC ! 88 and WHR ! 0.85 in 64.3 and 73.4%, respectively). The majority (78.1%) of the women had tumors that expressed at least one of the HR. BMI, WC and WHP were not related to the HR status in neither the pre-or postmenopausal women. Multivariate analysis confirmed these findings. Conclusions: BMI, WC or WHR may not be good predictors of HR status in breast malignancies in either pre-or postmenopausal women.
Our Dermatology Online, 2017
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 2020
Introduction Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma.... more Introduction Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma. Prognostic factors may help to evaluate the course of the disease and may also be useful in selecting appropriate treatment plans for patients. Aim To investigate the potential prognostic factors of MF and their correlations with MF stage. Material and methods We evaluated the records of patients with MF who were followed in our lymphoma clinic between 1998 and 2015. Age, sex, disease stage, peripheral blood eosinophilia, eosinophil cationic protein, serum total IgE, lactate dehydrogenase (LDH), and β2-microglobulin levels were investigated and recorded at the time of diagnosis. Results There was a statistically significant positive correlation between high β2-microglobulin levels and the advanced stage of disease (p < 0.001). The older group of patients had statistically significantly higher levels of β2-microglobulin compared to the younger group (p = 0.001). We found strong, signi...
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2016