Ozlem Taskapilioglu - Academia.edu (original) (raw)

Papers by Ozlem Taskapilioglu

Research paper thumbnail of Relapsing-Remitting Multipl Skleroz Hastalarında Serum Ürik Asit Düzeyinin Kognitif Fonksiyonlar ve Plak Sayısı ile İlişkisi

nöro psikiyatri arşivi, 2011

Relapsing-Remitting Multipl Skleroz Hastalarında Serum Ürik Asit Düzeyinin Kognitif Fonksiyonlar ... more Relapsing-Remitting Multipl Skleroz Hastalarında Serum Ürik Asit Düzeyinin Kognitif Fonksiyonlar ve Plak Sayısı ile İlişkisi Tahir Kurtuluş Yoldaş, Hava Dönmez Keklikoğlu, Özkan Zengin, Elif Banu Solak, Selda Keskin 2010; 47(4):333-337 ...

Research paper thumbnail of Caregiver Burden at Different Stages of Alzheimer’s Disease

Noro Psikiyatri Arsivi, 2016

Research paper thumbnail of Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response

Journal of the Neurological Sciences, 2016

Prophylactic therapy response varies in migraine patients. The present study investigated the rel... more Prophylactic therapy response varies in migraine patients. The present study investigated the relationship between the resistance to the drugs commonly used in prophylactic therapy and the possible polymorphic variants of proteins involved in the metabolism of these drugs. Migraine patients with the MDR1 3435TT genotype exhibited a better treatment response to topiramate than migraine patients with the CC and CT genotypes (p=0.020). The MDR1 C3435T polymorphism was also found to be a higher risk factor for topiramate treatment failure in a comparison of the number of days with migraine (β2=1.152, p=0.015). However, there was no significant relationship between the treatment response to topiramate and either the CYP2D6 or CYP2C19 polymorphism, and there were no significant correlations between the treatment responses to amitriptyline, propranolol, and valproic acid and the MDR1, CYP2D6 and CYP2C19 gene polymorphisms. This is the first study to investigate the effect of the polymorphic variants on prophylactic therapy response in migraine patients.

Research paper thumbnail of Presenting With Status Epilepticus That Neurosyphilis: Case Report

Journal of Neurology Research, Jul 5, 2012

Syphilis; which is a sexually transmitted disease that is caused by the agent Treponema Pallidum ... more Syphilis; which is a sexually transmitted disease that is caused by the agent Treponema Pallidum has been seen less frequently with penicillin therapy. In recent years, with the emergence of HIV infection and the increasing number of patients with immune deficiency, syphilis has started being seen frequently and gained importance. If the patients with primary and secondary syphilis are not treated, approximately 7-9% of them may develop neurosyphilis. Meningovasculary syphilis is characterized with conditions such as hemiparesis, aphasia, visual loss, confusion that are caused by cortical and subcortical infarcts. Thirty-six year old male and 35-year-old male patients presented to our hospital with status epilepticus. We decided to discuss neurosyphilis cases with literature that presented with generalized seizures, mental confusion, hemiparesis and had MRI findings compatible with herpes simplex encephalitis and lesions that disappeared with antibiotic therapy.

Research paper thumbnail of A Case Report of Etiology of Cerebral Venous Sinus Thrombosis Developed After Spinal Anesthesia in Asteroid, Doping Using Young Athlete

Journal of Neurology Research, Mar 12, 2014

Cerebral venous thrombosis (SVT) was defined for the first time in 1875. It is a rare entity that... more Cerebral venous thrombosis (SVT) was defined for the first time in 1875. It is a rare entity that can occur with different clinics. Superior sagittal sinus is affected most (70-80%), then transverse, sigmoid, and in a lesser extent, cavernous sinus involvement is seen. Cortical and cerebellar veins may also be involved. A 22-year-old male patient presented to the emergency room with mental confusion and seizures. According to the information received from his relatives, he was actively involved in sports for 2 years. That he was using amino acid weighted and high-energy multi-vitamin complexes within a day, and monthly having an injection called Deca-Durabolin: (nandrolone decanoate), is learned. One week before his coming to the hospital, that he had cruciate ligament surgery on his left knee and that spinal anesthesia was administered to him during the operation is determined. Thereafter, it is learnt that he had generalized tonic-clonic seizure and impairment of consciousness was added when he came to the hospital. During the patient's neurologic examination in the emergency service, it is observed that his consciousness tended to fall asleep, and existing of bilateral papilledema and spontaneous movements in the right, and bilateral Babinski was positive. In brain computed tomography and magnetic resonance imaging (MRI) of the patient, in the left temporo-parieto-occipital hemorrhagic infarct and in venous MR angiography, in left transfer sinus, sigmoid sinus and jugular sinus complete thrombus, in right transfer and lateral sinus, reduction in blood stream and a view matched with thrombus were detected. On the 16th day of his hospitalization, brain death was determined in patient. At the arrival of the patient to the clinic, mental confusion, being male, to be accompanied by intracranial hemorrhage shows that poor prognosis.

Research paper thumbnail of Targeting apoptosis through foxp1, and n-cadherin with glatiramer acetate in chick embryos during neural tube development

Turkish Neurosurgery, 2015

To demonstrate the effect of glatiramer acetate (GA) in chick embryos on neural tube (NT) develop... more To demonstrate the effect of glatiramer acetate (GA) in chick embryos on neural tube (NT) development, and to explore its effects of Foxp1, apoptosis, and N-cadherin. One hundred fertile, specific pathogen free eggs were divided into 5 groups for this study. The eggshell was windowed specifically at 24 hours of incubation. The embryos in Group 1 (n=20) were treated with 10 μl physiological saline; in Group 2 the embryos (n=20) were given 10 μl GA (equal to daily human therapeutic dose); 20 μl GA (equal to twice daily human therapeutic dose) was injected to embryos in Group 3 (n=20); in Group 4 and 5, 30 μl and 40 μl GA were administered to the embryos (n=20) (equal to x3 and x4 daily human therapeutic dose, respectively). Each egg was re-incubated for 24 hours more. Then, histological and immunohistochemical evaluation of the subjects were done. The embryos with NT defect showed FOXP1 expression without N- cadherin or staining with N-cadherin in another location in our study. We interpreted this result as GA leading to an NT closure defect by increasing FOXP expression. Moreover, we also showed the reverse relation between FOXP1 and N-cadherin at the immunohistochemical level for the first time. GA affects the spinal cord development through FOXP in the chick embryo model at high doses.

Research paper thumbnail of Vestibüler Schwannoma Cerrahisini Komplike Hale Getiren Tansiyon Pnömosefalus Nedenli Parkinsonizm

Turkiye Klinikleri Journal of Medical Sciences, 2011

Research paper thumbnail of Unusual Patient with Multiple Sclerosis and Shunt-Responsive Normal-Pressure Hydrocephalus

Clinical Neuroradiology, 2011

Research paper thumbnail of Persistent headache in a postpartum patient: the investigation and management

Research paper thumbnail of The retrospective evaluation of the patients diagnosed moyamoya disease at Uludağ University Hospital between 2006-2010

Turkish Journal of Cerebrovascular Diseases, 2011

Research paper thumbnail of Sociodemographics, clinical features, and psychiatric comorbidities of patients with psychogenic nonepileptic seizures: Experience at a specialized epilepsy center in Turkey

Research paper thumbnail of Onset of multiple sclerosis following post-partum depressive and manic episodes

Psychiatry and Clinical Neurosciences, 2007

Research paper thumbnail of Laryngeal dystonia in a patient with bilateral anterior cerebral artery infarction during treatment of delirium with haloperidol

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008

Research paper thumbnail of Migrende Yaşam Kalitesinin Değerlendirilmesi

Nöro Psikiyatri Arşivi, 2013

Quality of life is the perception of an individual's position in life associated with his... more Quality of life is the perception of an individual's position in life associated with his objectives, expectations, interests, and standard's of life. Health-related quality of life, on the other hand, includes satisfaction with his health and emotional reaction to his state of health. Primary headaches are encountered commonly in adults during their most productive years like end of puberty and at the beginning of 50's. Migraine alone is responsible for 1.3% of years with disability in the world, all headaches together being responsible for twice of this load. Headaches both worsen quality of life of individuals and place a significant burden on the society. This review will focus on the effects of primary headaches, especially migraine, on quality of life and tools used to evaluate these effects.

Research paper thumbnail of Sporadic Creutzfeldt-Jacob Disease: An 8-Year Experience from a Single Center in Turkey

Nöro Psikiyatri Arşivi, 2013

Research paper thumbnail of Nosocomial Leuconostoc Pseudomesenteroides Meningitis: A Case Report And Review Of The Literature

Medical Journal of Trakya University, 2009

... Bakar1 Case Report Leuconostoc spp. members of the Streptococcaceae fam-ily, are nonmotile, f... more ... Bakar1 Case Report Leuconostoc spp. members of the Streptococcaceae fam-ily, are nonmotile, facultative anaerobic gram-positive cocci that are naturally resistant to vancomycin (1). The first case with Leuconostoc spp. as ...

Research paper thumbnail of Hairy cell leukemia presenting with Guillain-Barre syndrome

Leukemia & Lymphoma, 2007

... Titre du document / Document title. Hairy cell leukemia presenting with Guillain-Barre syndro... more ... Titre du document / Document title. Hairy cell leukemia presenting with Guillain-Barre syndrome. Auteur(s) / Author(s). OZKAN Atilla ; TASKAPILIOGLU Ozlem ; BICAN Aylin ; OZKOCAMAN Vildan ; OZTURK Hulya ; OZKALEMKAS Fahir ; ALI Ridvan ; Revue / Journal Title. ...

Research paper thumbnail of Pathological yawning in a patient with anxiety and chronic disease anaemia

Journal of Psychopharmacology, 2008

Yawning, frequent in daily life, is accepted as a complex arousal reflex. Excessive yawning may b... more Yawning, frequent in daily life, is accepted as a complex arousal reflex. Excessive yawning may be due to neurological, psychiatric, infectious, gastrointestinal or metabolic diseases. This reflex has also been associated with different selective serotonin reuptake inhibitors. We report a female patient, with excessive yawning, who was on selective serotonin reuptake inhibitor treatment with the diagnosis of generalised anxiety disorder. She was then found to have endometrial carcinoma. Her complaints of palpitation, shortness of breath and loss of energy might be explained by a psychiatric disease and/or anaemia. Previous anaemic periods and partial response of her psychiatric symptoms during last 3 years alerted us to think about an organic cause. Investigations for chronic disease anaemia resulted in diagnosis of endometrial carcinoma. This case is a good example showing misdiagnosis caused by medical stigmatisation.

Research paper thumbnail of Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats

Journal of Clinical Neuroscience, 2009

We investigated the neuroprotective effects of pre-and postconditioning on infarct volume in the ... more We investigated the neuroprotective effects of pre-and postconditioning on infarct volume in the transient middle cerebral artery occlusion (MCAo) model in rats. Thirty-two male rats were divided into occlusion, preconditioning, postconditioning and both pre-and postconditioning groups. MCAo (120 minutes) was monitored with continuous cerebral tissue oxygen (O 2 ) pressure (PtiO 2 ). Pre-conditioning comprised 10 minutes of MCAo, 24 hours prior to the 120 minute MCAo. The postconditioning algorithm was 30 seconds of reperfusion followed by 30 seconds of MCAo. This cycle was repeated 3 times at the onset of reperfusion. Comparison of infarct volumes showed a significant difference between the conditioned groups and occlusion group. Although there was better protection in the preconditioning group compared with the other two conditioned groups, the results did not reach statistically significant levels. The results suggest that preconditioning, postconditioning and pre/post conditioning have protective effects on cerebral ischemia.

Research paper thumbnail of P211 Effect of modafinil on evoked potantials and fatigue in multiple sclerosis

Clinical Neurophysiology, 2008

The rational for this study was to investigate the behaviour of continuous drinking and to evalua... more The rational for this study was to investigate the behaviour of continuous drinking and to evaluate the time and number of repeated swallowing movements necessary for continuous drinking of water (CDW) in normal adult subjects and patients with multiple sclerosis (MS).

Research paper thumbnail of Relapsing-Remitting Multipl Skleroz Hastalarında Serum Ürik Asit Düzeyinin Kognitif Fonksiyonlar ve Plak Sayısı ile İlişkisi

nöro psikiyatri arşivi, 2011

Relapsing-Remitting Multipl Skleroz Hastalarında Serum Ürik Asit Düzeyinin Kognitif Fonksiyonlar ... more Relapsing-Remitting Multipl Skleroz Hastalarında Serum Ürik Asit Düzeyinin Kognitif Fonksiyonlar ve Plak Sayısı ile İlişkisi Tahir Kurtuluş Yoldaş, Hava Dönmez Keklikoğlu, Özkan Zengin, Elif Banu Solak, Selda Keskin 2010; 47(4):333-337 ...

Research paper thumbnail of Caregiver Burden at Different Stages of Alzheimer’s Disease

Noro Psikiyatri Arsivi, 2016

Research paper thumbnail of Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response

Journal of the Neurological Sciences, 2016

Prophylactic therapy response varies in migraine patients. The present study investigated the rel... more Prophylactic therapy response varies in migraine patients. The present study investigated the relationship between the resistance to the drugs commonly used in prophylactic therapy and the possible polymorphic variants of proteins involved in the metabolism of these drugs. Migraine patients with the MDR1 3435TT genotype exhibited a better treatment response to topiramate than migraine patients with the CC and CT genotypes (p=0.020). The MDR1 C3435T polymorphism was also found to be a higher risk factor for topiramate treatment failure in a comparison of the number of days with migraine (β2=1.152, p=0.015). However, there was no significant relationship between the treatment response to topiramate and either the CYP2D6 or CYP2C19 polymorphism, and there were no significant correlations between the treatment responses to amitriptyline, propranolol, and valproic acid and the MDR1, CYP2D6 and CYP2C19 gene polymorphisms. This is the first study to investigate the effect of the polymorphic variants on prophylactic therapy response in migraine patients.

Research paper thumbnail of Presenting With Status Epilepticus That Neurosyphilis: Case Report

Journal of Neurology Research, Jul 5, 2012

Syphilis; which is a sexually transmitted disease that is caused by the agent Treponema Pallidum ... more Syphilis; which is a sexually transmitted disease that is caused by the agent Treponema Pallidum has been seen less frequently with penicillin therapy. In recent years, with the emergence of HIV infection and the increasing number of patients with immune deficiency, syphilis has started being seen frequently and gained importance. If the patients with primary and secondary syphilis are not treated, approximately 7-9% of them may develop neurosyphilis. Meningovasculary syphilis is characterized with conditions such as hemiparesis, aphasia, visual loss, confusion that are caused by cortical and subcortical infarcts. Thirty-six year old male and 35-year-old male patients presented to our hospital with status epilepticus. We decided to discuss neurosyphilis cases with literature that presented with generalized seizures, mental confusion, hemiparesis and had MRI findings compatible with herpes simplex encephalitis and lesions that disappeared with antibiotic therapy.

Research paper thumbnail of A Case Report of Etiology of Cerebral Venous Sinus Thrombosis Developed After Spinal Anesthesia in Asteroid, Doping Using Young Athlete

Journal of Neurology Research, Mar 12, 2014

Cerebral venous thrombosis (SVT) was defined for the first time in 1875. It is a rare entity that... more Cerebral venous thrombosis (SVT) was defined for the first time in 1875. It is a rare entity that can occur with different clinics. Superior sagittal sinus is affected most (70-80%), then transverse, sigmoid, and in a lesser extent, cavernous sinus involvement is seen. Cortical and cerebellar veins may also be involved. A 22-year-old male patient presented to the emergency room with mental confusion and seizures. According to the information received from his relatives, he was actively involved in sports for 2 years. That he was using amino acid weighted and high-energy multi-vitamin complexes within a day, and monthly having an injection called Deca-Durabolin: (nandrolone decanoate), is learned. One week before his coming to the hospital, that he had cruciate ligament surgery on his left knee and that spinal anesthesia was administered to him during the operation is determined. Thereafter, it is learnt that he had generalized tonic-clonic seizure and impairment of consciousness was added when he came to the hospital. During the patient's neurologic examination in the emergency service, it is observed that his consciousness tended to fall asleep, and existing of bilateral papilledema and spontaneous movements in the right, and bilateral Babinski was positive. In brain computed tomography and magnetic resonance imaging (MRI) of the patient, in the left temporo-parieto-occipital hemorrhagic infarct and in venous MR angiography, in left transfer sinus, sigmoid sinus and jugular sinus complete thrombus, in right transfer and lateral sinus, reduction in blood stream and a view matched with thrombus were detected. On the 16th day of his hospitalization, brain death was determined in patient. At the arrival of the patient to the clinic, mental confusion, being male, to be accompanied by intracranial hemorrhage shows that poor prognosis.

Research paper thumbnail of Targeting apoptosis through foxp1, and n-cadherin with glatiramer acetate in chick embryos during neural tube development

Turkish Neurosurgery, 2015

To demonstrate the effect of glatiramer acetate (GA) in chick embryos on neural tube (NT) develop... more To demonstrate the effect of glatiramer acetate (GA) in chick embryos on neural tube (NT) development, and to explore its effects of Foxp1, apoptosis, and N-cadherin. One hundred fertile, specific pathogen free eggs were divided into 5 groups for this study. The eggshell was windowed specifically at 24 hours of incubation. The embryos in Group 1 (n=20) were treated with 10 μl physiological saline; in Group 2 the embryos (n=20) were given 10 μl GA (equal to daily human therapeutic dose); 20 μl GA (equal to twice daily human therapeutic dose) was injected to embryos in Group 3 (n=20); in Group 4 and 5, 30 μl and 40 μl GA were administered to the embryos (n=20) (equal to x3 and x4 daily human therapeutic dose, respectively). Each egg was re-incubated for 24 hours more. Then, histological and immunohistochemical evaluation of the subjects were done. The embryos with NT defect showed FOXP1 expression without N- cadherin or staining with N-cadherin in another location in our study. We interpreted this result as GA leading to an NT closure defect by increasing FOXP expression. Moreover, we also showed the reverse relation between FOXP1 and N-cadherin at the immunohistochemical level for the first time. GA affects the spinal cord development through FOXP in the chick embryo model at high doses.

Research paper thumbnail of Vestibüler Schwannoma Cerrahisini Komplike Hale Getiren Tansiyon Pnömosefalus Nedenli Parkinsonizm

Turkiye Klinikleri Journal of Medical Sciences, 2011

Research paper thumbnail of Unusual Patient with Multiple Sclerosis and Shunt-Responsive Normal-Pressure Hydrocephalus

Clinical Neuroradiology, 2011

Research paper thumbnail of Persistent headache in a postpartum patient: the investigation and management

Research paper thumbnail of The retrospective evaluation of the patients diagnosed moyamoya disease at Uludağ University Hospital between 2006-2010

Turkish Journal of Cerebrovascular Diseases, 2011

Research paper thumbnail of Sociodemographics, clinical features, and psychiatric comorbidities of patients with psychogenic nonepileptic seizures: Experience at a specialized epilepsy center in Turkey

Research paper thumbnail of Onset of multiple sclerosis following post-partum depressive and manic episodes

Psychiatry and Clinical Neurosciences, 2007

Research paper thumbnail of Laryngeal dystonia in a patient with bilateral anterior cerebral artery infarction during treatment of delirium with haloperidol

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008

Research paper thumbnail of Migrende Yaşam Kalitesinin Değerlendirilmesi

Nöro Psikiyatri Arşivi, 2013

Quality of life is the perception of an individual's position in life associated with his... more Quality of life is the perception of an individual's position in life associated with his objectives, expectations, interests, and standard's of life. Health-related quality of life, on the other hand, includes satisfaction with his health and emotional reaction to his state of health. Primary headaches are encountered commonly in adults during their most productive years like end of puberty and at the beginning of 50's. Migraine alone is responsible for 1.3% of years with disability in the world, all headaches together being responsible for twice of this load. Headaches both worsen quality of life of individuals and place a significant burden on the society. This review will focus on the effects of primary headaches, especially migraine, on quality of life and tools used to evaluate these effects.

Research paper thumbnail of Sporadic Creutzfeldt-Jacob Disease: An 8-Year Experience from a Single Center in Turkey

Nöro Psikiyatri Arşivi, 2013

Research paper thumbnail of Nosocomial Leuconostoc Pseudomesenteroides Meningitis: A Case Report And Review Of The Literature

Medical Journal of Trakya University, 2009

... Bakar1 Case Report Leuconostoc spp. members of the Streptococcaceae fam-ily, are nonmotile, f... more ... Bakar1 Case Report Leuconostoc spp. members of the Streptococcaceae fam-ily, are nonmotile, facultative anaerobic gram-positive cocci that are naturally resistant to vancomycin (1). The first case with Leuconostoc spp. as ...

Research paper thumbnail of Hairy cell leukemia presenting with Guillain-Barre syndrome

Leukemia & Lymphoma, 2007

... Titre du document / Document title. Hairy cell leukemia presenting with Guillain-Barre syndro... more ... Titre du document / Document title. Hairy cell leukemia presenting with Guillain-Barre syndrome. Auteur(s) / Author(s). OZKAN Atilla ; TASKAPILIOGLU Ozlem ; BICAN Aylin ; OZKOCAMAN Vildan ; OZTURK Hulya ; OZKALEMKAS Fahir ; ALI Ridvan ; Revue / Journal Title. ...

Research paper thumbnail of Pathological yawning in a patient with anxiety and chronic disease anaemia

Journal of Psychopharmacology, 2008

Yawning, frequent in daily life, is accepted as a complex arousal reflex. Excessive yawning may b... more Yawning, frequent in daily life, is accepted as a complex arousal reflex. Excessive yawning may be due to neurological, psychiatric, infectious, gastrointestinal or metabolic diseases. This reflex has also been associated with different selective serotonin reuptake inhibitors. We report a female patient, with excessive yawning, who was on selective serotonin reuptake inhibitor treatment with the diagnosis of generalised anxiety disorder. She was then found to have endometrial carcinoma. Her complaints of palpitation, shortness of breath and loss of energy might be explained by a psychiatric disease and/or anaemia. Previous anaemic periods and partial response of her psychiatric symptoms during last 3 years alerted us to think about an organic cause. Investigations for chronic disease anaemia resulted in diagnosis of endometrial carcinoma. This case is a good example showing misdiagnosis caused by medical stigmatisation.

Research paper thumbnail of Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats

Journal of Clinical Neuroscience, 2009

We investigated the neuroprotective effects of pre-and postconditioning on infarct volume in the ... more We investigated the neuroprotective effects of pre-and postconditioning on infarct volume in the transient middle cerebral artery occlusion (MCAo) model in rats. Thirty-two male rats were divided into occlusion, preconditioning, postconditioning and both pre-and postconditioning groups. MCAo (120 minutes) was monitored with continuous cerebral tissue oxygen (O 2 ) pressure (PtiO 2 ). Pre-conditioning comprised 10 minutes of MCAo, 24 hours prior to the 120 minute MCAo. The postconditioning algorithm was 30 seconds of reperfusion followed by 30 seconds of MCAo. This cycle was repeated 3 times at the onset of reperfusion. Comparison of infarct volumes showed a significant difference between the conditioned groups and occlusion group. Although there was better protection in the preconditioning group compared with the other two conditioned groups, the results did not reach statistically significant levels. The results suggest that preconditioning, postconditioning and pre/post conditioning have protective effects on cerebral ischemia.

Research paper thumbnail of P211 Effect of modafinil on evoked potantials and fatigue in multiple sclerosis

Clinical Neurophysiology, 2008

The rational for this study was to investigate the behaviour of continuous drinking and to evalua... more The rational for this study was to investigate the behaviour of continuous drinking and to evaluate the time and number of repeated swallowing movements necessary for continuous drinking of water (CDW) in normal adult subjects and patients with multiple sclerosis (MS).