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Papers by Oznur Adiguzel AKMAN

International journal of developmental disabilities, May 25, 2023

Journal of Intellectual Disability Research, 2021

BackgroundBrain‐derived neurotrophic factor (BDNF) and S100B are reported to play an important ro... more BackgroundBrain‐derived neurotrophic factor (BDNF) and S100B are reported to play an important role in neurodevelopment and may contribute to developmental pathogenesis in neuropsychiatric diseases. In this study, we aimed to examine the possible roles of BDNF and S100B in the pathogenesis of nonsyndromic intellectual disability (NS‐ID) and their relationship with cognitive performance.MethodsThirty‐three patients with intellectual disability (ID) and 30 typically developing children were compared. BDNF and S100B serum levels were measured with ELISA. The Wechsler Intelligence Scale for Children‐Revised Short form (WISC‐R) and Leiter intelligence test were administered to determine the intelligence levels of subjects. Leiter intelligence test was applied to 10 participants (30.31%) in the ID group because they had speech and communication problems. All other participants underwent WISC‐R.ResultsBrain‐derived neurotrophic factor levels were found to be significantly low in the patien...

Dyke-Davidoff-Masson sendromu (DDMS) ilk kez 1933 yılında Dyke, Davidoff ve Masson tarafından tan... more Dyke-Davidoff-Masson sendromu (DDMS) ilk kez 1933 yılında Dyke, Davidoff ve Masson tarafından tanımlanan, sıklıkla çocukluk döneminde ortaya çıkan, nöbet, hemipleji/ hemiparezi, zihinsel yetersizlik, serebral hemiatrofi, fasiyal asimetri, kalvaryal kalınlaşma, frontal sinüslerin hiperpnömatizasyonuyla karakterize nadir görülen bir sendromdur. Bu vakada, fokal epilepsi ve hemiparezi tanısı ile izlenen, eşlik eden fasiyal asimetri, zihinsel yetersizlik ve kraniyal görüntülemesinde DDMS ile uyumlu bulguları olan 15 yaşında bir kız hasta sunularak serebral hemiatrofi ayırıcı tanısında DDMS düşünülmesi gerektiği vurgulanmak istenmiştir. DDMS'nin tedavisi semptomatiktir ve tedavi epileptik nöbetler, hemiparezi veya hemipleji ve öğrenme güçlüğü gibi sorunlara yönelik olmalıdır. Sonuç olarak, epilepsi tanısı ile izlenen hastaların nörolojik muayenesinde fasial asimetri ve hemiparezi saptanması durumunda mutlaka kranyal MRG yapılmalı ve görüntülemede serebral hemiatrofi, kafatası kemiklerinde kalınlaşma gibi bulguların eşlik etmesi durumunda DDMS de aklımıza gelmeli ve diğer serebral hemiatrofi yapan nedenlerle ayırıcı tanı yapılmalıdır.

DergiPark (Istanbul University), Dec 19, 2022

Psychiatry and Clinical Psychopharmacology, 2018

Grief mania that is evaluated as psychogenic mania in the literature is related to manic episode ... more Grief mania that is evaluated as psychogenic mania in the literature is related to manic episode that emerges after the loss of a loved one. There are not many cases that associate causality of beginning of mania and mourning in the literature. It is known that mania is induced by traumatic events but the cases that do not suit stages of development of grief process are evaluated as pathological grief. In this case, the woman who experienced manic episode after her son's death is presented. This case is prepared because mania should be considered as possible grief reaction. Case presentation: A patient who is 40 years old, married, mother of 4 children is brought by relatives because of aggressiveness, tension, insomnia for 4 days, fast and talk a lot and nonsense laughing attacks. She was presented to hospital for stressful life events 2 years ago and started to be on medication (escitalopram 10 mg) because of depression and fibromiyaliji diagnosis. She used medication for 1.5 years and she did not use any medication for the last 6months. There is no history for mental disorder in her family. Psychological examination: her interest for the environment was increased, self-care ability got better, her temperament was cheerful, her sociability was respectful, amount of talking and tone of voice increased, mimic and gesture was appropriate for her temperament, sleeping decreased, thought flow increased and achieved goal of conversation late. Moreover, there were grandiose delusions and hypervigilance, affect was close to euphoria, her psychomotor behaviours increased and social functioning decreased. According to biochemical and radiological workup, there was no pathological situation. The client started to use Lithium 900 mg/day and Olanzapin 10 mg/day because of the bipolar disorder diagnosis. The patient's blood lithium level was 0.8mEq/L and lithium was used 1200 mg/day and then 10 days later the patient's blood lithium level was 0.72 mEq/L. According to clinical observations, the patient's manic symptoms remained. Furthermore, the patient started to cry occasionally after 1 month and her grandiosity disappeared. The patient was discharged from the hospital after 45 days. The patient met the criteria for manic episode in DSM 5. The patient did not take any medication for last 6 months. Thus, it is considered that this situation was not induced by medication. It puts the patient into risk group because she was treated for depression before but it is not considered as bipolar depression because there were psychiatric history in the family and depression that experienced 2 years ago was related to stressful life events. It is considered that this case experienced grief/funeral mania because there was contiguity between loss of her son and manic episode, the patient did not react this way to previous challenging life events and the patient was outside of the ordinary 5 stages of grief process.

Düşünen Adam, 2021

Objective: The role of endoplasmic reticulum (ER) stress in the pathogenesis of autism spectrum d... more Objective: The role of endoplasmic reticulum (ER) stress in the pathogenesis of autism spectrum disorder (ASD) has been previously reported in both experimental and postmortem studies. However, no circulating marker of ER stress has been identified so far in ASD patients. In the present study, the plasma level of glucose-regulated protein 78 (GRP78) was investigated in ASD patients as a potential marker for ER stress. Method: Plasma samples taken from healthy control subjects (n=26) and ASD patients (n=29) were used to evaluate circulating GRP78 levels. Plasma GRP78 concentrations were measured by ELISA. The severity of the disease in the ASD group was determined by the childhood autism rating scale. Results: There was no significant difference between the median values of plasma GRP78 levels in ASD (12.40) and healthy control groups (11.11) (p<0.218). Plasma GRP78 concentration was 12.81±4.90 ng/mL in the ASD group and was not significantly different from the control values (11.12±3.83 ng/mL). Conclusion: Although ER stress was associated with ASD, our results showed that plasma levels of GRP78 did not change in ASD patients. Our results suggest that GRP78 is not an appropriate circulatory marker to evaluate ER stress in ASD patients.

Turkish Journal of Child and Adolescent Mental Health, 2021

On beş yaşında erkek ergen, "iç sıkıntısı, huzursuzluk, önemsiz olayları kafasına takma, sayılarl... more On beş yaşında erkek ergen, "iç sıkıntısı, huzursuzluk, önemsiz olayları kafasına takma, sayılarla aşırı uğraşı ve abla takıntısı" yakınmaları ile polikliniğimize başvurdu. Küçük yaşlardan Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases and Associated Health Problems classify mental disorders as discrete categories. However, we often see in our clinical practice that sharp divisions are not possible when the human spirit is concerned and it is very difficult to categorize some patients into any cluster. In this article, we aimed to discuss the diagnostic problems of categorical classification systems through an adolescent case who is diagnosed with diffrent diagnoses (autistic disorder/Asperger Syndrome, Psychotic disorder, İdentity confusion and personality disorder) at diffrent psychiatry clinics.

Dusunen Adam: The Journal of Psychiatry and Neurological Sciences, 2021

Journal of Hydrodynamics, Ser. B, 2013

Expansion characteristics of twin combustion gas jets with high pressure in cylindrical filling l... more Expansion characteristics of twin combustion gas jets with high pressure in cylindrical filling liquid chamber * XUE Xiao-chun (薛晓春), YU Yong-gang (余永刚), ZHANG Qi (张琦)

European Journal of Therapeutics

Turkish Journal of Psychiatry