Péter Török - Profile on Academia.edu (original) (raw)

Papers by Péter Török

Diagnostics, Jul 4, 2023

The degree of cytoreduction achieved during primary debulking surgery (PDS) is an important pr... more 1) The degree of cytoreduction achieved during primary debulking surgery (PDS) is an important prognostic factor for the survival of patients with epithelial ovarian cancer (EOC). Our aim was to investigate the prognostic value of preoperative laboratory parameters for the outcome of PDS. (2) We analyzed the preoperative laboratory parameters of 150 serous EOC patients who underwent PDS between 2006 and 2013. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values of the variables for predicting the PDS outcome. We used binary logistic regression to examine the independent predictive value of the factors for incomplete cytoreduction. (3) Among the parameters, we established optimal cut-off values for cancer antigen (Ca)-125, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and plateletto-lymphocyte ratio (PLR) to predict the outcome of PDS. The results of binary logistic regression showed that stage (FIGO III-IV), MLR (>0.305), and Ca-125 (>169.15 kU/L) were independent significant predictors of the degree of tumor reduction achieved during PDS. (4) In the future, MLR, especially in combination with other parameters, may be useful in determining prognosis and selecting the best treatment option (PDS or neoadjuvant chemotherapy + interval debulking surgery) for ovarian cancer patients.

Orvosi Hetilap, Mar 1, 2017

Az infertilitás leggyakoribb és egyértelmű organikus oka a petevezetékek lezártsága. Az átjárható... more Az infertilitás leggyakoribb és egyértelmű organikus oka a petevezetékek lezártsága. Az átjárhatóság vizsgálatára már számos módszer áll rendelkezésünkre. A hiszteroszalpingográfia kontrasztanyagos röntgeneljárás, amely a méhüreg alaki rendellenességeit és a petevezetékek lefutását mutatja, azonban sugárterheléssel jár, és nem ad információt egyéb kismedencei eltérésekről. A szono-hiszteroszalpingográfiával hasonló érzékenységgel és fajlagossággal vizsgálhatjuk a méh üregét és a petevezetékek átjárhatóságát ultrahang segítségével, egyúttal a kismedencei képletek vizsgálatára is lehetőségünk van. A transvaginalis hidrolaparoszkópia egy új, minimálisan invazív vizsgálómódszer, amely során a hüvely hátsó boltozatán keresztül bevezetett endoszkóp segítségével a petevezetékek és petefészkek direkt vizsgálatára van mód. A laparoszkópos kromopertubáció a meddőségi kivizsgálás "gold standard"-ja, amely invazivitással és altatással jár, valamint az ellátó intézményt is jobban terheli. Biztonságos és költséghatékony átjárhatósági vizsgálat az office hiszteroszkópia során végzett szelektív pertubáció. Az ambulanter elvégezhető átjárhatósági vizsgálatok negatív prediktív értéke magas, így ezek a meddőségi kivizsgálás első vonalában választásra javasolt módszerek. Orv. Hetil., 2017, 158(9), 324-330. Kulcsszavak: infertilitás, petevezeték-átjárhatóság, hiszteroszalpingográfia, szono-hiszteroszalpingográfia, hidrolaparoszkópia, laparoszkópia, hiszteroszkópia Most common organic cause of infertility is the blockage of the Fallopian tubes. Several methods were introduced to evaluate tubal patency. Hysterosalpingography is a conventional radiology procedure using contrast medium, which gives an accurate image of the uterine cavity and the Fallopian tubes, but radiation exposure is necessary. Hysterocontrast-sonography similarly examines the uterine cavity and tubal patency by ultrasonography, and it enables to detect pelvic pathology, too. Transvaginal hydrolaparoscopy is a minimal invasive direct method using endoscope introduced into the abdominal cavity through the posterior vaginal fornix, both ovaries and tubal patency can be observed. Laparoscopy is the "gold standard" procedure in the tubal testing, however it is a more invasive procedure. A cost-effective testing method is the selective tubal pertubation performed via office hysteroscopy. Recent outpatient methods to detect tubal patency have high negative predictive values and recommended to be the first choice in infertility work-up.

Recognizing Ureter and Uterine Artery in Endoscopic Images Using a Convolutional Neural Network

Endoscope-based surgery has several beneficial effects regarding the rehabilitation of the patien... more Endoscope-based surgery has several beneficial effects regarding the rehabilitation of the patients, but has some drawbacks causing difficulties to medical experts, on the contrary. The main disadvantage is that the tactile information is loosed to expert who takes the surgical intervention. There are some organs (e.g. ureters and arteries) in the human body which have similar visual appearances, so the differentiation of them based on only visual expression via endoscopy is a challenging task to the medical experts. To support keyhole-surgery using state-of-the-art image processing solutions, we have developed a semi-automatic software which can distinguish ureters from arteries by a dedicated convolutional neural network (CNN). We have trained the CNN on 2000 images acquired during endoscopic surgery and tested on 500 test ones. 94.2% accuracy has been achieved in this two-classes classification task regarding a binary error function.

Journal of Minimally Invasive Gynecology, Apr 1, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

American Journal of Obstetrics and Gynecology, Jun 1, 2023

Purpose To evaluate the risk for endometrial cancer (EC) in a large series of asymptomatic patien... more Purpose To evaluate the risk for endometrial cancer (EC) in a large series of asymptomatic patients with thickened endometrium at ultrasound examination based on previously published data of a theoretical cohort. Methods In a prospective register study, a total of 1024 women with thickened endometrium in ultrasound examination undergoing histological diagnosis by dilation, hysteroscopy and curettage were evaluated. 124 patients were excluded due to current medication with tamoxifen and/or presence of HNPCC leaving 900 patients for further analysis. Results Mean [standard deviation (SD)] age of patients was 65.6 (8.6) years. Mean (SD) endometrial thickness was 11.9 (5.8) mm. 32 and 6 cases of EC and complex endometrial hyperplasia with atypia were found, respectively. In the univariate analysis, a statistically significant association between endometrial thickness, current use of antihypertensive medication, number of deliveries, and the presence of endometrial fluid in preoperative vaginal ultrasound (p < 0.05) with EC was found. A multivariate logistic regression model incorporating these parameters showed a statistically significant independent association of endometrial thickness, number of deliveries, and the presence of endometrial fluid in preoperative vaginal ultrasound (p < 0.05), but not current use of antihypertensive medication, with EC. Using a cut-off of the endometrial thickness of > 11 mm, the risk for "EC alone" and "EC and complex endometrial hyperplasia with atypia combined" was found to be 6.7% and 7.9%, respectively. Conclusions Our data compare favorably to a theoretical cohort suggesting a clinically reasonable cut-off of > 11 mm endometrial thickness to discriminate between "normal" and "pathological". The data regarding "risk for endometrial cancer" can be used for counseling affected women.

Climacteric, Jul 3, 2020

Endometrial cancer is the most common gynecological malignancy with a relatively good overall pro... more Endometrial cancer is the most common gynecological malignancy with a relatively good overall prognosis. It traditionally has two subtypes: type 1 (endometrioid carcinoma) and type 2 (non-endometrioid carcinoma). The prognosis is excellent for stage I endometrioid cancer, with a 5-year survival rate of 96%. However, the prognosis is much worse for women with high-risk endometrial cancer. Effective preoperative staging is important in order to tailor treatment and achieve optimal long-term survival. The majority of asymptomatic polyps detected by ultrasound are treated surgically. Conventionally, dilatation and curettage was performed to obtain a histological diagnosis, but nowadays hysteroscopy with biopsy is starting to be considered as the gold standard. Hysteroscopic resection seems to reduce the risk of underdiagnosed (atypical endometrial hyperplasia) endometrial cancer. To avoid the spread of malignant cells, hysteroscopy should be performed with concern to keep intrauterine pressure low. In comparison with cervical injection, the hysteroscopic method has a better detection rate in the para-aortic area during sentinel lymph node mapping. In the assessment of cervical involvement, the accuracy of magnetic resonance imaging is significantly higher than the accuracy of hysteroscopy. In fertility-sparing cases, hysteroscopic endometrium resection with progesterone therapy is an acceptable option.

Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affe... more Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affected reproductive parameters in eighty-six (86) TAI positive women referred to IVF treatment. Methods: All participants diagnosed with subclinical or overt hypothyroidism, while euthyroid on thyroxine replacement. Sixty-nine (69) female patients in the same IVF program, with no thyroid abnormalities served as controls (TAI negative group). Results: Statistically significant baseline hormone profile differences were found in multiple parameters between the two groups. TAI positive women were older (mean age 34.7±5.42 vs. 32.32±5.04 years; p=0.002), had higher FSH (8.4±3.49 U/L vs. 7.04±2.32 U/L; p=0.024), higher E2 (53.94±47.61 vs. 42.93±18.92 pg/ml; p=0.025) levels, while their AMH (2.88±2.62 vs. 3.6±1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64±0.96 vs. 1.66±0.65 uIU/ml; p= 0.652) between the two groups, FT3 (2.63±0.58 vs. 2.98±0.55 pg/ml; p=0.002) was l...

Diagnostics

The development of minimally invasive techniques has led to the creation of innovative alternativ... more The development of minimally invasive techniques has led to the creation of innovative alternatives in cases where traditional methods are not applicable. In modern gynecology, hysteroscopy has become the gold standard for the evaluation and treatment of intrauterine pathology. Endometrial ablation (EA) is a procedure that uses different types of energy to destroy the endometrium and is currently used as an alternative technique in cases of heavy menstrual bleeding when medical treatment has failed and uterine preservation is desired. The aim of this review was to evaluate the feasibility, safety, and clinical outcomes of hysteroscopic EA as an alternative in patients with abnormal uterine bleeding. A detailed computerized search of the literature was performed in the main electronic databases (MEDLINE, EMBASE, Web of Science, PubMed, and Cochrane Library), from 1994 to June 2022, to evaluate the outcomes in patients with abnormal uterine bleeding (AUB) undergoing EA using hysterosc...

Human Reproduction

Study question Is there any positive effect of adding new modalities to the traditional infertili... more Study question Is there any positive effect of adding new modalities to the traditional infertility work-up, like 3D sonography, office hysteroscopy and endometrial biopsy? Summary answer During infertility workup conventional diagnostic tests should be combined with new approaches (3D-TVS, OHSC and endometrial biopsy) to achieve more accurate and less invasive diagnostics. What is known already Female infertility can be explained by functional or organic abnormalities affecting the reproductive system. The most common organic causes include abnormalities within the uterine cavity (e.g. endometrial polyp, submucosal fibroid, intrauterine adhesion), morphological disorders (e.g. dysmorphic uterus, uterine septum) and abnormalities of the endometrium (e.g. chronic endometritis). Study design, size, duration In our retrospective study, we examined patients with primary and secondary infertility. All the patients were assessed by 3D-TVS and OHSC to detect morphological and intrauterine ...

Medicina

Background and Objectives: Hysteroscopy is a reliable technique which is highly useful for the ev... more Background and Objectives: Hysteroscopy is a reliable technique which is highly useful for the evaluation and management of intrauterine pathology. Recently, the widespread nature of in-office procedures without the need for anesthesia has been requesting validation of practical approach in order to reduce procedure-related pain. In this regard, we performed a comprehensive review of literature regarding pain management in office hysteroscopic procedures. Materials and Methods: MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), Global Health, Health Technology Assessment Database and Web of Science, other research registers (for example Clinical Trials database) were searched. We searched for all original articles regarding pain relief strategy during office hysteroscopy, without date restriction. Results have been collected and recommendations have been summarized according ...

Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice

Journal of Gynecology Obstetrics and Human Reproduction

Reproductive outcomes after expectant and surgical management for tubal pregnancy: a retrospective study

Minimally Invasive Therapy & Allied Technologies

Background: The management of ectopic pregnancy is widely debated. Salpingectomy, salpingostomy, ... more Background: The management of ectopic pregnancy is widely debated. Salpingectomy, salpingostomy, and expectant management are widely performed, but the best approach in terms of keeping good future spontaneous fertility chances is yet to be determined. Material and methods: We performed a retrospective analysis (Clinical Trial ID: NCT05479786) of the medical records of patients with an ultrasonographic or surgical diagnosis of tubal ectopic pregnancy that were admitted to the University of Debrecen Clinical Centre between 2012 and 2020. Results: A total of 312 patients were included in the analysis. Patients managed expectantly and patients treated with salpingostomy had significantly higher rates of clinical pregnancy than patients treated with salpingectomy. Pregnancy outcomes and recurrence rates were comparable between the study groups. Salpingectomy was found to decrease the likelihood of conceiving spontaneously by 65%. A stratified analysis based on serum β-HCG levels demonstrated that all treatment modalities carry the same reproductive opportunities for patients presenting with β-HCG levels ≤ 1745 IU/L. Conclusion: Salpingectomy was found to decrease the patient's chance of achieving a natural conception. Conservative approaches should be considered with caution only when the patient's clinical condition permits, and the patient is appropriately counseled.

International Journal of Molecular Sciences

Endometrial cancer represents the fifth most common cancer in women, and the most common gynecolo... more Endometrial cancer represents the fifth most common cancer in women, and the most common gynecological malignancy in developed countries [...]

Reproductive Sciences

Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocr... more Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders, the laboratory parameters were corrected before IVF treatment. One hundred sixty one patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32.5%), diminished ovarian reserve (23.8%), insulin resistance (22.5%), PCOS (15.2%), hyperprolactinaemia (13.4%), obesity (12.1%), hypogonadotropic hypogonadism (0.8%) and congenital adrenal hyperplasia (0.2%). Before the IVF treatment, systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI and FSH were found in the study group, while AMH level was lower. There were no...

Office Hysteroscopy as a Feasible Method for Diagnosing and Treating Intrauterine Lesions - Data of a Private Office in Hungary

Is there proof of transferability of laparoscopic psychomotor skills from the simulator laboratory to the operating room? Results from a systematic review

Journal of Obstetrics and Gynaecology, 2021

Abstract This systematic review aims to understand better the translation of laparoscopic psychom... more Abstract This systematic review aims to understand better the translation of laparoscopic psychomotor skills, acquired in dry lab training, into a direct patient benefit in actual clinical practice in the operating room. The review was performed according to PRISMA guidance, searching database-specific filters for controlled trials: ‘laparoscopy’, ‘simulator’, ‘surgical training’, ‘dry lab’, ‘psychomotor skills’. We included only RCTs in which the study population was the surgical trainee or novice surgeon with no prior simulation training, and the intervention was simulation training in laparoscopic surgery, regardless of subspecialty. Ten studies were included in this systematic review. The mean performance score was higher compared to the control groups. Fewer errors were noted in the intervention groups. No clinical patient outcomes (mortality, morbidity, quality of life) were addressed in these studies. All the trials were at high risk of bias. Training outside the operating room may lead to better surgical performance and less operative time. Nevertheless, additional studies with better designs are needed to provide more robust evidence.

Virtual sonographic hysteroscopy in assisted reproduction: A retrospective cost‐effectiveness analysis

International Journal of Gynecology & Obstetrics, 2021

ObjectiveTo analyze the cost‐effectiveness of virtual sonographic hysteroscopy (VSH) performed be... more ObjectiveTo analyze the cost‐effectiveness of virtual sonographic hysteroscopy (VSH) performed before in vitro fertilization (IVF) (Scenario 1), frozen embryo transfer (Scenario 2), and oocyte donation (Scenario 3) attempts.MethodsA retrospective analysis of data extracted from patients’ files was conducted. Before undergoing the assigned treatment, VSH was offered to all patients. Cost‐effectiveness was calculated on the basis of cost per live birth. The total cost was compared with a control group of patients who declined to have hysteroscopy before their treatment.ResultsA total of 292 women were involved. Virtual sonographic hysteroscopy was performed in 192 women. Conventional operative hysteroscopy was subsequently required in 34 of them (17.7%). Subsequent assisted reproduction attempts resulted in live birth in 111 women—34/69 (49.3%), 35/69 (50.7%), and 42/54 (77.8%) in Scenarios 1, 2, and 3, respectively. This compared favorably with 100 women who declined VSH, with live b...

Archives of Gynecology and Obstetrics, 2020

Purpose To investigate the effectiveness and risks of different surgical therapies for isthmocele... more Purpose To investigate the effectiveness and risks of different surgical therapies for isthmocele in symptomatic women with abnormal uterine bleeding, infertility, or for the prevention of obstetric complications, considering safety and surgical complications. Methods PubMed/MEDLINE, Scopus, Embase, Science Direct, and Cochrane Library were systematically searched (n° CRD4201912035) for original articles on the surgical treatment of isthmocele published between 1950 and 2018. Data synthesis was completed using MedCalc 16.4.3. The body of evidence was assessed using the GRADE methodology. We retrieved 33 publications: 28 focused on a single surgical technique, and five comparing different techniques. Meta-analysis showed an improvement of symptoms in 85.00% (75.05-92.76%) of women after hysteroscopic correction, 92.77% (85.53-97.64%) after laparoscopic/robotic correction, and 82.52% (67.53-93.57%) after vaginal correction. Hysteroscopic surgery was associated with the lowest risk of complications (0.76%, 0.20-1.66%). Conclusions We found adequate evidence supporting the use of surgery for the treatment of symptomatic isthmocele, as it was found to improve the bleeding symptoms in more than 80% of patients. Differently, we found a lack of evidence regarding the role of surgery with the purpose of improving fertility or reducing the risk of obstetric complications in women with asymptomatic isthmocele. The hysteroscopic correction of isthmocele may be the safest and most effective strategy in those patients with adequate residual myometrial thickness overlying the isthmocele. Laparoscopic and vaginal surgeries may be the preferred options for patients with a thinner residual myometrium over the defect (< 2.5 mm) and when hysteroscopic treatment is inconclusive.

International Journal of Food Sciences and Nutrition, 2019

Vitamin D is an important nutrient involved in many fundamental health outcomes. However, its inf... more Vitamin D is an important nutrient involved in many fundamental health outcomes. However, its influence on female reproductive function remains ambiguous. Cholecalciferol seems to have a role in the reproductive processes and in the patients affected by polycystic ovary syndrome, endometriosis, uterine myomas and premature ovarian failure. Moreover, it may play an important role in the assisted reproductive techniques, given that it is capable of influencing oocyte quality, but also an adequate preparation of the endometrium for embryonic implantation. Although promising, available evidence is based on a limited number of in vitro, in vivo and clinical studies. We provide an overview of the association between vitamin D and female infertility reporting the most recent data published in the literature. Nevertheless, properly randomised clinical trials are mandatory to achieve more conclusive results about the promising role of vitamin D in the management of female assisted reproduction.