PABLO ANTONIO NICOLAS FRIAS MARTINEZ (original) (raw)

Papers by PABLO ANTONIO NICOLAS FRIAS MARTINEZ

Anales De La Real Academia Nacional De Medicina, 2011

La osteoporosis postmenopausica es en la actualidad un gran problema sanitario. El avance del con... more La osteoporosis postmenopausica es en la actualidad un gran problema sanitario. El avance del conocimiento sobre el cometido celular preferente de osteocitos, osteoblastos y osteoclastos en el tejido oseo, de la actividad bioquimica y de la expresion genica, de la interaccion con la actividad fisica, de las medidas y dieta nutricional, asi como de los diversos medicamentos existentes en la actualidad, se exponen en interaccion con los estudios clinicos de etidronato y calcitonina, y paratohormona recombinante 1-84. Se concluye en relacion con su actividad a los dieciocho meses de la administracion y de su valoracion mediante densidad mineral osea, marcadores bioquimicos y produccion de fracturas

RESUMEN Las nuevas tecnologías aportan a la educación aspectos innovadores que permiten mejorar l... more RESUMEN Las nuevas tecnologías aportan a la educación aspectos innovadores que permiten mejorar las formas de enseñar y aprender. Una de las principales innovaciones son los sistemas de educación a distancia, que ofrecen formación continua a estudiantes que por diversas razones no pueden asistir a clases. Como en la enseñanza presencial, en la enseñanza virtual es necesario que los alumnos logren una asimilación efectiva del conocimiento. Sin embargo, frecuentemente tal asimilación no ocurre porque los cursos de e-learning se diseñan sin considerar las características particulares de cada estudiante. Actualmente, los procesos de aprendizaje centrados en el alumno requieren que estos sistemas sean capaces de personalizar la enseñanza a las características y necesidades individuales de cada estudiante.

Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto

Xiv Conferencia Interamericana De Educacion Matematica, Mar 31, 2015

IEEE Transactions on Circuits and Systems, 1990

Consider the smooth (C") nonlinear dynamical system dx/dr = f (.x) + g(x) U with f and g locally ... more Consider the smooth (C") nonlinear dynamical system dx/dr = f (.x) + g(x) U with f and g locally defined smooth \rector fields and /I a C" function. Equation (A.l) is referred as the triple (f , g , h). The set hK'(0) = { x : y = h (x) = O)} is assumed to be a lo cull^ regukur ititegrohle niunrfold (Boothby [ll]). L,v denotes the Lie dcrivative (directional derivative [ll]) of the smooth function 11 in the direction of the vector field +. Definrrioti A.1 /7]: A variable structure feedback control law: .p = h (x) (A.1) U + (x) , U-(.x) , for y > 0 for y < 0 is said to locally create a sliding regirtit. on hK'(0) if and only if lim L,+gu+ h < O and lim L,+gu-/7 > 0 (A.3) y-+ o ,- .-0 where u ' (x) and U-(x) are given smooth scalar feedback control functions. Without loss of generality we assume that, locally, u ' (x) > u-(x) .

ABSTRACT En: Padres y madres de alumnos alumnas Madrid 2005, n. 82, abril-mayo ; p. 34-37 Se expo... more ABSTRACT En: Padres y madres de alumnos alumnas Madrid 2005, n. 82, abril-mayo ; p. 34-37 Se expone la importancia de la familia y los agentes sociales en la educación. El informe PISA destaca que la actitud de la familia respecto a la escuela y a la educación de los hijos favorece la actitud social y cultural de éstos. Se ofrecen apoyos para que la familia realice su doble papel, tomando conciencia de la importancia que puede tener en la educación matemática de los hijos; creándole hábitos intelectuales y sociales relacionados con las matemáticas; y reivindicando ante los agentes sociales que organicen actividades educativas que beneficien a todos. Se pretende ayudar a los padres a que contribuyan con su actuación en la creación de hábitos relacionados con las Matemáticas que ayuden al niño a desenvolverse en el entorno

Microelectronics Journal, 1994

A representative catalogue of high-frequency sinusoidal oscillators using the current conveyor as... more A representative catalogue of high-frequency sinusoidal oscillators using the current conveyor as the active element is proposed. To the inherent advantages of current mode processing is added compatibility with the CMOS technology of the proposed topologies. The new structures potentially mean a drastic reduction in silicon area and an expansion in the frequency range of operation as compared with their counterparts in voltage mode.

Revista Científica de la Sociedad Española de Enfermería Neurológica, 2012

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2015

The perceived pain on injection site caused by subcutaneous (SC) self-injection may negatively af... more The perceived pain on injection site caused by subcutaneous (SC) self-injection may negatively affect acceptance and adherence to treatment in patients with multiple sclerosis (MS). Pain on injection may be caused by inaccurate injection technique, inadequate needle length adjustment, or repeated use of the same injection body area. However, information is lacking concerning the optimal needle depth to minimize the injection pain. The purpose of this program was to characterize the perceived injection-site pain associated with the use of various injection depths of the autoinjector of glatiramer acetate (GA) based on SC tissue thickness (SCT) of the injection site. This was a pilot program performed by MS-specialized nurses in patients with MS new to GA. Patients were trained by MS nurses on the preparation and administration of SC injection and on an eight-site rotation (left and right arms, thighs, abdomen, and upper quadrant of the buttock). The needle length setting was selected...

Pediatric Cardiology, 2011

The clinical and hemodynamic effects of compassionate therapy with levosimendan were evaluated in... more The clinical and hemodynamic effects of compassionate therapy with levosimendan were evaluated in a 14-year-old patient with end-stage renal disease and arterial hypertension secondary to glycogenosis type Ia. The patient previously had normal heart function but experienced acute development of severe myocardial dysfunction resistant to diuretic therapy and inotropic support. Levosimendan administration was followed by a marked clinical and echocardiographic improvement. The authors believe that levosimendan may be useful for cases of resistant acute heart failure with arterial hypertension. Although administration of levosimendan is not recommended for patients with chronic renal disease, no adverse effect was observed. Therapeutic action for these patients seems to last longer than for patients with a normal kidney.

Microelectronics Journal, 1989

A general method is proposed for the synthesis of RC active circuits. The generated systems prese... more A general method is proposed for the synthesis of RC active circuits. The generated systems present zero transfer function sensitivity with respect to the operational amplifier's time constant. Examples are given to illustrate the application of this method and the performance of generated circuits.

International Journal of Electronics, 1990

... compensation. Electronics and Wireless World, 93,486-488. SOLIMAN, AM, and ISMAIL, M., 1979, ... more ... compensation. Electronics and Wireless World, 93,486-488. SOLIMAN, AM, and ISMAIL, M., 1979, Active compensation of op.-amps. IEEE Trans-actions on Circuits and Systems, 26, 112-1 17. SOLOMON, JE, 1974, The monolithic amplifier, a tutorial study. ...

IEEE Transactions on Instrumentation and Measurement, 1991

In this paper, a new set of 12 sinusoidal oscillators is introduced. These oscillators use two op... more In this paper, a new set of 12 sinusoidal oscillators is introduced. These oscillators use two opamps and their oscillation frequency is independent of the gain-bandwidth products of these active elements when a single pole rolloff model is considered. This property is achieved by virtue of the configurations introduced in this paper, i.e., no adjustment is required.

European Journal of Engineering Education, 1990

ABSTRACT

Electronics Letters, 1990

Electronics Letters, 1992

Aquaculture Economics & Management, 2004

Abstract The performance of individual firms often is enhanced by membership in a group or cluste... more Abstract The performance of individual firms often is enhanced by membership in a group or cluster of other firms engaged in similar activities. This paper examines a cluster of Honduran fish farmers in terms of the patterns of relationships that allowed them to initiate ...

Annals of the New York Academy of Sciences, 2008

The normal developmental tasks and roles of adolescence are altered with a diagnosis of a reprodu... more The normal developmental tasks and roles of adolescence are altered with a diagnosis of a reproductive disorder. The crisis of impaired fertility affects both parent and child, stressing the family system. For the adolescent girl, a reproductive disorder impacts her developing sense of self, body-image and sexuality which, in turn, can affect her self-esteem and relationships with others. Because of the sexual nature of a reproductive disorder, feelings of embarrassment or protectiveness are often engendered that can make it difficult for families to discuss. Nonetheless, families do best with openness and honesty regarding the condition and should be discouraged from keeping the diagnosis a secret. Adolescence encompasses a broad spectrum of emotional maturity, which needs to be considered by parents and clinicians when communicating information. Understanding that the family is an emotional unit, a family systems approach to deal with health issues is most appropriate. In this context, parents need to first deal with their own feelings about the diagnosis, before they can help their child. Secondly, parents must be provided with tools to build an ongoing conversation with their child that will avoid stigmatizing her condition and handicapping her growth into healthy adulthood. The goal for parent and clinician is to help the adolescent girl formulate positive selfesteem and body image, despite impaired fertility. Adolescence is a transition time of profound physical, cognitive and psychosocial changes. The maturation from childhood to adulthood is marked by a transformation of mind and body as a girl develops into a young woman, capable of reproduction. For most young women, the metamorphosis of adolescence occurs in a gradual, continuous, and generally uneventful process, despite the normal ups and downs of life. However, when an adolescent and her family are faced with a health crisis impacting her future reproductive capacity, the norm is disrupted and the family must adapt to a new variety of normal with unknowns and uncertainty about the future. To understand the potential psychological impact of a medical condition affecting future fertility in a girl, it is important to first briefly consider the normal stages, goals, and tasks of

Advances in Therapy, 2012

Introduction: Endermology is a mechanical massage therapy that enables fat mobilization and body ... more Introduction: Endermology is a mechanical massage therapy that enables fat mobilization and body contouring. The authors' aim was to assess the effect of endermology on indurations and panniculitis/lipoatrophy associated with subcutaneous administration of glatiramer acetate in patients with multiple sclerosis (MS). Methods: This was a multicenter pilot experience carried out in patients with MS treated with glatiramer acetate who showed indurations and/ or panniculitis/lipoatrophy at the injection site. Patients underwent endermology and glatiramer acetate treatment according to clinical practice. The primary endpoint was the change in indurations and/or panniculitis/lipoatrophy after 12 endermology sessions. Results: Between April and July 2011, a total of 13 evaluable patients were included (mean age, 40.7±3.1 years; female, 100%; white, 100%; mean MS duration, 10.1±2.3 years; previous MS treatment, 46.2%; mean glatiramer acetate treatment duration, 27.3±9.5 months). Eleven patients (84.6%) showed local indurations (mean diameter, 3.4±0.5 cm; mean number, 9.0±1.0) and six patients (46.2%) areas of panniculitis/ lipoatrophy (mean number, 5.0±1.1). After 12 endermology sessions, patients with indurations reported having experienced a reduction in size (10 patients [90.9%]; mean diameter, 0.1±0.05 cm; P<0.