P. Ghali - Academia.edu (original) (raw)

Papers by P. Ghali

Research paper thumbnail of Magnitude of change in alpha-fetoprotein in response to transarterial chemoembolization predicts survival in patients undergoing liver transplantation for hepatocellular carcinoma

Current oncology (Toronto, Ont.), 2013

Downsizing strategies are often attempted for patients with hepatocellular carcinoma (hcc) before... more Downsizing strategies are often attempted for patients with hepatocellular carcinoma (hcc) before liver transplantation (lt). The objective of the present study was to determine clinical predictors of favourable survival outcomes after transarterial chemoembolization (tace) before lt for hcc outside the Milan criteria, so as to better select candidates for this strategy. In this retrospective study, patients with hcc tumours either beyond Milan criteria (single lesion > 5 cm, 3 lesions with 1 or more > 3 cm) or at the upper limit of Milan criteria (single lesions between 4.1 cm and 5.0 cm), with a predicted waiting time of more than 3 months, received carboplatin-based tace treatments. Exclusion criteria for tace included Child-Pugh C cirrhosis or the presence of portal vein invasion or extrahepatic disease on imaging. Only patients without tumour progression after tace underwent lt. Of 160 hcc patients who received liver grafts between 1997 and 2010, 35 were treated with tace...

Research paper thumbnail of Multidisciplinary Canadian consensus recommendations for the management and treatment of hepatocellular carcinoma

Current Oncology, 2011

Globally, hepatocellular carcinoma (hcc) is the third most common cause of death from cancer, aft... more Globally, hepatocellular carcinoma (hcc) is the third most common cause of death from cancer, after lung and stomach cancer. The incidence of hcc in Canada is increasing and is expected to continue to increase over the next decade. Given the high mortality rate associated with hcc, steps are required to mitigate the impact of the disease. To address this challenging situation, a panel of 17 hcc experts, representing gastroenterologists, hepatologists, hepatobiliary surgeons, medical oncologists, pathologists, and radiologists from across Canada, convened to provide a framework that, using an evidence-based approach, will assist clinicians in optimizing the management and treatment of hcc. The recommendations, summarized here, were developed based on a rigorous methodology in a pre-specified process that was overseen by the steering committee. Specific topics were identified by the steering committee and delegated to a group of content experts within the expert panel, who then systematically reviewed the literature on that topic and drafted the related content and recommendations. The set of recommendations for each topic were reviewed and assigned a level of evidence and grade according to the levels of evidence set out by the Centre for Evidence-based Medicine, Oxford, United Kingdom. Agreement on the level of evidence for each recommendation was achieved by consensus. Consensus was defined as agreement by a two-thirds majority of the 17 members of the expert panel. Recommendations were subject to iterative review and modification by the expert panel until consensus could be achieved.

Research paper thumbnail of CALCINEURIN INHIBITOR SUBSTITUTION (" RETIREMENT") WITH ANTI-CD25 MONOCLONAL ANTIBODIES: A NOVEL STRATEGY IN LONG-TERM LIVER TRANSPLANT PATIENTS WITH PROGRESSIVE RENAL DYSFUNCTION

Research paper thumbnail of An unusual cause of lower gastrointestinal bleeding

Liver Transplantation, 2008

Research paper thumbnail of 10YEAR RESULTS USING ATG-INDUCTION AND PROLONGED DELAY OF CNI IN LIVER TRANSPLANT RECIPIENTS: IMPACT ON THE NEED FOR CHRONIC DIALYSIS: 1243

Research paper thumbnail of Association of preoperative parameters with postoperative mortality and long-term survival after liver transplantation

Canadian Journal of Surgery, 2011

The ability of Child-Turcotte-Pugh (CTP) or Model for End-Stage Liver Disease (MELD) scores to pr... more The ability of Child-Turcotte-Pugh (CTP) or Model for End-Stage Liver Disease (MELD) scores to predict recipient survival after liver transplantation is controversial. This analysis aims to identify preoperative parameters that might be associated with early postoperative mortality and long-term survival after liver transplantation.

Research paper thumbnail of Magnitude of change in alpha-fetoprotein in response to transarterial chemoembolization predicts survival in patients undergoing liver transplantation for hepatocellular carcinoma

Current oncology (Toronto, Ont.), 2013

Downsizing strategies are often attempted for patients with hepatocellular carcinoma (hcc) before... more Downsizing strategies are often attempted for patients with hepatocellular carcinoma (hcc) before liver transplantation (lt). The objective of the present study was to determine clinical predictors of favourable survival outcomes after transarterial chemoembolization (tace) before lt for hcc outside the Milan criteria, so as to better select candidates for this strategy. In this retrospective study, patients with hcc tumours either beyond Milan criteria (single lesion > 5 cm, 3 lesions with 1 or more > 3 cm) or at the upper limit of Milan criteria (single lesions between 4.1 cm and 5.0 cm), with a predicted waiting time of more than 3 months, received carboplatin-based tace treatments. Exclusion criteria for tace included Child-Pugh C cirrhosis or the presence of portal vein invasion or extrahepatic disease on imaging. Only patients without tumour progression after tace underwent lt. Of 160 hcc patients who received liver grafts between 1997 and 2010, 35 were treated with tace...

Research paper thumbnail of Multidisciplinary Canadian consensus recommendations for the management and treatment of hepatocellular carcinoma

Current Oncology, 2011

Globally, hepatocellular carcinoma (hcc) is the third most common cause of death from cancer, aft... more Globally, hepatocellular carcinoma (hcc) is the third most common cause of death from cancer, after lung and stomach cancer. The incidence of hcc in Canada is increasing and is expected to continue to increase over the next decade. Given the high mortality rate associated with hcc, steps are required to mitigate the impact of the disease. To address this challenging situation, a panel of 17 hcc experts, representing gastroenterologists, hepatologists, hepatobiliary surgeons, medical oncologists, pathologists, and radiologists from across Canada, convened to provide a framework that, using an evidence-based approach, will assist clinicians in optimizing the management and treatment of hcc. The recommendations, summarized here, were developed based on a rigorous methodology in a pre-specified process that was overseen by the steering committee. Specific topics were identified by the steering committee and delegated to a group of content experts within the expert panel, who then systematically reviewed the literature on that topic and drafted the related content and recommendations. The set of recommendations for each topic were reviewed and assigned a level of evidence and grade according to the levels of evidence set out by the Centre for Evidence-based Medicine, Oxford, United Kingdom. Agreement on the level of evidence for each recommendation was achieved by consensus. Consensus was defined as agreement by a two-thirds majority of the 17 members of the expert panel. Recommendations were subject to iterative review and modification by the expert panel until consensus could be achieved.

Research paper thumbnail of CALCINEURIN INHIBITOR SUBSTITUTION (" RETIREMENT") WITH ANTI-CD25 MONOCLONAL ANTIBODIES: A NOVEL STRATEGY IN LONG-TERM LIVER TRANSPLANT PATIENTS WITH PROGRESSIVE RENAL DYSFUNCTION

Research paper thumbnail of An unusual cause of lower gastrointestinal bleeding

Liver Transplantation, 2008

Research paper thumbnail of 10YEAR RESULTS USING ATG-INDUCTION AND PROLONGED DELAY OF CNI IN LIVER TRANSPLANT RECIPIENTS: IMPACT ON THE NEED FOR CHRONIC DIALYSIS: 1243

Research paper thumbnail of Association of preoperative parameters with postoperative mortality and long-term survival after liver transplantation

Canadian Journal of Surgery, 2011

The ability of Child-Turcotte-Pugh (CTP) or Model for End-Stage Liver Disease (MELD) scores to pr... more The ability of Child-Turcotte-Pugh (CTP) or Model for End-Stage Liver Disease (MELD) scores to predict recipient survival after liver transplantation is controversial. This analysis aims to identify preoperative parameters that might be associated with early postoperative mortality and long-term survival after liver transplantation.