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Research paper thumbnail of In vivo and in vitro evaluation of the residual allergenicity of partially hydrolysed infant formulas

Toxicology Letters, 2011

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Research paper thumbnail of Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1

Frontiers in immunology, 2015

Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal prote... more Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal protection against pathogens and long-term protection against allergies and autoimmune diseases. Although several proteins have been identified to have anti-viral or anti-bacterial effects like secretory IgA or lactoferrin, the mechanisms of immune modulation are not fully understood. Recent studies identified important beneficial effects of glycans in human milk, such as those expressed in oligosaccharides or on glycoproteins. Glycans are recognized by the carbohydrate receptors C-type lectins on dendritic cell (DC) and specific tissue macrophages, which exert important functions in immune modulation and immune homeostasis. A well-characterized C-type lectin is dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), which binds terminal fucose. The present study shows that in human milk, MUC1 is the major milk glycoprotein that binds to the lectin domain of...

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Research paper thumbnail of Mitogens affecting similar T-cell stimulation pathways result in different kinetics of cytokine production, proliferation, cell death and cellular subsets

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Research paper thumbnail of Human milk: a source of more life than we imagine

Beneficial Microbes

The presence of bacteria in human milk has been acknowledged since the seventies. For a long time... more The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in case of infections and therefore the presence of non-pathogenic bacteria was yet unknown. During the last decades, the use of more sophisticated culture-dependent and -independent techniques, and the steady development of the -omic approaches are opening up the new concept of the 'milk microbiome', a complex ecosystem with a greater diversity than previously anticipated. In this review, possible mechanisms by which bacteria can reach the mammary gland (contamination versus active migration) are discussed. In addition, the potential roles of human milk for both infant and maternal health are summarised. A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues...

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Research paper thumbnail of The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V

European Journal of Nutrition, 2015

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Research paper thumbnail of Effect of nutrient deficiencies on in vitro T<sub>h</sub>1 and T<sub>h</sub>2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection

Malaria Journal

Abstract Background An appropriate balance between pro-inflammatory and anti-inflammatory cytokin... more Abstract Background An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology. In malaria endemic countries, this immunological balance may be influenced by micronutrient deficiencies. Methods Peripheral blood mononuclear cells from Tanzanian preschool children were stimulated in vitro with Plasmodium falciparum -parasitized red blood cells to determine T-cell responses to malaria under different conditions of nutrient deficiencies and malaria status. Results The data obtained indicate that zinc deficiency is associated with an increase in TNF response by 37%; 95% CI: 14% to 118% and IFN-γ response by 74%; 95% CI: 24% to 297%. Magnesium deficiency, on the other hand, was associated with an increase in production of IL-13 by 80%; 95% CI: 31% to 371% and a reduction in IFN-γ production. These results reflect a shift in cytokine...

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Research paper thumbnail of Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1

Frontiers in immunology, 2015

Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal prote... more Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal protection against pathogens and long-term protection against allergies and autoimmune diseases. Although several proteins have been identified to have anti-viral or anti-bacterial effects like secretory IgA or lactoferrin, the mechanisms of immune modulation are not fully understood. Recent studies identified important beneficial effects of glycans in human milk, such as those expressed in oligosaccharides or on glycoproteins. Glycans are recognized by the carbohydrate receptors C-type lectins on dendritic cell (DC) and specific tissue macrophages, which exert important functions in immune modulation and immune homeostasis. A well-characterized C-type lectin is dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), which binds terminal fucose. The present study shows that in human milk, MUC1 is the major milk glycoprotein that binds to the lectin domain of...

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Research paper thumbnail of Non-digestible oligosaccharides modulate intestinal immune activation and suppress cow's milk allergic symptoms

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014

Cow's milk allergy is a common food allergy in childhood and no effective preventive or curat... more Cow's milk allergy is a common food allergy in childhood and no effective preventive or curative treatment is available. This study aimed at comparing single short-chain galacto- (scGOS), long-chain fructo- (lcFOS) or pectin-derived acidic oligosaccharides (pAOS) and/or mixtures of scGOS/lcFOS (GF) or scGOS/lcFOS/pAOS (GFA) to prevent or treat food allergy. In the preventive protocol, C3H/HeOuJ mice were fed diets containing single oligosaccharides or mixtures GF or GFA throughout the study protocol. In the treatment protocol, GF or GFA was provided for 4 wk starting after the last sensitization. The allergic skin response and anaphylaxis scores were determined, after oral challenge whey-specific immunoglobulins were measured, and qPCR for T-cell markers and Foxp3 counts using immunohistochemistry were performed on the small intestine and colon. Only in the preventive setting, the GF or GFA mixture, but not the single oligosaccharides, reduced the allergic skin response and whey...

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Research paper thumbnail of Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice

Respiratory research, 2004

Previously, we demonstrated that OVA-loaded macrophages (OVA-Mphi) partially suppress OVA-induced... more Previously, we demonstrated that OVA-loaded macrophages (OVA-Mphi) partially suppress OVA-induced airway manifestations of asthma in BALB/c mice. In vitro studies showed that OVA-Mphi start to produce IL-10 upon interaction with allergen-specific T cells, which might mediate their immunosuppressive effects. Herein, we examined whether IL-10 is essential for the immunosuppressive effects of OVA-Mphi in vivo, and whether ex vivo stimulation of the IL-10 production by OVA-Mphi could enhance these effects. Peritoneal Mphi were loaded with OVA and stimulated with LPS or immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) in vitro. The increase of IL-10 production was examined and, subsequently, ex vivo stimulated OVA-Mphi were used to treat (i.v.) OVA-sensitized mice. To further explore whether Mphi-derived IL-10 mediates the immunosuppressive effects, Mphi isolated from IL-10-/- mice were used for treatment. We found that stimulation with LPS or ISS-ODN highly increased the IL-10 ...

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Research paper thumbnail of CD4+ dominance and Th2 cytokine profile in lung microenvironment during allergic inflammation is a result of decreased CD8 and natural killer cells influx

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Research paper thumbnail of A comparison of BALB/C and C57BL/6 mice in a model of allergic inflammation

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Research paper thumbnail of The presence of IL-5 enhances isotype switching to IgE in CD4 knockout mice, while it does not overcome the decrease in the OVA specific IgE secretion

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Research paper thumbnail of P22 – Set-up and validation of a mouse model for food-allergy induced atopic dermatitis

Clinical and Translational Allergy, 2014

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Research paper thumbnail of Multicenter validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulae

Clinical and Translational Allergy, 2013

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Research paper thumbnail of Induction and regulation of allergen-specific IgE

Wageningen UR Frontis Series, 2005

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Research paper thumbnail of C8 Immunopharmacology of probiotics and prebiotics

Principles of Immunopharmacology, 2011

Page 1. Introduction The medicinal properties of various nutritional com-ponents have been apprec... more Page 1. Introduction The medicinal properties of various nutritional com-ponents have been appreciated since ancient times. Hippocrates (460–377 BC), for example, stated: “Let medicine be thy food and food be thy medicine”. ...

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Research paper thumbnail of Pharma-Nutrition

AAPS Advances in the Pharmaceutical Sciences Series, 2014

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Research paper thumbnail of Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas

Toxicology Letters, 2013

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Research paper thumbnail of New Production of Eosinophils and the Corresponding Th1/Th2 Balance in the Lungs after Allergen Exposure in BALB/ c and C57BL/6 Mice

Scandinavian Journal of Immunology, 2010

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Research paper thumbnail of Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey

Malaria Journal, 2010

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Research paper thumbnail of In vivo and in vitro evaluation of the residual allergenicity of partially hydrolysed infant formulas

Toxicology Letters, 2011

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Research paper thumbnail of Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1

Frontiers in immunology, 2015

Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal prote... more Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal protection against pathogens and long-term protection against allergies and autoimmune diseases. Although several proteins have been identified to have anti-viral or anti-bacterial effects like secretory IgA or lactoferrin, the mechanisms of immune modulation are not fully understood. Recent studies identified important beneficial effects of glycans in human milk, such as those expressed in oligosaccharides or on glycoproteins. Glycans are recognized by the carbohydrate receptors C-type lectins on dendritic cell (DC) and specific tissue macrophages, which exert important functions in immune modulation and immune homeostasis. A well-characterized C-type lectin is dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), which binds terminal fucose. The present study shows that in human milk, MUC1 is the major milk glycoprotein that binds to the lectin domain of...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mitogens affecting similar T-cell stimulation pathways result in different kinetics of cytokine production, proliferation, cell death and cellular subsets

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Human milk: a source of more life than we imagine

Beneficial Microbes

The presence of bacteria in human milk has been acknowledged since the seventies. For a long time... more The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in case of infections and therefore the presence of non-pathogenic bacteria was yet unknown. During the last decades, the use of more sophisticated culture-dependent and -independent techniques, and the steady development of the -omic approaches are opening up the new concept of the 'milk microbiome', a complex ecosystem with a greater diversity than previously anticipated. In this review, possible mechanisms by which bacteria can reach the mammary gland (contamination versus active migration) are discussed. In addition, the potential roles of human milk for both infant and maternal health are summarised. A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V

European Journal of Nutrition, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Effect of nutrient deficiencies on in vitro T<sub>h</sub>1 and T<sub>h</sub>2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection

Malaria Journal

Abstract Background An appropriate balance between pro-inflammatory and anti-inflammatory cytokin... more Abstract Background An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology. In malaria endemic countries, this immunological balance may be influenced by micronutrient deficiencies. Methods Peripheral blood mononuclear cells from Tanzanian preschool children were stimulated in vitro with Plasmodium falciparum -parasitized red blood cells to determine T-cell responses to malaria under different conditions of nutrient deficiencies and malaria status. Results The data obtained indicate that zinc deficiency is associated with an increase in TNF response by 37%; 95% CI: 14% to 118% and IFN-γ response by 74%; 95% CI: 24% to 297%. Magnesium deficiency, on the other hand, was associated with an increase in production of IL-13 by 80%; 95% CI: 31% to 371% and a reduction in IFN-γ production. These results reflect a shift in cytokine...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1

Frontiers in immunology, 2015

Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal prote... more Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal protection against pathogens and long-term protection against allergies and autoimmune diseases. Although several proteins have been identified to have anti-viral or anti-bacterial effects like secretory IgA or lactoferrin, the mechanisms of immune modulation are not fully understood. Recent studies identified important beneficial effects of glycans in human milk, such as those expressed in oligosaccharides or on glycoproteins. Glycans are recognized by the carbohydrate receptors C-type lectins on dendritic cell (DC) and specific tissue macrophages, which exert important functions in immune modulation and immune homeostasis. A well-characterized C-type lectin is dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), which binds terminal fucose. The present study shows that in human milk, MUC1 is the major milk glycoprotein that binds to the lectin domain of...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Non-digestible oligosaccharides modulate intestinal immune activation and suppress cow's milk allergic symptoms

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014

Cow's milk allergy is a common food allergy in childhood and no effective preventive or curat... more Cow's milk allergy is a common food allergy in childhood and no effective preventive or curative treatment is available. This study aimed at comparing single short-chain galacto- (scGOS), long-chain fructo- (lcFOS) or pectin-derived acidic oligosaccharides (pAOS) and/or mixtures of scGOS/lcFOS (GF) or scGOS/lcFOS/pAOS (GFA) to prevent or treat food allergy. In the preventive protocol, C3H/HeOuJ mice were fed diets containing single oligosaccharides or mixtures GF or GFA throughout the study protocol. In the treatment protocol, GF or GFA was provided for 4 wk starting after the last sensitization. The allergic skin response and anaphylaxis scores were determined, after oral challenge whey-specific immunoglobulins were measured, and qPCR for T-cell markers and Foxp3 counts using immunohistochemistry were performed on the small intestine and colon. Only in the preventive setting, the GF or GFA mixture, but not the single oligosaccharides, reduced the allergic skin response and whey...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice

Respiratory research, 2004

Previously, we demonstrated that OVA-loaded macrophages (OVA-Mphi) partially suppress OVA-induced... more Previously, we demonstrated that OVA-loaded macrophages (OVA-Mphi) partially suppress OVA-induced airway manifestations of asthma in BALB/c mice. In vitro studies showed that OVA-Mphi start to produce IL-10 upon interaction with allergen-specific T cells, which might mediate their immunosuppressive effects. Herein, we examined whether IL-10 is essential for the immunosuppressive effects of OVA-Mphi in vivo, and whether ex vivo stimulation of the IL-10 production by OVA-Mphi could enhance these effects. Peritoneal Mphi were loaded with OVA and stimulated with LPS or immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) in vitro. The increase of IL-10 production was examined and, subsequently, ex vivo stimulated OVA-Mphi were used to treat (i.v.) OVA-sensitized mice. To further explore whether Mphi-derived IL-10 mediates the immunosuppressive effects, Mphi isolated from IL-10-/- mice were used for treatment. We found that stimulation with LPS or ISS-ODN highly increased the IL-10 ...

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Research paper thumbnail of CD4+ dominance and Th2 cytokine profile in lung microenvironment during allergic inflammation is a result of decreased CD8 and natural killer cells influx

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A comparison of BALB/C and C57BL/6 mice in a model of allergic inflammation

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The presence of IL-5 enhances isotype switching to IgE in CD4 knockout mice, while it does not overcome the decrease in the OVA specific IgE secretion

Bookmarks Related papers MentionsView impact

Research paper thumbnail of P22 – Set-up and validation of a mouse model for food-allergy induced atopic dermatitis

Clinical and Translational Allergy, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Multicenter validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulae

Clinical and Translational Allergy, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Induction and regulation of allergen-specific IgE

Wageningen UR Frontis Series, 2005

Bookmarks Related papers MentionsView impact

Research paper thumbnail of C8 Immunopharmacology of probiotics and prebiotics

Principles of Immunopharmacology, 2011

Page 1. Introduction The medicinal properties of various nutritional com-ponents have been apprec... more Page 1. Introduction The medicinal properties of various nutritional com-ponents have been appreciated since ancient times. Hippocrates (460–377 BC), for example, stated: “Let medicine be thy food and food be thy medicine”. ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Pharma-Nutrition

AAPS Advances in the Pharmaceutical Sciences Series, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas

Toxicology Letters, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of New Production of Eosinophils and the Corresponding Th1/Th2 Balance in the Lungs after Allergen Exposure in BALB/ c and C57BL/6 Mice

Scandinavian Journal of Immunology, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey

Malaria Journal, 2010

Bookmarks Related papers MentionsView impact