P. Navarrete - Academia.edu (original) (raw)
Papers by P. Navarrete
Revista medica de Chile
Fetal drug addiction is a serious public health problem. In the United States 10 to 15% of childr... more Fetal drug addiction is a serious public health problem. In the United States 10 to 15% of children have been exposed "in utero" to cocaine. In a Chilean public health service, more than 200 offspring of cocaine free base abuser have been detected. To analyze the clinical and social features of 100 children exposed to cocaine free base during fetal development. Clinical features of children born from cocaine free base consume mothers were described at birth. During subsequent follow up, growth and development, disease episodes, developmental alterations and social situation were recorded. Data was compared with other newborns from the same health service. Compared to their normal counterparts, exposed children has a lower birth weight, the frequency of premature babies was thrice higher, and small-for-gestational age children were four times more common. There was also a higher prevalence of cardiac malformations, seizures and apnea. Hospital admissions were more frequent,...
EMC 2008 14th European Microscopy Congress 1–5 September 2008, Aachen, Germany, 2008
Hematopoietic precursor cells (HPCs) hold tremendous potential in the emerging field of cell-base... more Hematopoietic precursor cells (HPCs) hold tremendous potential in the emerging field of cell-based therapies. The purpose of this therapy is to replace, repair or enhance the biological function of damaged tissue or organs. This can be achieved by the transplantation of cells in sufficient number and quality to restore function. Transplantation of HPCs requires the ability to preserve cells. Cell
BMC microbiology, Jan 30, 2004
Salmonella enterica and Campylobacter jejuni are amongst the more prevalent bacterial pathogens t... more Salmonella enterica and Campylobacter jejuni are amongst the more prevalent bacterial pathogens that cause foodborne diseases. These microorganisms are common contaminants of poultry and poultry products. This study was aimed to evaluate the antibacterial activity of metallic copper surfaces on these important enteropathogens, and to determine the potential acquisition of copper by food exposed to this metal. The antibacterial activity of copper surfaces was evaluated overlying them with suspensions of 10(6) CFU/ml of S. enterica and C. jejuni. Bacterial counts obtained after 0, 2, 4 and 8 hours at 10 degrees C and 25 degrees C were compared with those obtained in stainless steel and a synthetic polymer as control surfaces. The results showed that when these enteropathogens were kept in contact with copper a significant antibacterial activity was noted, on the contrary when the same load of pathogen suspensions were tested over the control surfaces it was found that the bacterial co...
Revista médica de Chile, 1993
Among children living in orphanages of the Metropolitan Region, the paternal alcohol ingestion pa... more Among children living in orphanages of the Metropolitan Region, the paternal alcohol ingestion patterns were investigated. According to abnormal parental alcohol ingestion, a sample of 291 children was studied, of whom 32% were living in simple protection homes for infants with normal intellectual coefficient and 52% in homes for mentally retarded boys. There was a higher frequency and intensity of abnormal alcohol ingestion among parents of infants living in homes for the mentally retarded. Among these, 29% of mothers were illiterate and 11% had incomplete primary school education compared to mothers of simple protection homes in whom the frequency of illiteracy was 10% and of incomplete primary education, 50%. Twenty percent of fathers of children living in homes for the mentally retarded were unemployed, 16% had occasional jobs and 11% had a stable work; these numbers were 11, 30 and 15% respectively for fathers of simple protection homes. Among infants living in homes for the me...
Revista chilena de obstetricia y ginecología, 1986
![Research paper thumbnail of [Carriage of enterotoxigenic Staphylococcus aureus in food handlers]](https://attachments.academia-assets.com/48509795/thumbnails/1.jpg)
](Revista médica de Chile, 2002
One of the most common pathogens causing alimentary toxi-infections is Staphylococcus aureus (S a... more One of the most common pathogens causing alimentary toxi-infections is Staphylococcus aureus (S aureus). The presence of S aureus in food, indicates flaws during food manipulations. For this reason most sanitary norms require the detection of S aureus carriers. To determine the carriage rate of enterotoxin producing S aureus strains in food handlers, and to evaluate the antibiotic susceptibility to six antimicrobial agents. A total of 102 food handlers from 19 restaurants in Santiago, were analyzed. Samples for microbiological analysis were obtained with a swab from the retropharynx. S aureus grew in 35 out of the 102 samples obtained (34%). Further analysis revealed that 19/35 (54%) strains were able to produce enterotoxins. Therefore the corrected carriage rate was 19% (19/102). The most frequently detected enterotoxin was the type A (12/19). All S aureus isolates were resistant to penicillin and susceptible to oxacillin, clindamycin, kanamycin, vancomycin and linezolid. The carri...
Encyclopedia of Metagenomics, 2013
Transplantation Proceedings, 2008
Systems Biology in Reproductive Medicine, 2010
Journal of Aquatic Animal Health, 2008
International Journal of Gynecology & Obstetrics, 2000
International Journal of Food Microbiology, 2008
Intensive Care Medicine, 1992
Clinical and Vaccine Immunology, 2002
Archives of Otolaryngology–Head & Neck Surgery, 2007
To evaluate serum vascular endothelial growth factor (VEGF) as a prognostic factor in patients wi... more To evaluate serum vascular endothelial growth factor (VEGF) as a prognostic factor in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck treated with metronomic (weekly) paclitaxel. Before-and-after trial. A total of 33 consecutive patients were enrolled. Patients with recurrent and/or metastatic cancer of the head and neck refractory to platinum-based chemotherapy met inclusion criteria. Tertiary referral center. Patients were treated weekly with 80 mg/m(2) of paclitaxel for 6 weeks. Blood samples were collected after each dose and analyzed for serum VEGF using enzyme-linked immunosorbent assay kits. Nonparametric tests were used to analyze serum VEGF levels. In 33 patients, complete response was achieved in 1 (3%) and partial response in 20 (61%). No differences were found between responders and nonresponders with different levels of serum VEGF at any of the measurement times (baseline, after the first dose, and after the sixth dose). In responders, the median level of serum VEGF decreased after the first dose compared with baseline, but by the sixth dose, the median serum VEGF level had returned to baseline levels in all groups. The intensity of the serum VEGF level decrease (simple decrease, a decrease of at least 30%, or a decrease of at least 70%) was not related to response. The progression-to-disease time increased in the patients with a serum VEGF level reduction of at least 30% (P = .01) after 6 doses and decreased in patients with initially high levels, which remained high after the sixth dose (P = .03). Serum VEGF levels after the first dose of paclitaxel may predict response to weekly paclitaxel in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Initially high serum VEGF levels that persist after the sixth dose predict a shorter period until tumor progression.
Aquaculture Research, 2010
Aquaculture Nutrition, 2013
Revista medica de Chile
Fetal drug addiction is a serious public health problem. In the United States 10 to 15% of childr... more Fetal drug addiction is a serious public health problem. In the United States 10 to 15% of children have been exposed "in utero" to cocaine. In a Chilean public health service, more than 200 offspring of cocaine free base abuser have been detected. To analyze the clinical and social features of 100 children exposed to cocaine free base during fetal development. Clinical features of children born from cocaine free base consume mothers were described at birth. During subsequent follow up, growth and development, disease episodes, developmental alterations and social situation were recorded. Data was compared with other newborns from the same health service. Compared to their normal counterparts, exposed children has a lower birth weight, the frequency of premature babies was thrice higher, and small-for-gestational age children were four times more common. There was also a higher prevalence of cardiac malformations, seizures and apnea. Hospital admissions were more frequent,...
EMC 2008 14th European Microscopy Congress 1–5 September 2008, Aachen, Germany, 2008
Hematopoietic precursor cells (HPCs) hold tremendous potential in the emerging field of cell-base... more Hematopoietic precursor cells (HPCs) hold tremendous potential in the emerging field of cell-based therapies. The purpose of this therapy is to replace, repair or enhance the biological function of damaged tissue or organs. This can be achieved by the transplantation of cells in sufficient number and quality to restore function. Transplantation of HPCs requires the ability to preserve cells. Cell
BMC microbiology, Jan 30, 2004
Salmonella enterica and Campylobacter jejuni are amongst the more prevalent bacterial pathogens t... more Salmonella enterica and Campylobacter jejuni are amongst the more prevalent bacterial pathogens that cause foodborne diseases. These microorganisms are common contaminants of poultry and poultry products. This study was aimed to evaluate the antibacterial activity of metallic copper surfaces on these important enteropathogens, and to determine the potential acquisition of copper by food exposed to this metal. The antibacterial activity of copper surfaces was evaluated overlying them with suspensions of 10(6) CFU/ml of S. enterica and C. jejuni. Bacterial counts obtained after 0, 2, 4 and 8 hours at 10 degrees C and 25 degrees C were compared with those obtained in stainless steel and a synthetic polymer as control surfaces. The results showed that when these enteropathogens were kept in contact with copper a significant antibacterial activity was noted, on the contrary when the same load of pathogen suspensions were tested over the control surfaces it was found that the bacterial co...
Revista médica de Chile, 1993
Among children living in orphanages of the Metropolitan Region, the paternal alcohol ingestion pa... more Among children living in orphanages of the Metropolitan Region, the paternal alcohol ingestion patterns were investigated. According to abnormal parental alcohol ingestion, a sample of 291 children was studied, of whom 32% were living in simple protection homes for infants with normal intellectual coefficient and 52% in homes for mentally retarded boys. There was a higher frequency and intensity of abnormal alcohol ingestion among parents of infants living in homes for the mentally retarded. Among these, 29% of mothers were illiterate and 11% had incomplete primary school education compared to mothers of simple protection homes in whom the frequency of illiteracy was 10% and of incomplete primary education, 50%. Twenty percent of fathers of children living in homes for the mentally retarded were unemployed, 16% had occasional jobs and 11% had a stable work; these numbers were 11, 30 and 15% respectively for fathers of simple protection homes. Among infants living in homes for the me...
Revista chilena de obstetricia y ginecología, 1986
Revista médica de Chile, 2002
One of the most common pathogens causing alimentary toxi-infections is Staphylococcus aureus (S a... more One of the most common pathogens causing alimentary toxi-infections is Staphylococcus aureus (S aureus). The presence of S aureus in food, indicates flaws during food manipulations. For this reason most sanitary norms require the detection of S aureus carriers. To determine the carriage rate of enterotoxin producing S aureus strains in food handlers, and to evaluate the antibiotic susceptibility to six antimicrobial agents. A total of 102 food handlers from 19 restaurants in Santiago, were analyzed. Samples for microbiological analysis were obtained with a swab from the retropharynx. S aureus grew in 35 out of the 102 samples obtained (34%). Further analysis revealed that 19/35 (54%) strains were able to produce enterotoxins. Therefore the corrected carriage rate was 19% (19/102). The most frequently detected enterotoxin was the type A (12/19). All S aureus isolates were resistant to penicillin and susceptible to oxacillin, clindamycin, kanamycin, vancomycin and linezolid. The carri...
Encyclopedia of Metagenomics, 2013
Transplantation Proceedings, 2008
Systems Biology in Reproductive Medicine, 2010
Journal of Aquatic Animal Health, 2008
International Journal of Gynecology & Obstetrics, 2000
International Journal of Food Microbiology, 2008
Intensive Care Medicine, 1992
Clinical and Vaccine Immunology, 2002
Archives of Otolaryngology–Head & Neck Surgery, 2007
To evaluate serum vascular endothelial growth factor (VEGF) as a prognostic factor in patients wi... more To evaluate serum vascular endothelial growth factor (VEGF) as a prognostic factor in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck treated with metronomic (weekly) paclitaxel. Before-and-after trial. A total of 33 consecutive patients were enrolled. Patients with recurrent and/or metastatic cancer of the head and neck refractory to platinum-based chemotherapy met inclusion criteria. Tertiary referral center. Patients were treated weekly with 80 mg/m(2) of paclitaxel for 6 weeks. Blood samples were collected after each dose and analyzed for serum VEGF using enzyme-linked immunosorbent assay kits. Nonparametric tests were used to analyze serum VEGF levels. In 33 patients, complete response was achieved in 1 (3%) and partial response in 20 (61%). No differences were found between responders and nonresponders with different levels of serum VEGF at any of the measurement times (baseline, after the first dose, and after the sixth dose). In responders, the median level of serum VEGF decreased after the first dose compared with baseline, but by the sixth dose, the median serum VEGF level had returned to baseline levels in all groups. The intensity of the serum VEGF level decrease (simple decrease, a decrease of at least 30%, or a decrease of at least 70%) was not related to response. The progression-to-disease time increased in the patients with a serum VEGF level reduction of at least 30% (P = .01) after 6 doses and decreased in patients with initially high levels, which remained high after the sixth dose (P = .03). Serum VEGF levels after the first dose of paclitaxel may predict response to weekly paclitaxel in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Initially high serum VEGF levels that persist after the sixth dose predict a shorter period until tumor progression.
Aquaculture Research, 2010
Aquaculture Nutrition, 2013