Putu Paskarani - Academia.edu (original) (raw)

Papers by Putu Paskarani

Research, Society and Development

Introduction: Kaposi sarcoma is a rare and challenging case especially in immunosuppressed patien... more Introduction: Kaposi sarcoma is a rare and challenging case especially in immunosuppressed patients that frequently doesn’t have specific manifestation. It usually caused by human herpes virus 8 virus infection and male patient with multiple lesion has high mortality rates. The aim of this study is to report 34 y.o Male with incidental histopathological findings of kaposi sarcoma without clinical history of Human Immunodeficiency Virus (HIV). Methodology: Descriptive study of the case report type, whose data were obtained from the patient's medical record. Result: This paper will report 34-year-old young adult male with clinically diagnosed with poroma and differential diagnosis of squamous cell carcinoma and pyogenic granuloma. The clinical sign was multiple skin lesion appear on his right nose and thumb in the last 6 months. The nodules are solitary with oval shape, erythema, firm borders and the nodule surface covered with brownish-yellow squama. In addition, imaging examina...

Indonesian Journal of Cancer

Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gas... more Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gastrointestinal FL is a rare case, accounting for less than 4% of all primary lymphoma of the gastrointestinal tract. Duodenal-type Follicular Lymphoma (DTFL) was included in an entity of primary intestinal FL. However, in the 2017 World Health Organization (WHO) Classification, this entity was included in a specific variant called DTFL. In this article, we report a case of DTFL in a 56-year-old man which was incidentally found during upper gastrointestinal endoscopy Case Presentation: : We report a case of incidentally found DTFL in a 56-year-old man during an endoscopy. The endoscopic finding showed a small, hypertrophic, or nodular lesion on part two duodenum. Microscopic evaluation of duodenal mucosa consists of proliferative atypical lymphoid cells arranged in follicular architecture. The lesion was confined to the lamina propria. The atypical lymphoid cells were dominated by monotono...

Research, Society and Development

Primary breast lymphoma (PBL) is a rare but distinct subtype of extranodal lymphoma, comprising 0... more Primary breast lymphoma (PBL) is a rare but distinct subtype of extranodal lymphoma, comprising 0.5% of breast malignancies, approximately 1% of all non-Hodgkin's lymphomas (NHL) and <3% of extranodal lymphomas. Because the cases are rare, the diagnosis is difficult to establish by routine histopathological examination alone. This paper reports a case of a 53-year-old woman, complaining of a lump in the left breast. The lump is said to have been noticed since approximately 2 years ago on the nipple. The patient said that initially the lump was the size of a grape and then realized that it had enlarged since 3 weeks ago with a more chewy texture. Ultrasound of the left mammary, heterogeneous solid lesion with indistinct borders with dilatation of the drawerous duct with the appearance of intraductal calcification filling the superolateral and superomedial quadrants of the left mammary suggestively malignant (BIRADS 5). The microscopic appearance of the FNAB suggested a maligna...

Research, Society and Development, Nov 12, 2022

Introduction: Ectopic deciduosis refers to decidual tissue outside the uterus. Ectopic decidua ap... more Introduction: Ectopic deciduosis refers to decidual tissue outside the uterus. Ectopic decidua appears on the surface of the female reproductive organs and peritoneum; however, rare cases can be found in the appendix, lymph nodes, lungs, kidneys, and skin. Deciduosis is a benign condition that usually does not cause any symptoms and resolves spontaneously 4-6 weeks after delivery. However, an ectopic decidua involving the appendix wall often causes appendicitis and presents with acute abdominal signs. Methodology: The descriptive study of the case report type and the data obtained from the patient's medical record. Case presentation: This paper reports a woman aged 29 years with complaints of abdominal pain, like being stabbed in the pit of the stomach and then to the lower right abdomen for two days. A physical examination revealed tenderness in the lower abdomen with a positive McBurney sign. At that time, the patient was pregnant with a gestational age of 20-21 weeks. The patient underwent an appendectomy with the tissue sent to the anatomic pathology laboratory with the presence of decidual cells in the subserous layer and serous fat, and it was concluded as deciduosis of the appendix. Conclusion: Based on clinical and laboratory findings, the patient was diagnosed with deciduosis of the appendix.

Indonesian Journal of Cancer

Introduction: Metaplastic Breast Carcinoma (MBC) is quite a challenging case because metaplastic ... more Introduction: Metaplastic Breast Carcinoma (MBC) is quite a challenging case because metaplastic breast cancer is one of the rarest subtypes of invasive breast cancer. It is reported that MBC occurs only 0.2 to 1% throughout the world. The metaplastic changes can be squamous cells or other mesenchymal cell types. Clinically, MBC presents as a large palpable mass and may be associated with rapid growth. The size of MBC tends to be larger compared with other types of invasive breast cancer ranging from 1 to more than 10 cm. Although there are several main categories of MBC, some carcinoma can be difficult to classify due to their unusual histologic patterns. This case report study is to provide a clinicopathological overview and approach to MBC.Case Presentation: We reported a 49-year-old woman who suffered from a breast mass that rapidly grew for less than one year. The microscopic findings showed squamous cell carcinoma. While molecular studies revealed triple negative results for h...

Indonesian Journal of Cancer, Sep 29, 2022

Research, Society and Development

Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of... more Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of mast cells accumulating in one or more organ systems. Systemic mastocytosis is generally diagnosed after the second decade of life, reported male-to-female ratios range from 1:1 to 1:1.5. Case description : A 54-year-old woman came complaining weakness and diarrhea for the last 2 months. Symptoms are watery stools for 2-4 times a day and nausea. Physical examination found that the body temperature was 37.60C, tachycardia, increased bowel sounds, and tenderness on stomach. An endoscopic examination was performed with results: transverse colon appears with polyps with a size of 3 mm, with a mosaic pattern of mucosa. The mucosa of the ascending colon and caecum also appears to be a mosaic pattern. Biopsy was sent for histopathological examination. Morphological features show significant increase of eosinophils & mast cells, differentially diagnosed with Mastocytosis colitis, Eosinophilic c...

Research, Society and Development

Introduction: Intravascular lymphoma (IVL) is a rare subtype of non-Hodgkin extranodal lymphoma w... more Introduction: Intravascular lymphoma (IVL) is a rare subtype of non-Hodgkin extranodal lymphoma with characterized by a positive CD20 B cell proliferation in small lumens and medium-sized blood vessels, except veins and large arteries. Blood vessels in the central nervous system (CNS) and the skin is most often affected. These tumors usually occur in older adults and aggressive. Methodology: Descriptive study of the case report type, whose data were obtained from the patient’s medical record and has received the patient's consent to be published. Case presentation: This paper reports a 63-year-old man, who suffered Parkinson disease and neurological symptoms for 6 months. From imaging, there is a chronic subacute subdural hematoma in the right frontotemporoparietal area. Operation performed, histopathological examination of the tissue with Hematoxylin-Eosin staining and immunohistochemical examination confirmed diagnosis Intravascular Large Cell non-Hodgkin Lymphoma (IVLCL) type...

Research, Society and Development

Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion whi... more Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion which can affect both children and adult. The diagnosis of pedunculated lipofibroma can be confused with other benign papillomas due to their characteristic appearance. Objective: To define the clinicopathological findings of pedunculated lipofibroma. Methodology: Descriptive study as case report type, which use secondary data from patient medical record. Case presentation: This paper reports a 39-year-old woman, who has a slow growing mass lesion on her left thigh for almost 3 years. The lesion start impending her daily life due to pain and the lesion get bigger which make her get trouble especially when she wants to wear her jeans. The diagnosis of pedunculated lipofibroma can be confirmed by the histopathologic findings showing isolated groups of ectopic mature adipocytes within the dermis. Generally, the tumor itself doesn’t need any specific treatment, however the location and size aff...

Research, Society and Development, 2022

Introdução: A lobomicose é uma das infecções fúngicas mais raramente relatadas em todo o mundo. A... more Introdução: A lobomicose é uma das infecções fúngicas mais raramente relatadas em todo o mundo. A maioria dos casos relatados de lobomicose é endêmica na América Central e do Sul, especialmente em torno da Amazônia. As áreas do corpo afetadas geralmente são as orelhas, extremidades inferiores, extremidades superiores, rosto, tórax e costas. Objetivo: apresentar a evolução da lobomicose após corticoterapia de longa duração. Metodologia: Estudo descritivo do tipo relato de caso, cujos dados foram obtidos no prontuário do paciente. Apresentação do caso: Este artigo relata uma mulher de 23 anos, que sofreu feridas que cobriam quase toda a superfície do corpo sem qualquer febre. Ao exame físico, foram encontradas múltiplas úlceras com maceração das bordas da ferida e múltiplas saliências avermelhadas nas regiões anterior e posterior do tronco. Não há aparecimento de quelóides. O paciente tinha história de pênfigo vulgar e pênfigo vegetante e estava em uso de corticoterapia por longo praz...

International Journal of Medical Reviews and Case Reports, 2022

Background: Our pandemic of covid-19 has not ended yet. However, we have to move forward that oth... more Background: Our pandemic of covid-19 has not ended yet. However, we have to move forward that other important aspects of research need to be continued, cancer cases as one health problem that we should have noticed. Because nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia partly because the region has nearly 60% of the global population. 1−3 One in 5 men and one in 6 women worldwide develop cancer during their lifetime. As one of the parts of the Indonesian Country, Bali had no cancer registry yet. Methods: Our crossectional study gathers secondary data of pathology reports from 2017-2019 and records clinicopathological aspects like age, gender, and cancer topography. We collected cancer registries from government and private hospitals in Bali. We used consecutive sampling for the malignant lesion. The data were statistically analysed by SPSS version 23. Results: There are 4821 cancer cases recorded, 3020 cases (62,6%) in females and 1801 cases (37,4%) in men. The most common cancer in females was breast cancer accounted for 15% of cases, and nasopharyngeal cancer accounted for 4,9% as the most common cancer in men. In addition, the peak age of cancer is predominantly at 50-54 years in females and 60-64 years old in men. The highest frequency of females and males who had cancer were between ages 51-55 years old. Moreover, based on each sex, the prevalence rate of males who suffered from cancer was 2.8%, and females were 4.7%. Conclusions: Our study gives preliminary data about cancer epidemiology based on clinicopathology data (age, gender and cancer topography), especially in Bali. We believe our study will be valuable for further research and primary prevention of the cancer burden in Bali.

Indonesian Journal of Cancer, 2020

Introduction: Kimura’s disease (KD) in Indonesia is quite rare. It is a distinct benign reactive ... more Introduction: Kimura’s disease (KD) in Indonesia is quite rare. It is a distinct benign reactive process; however, it is usually mimicking malignancy. It usually affects young adults with a peak incidence in three decades, and men are mostly affected compared to women with a 3:1 ratio. KD is a chronic inflammatory disorder characterized by lymphoid hyperplasia, eosinophilia, and associated with soft tissue swelling that usually arises in head and neck regions with regional lymphadenopathy.Case Presentation: Herein, we report a case in a 55-year-old man from East Indonesia who presented a huge lump on his left head and neck regions. The lump started about 8 years ago. Physical examination found a tumor mass of 20 x 10 cm with indistinct border and multiple lymphadenopathies left coli with the biggest size of 1.3 x 0.7 x 0.5 cm. Peripheral blood examination shows marked eosinophilia. Nasopharyngeal CT scan revealed soft tissue masses and multiple lymphadenopathies suspected of maligna...

International Journal of Medical Reviews and Case Reports, 2021

Indonesian Journal of Cancer, Mar 30, 2020

Background: Claudin-1 is a tight junction protein in the cell that organizes paracellular permeab... more Background: Claudin-1 is a tight junction protein in the cell that organizes paracellular permeability and epithelial polarity and maintains apical cell-to-cell adhesion. Deregulation of claudin-1 homeostasis will play pivotal role in tumorigenesis, migration, and metastasis of colorectal cancer through a complex signaling pathway. This study investigated the association of claudin-1 expression and clinicopathological factors in colorectal adenocarcinoma. Methods: This study was a cross-sectional study of 43 colorectal cancer patients. Each clinicopathological parameter data was divided into 2 categories; depth of tumor invasion (T3, T4), degree of tumor differentiation (low, high grade), tumor location (right, left), sex (man, woman) and age (<60, ≥60 y.o). Claudin-1 expression was examined by the immunohistochemistry method and evaluated by H-Score method. The H-score cut off was determined by the mean value of 148. The difference of claudin-1 expression score with tumor depth invasion and age was analyzed by Independent t-test, and then the degree of differentiation, tumor location and sex were analyzed by Mann-Whitney. All variables were analyzed by the Chi-square analysis with a significance value of P<.05. Results: There was a significant mean difference of claudin-1 expression between T3 and T4 tumors (P=.041; 95% CI 1.7-75.1). Tumor with low expression of claudin-1 was 2.5 times more likely to be found in tumor with invasion depth T4 rather than T3 (P=.023; 95% CI 1.5-48). In addition, tumor with low expression of claudin-1 was 0.2 times more likely to be found in the high-grade tumor (P=.001; 95% CI 0.07-0.4). Claudin-1 expression was not statistically significant in different tumor locations, sex and age group. Conclusions: There was mean difference in claudin-1 expression between T3 and T4 tumors, and between low-and high-grade tumors. The low claudin-1 expression is associated with tumor depth invasion and poorly differentiated tumors. Therefore, the use of claudin-1 as an additional prognostic factor in colorectal cancer is proposed.

Research, Society and Development

Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion whi... more Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion which can affect both children and adult. The diagnosis of pedunculated lipofibroma can be confused with other benign papillomas due to their characteristic appearance. Objective: To define the clinicopathological findings of pedunculated lipofibroma. Methodology: Descriptive study as case report type, which use secondary data from patient medical record. Case presentation: This paper reports a 39-year-old woman, who has a slow growing mass lesion on her left thigh for almost 3 years. The lesion start impending her daily life due to pain and the lesion get bigger which make her get trouble especially when she wants to wear her jeans. The diagnosis of pedunculated lipofibroma can be confirmed by the histopathologic findings showing isolated groups of ectopic mature adipocytes within the dermis. Generally, the tumor itself doesn’t need any specific treatment, however the location and size aff...

Research, Society and Development

Introduction: Kaposi sarcoma is a rare and challenging case especially in immunosuppressed patien... more Introduction: Kaposi sarcoma is a rare and challenging case especially in immunosuppressed patients that frequently doesn’t have specific manifestation. It usually caused by human herpes virus 8 virus infection and male patient with multiple lesion has high mortality rates. The aim of this study is to report 34 y.o Male with incidental histopathological findings of kaposi sarcoma without clinical history of Human Immunodeficiency Virus (HIV). Methodology: Descriptive study of the case report type, whose data were obtained from the patient's medical record. Result: This paper will report 34-year-old young adult male with clinically diagnosed with poroma and differential diagnosis of squamous cell carcinoma and pyogenic granuloma. The clinical sign was multiple skin lesion appear on his right nose and thumb in the last 6 months. The nodules are solitary with oval shape, erythema, firm borders and the nodule surface covered with brownish-yellow squama. In addition, imaging examina...

Indonesian Journal of Cancer

Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gas... more Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gastrointestinal FL is a rare case, accounting for less than 4% of all primary lymphoma of the gastrointestinal tract. Duodenal-type Follicular Lymphoma (DTFL) was included in an entity of primary intestinal FL. However, in the 2017 World Health Organization (WHO) Classification, this entity was included in a specific variant called DTFL. In this article, we report a case of DTFL in a 56-year-old man which was incidentally found during upper gastrointestinal endoscopy Case Presentation: : We report a case of incidentally found DTFL in a 56-year-old man during an endoscopy. The endoscopic finding showed a small, hypertrophic, or nodular lesion on part two duodenum. Microscopic evaluation of duodenal mucosa consists of proliferative atypical lymphoid cells arranged in follicular architecture. The lesion was confined to the lamina propria. The atypical lymphoid cells were dominated by monotono...

Research, Society and Development

Primary breast lymphoma (PBL) is a rare but distinct subtype of extranodal lymphoma, comprising 0... more Primary breast lymphoma (PBL) is a rare but distinct subtype of extranodal lymphoma, comprising 0.5% of breast malignancies, approximately 1% of all non-Hodgkin's lymphomas (NHL) and <3% of extranodal lymphomas. Because the cases are rare, the diagnosis is difficult to establish by routine histopathological examination alone. This paper reports a case of a 53-year-old woman, complaining of a lump in the left breast. The lump is said to have been noticed since approximately 2 years ago on the nipple. The patient said that initially the lump was the size of a grape and then realized that it had enlarged since 3 weeks ago with a more chewy texture. Ultrasound of the left mammary, heterogeneous solid lesion with indistinct borders with dilatation of the drawerous duct with the appearance of intraductal calcification filling the superolateral and superomedial quadrants of the left mammary suggestively malignant (BIRADS 5). The microscopic appearance of the FNAB suggested a maligna...

Research, Society and Development, Nov 12, 2022

Introduction: Ectopic deciduosis refers to decidual tissue outside the uterus. Ectopic decidua ap... more Introduction: Ectopic deciduosis refers to decidual tissue outside the uterus. Ectopic decidua appears on the surface of the female reproductive organs and peritoneum; however, rare cases can be found in the appendix, lymph nodes, lungs, kidneys, and skin. Deciduosis is a benign condition that usually does not cause any symptoms and resolves spontaneously 4-6 weeks after delivery. However, an ectopic decidua involving the appendix wall often causes appendicitis and presents with acute abdominal signs. Methodology: The descriptive study of the case report type and the data obtained from the patient's medical record. Case presentation: This paper reports a woman aged 29 years with complaints of abdominal pain, like being stabbed in the pit of the stomach and then to the lower right abdomen for two days. A physical examination revealed tenderness in the lower abdomen with a positive McBurney sign. At that time, the patient was pregnant with a gestational age of 20-21 weeks. The patient underwent an appendectomy with the tissue sent to the anatomic pathology laboratory with the presence of decidual cells in the subserous layer and serous fat, and it was concluded as deciduosis of the appendix. Conclusion: Based on clinical and laboratory findings, the patient was diagnosed with deciduosis of the appendix.

Indonesian Journal of Cancer

Introduction: Metaplastic Breast Carcinoma (MBC) is quite a challenging case because metaplastic ... more Introduction: Metaplastic Breast Carcinoma (MBC) is quite a challenging case because metaplastic breast cancer is one of the rarest subtypes of invasive breast cancer. It is reported that MBC occurs only 0.2 to 1% throughout the world. The metaplastic changes can be squamous cells or other mesenchymal cell types. Clinically, MBC presents as a large palpable mass and may be associated with rapid growth. The size of MBC tends to be larger compared with other types of invasive breast cancer ranging from 1 to more than 10 cm. Although there are several main categories of MBC, some carcinoma can be difficult to classify due to their unusual histologic patterns. This case report study is to provide a clinicopathological overview and approach to MBC.Case Presentation: We reported a 49-year-old woman who suffered from a breast mass that rapidly grew for less than one year. The microscopic findings showed squamous cell carcinoma. While molecular studies revealed triple negative results for h...

Indonesian Journal of Cancer, Sep 29, 2022

Research, Society and Development

Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of... more Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of mast cells accumulating in one or more organ systems. Systemic mastocytosis is generally diagnosed after the second decade of life, reported male-to-female ratios range from 1:1 to 1:1.5. Case description : A 54-year-old woman came complaining weakness and diarrhea for the last 2 months. Symptoms are watery stools for 2-4 times a day and nausea. Physical examination found that the body temperature was 37.60C, tachycardia, increased bowel sounds, and tenderness on stomach. An endoscopic examination was performed with results: transverse colon appears with polyps with a size of 3 mm, with a mosaic pattern of mucosa. The mucosa of the ascending colon and caecum also appears to be a mosaic pattern. Biopsy was sent for histopathological examination. Morphological features show significant increase of eosinophils & mast cells, differentially diagnosed with Mastocytosis colitis, Eosinophilic c...

Research, Society and Development

Introduction: Intravascular lymphoma (IVL) is a rare subtype of non-Hodgkin extranodal lymphoma w... more Introduction: Intravascular lymphoma (IVL) is a rare subtype of non-Hodgkin extranodal lymphoma with characterized by a positive CD20 B cell proliferation in small lumens and medium-sized blood vessels, except veins and large arteries. Blood vessels in the central nervous system (CNS) and the skin is most often affected. These tumors usually occur in older adults and aggressive. Methodology: Descriptive study of the case report type, whose data were obtained from the patient’s medical record and has received the patient's consent to be published. Case presentation: This paper reports a 63-year-old man, who suffered Parkinson disease and neurological symptoms for 6 months. From imaging, there is a chronic subacute subdural hematoma in the right frontotemporoparietal area. Operation performed, histopathological examination of the tissue with Hematoxylin-Eosin staining and immunohistochemical examination confirmed diagnosis Intravascular Large Cell non-Hodgkin Lymphoma (IVLCL) type...

Research, Society and Development

Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion whi... more Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion which can affect both children and adult. The diagnosis of pedunculated lipofibroma can be confused with other benign papillomas due to their characteristic appearance. Objective: To define the clinicopathological findings of pedunculated lipofibroma. Methodology: Descriptive study as case report type, which use secondary data from patient medical record. Case presentation: This paper reports a 39-year-old woman, who has a slow growing mass lesion on her left thigh for almost 3 years. The lesion start impending her daily life due to pain and the lesion get bigger which make her get trouble especially when she wants to wear her jeans. The diagnosis of pedunculated lipofibroma can be confirmed by the histopathologic findings showing isolated groups of ectopic mature adipocytes within the dermis. Generally, the tumor itself doesn’t need any specific treatment, however the location and size aff...

Research, Society and Development, 2022

Introdução: A lobomicose é uma das infecções fúngicas mais raramente relatadas em todo o mundo. A... more Introdução: A lobomicose é uma das infecções fúngicas mais raramente relatadas em todo o mundo. A maioria dos casos relatados de lobomicose é endêmica na América Central e do Sul, especialmente em torno da Amazônia. As áreas do corpo afetadas geralmente são as orelhas, extremidades inferiores, extremidades superiores, rosto, tórax e costas. Objetivo: apresentar a evolução da lobomicose após corticoterapia de longa duração. Metodologia: Estudo descritivo do tipo relato de caso, cujos dados foram obtidos no prontuário do paciente. Apresentação do caso: Este artigo relata uma mulher de 23 anos, que sofreu feridas que cobriam quase toda a superfície do corpo sem qualquer febre. Ao exame físico, foram encontradas múltiplas úlceras com maceração das bordas da ferida e múltiplas saliências avermelhadas nas regiões anterior e posterior do tronco. Não há aparecimento de quelóides. O paciente tinha história de pênfigo vulgar e pênfigo vegetante e estava em uso de corticoterapia por longo praz...

International Journal of Medical Reviews and Case Reports, 2022

Background: Our pandemic of covid-19 has not ended yet. However, we have to move forward that oth... more Background: Our pandemic of covid-19 has not ended yet. However, we have to move forward that other important aspects of research need to be continued, cancer cases as one health problem that we should have noticed. Because nearly half of the new cases and more than half of the cancer deaths worldwide in 2018 are estimated to occur in Asia partly because the region has nearly 60% of the global population. 1−3 One in 5 men and one in 6 women worldwide develop cancer during their lifetime. As one of the parts of the Indonesian Country, Bali had no cancer registry yet. Methods: Our crossectional study gathers secondary data of pathology reports from 2017-2019 and records clinicopathological aspects like age, gender, and cancer topography. We collected cancer registries from government and private hospitals in Bali. We used consecutive sampling for the malignant lesion. The data were statistically analysed by SPSS version 23. Results: There are 4821 cancer cases recorded, 3020 cases (62,6%) in females and 1801 cases (37,4%) in men. The most common cancer in females was breast cancer accounted for 15% of cases, and nasopharyngeal cancer accounted for 4,9% as the most common cancer in men. In addition, the peak age of cancer is predominantly at 50-54 years in females and 60-64 years old in men. The highest frequency of females and males who had cancer were between ages 51-55 years old. Moreover, based on each sex, the prevalence rate of males who suffered from cancer was 2.8%, and females were 4.7%. Conclusions: Our study gives preliminary data about cancer epidemiology based on clinicopathology data (age, gender and cancer topography), especially in Bali. We believe our study will be valuable for further research and primary prevention of the cancer burden in Bali.

Indonesian Journal of Cancer, 2020

Introduction: Kimura’s disease (KD) in Indonesia is quite rare. It is a distinct benign reactive ... more Introduction: Kimura’s disease (KD) in Indonesia is quite rare. It is a distinct benign reactive process; however, it is usually mimicking malignancy. It usually affects young adults with a peak incidence in three decades, and men are mostly affected compared to women with a 3:1 ratio. KD is a chronic inflammatory disorder characterized by lymphoid hyperplasia, eosinophilia, and associated with soft tissue swelling that usually arises in head and neck regions with regional lymphadenopathy.Case Presentation: Herein, we report a case in a 55-year-old man from East Indonesia who presented a huge lump on his left head and neck regions. The lump started about 8 years ago. Physical examination found a tumor mass of 20 x 10 cm with indistinct border and multiple lymphadenopathies left coli with the biggest size of 1.3 x 0.7 x 0.5 cm. Peripheral blood examination shows marked eosinophilia. Nasopharyngeal CT scan revealed soft tissue masses and multiple lymphadenopathies suspected of maligna...

International Journal of Medical Reviews and Case Reports, 2021

Indonesian Journal of Cancer, Mar 30, 2020

Background: Claudin-1 is a tight junction protein in the cell that organizes paracellular permeab... more Background: Claudin-1 is a tight junction protein in the cell that organizes paracellular permeability and epithelial polarity and maintains apical cell-to-cell adhesion. Deregulation of claudin-1 homeostasis will play pivotal role in tumorigenesis, migration, and metastasis of colorectal cancer through a complex signaling pathway. This study investigated the association of claudin-1 expression and clinicopathological factors in colorectal adenocarcinoma. Methods: This study was a cross-sectional study of 43 colorectal cancer patients. Each clinicopathological parameter data was divided into 2 categories; depth of tumor invasion (T3, T4), degree of tumor differentiation (low, high grade), tumor location (right, left), sex (man, woman) and age (<60, ≥60 y.o). Claudin-1 expression was examined by the immunohistochemistry method and evaluated by H-Score method. The H-score cut off was determined by the mean value of 148. The difference of claudin-1 expression score with tumor depth invasion and age was analyzed by Independent t-test, and then the degree of differentiation, tumor location and sex were analyzed by Mann-Whitney. All variables were analyzed by the Chi-square analysis with a significance value of P<.05. Results: There was a significant mean difference of claudin-1 expression between T3 and T4 tumors (P=.041; 95% CI 1.7-75.1). Tumor with low expression of claudin-1 was 2.5 times more likely to be found in tumor with invasion depth T4 rather than T3 (P=.023; 95% CI 1.5-48). In addition, tumor with low expression of claudin-1 was 0.2 times more likely to be found in the high-grade tumor (P=.001; 95% CI 0.07-0.4). Claudin-1 expression was not statistically significant in different tumor locations, sex and age group. Conclusions: There was mean difference in claudin-1 expression between T3 and T4 tumors, and between low-and high-grade tumors. The low claudin-1 expression is associated with tumor depth invasion and poorly differentiated tumors. Therefore, the use of claudin-1 as an additional prognostic factor in colorectal cancer is proposed.

Research, Society and Development

Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion whi... more Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion which can affect both children and adult. The diagnosis of pedunculated lipofibroma can be confused with other benign papillomas due to their characteristic appearance. Objective: To define the clinicopathological findings of pedunculated lipofibroma. Methodology: Descriptive study as case report type, which use secondary data from patient medical record. Case presentation: This paper reports a 39-year-old woman, who has a slow growing mass lesion on her left thigh for almost 3 years. The lesion start impending her daily life due to pain and the lesion get bigger which make her get trouble especially when she wants to wear her jeans. The diagnosis of pedunculated lipofibroma can be confirmed by the histopathologic findings showing isolated groups of ectopic mature adipocytes within the dermis. Generally, the tumor itself doesn’t need any specific treatment, however the location and size aff...