Paola Prometti - Academia.edu (original) (raw)

Papers by Paola Prometti

La Clinica terapeutica, 2015

Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous syst... more Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous system, characterized by aggressive deterioration of white matter pathways throughout the subcortical brain parenchyma. This disease leads the patient to a total dependence in all activities of daily (ADLs) living in few months. The literature on rehabilitation of progressive multifocal leukoencephalopathy is scanty and, at present, it is unknown whether rehabilitation may modify the course of disability in this disease. This paper describes the functional course of a patients with progressive multifocal leukoencephalopathy who incurred in a severe functional impairment of ADLs after an unintentional fall and prolonged bed rest. The multidisciplinary in-hospital rehabilitation program and integrated homecare approach allowed the patient to improve her functional capacities and go on with living at home.

Life, Apr 20, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Acta Neurologica Belgica, Oct 5, 2021

PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance S... more PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance Scale (BBS) items were important determinants of improvement in functional abilities in patients with peripheral neuropathy (PN). METHODS Data were collected in 75 older patients with PN performing a standard motor rehabilitation program. Backward stepwise multiple regression analyses were performed to identify determinants of outcome measures. Gain in total and motor Functional Independence Measure (FIM) and gain in motor-FIM areas were the outcome measures. RESULTS Among BBS items, at the end of rehabilitation, the score was higher in "sitting unsupported" (3.94 ± 0.22) and lower in "standing on one foot" (1.18 ± 1.06). The gain was higher in "standing to sitting" (1.02 ± 0.67) and "standing unsupported" (1.00 ± 1.00), and lower in "sitting unsupported" (0.22 ± 0.60) and "standing on one foot" (0.65 ± 0.77). "Standing unsupported" was the only determinant of gain in motor-FIM (beta - 0.36, p = 0.002) and gain in self-care (beta - 0.37, p = 0.002). The R2 value of the models was 0.13 and 0.14, respectively. No independent variable was a determinant of gain in total-FIM. CONCLUSIONS The study shows that "unsupported standing" is an important determinant of results of ADL rehabilitation in PN patients and indicates that ability to stand without support for a fairly long time is an essential requirement to achieve with rehabilitation higher gain levels in functional abilities in PN patients.

Pain Medicine, Oct 1, 2011

Objective. The aim of this study was to evaluate the effect of intraarticular injections of corti... more Objective. The aim of this study was to evaluate the effect of intraarticular injections of corticosteroids (triamcinolone) in patients with symptomatic rotator cuff tears (RCT). Design. Randomized controlled study. Setting. Rehabilitation unit. Patients. Sixty patients with full-thickness RCT were enrolled in the study. Patients were randomly divided into three equal groups of 20 patients. The first group received single intraarticular injection of 40 mg triamcinolone, the second group received two injections of 40 mg triamcinolone at 21-day interval, and the third group received no treatment (control group). All patients underwent rehabilitation sessions. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant-Murley score. Measures. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant-Murley score. Results. Pain at night score of both groups who received triamcinolone was lower than that of Control Group at 1 month (P < 0.05 and P < 0.01 in first and second groups, respectively) and at 3 months (P < 0.05 and P < 0.01 in the first and second groups, respectively). Similarly, activity pain score of groups treated with triamcinolone was lower than that of the control group at 1 month (P < 0.001 in both groups) and at 3 months (P < 0.001 in both groups). There was no statistically significant difference in pain at night between the first and second groups at 1 and at 3 months. There was no statistically significant difference among groups at 3 and 6 months in Constant-Murley scores. Conclusions. Our study indicates that intraarticular injection of triamcinolone improves pain relief for 3 months in RCT and its action is not prolonged or potentiated by two injections of the drug done at 21-day intervals.

Aging Clinical and Experimental Research, Jul 14, 2021

Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). T... more Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). This prospective observational study aimed to identify possible factors predicting the functional abilities in older patients with PN undergoing motor rehabilitation. Methods Data were collected in 80 PN patients, aged over 65 years, performing a standard inpatient motor rehabilitation program. The total Functional Independence Measure (FIM) score after rehabilitation, as well as efficiency and effectiveness in total-FIM, were the outcome measures. Backward multiple regression analyses identified the predictors of functional status. Results At the end of rehabilitation, total-FIM score was 102.66 ± 10.75, efficiency in total-FIM 0.64 ± 0.29 and effectiveness in total-FIM 48.81 ± 15.35%. Katz index at admission was a predictor of the final total-FIM score (beta 0.46, p < 0.001) and efficiency in total-FIM (beta − 0.38, p = 0.001). Conversely, age was a predictor of the final total-FIM score (beta − 0.31, p = 0.002) and effectiveness in total-FIM (beta − 0.49, p < 0.001). The R 2 values of the models were, respectively, 0.39, 0.15, and 0.24. Discussion In PN patients, functional impairment at admission and age are important predictors of functional abilities at the end of rehabilitation. Conclusions These findings suggest the need for more intensive rehabilitation in older, more disabled PN patients because they risk achieving lower functional levels with standard rehabilitation programs.

Aging Clinical and Experimental Research, Mar 21, 2019

Background and aim The aim of this prospective observational cohort study was to verify the relat... more Background and aim The aim of this prospective observational cohort study was to verify the relationship between number of drugs used and functional outcome in hip fracture patients undergoing rehabilitation. Methods This study was conducted on 139 patients with hip fracture who underwent a rehabilitation program. Efficiency rate in the Functional Independence Measure (FIM) and Berg Balance Scale (BBS), and length of stay (LOS) were the outcome measures. Results At the end of rehabilitation, 66.1% of patients showed an increase in number of drugs used, while 33.9% used the same or lower number of drugs than at admission. At the end of rehabilitation patients with increased pharmacotherapy took a higher total number of drug classes (p = 0.001), had longer LOS (p = 0.009) and lower Berg efficiency (p = 0.048) than patients with the same or lower pharmacotherapy. The number of drugs used at discharge was an independent determinant of LOS (beta = 0.19, p = 0.022) and FIM efficiency (beta = − 0.20, p = 0.025). Age was a determinant of LOS (beta = 0.17, p = 0.044) and BBS efficiency (beta = − 0.23, p = 0.009), while CIRS severity was a determinant of BBS efficiency only (beta = − 0.22, p = 0.016). Discussion Findings of study indicate that in hip fracture patients, the number of drugs prescribed at discharge is an important indicator of LOS and rehabilitation efficiency. Conclusions These findings can help the physician to better plan the rehabilitation of hip fracture patients who require polypharmacy.

The Open Neurology Journal, Aug 26, 2016

Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supportin... more Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach.

Aging Clinical and Experimental Research, Apr 1, 2012

To describe the unusual course of a patient with cerebellar ataxia who underwent rehabilitation. ... more To describe the unusual course of a patient with cerebellar ataxia who underwent rehabilitation. At admission, the patient underwent motor rehabilitation and assessment by Tinetti Assessment, Klockgether Score, National Institute of Health Stroke Scale, Trunk Control Test, Fugl-Meyer Scale, Barthel Index, and Mini Mental State Examination. The patient showed very rapid and severe decline of motor and functional tests during the first month of hospitalization and complete dependence in &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;2 months, despite rehabilitation. He died 10 months after onset, with a neuro-pathological diagnosis of sporadic Creutzfeldt-Jakob disease (CJD). Our case report suggests that sporadic CJD must be hypothesized when ataxia worsens rapidly and severely despite rehabilitation.

Journal of Chemotherapy, 2002

In this open, prospective, study were enrolled 204 hospitalized elderly patients with severe (88 ... more In this open, prospective, study were enrolled 204 hospitalized elderly patients with severe (88 males, 116 females, age range 70-94). Patients were randomized to receive one of the following antibiotic treatment regimens: meropenem 500 mg i.v. t.i.d. (52); imipenem/cilastatin 500 mg i.v. t.i.d. (51), clarithromycin 500 mg + ceftriaxone 1 g i.v. b.i.d. (52), clarithromycin 500 mg + amikacin 250 mg i.v. b.i.d. (49). In 99 cases causative germs were isolated (24 meropenem, 26 imipenem, 23 clarithromycin + ceftriaxone, 26 ceftriaxone + amikacin). A satisfactory clinical, bacteriological response was achieved respectively in 86.5% 77% in meropenem; 86.3% 71% in imipenem/cilastatin; 69% 61% in ceftriaxone + clarithromycin and in 85.7% 77% in clarithromycin + amikacin.

We provide the raw data used for the following article: Gialanella B, Santoro R, Prometti P, Gior... more We provide the raw data used for the following article: Gialanella B, Santoro R, Prometti P, Giordano A, Monguzzi V, Comini L, Olivares A, Grioni G.<br> <em>Functional recovery in hip fracture patients: the role of pharmacotherapy</em>.<br> "Aging Clin Exp Res." 2020 Jan;32(1):49-57.<br> doi: 10.1007/s40520-019-01175-w. Epub 2019 Mar 21. PMID: 30900212. <strong>Background and aim: </strong>The aim of this prospective observational cohort study was to verify the relationship between number of drugs used and functional outcome in hip fracture patients undergoing rehabilitation. <strong>Methods: </strong>This study was conducted on 139 patients with hip fracture who underwent a rehabilitation program. Efficiency rate in the Functional Independence Measure (FIM) and Berg Balance Scale (BBS), and length of stay (LOS) were the outcome measures. <strong>Results: </strong>At the end of rehabilitation, 66.1% of patie...

Aging Clinical and Experimental Research, 2021

Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). T... more Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). This prospective observational study aimed to identify possible factors predicting the functional abilities in older patients with PN undergoing motor rehabilitation. Methods Data were collected in 80 PN patients, aged over 65 years, performing a standard inpatient motor rehabilitation program. The total Functional Independence Measure (FIM) score after rehabilitation, as well as efficiency and effectiveness in total-FIM, were the outcome measures. Backward multiple regression analyses identified the predictors of functional status. Results At the end of rehabilitation, total-FIM score was 102.66 ± 10.75, efficiency in total-FIM 0.64 ± 0.29 and effectiveness in total-FIM 48.81 ± 15.35%. Katz index at admission was a predictor of the final total-FIM score (beta 0.46, p < 0.001) and efficiency in total-FIM (beta − 0.38, p = 0.001). Conversely, age was a predictor of the final total-FIM score (beta − 0.31, p = 0.002) and effectiveness in total-FIM (beta − 0.49, p < 0.001). The R 2 values of the models were, respectively, 0.39, 0.15, and 0.24. Discussion In PN patients, functional impairment at admission and age are important predictors of functional abilities at the end of rehabilitation. Conclusions These findings suggest the need for more intensive rehabilitation in older, more disabled PN patients because they risk achieving lower functional levels with standard rehabilitation programs.

Objective. The aim of this study was to evaluate the effect of intraarticular injections of corti... more Objective. The aim of this study was to evaluate the effect of intraarticular injections of corticosteroids (triamcinolone) in patients with symptomatic rotator cuff tears (RCT). Design. Randomized controlled study. Setting. Rehabilitation unit. Patients. Sixty patients with full-thickness RCT were enrolled in the study. Patients were randomly divided into three equal groups of 20 patients. The first group received single intraarticular injection of 40 mg triamcinolone, the second group received two injections of 40 mg triamcinolone at 21-day interval, and the third group received no treatment (control group). All patients underwent rehabilitation sessions. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant‐Murley score. Measures. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant-Murley score. Results. Pain at night score of both groups who rec...

Medicina Dello Sport, 2015

La Clinica terapeutica, 2016

Atypical subtrochanteric and diaphyseal femoral fractures (AFF) have been suggested to be associa... more Atypical subtrochanteric and diaphyseal femoral fractures (AFF) have been suggested to be associated with the use of bisphosphonates (BPs), but the role of these drugs is still under debate. A 64-year old female, never treated with BPs was admitted to our Rehabilitation Institute because of a recent right AFF. The patient began suffering from low back pain radiating to the groin and to the anterior regions of the right thigh and leg, A nuclear magnetic resonance (NMR) of the lumbar spine showed disc protrusions at the L3-L4 and L5-S1 levels with impingement of the spinal nerve root. Therefore she was treated with analgesic, anti-inflammatory and muscle relaxing compounds for nine months without reduction of symptoms. Being the pain still present, the patient felt down the street breaking the right femoral neck and the femoral distal shaft. Following the ASBMR criteria the fracture was classified as a complete AFF and the patient underwent surgical ostheosynthesis with nail. A bone b...

Acta Neurologica Belgica, 2021

PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance S... more PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance Scale (BBS) items were important determinants of improvement in functional abilities in patients with peripheral neuropathy (PN). METHODS Data were collected in 75 older patients with PN performing a standard motor rehabilitation program. Backward stepwise multiple regression analyses were performed to identify determinants of outcome measures. Gain in total and motor Functional Independence Measure (FIM) and gain in motor-FIM areas were the outcome measures. RESULTS Among BBS items, at the end of rehabilitation, the score was higher in "sitting unsupported" (3.94 ± 0.22) and lower in "standing on one foot" (1.18 ± 1.06). The gain was higher in "standing to sitting" (1.02 ± 0.67) and "standing unsupported" (1.00 ± 1.00), and lower in "sitting unsupported" (0.22 ± 0.60) and "standing on one foot" (0.65 ± 0.77). "Standing unsupported" was the only determinant of gain in motor-FIM (beta - 0.36, p = 0.002) and gain in self-care (beta - 0.37, p = 0.002). The R2 value of the models was 0.13 and 0.14, respectively. No independent variable was a determinant of gain in total-FIM. CONCLUSIONS The study shows that "unsupported standing" is an important determinant of results of ADL rehabilitation in PN patients and indicates that ability to stand without support for a fairly long time is an essential requirement to achieve with rehabilitation higher gain levels in functional abilities in PN patients.

European Geriatric Medicine, 2020

The aim of study was to identify factors predicting balance in older hip fracture patients underg... more The aim of study was to identify factors predicting balance in older hip fracture patients undergoing motor rehabilitation. The aim of study was to identify factors predicting balance in older hip fracture patients undergoing motor rehabilitation. Findings Cognitive function, comorbidity and hip muscles strength are important predictors of balance in hip fracture patients. Message Knowledge of specific predictors could be useful for physicians to identify patients needing specific rehabilitation programs for balance.

La Clinica terapeutica, 2015

Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous syst... more Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous system, characterized by aggressive deterioration of white matter pathways throughout the subcortical brain parenchyma. This disease leads the patient to a total dependence in all activities of daily (ADLs) living in few months. The literature on rehabilitation of progressive multifocal leukoencephalopathy is scanty and, at present, it is unknown whether rehabilitation may modify the course of disability in this disease. This paper describes the functional course of a patients with progressive multifocal leukoencephalopathy who incurred in a severe functional impairment of ADLs after an unintentional fall and prolonged bed rest. The multidisciplinary in-hospital rehabilitation program and integrated homecare approach allowed the patient to improve her functional capacities and go on with living at home.

Life, Apr 20, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Acta Neurologica Belgica, Oct 5, 2021

PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance S... more PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance Scale (BBS) items were important determinants of improvement in functional abilities in patients with peripheral neuropathy (PN). METHODS Data were collected in 75 older patients with PN performing a standard motor rehabilitation program. Backward stepwise multiple regression analyses were performed to identify determinants of outcome measures. Gain in total and motor Functional Independence Measure (FIM) and gain in motor-FIM areas were the outcome measures. RESULTS Among BBS items, at the end of rehabilitation, the score was higher in "sitting unsupported" (3.94 ± 0.22) and lower in "standing on one foot" (1.18 ± 1.06). The gain was higher in "standing to sitting" (1.02 ± 0.67) and "standing unsupported" (1.00 ± 1.00), and lower in "sitting unsupported" (0.22 ± 0.60) and "standing on one foot" (0.65 ± 0.77). "Standing unsupported" was the only determinant of gain in motor-FIM (beta - 0.36, p = 0.002) and gain in self-care (beta - 0.37, p = 0.002). The R2 value of the models was 0.13 and 0.14, respectively. No independent variable was a determinant of gain in total-FIM. CONCLUSIONS The study shows that "unsupported standing" is an important determinant of results of ADL rehabilitation in PN patients and indicates that ability to stand without support for a fairly long time is an essential requirement to achieve with rehabilitation higher gain levels in functional abilities in PN patients.

Pain Medicine, Oct 1, 2011

Objective. The aim of this study was to evaluate the effect of intraarticular injections of corti... more Objective. The aim of this study was to evaluate the effect of intraarticular injections of corticosteroids (triamcinolone) in patients with symptomatic rotator cuff tears (RCT). Design. Randomized controlled study. Setting. Rehabilitation unit. Patients. Sixty patients with full-thickness RCT were enrolled in the study. Patients were randomly divided into three equal groups of 20 patients. The first group received single intraarticular injection of 40 mg triamcinolone, the second group received two injections of 40 mg triamcinolone at 21-day interval, and the third group received no treatment (control group). All patients underwent rehabilitation sessions. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant-Murley score. Measures. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant-Murley score. Results. Pain at night score of both groups who received triamcinolone was lower than that of Control Group at 1 month (P < 0.05 and P < 0.01 in first and second groups, respectively) and at 3 months (P < 0.05 and P < 0.01 in the first and second groups, respectively). Similarly, activity pain score of groups treated with triamcinolone was lower than that of the control group at 1 month (P < 0.001 in both groups) and at 3 months (P < 0.001 in both groups). There was no statistically significant difference in pain at night between the first and second groups at 1 and at 3 months. There was no statistically significant difference among groups at 3 and 6 months in Constant-Murley scores. Conclusions. Our study indicates that intraarticular injection of triamcinolone improves pain relief for 3 months in RCT and its action is not prolonged or potentiated by two injections of the drug done at 21-day intervals.

Aging Clinical and Experimental Research, Jul 14, 2021

Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). T... more Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). This prospective observational study aimed to identify possible factors predicting the functional abilities in older patients with PN undergoing motor rehabilitation. Methods Data were collected in 80 PN patients, aged over 65 years, performing a standard inpatient motor rehabilitation program. The total Functional Independence Measure (FIM) score after rehabilitation, as well as efficiency and effectiveness in total-FIM, were the outcome measures. Backward multiple regression analyses identified the predictors of functional status. Results At the end of rehabilitation, total-FIM score was 102.66 ± 10.75, efficiency in total-FIM 0.64 ± 0.29 and effectiveness in total-FIM 48.81 ± 15.35%. Katz index at admission was a predictor of the final total-FIM score (beta 0.46, p < 0.001) and efficiency in total-FIM (beta − 0.38, p = 0.001). Conversely, age was a predictor of the final total-FIM score (beta − 0.31, p = 0.002) and effectiveness in total-FIM (beta − 0.49, p < 0.001). The R 2 values of the models were, respectively, 0.39, 0.15, and 0.24. Discussion In PN patients, functional impairment at admission and age are important predictors of functional abilities at the end of rehabilitation. Conclusions These findings suggest the need for more intensive rehabilitation in older, more disabled PN patients because they risk achieving lower functional levels with standard rehabilitation programs.

Aging Clinical and Experimental Research, Mar 21, 2019

Background and aim The aim of this prospective observational cohort study was to verify the relat... more Background and aim The aim of this prospective observational cohort study was to verify the relationship between number of drugs used and functional outcome in hip fracture patients undergoing rehabilitation. Methods This study was conducted on 139 patients with hip fracture who underwent a rehabilitation program. Efficiency rate in the Functional Independence Measure (FIM) and Berg Balance Scale (BBS), and length of stay (LOS) were the outcome measures. Results At the end of rehabilitation, 66.1% of patients showed an increase in number of drugs used, while 33.9% used the same or lower number of drugs than at admission. At the end of rehabilitation patients with increased pharmacotherapy took a higher total number of drug classes (p = 0.001), had longer LOS (p = 0.009) and lower Berg efficiency (p = 0.048) than patients with the same or lower pharmacotherapy. The number of drugs used at discharge was an independent determinant of LOS (beta = 0.19, p = 0.022) and FIM efficiency (beta = − 0.20, p = 0.025). Age was a determinant of LOS (beta = 0.17, p = 0.044) and BBS efficiency (beta = − 0.23, p = 0.009), while CIRS severity was a determinant of BBS efficiency only (beta = − 0.22, p = 0.016). Discussion Findings of study indicate that in hip fracture patients, the number of drugs prescribed at discharge is an important indicator of LOS and rehabilitation efficiency. Conclusions These findings can help the physician to better plan the rehabilitation of hip fracture patients who require polypharmacy.

The Open Neurology Journal, Aug 26, 2016

Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supportin... more Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach.

Aging Clinical and Experimental Research, Apr 1, 2012

To describe the unusual course of a patient with cerebellar ataxia who underwent rehabilitation. ... more To describe the unusual course of a patient with cerebellar ataxia who underwent rehabilitation. At admission, the patient underwent motor rehabilitation and assessment by Tinetti Assessment, Klockgether Score, National Institute of Health Stroke Scale, Trunk Control Test, Fugl-Meyer Scale, Barthel Index, and Mini Mental State Examination. The patient showed very rapid and severe decline of motor and functional tests during the first month of hospitalization and complete dependence in &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;2 months, despite rehabilitation. He died 10 months after onset, with a neuro-pathological diagnosis of sporadic Creutzfeldt-Jakob disease (CJD). Our case report suggests that sporadic CJD must be hypothesized when ataxia worsens rapidly and severely despite rehabilitation.

Journal of Chemotherapy, 2002

In this open, prospective, study were enrolled 204 hospitalized elderly patients with severe (88 ... more In this open, prospective, study were enrolled 204 hospitalized elderly patients with severe (88 males, 116 females, age range 70-94). Patients were randomized to receive one of the following antibiotic treatment regimens: meropenem 500 mg i.v. t.i.d. (52); imipenem/cilastatin 500 mg i.v. t.i.d. (51), clarithromycin 500 mg + ceftriaxone 1 g i.v. b.i.d. (52), clarithromycin 500 mg + amikacin 250 mg i.v. b.i.d. (49). In 99 cases causative germs were isolated (24 meropenem, 26 imipenem, 23 clarithromycin + ceftriaxone, 26 ceftriaxone + amikacin). A satisfactory clinical, bacteriological response was achieved respectively in 86.5% 77% in meropenem; 86.3% 71% in imipenem/cilastatin; 69% 61% in ceftriaxone + clarithromycin and in 85.7% 77% in clarithromycin + amikacin.

We provide the raw data used for the following article: Gialanella B, Santoro R, Prometti P, Gior... more We provide the raw data used for the following article: Gialanella B, Santoro R, Prometti P, Giordano A, Monguzzi V, Comini L, Olivares A, Grioni G.<br> <em>Functional recovery in hip fracture patients: the role of pharmacotherapy</em>.<br> "Aging Clin Exp Res." 2020 Jan;32(1):49-57.<br> doi: 10.1007/s40520-019-01175-w. Epub 2019 Mar 21. PMID: 30900212. <strong>Background and aim: </strong>The aim of this prospective observational cohort study was to verify the relationship between number of drugs used and functional outcome in hip fracture patients undergoing rehabilitation. <strong>Methods: </strong>This study was conducted on 139 patients with hip fracture who underwent a rehabilitation program. Efficiency rate in the Functional Independence Measure (FIM) and Berg Balance Scale (BBS), and length of stay (LOS) were the outcome measures. <strong>Results: </strong>At the end of rehabilitation, 66.1% of patie...

Aging Clinical and Experimental Research, 2021

Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). T... more Background and aims Little is known about the outcome predictors in peripheral neuropathy (PN). This prospective observational study aimed to identify possible factors predicting the functional abilities in older patients with PN undergoing motor rehabilitation. Methods Data were collected in 80 PN patients, aged over 65 years, performing a standard inpatient motor rehabilitation program. The total Functional Independence Measure (FIM) score after rehabilitation, as well as efficiency and effectiveness in total-FIM, were the outcome measures. Backward multiple regression analyses identified the predictors of functional status. Results At the end of rehabilitation, total-FIM score was 102.66 ± 10.75, efficiency in total-FIM 0.64 ± 0.29 and effectiveness in total-FIM 48.81 ± 15.35%. Katz index at admission was a predictor of the final total-FIM score (beta 0.46, p < 0.001) and efficiency in total-FIM (beta − 0.38, p = 0.001). Conversely, age was a predictor of the final total-FIM score (beta − 0.31, p = 0.002) and effectiveness in total-FIM (beta − 0.49, p < 0.001). The R 2 values of the models were, respectively, 0.39, 0.15, and 0.24. Discussion In PN patients, functional impairment at admission and age are important predictors of functional abilities at the end of rehabilitation. Conclusions These findings suggest the need for more intensive rehabilitation in older, more disabled PN patients because they risk achieving lower functional levels with standard rehabilitation programs.

Objective. The aim of this study was to evaluate the effect of intraarticular injections of corti... more Objective. The aim of this study was to evaluate the effect of intraarticular injections of corticosteroids (triamcinolone) in patients with symptomatic rotator cuff tears (RCT). Design. Randomized controlled study. Setting. Rehabilitation unit. Patients. Sixty patients with full-thickness RCT were enrolled in the study. Patients were randomly divided into three equal groups of 20 patients. The first group received single intraarticular injection of 40 mg triamcinolone, the second group received two injections of 40 mg triamcinolone at 21-day interval, and the third group received no treatment (control group). All patients underwent rehabilitation sessions. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant‐Murley score. Measures. Outcome measures were pain, evaluated using a visual analog scale, and shoulder functional status, evaluated by Constant-Murley score. Results. Pain at night score of both groups who rec...

Medicina Dello Sport, 2015

La Clinica terapeutica, 2016

Atypical subtrochanteric and diaphyseal femoral fractures (AFF) have been suggested to be associa... more Atypical subtrochanteric and diaphyseal femoral fractures (AFF) have been suggested to be associated with the use of bisphosphonates (BPs), but the role of these drugs is still under debate. A 64-year old female, never treated with BPs was admitted to our Rehabilitation Institute because of a recent right AFF. The patient began suffering from low back pain radiating to the groin and to the anterior regions of the right thigh and leg, A nuclear magnetic resonance (NMR) of the lumbar spine showed disc protrusions at the L3-L4 and L5-S1 levels with impingement of the spinal nerve root. Therefore she was treated with analgesic, anti-inflammatory and muscle relaxing compounds for nine months without reduction of symptoms. Being the pain still present, the patient felt down the street breaking the right femoral neck and the femoral distal shaft. Following the ASBMR criteria the fracture was classified as a complete AFF and the patient underwent surgical ostheosynthesis with nail. A bone b...

Acta Neurologica Belgica, 2021

PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance S... more PURPOSE This prospective observational cohort study aimed to verify whether single Berg Balance Scale (BBS) items were important determinants of improvement in functional abilities in patients with peripheral neuropathy (PN). METHODS Data were collected in 75 older patients with PN performing a standard motor rehabilitation program. Backward stepwise multiple regression analyses were performed to identify determinants of outcome measures. Gain in total and motor Functional Independence Measure (FIM) and gain in motor-FIM areas were the outcome measures. RESULTS Among BBS items, at the end of rehabilitation, the score was higher in "sitting unsupported" (3.94 ± 0.22) and lower in "standing on one foot" (1.18 ± 1.06). The gain was higher in "standing to sitting" (1.02 ± 0.67) and "standing unsupported" (1.00 ± 1.00), and lower in "sitting unsupported" (0.22 ± 0.60) and "standing on one foot" (0.65 ± 0.77). "Standing unsupported" was the only determinant of gain in motor-FIM (beta - 0.36, p = 0.002) and gain in self-care (beta - 0.37, p = 0.002). The R2 value of the models was 0.13 and 0.14, respectively. No independent variable was a determinant of gain in total-FIM. CONCLUSIONS The study shows that "unsupported standing" is an important determinant of results of ADL rehabilitation in PN patients and indicates that ability to stand without support for a fairly long time is an essential requirement to achieve with rehabilitation higher gain levels in functional abilities in PN patients.

European Geriatric Medicine, 2020

The aim of study was to identify factors predicting balance in older hip fracture patients underg... more The aim of study was to identify factors predicting balance in older hip fracture patients undergoing motor rehabilitation. The aim of study was to identify factors predicting balance in older hip fracture patients undergoing motor rehabilitation. Findings Cognitive function, comorbidity and hip muscles strength are important predictors of balance in hip fracture patients. Message Knowledge of specific predictors could be useful for physicians to identify patients needing specific rehabilitation programs for balance.