Pamela Grim - Academia.edu (original) (raw)
Papers by Pamela Grim
Journal of Clinical Psychopharmacology, Feb 1, 1990
Annals of Emergency Medicine, May 1, 1989
Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early t... more Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early therapy. The earliest possible time to treat is during the initial evaluation of the patient in the home or ambulance, which requires accurate diagnosis of acute myocardial infarction in the prehospital setting. In our study, paramedics evaluated patients who had chest pain with a 12-lead ECG transmitted by cellular telephone and a checklist for inclusion and exclusion criteria for thrombolytic therapy. This information was transmitted to a hospital-based telemetry physician who diagnosed or excluded acute myocardial infarction and made a mock decision to withhold or administer a thrombolytic agent. Forty-eight patients with chest pain were evaluated. Six were diagnosed as having overt acute myocardial infarction by the hospital-based telemetry physician. All six patients had the diagnosis substantiated by both ECG and enzyme studies on hospital admission. Based on the data supplied by paramedics, two of these six patients were considered eligible for thrombolytic therapy by the physician. Hospital evaluation confirmed the prehospital decision to treat with a thrombolytic agent. In addition, all other patients were appropriately diagnosed as ineligible. Prehospital ECG diagnosis resulted in two patients going directly to the catheterization lab, thereby bypassing the emergency department. Overt acute myocardial infarction can be accurately identified by a prehospital-acquired 12-lead ECG transmitted to a hospital-based physician. Our study demonstrates that in conjunction with specially trained paramedics, the hospital physician can decide whether to administer thrombolytic therapy to such patients in the prehospital setting.
JAMA, Jul 14, 1989
... to try such ideas without a randomized, controlled study comparing the pro-posed method with ... more ... to try such ideas without a randomized, controlled study comparing the pro-posed method with the standard, feder-ally prescribed method. ... J. Douglas Leith, MD Brockton (Mass) Hospital 1. Grim PS, Singer PA, Gramelspacher GP, Feldman T, Childers RW, Siegler M. Informed ...
Annals of Emergency Medicine, 1989
Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early t... more Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early therapy. The earliest possible time to treat is during the initial evaluation of the patient in the home or ambulance, which requires accurate diagnosis of acute myocardial infarction in the prehospital setting. In our study, paramedics evaluated patients who had chest pain with a 12-lead ECG transmitted by cellular telephone and a checklist for inclusion and exclusion criteria for thrombolytic therapy. This information was transmitted to a hospital-based telemetry physician who diagnosed or excluded acute myocardial infarction and made a mock decision to withhold or administer a thrombolytic agent. Forty-eight patients with chest pain were evaluated. Six were diagnosed as having overt acute myocardial infarction by the hospital-based telemetry physician. All six patients had the diagnosis substantiated by both ECG and enzyme studies on hospital admission. Based on the data supplied by paramedics, two of these six patients were considered eligible for thrombolytic therapy by the physician. Hospital evaluation confirmed the prehospital decision to treat with a thrombolytic agent. In addition, all other patients were appropriately diagnosed as ineligible. Prehospital ECG diagnosis resulted in two patients going directly to the catheterization lab, thereby bypassing the emergency department. Overt acute myocardial infarction can be accurately identified by a prehospital-acquired 12-lead ECG transmitted to a hospital-based physician. Our study demonstrates that in conjunction with specially trained paramedics, the hospital physician can decide whether to administer thrombolytic therapy to such patients in the prehospital setting.
The Medical letter on drugs and therapeutics, 1978
Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greate... more Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm. Despite over a century of use in medical settings, hyperbaric oxygen remains a controversial therapy. The last 20 years have seen a clarification of the mechanism of action of hyperbaric therapy and a greater understanding of its potential benefit. However, despite the substantial evidence that hyperbaric oxygen may have a therapeutic effect in certain carefully defined disease states, many practitioners remain unaware of these findings or are concerned about using hyperbaric therapy because of the controversy it has engendered. This review examines the indications currently considered appropriate for hyperbaric oxygen and briefly evaluates animal and clinical data substantiating these indications. Areas in which the mechanism of action of hyperbaric oxygen is still not well understood, as well as possible new areas of applications, are discussed. (JAMA. 1990;263:2216-2220)
International Journal of Neuroscience, 1981
Annals of Emergency Medicine
Biological psychiatry, 1981
International Journal of Neuroscience, 1982
Eleven right-handed subjects were administered a dichotic listening test to assess cerebral hemis... more Eleven right-handed subjects were administered a dichotic listening test to assess cerebral hemispheric dominance, both under a drug-free condition and following systemic injection of the barbiturate, amobarbital. The finding of increased right ear advantage during the drug period reflects increased left cerebral dominance, and suggests that amobarbital may have an asymmetric, pharmacological effect on the two cerebral hemispheres.
Review of Scientific Instruments, 1999
A simple, manually adjustable hydrostatic cell for electromagnetic, ultrasonic, and photoacoustic... more A simple, manually adjustable hydrostatic cell for electromagnetic, ultrasonic, and photoacoustic studies in absolute pressure ranges from 40 kPa to 5.5 MPa is described. The cell consists of two 3-mm-thick quartz windows enclosing a 1.3-cm-diameter hole bored through a 2.54-cm-long cube block of stainless steel. Four 3-mm-diameter counterbored and taper-threaded holes on the cube walls provide minimally intrusive, chemically inert ports for temperature and acoustical monitoring. Pressure is easily varied within the cell by means of a stainless steel threaded shaft with an O-ring seal at the end, situated inside a matched internally threaded housing. An example of photoacoustic waveforms acquired under conditions of varying hydrostatic pressure is provided.
New England Journal of Medicine, 2004
New England Journal of Medicine, 2004
JAMA: The Journal of the American Medical Association, 1990
ABSTRACT Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressu... more ABSTRACT Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm. Despite over a century of use in medical settings, hyperbaric oxygen remains a controversial therapy. The last 20 years have seen a clarification of the mechanism of action of hyperbaric therapy and a greater understanding of its potential benefit. However, despite the substantial evidence that hyperbaric oxygen may have a therapeutic effect in certain carefully defined disease states, many practitioners remain unaware of these findings or are concerned about using hyperbaric therapy because of the controversy it has engendered. This review examines the indications currently considered appropriate for hyperbaric oxygen and briefly evaluates animal and clinical data substantiating these indications. Areas in which the mechanism of action of hyperbaric oxygen is still not well understood, as well as possible new areas of applications, are discussed.(JAMA. 1990;263:2216-2220)
JAMA: The Journal of the American Medical Association, 1990
... Hans-Olav Adami, MD Lars Klareskog, MD Lars Holmberg, MD Jan Pont\l=e'\n,MD IngemarPerss... more ... Hans-Olav Adami, MD Lars Klareskog, MD Lars Holmberg, MD Jan Pont\l=e'\n,MD IngemarPersson, MD University Hospital Uppsala, Sweden Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy To the Editor. ... 5. Raphael JC, Elkharrat D, Jars-Guincestre MC, et al. ...
Journal of Clinical Psychopharmacology, Feb 1, 1990
Annals of Emergency Medicine, May 1, 1989
Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early t... more Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early therapy. The earliest possible time to treat is during the initial evaluation of the patient in the home or ambulance, which requires accurate diagnosis of acute myocardial infarction in the prehospital setting. In our study, paramedics evaluated patients who had chest pain with a 12-lead ECG transmitted by cellular telephone and a checklist for inclusion and exclusion criteria for thrombolytic therapy. This information was transmitted to a hospital-based telemetry physician who diagnosed or excluded acute myocardial infarction and made a mock decision to withhold or administer a thrombolytic agent. Forty-eight patients with chest pain were evaluated. Six were diagnosed as having overt acute myocardial infarction by the hospital-based telemetry physician. All six patients had the diagnosis substantiated by both ECG and enzyme studies on hospital admission. Based on the data supplied by paramedics, two of these six patients were considered eligible for thrombolytic therapy by the physician. Hospital evaluation confirmed the prehospital decision to treat with a thrombolytic agent. In addition, all other patients were appropriately diagnosed as ineligible. Prehospital ECG diagnosis resulted in two patients going directly to the catheterization lab, thereby bypassing the emergency department. Overt acute myocardial infarction can be accurately identified by a prehospital-acquired 12-lead ECG transmitted to a hospital-based physician. Our study demonstrates that in conjunction with specially trained paramedics, the hospital physician can decide whether to administer thrombolytic therapy to such patients in the prehospital setting.
JAMA, Jul 14, 1989
... to try such ideas without a randomized, controlled study comparing the pro-posed method with ... more ... to try such ideas without a randomized, controlled study comparing the pro-posed method with the standard, feder-ally prescribed method. ... J. Douglas Leith, MD Brockton (Mass) Hospital 1. Grim PS, Singer PA, Gramelspacher GP, Feldman T, Childers RW, Siegler M. Informed ...
Annals of Emergency Medicine, 1989
Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early t... more Maximum benefit from thrombolytic therapy in acute myocardial infarction is obtained with early therapy. The earliest possible time to treat is during the initial evaluation of the patient in the home or ambulance, which requires accurate diagnosis of acute myocardial infarction in the prehospital setting. In our study, paramedics evaluated patients who had chest pain with a 12-lead ECG transmitted by cellular telephone and a checklist for inclusion and exclusion criteria for thrombolytic therapy. This information was transmitted to a hospital-based telemetry physician who diagnosed or excluded acute myocardial infarction and made a mock decision to withhold or administer a thrombolytic agent. Forty-eight patients with chest pain were evaluated. Six were diagnosed as having overt acute myocardial infarction by the hospital-based telemetry physician. All six patients had the diagnosis substantiated by both ECG and enzyme studies on hospital admission. Based on the data supplied by paramedics, two of these six patients were considered eligible for thrombolytic therapy by the physician. Hospital evaluation confirmed the prehospital decision to treat with a thrombolytic agent. In addition, all other patients were appropriately diagnosed as ineligible. Prehospital ECG diagnosis resulted in two patients going directly to the catheterization lab, thereby bypassing the emergency department. Overt acute myocardial infarction can be accurately identified by a prehospital-acquired 12-lead ECG transmitted to a hospital-based physician. Our study demonstrates that in conjunction with specially trained paramedics, the hospital physician can decide whether to administer thrombolytic therapy to such patients in the prehospital setting.
The Medical letter on drugs and therapeutics, 1978
Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greate... more Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm. Despite over a century of use in medical settings, hyperbaric oxygen remains a controversial therapy. The last 20 years have seen a clarification of the mechanism of action of hyperbaric therapy and a greater understanding of its potential benefit. However, despite the substantial evidence that hyperbaric oxygen may have a therapeutic effect in certain carefully defined disease states, many practitioners remain unaware of these findings or are concerned about using hyperbaric therapy because of the controversy it has engendered. This review examines the indications currently considered appropriate for hyperbaric oxygen and briefly evaluates animal and clinical data substantiating these indications. Areas in which the mechanism of action of hyperbaric oxygen is still not well understood, as well as possible new areas of applications, are discussed. (JAMA. 1990;263:2216-2220)
International Journal of Neuroscience, 1981
Annals of Emergency Medicine
Biological psychiatry, 1981
International Journal of Neuroscience, 1982
Eleven right-handed subjects were administered a dichotic listening test to assess cerebral hemis... more Eleven right-handed subjects were administered a dichotic listening test to assess cerebral hemispheric dominance, both under a drug-free condition and following systemic injection of the barbiturate, amobarbital. The finding of increased right ear advantage during the drug period reflects increased left cerebral dominance, and suggests that amobarbital may have an asymmetric, pharmacological effect on the two cerebral hemispheres.
Review of Scientific Instruments, 1999
A simple, manually adjustable hydrostatic cell for electromagnetic, ultrasonic, and photoacoustic... more A simple, manually adjustable hydrostatic cell for electromagnetic, ultrasonic, and photoacoustic studies in absolute pressure ranges from 40 kPa to 5.5 MPa is described. The cell consists of two 3-mm-thick quartz windows enclosing a 1.3-cm-diameter hole bored through a 2.54-cm-long cube block of stainless steel. Four 3-mm-diameter counterbored and taper-threaded holes on the cube walls provide minimally intrusive, chemically inert ports for temperature and acoustical monitoring. Pressure is easily varied within the cell by means of a stainless steel threaded shaft with an O-ring seal at the end, situated inside a matched internally threaded housing. An example of photoacoustic waveforms acquired under conditions of varying hydrostatic pressure is provided.
New England Journal of Medicine, 2004
New England Journal of Medicine, 2004
JAMA: The Journal of the American Medical Association, 1990
ABSTRACT Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressu... more ABSTRACT Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm. Despite over a century of use in medical settings, hyperbaric oxygen remains a controversial therapy. The last 20 years have seen a clarification of the mechanism of action of hyperbaric therapy and a greater understanding of its potential benefit. However, despite the substantial evidence that hyperbaric oxygen may have a therapeutic effect in certain carefully defined disease states, many practitioners remain unaware of these findings or are concerned about using hyperbaric therapy because of the controversy it has engendered. This review examines the indications currently considered appropriate for hyperbaric oxygen and briefly evaluates animal and clinical data substantiating these indications. Areas in which the mechanism of action of hyperbaric oxygen is still not well understood, as well as possible new areas of applications, are discussed.(JAMA. 1990;263:2216-2220)
JAMA: The Journal of the American Medical Association, 1990
... Hans-Olav Adami, MD Lars Klareskog, MD Lars Holmberg, MD Jan Pont\l=e'\n,MD IngemarPerss... more ... Hans-Olav Adami, MD Lars Klareskog, MD Lars Holmberg, MD Jan Pont\l=e'\n,MD IngemarPersson, MD University Hospital Uppsala, Sweden Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy To the Editor. ... 5. Raphael JC, Elkharrat D, Jars-Guincestre MC, et al. ...