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Papers by Paramita Narwidina

Jurnal Pendidikan Kedokteran Indonesia, Dec 29, 2023

Background: Due to the content of lectures for nutrient handling often delivered from one scienti... more Background: Due to the content of lectures for nutrient handling often delivered from one scientific discipline, students do not gain a comprehensive understanding. The flipped classroom learning approach helps improve students' overall comprehension by integrating multiple scientific disciplines such as physiology, anatomy, biochemistry, and histology. The purpose of this study is to assess the efficacy of the flipped classroom learning approach in nutrition management lectures that incorporate physiology, anatomy, biochemistry, and histology. Methods: A basic pre-post test design was employed in this research. The flipped classroom method was used by first asking students to learn the topic via instructional videos, lecture files, and a pre-test (58 questions) on the eLOK UGM platform. The panel discussion was then carried out by lectures from four departments, including physiology, anatomy, biochemistry, and histology, via the Zoom platform (virtual synchronous learning). Finally, students were required to do a post-test with the same content as the pre-test. Results: According to the findings of this study, the average pre-test score of college participants was less than 80, whereas the average post-test score was 84.22, with 73.20% of the participants scoring higher than 80. The integrated panel discussion affected male participants' N-Gain scores. Male participants scored 0.74 (high category) while female participants scored 0.69 (medium category). Conclusions: The flipped classroom method can support approaches from departments of anatomy, physiology, histology, and biochemistry -in a relatively time-efficient but more effective means of improving understanding of nutrient handling.

Hayati Journal of Biosciences, Oct 8, 2023

In various organs, such as the heart, kidneys, and colon, hypoxia enhances the generation of reac... more In various organs, such as the heart, kidneys, and colon, hypoxia enhances the generation of reactive oxygen species (ROS). However, the effects of reoxygenation, as occurs in intermittent hypoxia (IH) to achieve full recovery of hypoxic organs, are not yet clear. The acclimatization response can boost blood oxygen transport capacity, while hypoxia ROS can impact erythrocytes and plasma behavior, resulting in poor peripheral blood flow. This study aimed to study the antioxidant impact of puree Ficus carica (PFC) in rats with IH-induced oxidative stress. Twenty-nine Sprague-Dawley rats were randomly divided into five groups: group N (control, untreated and not exposed to IH, and Group HC was exposed to hypoxia and received distilled water. Group HPF-6.25, HPF-12.5, and HPF-25 (n = 6) received PFC with doses 6.25; 12.5; and 25 ml/kg/d, respectively for 4 weeks before IH exposure. At the end of 4 weeks, all animals except controls were exposed to IH (10% O 2 and 90% N2; 4 hours/day for one week). Hematological parameters were measured with several oxidative stress indicators. Hypoxic rats exhibited substantially higher hemoglobin, hematocrit, and mean corpuscular hemoglobin concentrations. All groups exposed to IH showed increased malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity in the heart, kidneys, and colon. The increasing MDA and decreasing SOD compared to controls and pre-treatment using PFC had a dosedependent protective effect on the heart, kidneys, and colon.

Media Publikasi Promosi Kesehatan Indonesia (MPPKI)

Latar belakang: Kelahiran bayi dengan Berat Badan Lahir Rendah (BBLR) menjadi penyebab utama kema... more Latar belakang: Kelahiran bayi dengan Berat Badan Lahir Rendah (BBLR) menjadi penyebab utama kematian prenatal dan terjadinya masalah pada masa tumbuh kembang. Banyak faktor yang menyebabkan kejadian BBLR meningkat, diantaranya usia Ibu saat melahirkan, kadar Hemoglobin (Hb), trombosit dan leukosit yang tidak berada dalam rentang normal. Tujuan: Untuk mengetahui hubungan antara usia saat melahirkan, kadar Hb, trombosit, dan leukosit Ibu hamil dengan kejadian BBLR di RS Islam Sultan Agung Semarang, periode Januari 2017-2018. Metode: Penelitian observasional dengan desain cross sectional menggunakan data rekam medis pasien. Data diambil dari 63 Ibu hamil yang dirawat selama periode Januari 2017-2018 di RS Islam Sultan Agung. Data penelitian dianalisis mengunakan uji Chi Square. Hasil: Ibu dengan usia beresiko berpotensi 0,912 kali melahirkan bayi dengan BBLR dibandingkan dengan Ibu berusia tidak beresiko, walaupun secara statistik tidak bermakna. Ibu dengan kadar leukosit ≤13.000/µL m...

Jurnal Keperawatan Respati Yogyakarta

A placenta previa develops in the lower part of the uterus, covering the internal uterine ostium ... more A placenta previa develops in the lower part of the uterus, covering the internal uterine ostium entirely or partially. The risk of maternal and infant mortality and morbidity rises as the placenta's inadequate vascularization expands to cover the entire birth canal. Hemoglobin (Hb) level is a biochemical indicator to determine the nutritional status of pregnant women, and reduced blood supply to the placenta can be caused by a lack of Hb levels in pregnant women. The purpose of this study was to determine the association between Hb level in gravida patients and the incidence of placenta previa at Sultan Agung Islamic Hospital, Semarang. This research was an observational analytic study with a cross-sectional design, which was conducted on 97 respondents who met the inclusion and exclusion criteria. The data was taken from the patient's medical record document from January 2017 - January 2018 at Sultan Agung Islamic Hospital. Analysis of the research data using the Chi-Squa...

Sains Medika : Jurnal Kedokteran dan Kesehatan

Hemoglobin (Hb) level is a biochemical indicator of the nutritional status of pregnant women, and... more Hemoglobin (Hb) level is a biochemical indicator of the nutritional status of pregnant women, and a low Hb level reduces blood supply to the placenta, which influences the incidence of placenta previa. A placenta previa develops in the lower portion of the uterus, completely or partially expanding to cover the entire birth canal and the internal uterine ostium. The APGAR score is commonly used as a predictor of infant mortality and long-term disability and as an indicator of infant health at birth. The risk of maternal and infant mortality and morbidity increases in placenta previa patients with inadequate vascularization, which can be caused by low Hb levels. This study aimed to determine the relationship between Hb levels and APGAR scores in patients with placenta previa at Sultan Agung Islamic Hospital in Semarang. This analytic observation study is a cross-sectional analysis with purposive sampling method. From January 2017 to January 2018, all placenta previa patients hospitali...

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Banana peel (Musa balbisiana Colla) already has a diverse variety of nutritional bene... more BACKGROUND: Banana peel (Musa balbisiana Colla) already has a diverse variety of nutritional benefits, but its perishable nature necessitates additional food processing, one of which is banana peel floss. AIM: The objective of this study was to examine the antidepressant effects of banana peel floss in experimental animals subjected to chronic mild stress (CMS) for 6 weeks. METHODS: Animals were randomly assigned into five groups. The first group was fed a control diet without CMS as a negative control. The other four groups were exposed to CMS and fed a control diet as a positive control, with three of the five groups fed a control diet supplemented with 15%, 30%, and 60% banana peel floss. The tail suspension test (TST) and the Morris water maze were used as behavioral parameters in this study (MWM). Cortisol and serotonin levels were measured in two stages: after CMS exposure or before banana peel floss intervention, and after 4 weeks of banana peel floss intervention. RESULTS: T...

Hayati Journal of Biosciences, Feb 24, 2022

Uncontrolled diabetes mellitus (DM) has been linked to depression and lipid metabolism impairment... more Uncontrolled diabetes mellitus (DM) has been linked to depression and lipid metabolism impairment. Serotonin (5-HT) has been known to improve lipid metabolism and affect mood. The 5-Hydroxytryptophan (5-HTP) in banana peel flour (BPF) is a precursor to synthesize 5-HT in the body, which is linked to initiating liver regeneration via HTR2B receptors. The impact of 5-HTP in the diet on HTR2B receptor expression has yet to be thoroughly investigated. We aimed to elucidate the correlation between serum lipid profile and immobility time in Tail Suspension Test (TST) as depressive-like behavior and compare the expression of HTR2B receptor in healthy and diabetic rats. Male Wistar (Rattus norvegicus) rats were assigned to the control and treatment groups in a DM model with streptozotocin (60 mg/kg) injected intraperitoneally, then either fed standard diet or BPF 10% supplemented standard diet for 21 days. Immunohistochemical staining was used to examine the expression of 5-HT, HTR2B receptors. We determined that diabetic rats fed the standard diet supplemented 10% BPF group showed significantly lower concentrations of total cholesterol and triglycerides compared to diabetic rats fed a standard diet and it was positively correlated between total cholesterol and LDL with the duration of immobility time in TST. The average immunoreactivity score in diabetic rats fed 10% BPF was the highest among the other groups, indicating that the available BPF dose is sufficient for HTR2B activation, which will support the liver cell regeneration process, and should be investigated further.

International Journal of Pharmacy and Pharmaceutical Sciences, 2020

Objective: This study aimed to evaluate the antidiabetic and antidepressant effects of banana pee... more Objective: This study aimed to evaluate the antidiabetic and antidepressant effects of banana peel flakes in streptozotocin-induced diabetic rats. Methods: Twenty-five male Wistar rats were classified into five groups with different treatments. Groups I to IV were diabetic rats model groups that consumed only standard diet, standard diet containing 5%, 10%, and 20% of banana peel flakes, respectively. While group V was a healthy control group fed a standard diet. Immunohistochemistry staining was measured to examine serotonin expression in the colon and pancreas. Results: The diabetic rats treated with 20% banana peel flakes had a lower blood glucose concentration (p<0.05) compared with diabetic control and showed a shorter duration of immobility time (p<0.05) than the healthy control. Additionally, compared with diabetic control, the diabetic rats treated with 5% banana peel flakes showed higher serotonin expression (p<0.05) in the colon. In contrast, serotonin expression ...

Journal of Applied Pharmaceutical Science, 2021

The body's immunity can be increased by physical exercise. High-intensity physical exercise (HIPE... more The body's immunity can be increased by physical exercise. High-intensity physical exercise (HIPE) can disturb the body's digestive system and cause an imbalance of the microbiome population between pathogenic and nonpathogenic bacteria. This posttest-only control group study was conducted on 18 male Wistar rats which were divided into three groups (n = 6): (1) control (nonexercised); (2) moderate-intensity physical exercise (MIPE) (30 minutes at 55%VO 2 max/day, 5 days per week); and (3) high-intensity physical exercise (HIPE) (30 minutes at 85% VO 2 max/day, 5 days per week). After 5 weeks, subjects' cecum was isolated from the gut and colony-forming units were counted for the total lactic acid bacteria, Lactobacillus spp., and Escherichia coli. Microbiological analysis of the cecal contents indicated that, in comparisons between the control, the MIPE, and the HIPE groups, there were no statistically significant differences between the bacterial groups except for E. coli between the MIPE and HIPE groups (p < 0.05). Additionally, the MIPE group showed a significantly higher acetate and propionic acid concentration compared to the HIPE and control groups (p < 0.05). Moderate but not high-intensity exercise may contribute to better well-being of the microbiota environment as shown by the significantly higher acetic and propionic acid production.

Pengembangan minuman isotonik antosianin beras hitam (Oryza sativa L. indica) dan efeknya terhadap kebugaran dan aktivitas antioksidan pada manusia pasca stres fisik :: A case control study

Covering the Cover

Gastroenterology, 2013

Under long-term hyperglycemic conditions, metabolic abnormalities in the body can cause oxidative... more Under long-term hyperglycemic conditions, metabolic abnormalities in the body can cause oxidative stress, with NAFLD being one of the complications. Banana peels are high in tryptophan, which is a precursor to serotonin in the body. Serotonin regulates body homeostasis, including blood glucose levels, and has also been linked to increased liver regeneration in rats. Based on the above, this study aimed to investigate the hepatoprotective effects of banana peel flour (BPF) on liver enzymes changes in rats. Twentyfive male Wistar rats were separated into five groups (n=5), including Group I was a healthy control group fed a standard diet, while Groups II to V were diabetic rats model groups that consumed a standard diet supplemented with BPF 0%, 5%, 10%, and 20%, respectively for four weeks. At the end of the experiment, the rats were bled and enzyme changes in ALT, AST, and Hematoxylin-Eosin (HE) staining were analyzed with the NAFLD score to examine hepatocellular morphology. The effect of BPF intervention on serum ALT and AST levels are not dosed dependent but the effects are comparable. BPF groups intervention produced a significant (P<0.05) decrease in serum levels of ALT and AST compared to the diabetic control group. The NAFLD score with HE staining showed substantial improvements in liver morphology, which was better seen at a 20% BPF dose. The current study supported the hypothesis that BPF had a hepatoprotective effect in diabetic rats and its effect may be due to the mechanism of controlling the hepatic enzyme transaminase and inducing liver regeneration.