Parimal Katolkar - Academia.edu (original) (raw)

Papers by Parimal Katolkar

International Journal of Drug Development and Research, 2012

Drug Delivery System relates to the production of a drug, its delivery medium, and the way of adm... more Drug Delivery System relates to the production of a drug, its delivery medium, and the way of administration. Drug delivery systems are even used for administering nitroglycerin. In addition, it is also used in nicotine patches thereby helping people to cease and withdraw tobacco consumption. Transdermal drug delivery(TDDS) is the noninvasive delivery of medications from the surface of

Int. J. Drug Dev. & …, 2012

Drug Delivery System relates to the production of a drug, its delivery medium, and the way of adm... more Drug Delivery System relates to the production of a drug, its delivery medium, and the way of administration. Drug delivery systems are even used for administering nitroglycerin. In addition, it is also used in nicotine patches thereby helping people to cease and withdraw tobacco consumption. Transdermal drug delivery(TDDS) is the noninvasive delivery of medications from the surface of

Research journal of pharmacy and technology, Jul 23, 2023

Research Journal of Pharmacy and Technology

Objective: Prostate cancer is a disease in which the malignant cells form in the tissues of the p... more Objective: Prostate cancer is a disease in which the malignant cells form in the tissues of the prostate. Once more, medicinal plants are being researched for the treatment of lung cancer. Prototypical compounds found in medicinal plants have been the source of many conventional medications. In-silico testing of Phyllanthus niruri phytoconstituents for anticancer efficacy was a part of our investigation. Design: Utilizing Discovery studio, molecular docking is done to assess the pattern of interaction between the phytoconstituents from the Phyllanthus niruri plant and the crystal structure of the anticancer proteins (PDB ID: 5OTE). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that luteolin (-8.2kcal/mol), and caffeic acid (-6.5kcal/mol), for 5OTE macromolecule has best binding affinity towards MRCK for anticancer activity on prostate as compared to the standard drug lenvatinib mesylate (-3.4kc...

Asian Journal of Pharmacy and Technology, 2014

The aim of present study was to screen of fungus capable of degrading and decolorizing Direct Ora... more The aim of present study was to screen of fungus capable of degrading and decolorizing Direct Orange 102 dye. The said fungus was isolated from soil of dumping area near Nagpur (MH) India. Decolourization of fungus carried out by isolation of fungus by serial dilution of soil followed by pour plate technique was followed the colonies showing zone of decolourization are picked for further study. The isolated fungus was identified by macroscopic and microscopic study. Isolated fungus was named as green fungi and white fungi. This fungus showed decolourization at room temperature under static condition. Enzyme assay was performed at different weather conditions. The decolourization was due to bioabsorption or biodegradation, fungus were grown in liquid culture growth medium using bagasse particles as a natural lignin source using n-propanol as a substrate at wavelength 300 nm, spectrophotometrically. The enzymatic characteristics (pH and temperature) of ligninperoxidase were studied using n-propanol as substrate. The isolated fungus was co-immobilized in Ca-alginate beads and their decolourization efficiency was determined. The isolated bacteria and fungus were immobilized and showed decolourizing activity.

Der Pharmacia Lettre, 2010

The present study aimed to explore antioxidant potential of bark of Erythrina indica (Leguminosea... more The present study aimed to explore antioxidant potential of bark of Erythrina indica (Leguminoseae). The antioxidant activity of the methanolic extracts of the Erythrina indica was evaluated in-vitro by various Experimental Parameters such as DPPH free radical scarvenging activity, reducing power and nitric oxide scarvenging activity, total phenolic content were also determined. Result showed that Erythrina indica displayed potent antioxidant.

International Journal of Ayurvedic Medicine, Jul 3, 2023

Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequat... more Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequate or dysfunctional insulin. Once more, medicinal plants are being researched for the treatment of diabetes. Prototypical compounds found in medicinal plants have been the source of many conventional medications. The part of our investigation was to test the phytoconstituents of Manilkara hexandra for antidiabetic efficacy, in-silico. Methods: The pattern of interaction between the phytoconstituents from the Manilkara hexandra (Roxb.) Dubard, plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 4LY9). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that quercetin (-9.3 kcal/mol), kaempferol (-9.1 kcal/mol), p-coumaric acid (-6.4 kcal/mol) and cinnamic acid (-6.3 kcal/mol) for 4LY9 macromolecule has best binding towards antidiabetic activity as compared to the standard drug metformin (-5.0 kcal/mol). According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds. Conclusion: Results from the binding potential of phytoconstituents aimed at antidiabetic activity were encouraging. It promotes the usage of Manilkara hexandra and offers crucial details on pharmaceutical research and clinical care. 491

Asian Journal of Pharmacy and Technology, May 25, 2022

Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herba... more Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Hair loss problem is of great significance to both men and women. Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetics, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs. Herbs are starting material for any medicine research. Approximately about 80% residents recommended herbal drugs for their beneficial effects along with fewer side effects as compared synthetic drugs.

Research Journal of Pharmacy and Technology, 2015

The aim of the present study was to evaluate the decolourizing and degradation activity of isolat... more The aim of the present study was to evaluate the decolourizing and degradation activity of isolated Pseudomonas sp. on Direct Orange 102 dye. The said bacterial spp. was isolated from soil of dumping area of Nagpur (MH) India. Bacterial decolourization and screening of decolorizing bacteria were done by using dye. Colorless colonies was obtained and then it's characterization including morphological characteristics, biochemical characterization was carried out and from biochemical analysis bacteria found to be Pseudomonas sp. In further study, effect of physiochemical parameter such as temperature, pH, concentration, carbon source, nitrogen source and potassium source on decolourization of Direct Orange 102 dye at wavelength 480 nm was carried out. The analysis on dye degraded metabolite was done with TLC show difference in the Rf value confirms the degradation of dye. The isolated bacteria were co-immobilized in Ca-alginate beads and its decolourization efficiency was determined and found to be increase with increase in time.

Research Journal of Pharmacy and Technology, Apr 28, 2012

The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proli... more The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proliferative activity of different extract of bark of Belanites aegyptiaca. The Anti-mitotic activity was screened using Allium cepa root meristamatic cells which have been used extensively in screening of drug with antimitotic activity using methotrexate as a standard. The anti-proliferative activity was screened using Yeast as a model system. The methanolic extract showed lowest mitotic index. Methanolic extract have maximum growth inhibition of yeast cells, growth inhibition increases as concentration of extract increases.

Research Square (Research Square), Dec 29, 2022

Insulin de ciency or malfunction leads to diabetes mellitus, a serious metabolic disorder. Once m... more Insulin de ciency or malfunction leads to diabetes mellitus, a serious metabolic disorder. Once more, studies on the use of medicinal plants to treat diabetes are ongoing. Many common drugs have been made from prototypical substances derived from medicinal plants. Our work included in-silico testing of Manilkara hexandra phytoconstituents for antidiabetic activity. Design: The pattern of interaction between the phytoconstituents from the Manilkara hexandra plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 3REE). Later, the toxicity and pharmacokinetic pro le were screened using SwissADME and pkCSM. Results The docking data reveal that compared to the common medication metformin (-4.1 kcal/mol); quercetin (-7.1 kcal/mol), kaempferol (-7.1 kcal/mol), P-coumaric acid (-6.2 kcal/mol), and cinnamic acid (-6.0 kcal/mol) have the greatest binding a nity for mitoNEET for antidiabetic action. According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds. Conclusion The binding potential of phytoconstituents with an eye on antidiabetic activities produced positive results. It provides vital information on clinical treatment and pharmacological research while advocating the use of Manilkara hexandra.

Asian Journal of Pharmaceutical and Clinical Research

High-performance liquid chromatography (HPLC) technique for cyamemazine tartrate (CYMT) was devel... more High-performance liquid chromatography (HPLC) technique for cyamemazine tartrate (CYMT) was developed and validated according to the International Conference on Harmonization (ICH) Q2 (R1) guidelines. The developed and validated method for estimating CYMT from a bulk and its pharmaceutical dosage form was found to be a simple, precise, accurate, fast, and stable reverse phase HPLC (RP-HPLC) approach. For chromatographic separation, a Hypersil BDS C18 (250 mm × 4.6 mm, particle size: 5 μm) column was employed with a mobile phase of methanol and buffer (80:20 v/v) flow rate at 1.0 ml/min at room temperature. For detection, a wavelength of 270 nm was utilized. With a run period of 10 min, the CYMT was eluted at 4.38 min. With a correlation coefficient (r2) of above 0.9996, and limits of detection and quantitation (LOD and LOQ) of 0.27 and 0.80 μg, respectively, the method exhibited a dynamic linear response across 30–90 μg/ml. The repeatability of batch injections for intra- and inter-...

Asian Journal of Pharmaceutical and Clinical Research

Many drug molecules comprises of benzo fused heterocycles with two nitrogen atoms, that is, benzi... more Many drug molecules comprises of benzo fused heterocycles with two nitrogen atoms, that is, benzimidazole and its derivatives. Many biological active molecules contain that 2-aminobenzimidazole cores are among the foremost common structural components in medicinal chemistry. 2-aminobenzimidazole and its derivative have wide range of biological and pharmaceutical activities. In this review, the authors summarize synthesis, various chemical reactions, and biological activities of 2-aminobenzimidazole and its derivative.

Asian Journal of Pharmacy and Technology

Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herba... more Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Hair loss problem is of great significance to both men and women. Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetics, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs. Herbs are starting material for any medicine research. Approximately about 80% residents recommended herbal drugs for their beneficial effects ...

Research Journal of Pharmacy and Technology, 2012

The dried bark of Manilkara hexandra is used traditionally, as an antidiabetic agent in India. To... more The dried bark of Manilkara hexandra is used traditionally, as an antidiabetic agent in India. To determine if there is a scientific basis for this use, the effects of the methanolic extracts on blood glucose levels were assessed in normoglycemic and alloxan induced diabetic rats. Blood glucose levels were evaluated at the intervals of 0, 1, 2, 3 and 6 h. Treatment of alloxan induced diabetic rats with Manilkara hexandra reduced glucose levels significantly and the extract is devoid of a significant hypoglycemic effect in normal rats. The finding of the present study in Manilkara hexandra lends credence to its folklore use in the management and/or control of type II diabetes.

Research Journal of Pharmaceutical Dosage Forms and Technology, 2010

Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing differ... more Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing different superdisintegrants and disintegrants such as microcrystalline cellulose and sodium starch glycolate, crosscarmellose sodium, crosspovidon, in different concentrations by direct compression method, formulation were evaluated for the standard of dispersible tablets and were compare with marketed product. The formulated tablets fulfilled all official (I.P.) requirement of dispersible tablet and give fast dissolution of amoxicillin plus cloxacillin sodium when compared to conventional marketed tablet of same drug. Study reveals that Dispersible tablet formulated by osscarmellose sodium employing gave fastest dissolution of amoxicillin plus cloxacillin sodium.

Research Journal of Pharmacy and Technology, 2010

The work presented here deals with formulation, evaluation and validation of liquid oral preparat... more The work presented here deals with formulation, evaluation and validation of liquid oral preparation of Gymnema sylvestre and Stevia rebaudiana and their combination to study its antidiabetic activity. The antihyperglycemic activity of aqueous extract of Gymnema sylvestre and their combination were evaluated; diabetes was induced in albino rats of either sex by a single intraperitoneal injection of aqueous alloxan monohydrate (120 mg/kg). Single dose study with aqueous extract of Gymnema sylvestre (100 mg/kg) -Combination treated, equal proportion, 100 ml/kg and showed significant (p < 0.001) decrease in serum glucose level at 2, 4 and 6 hr. Continuous treatment with aqueous extract of Gymnema sylvestre (100 mg/kg), Combination treated, equal proportion, 100 ml/kg for a period of 28 days showed a significant decrease (p < 0.001) in serum glucose level in diabetic rats. Maximum reduction of serum glucose level occurred -Combination treated, equal proportion, 100 ml/kg. It may b...

International Journal of Research and Development in Pharmacy and Life Sciences, 2013

The simple, precise and economic UV methods have been developed for estimation of Cefixime in sin... more The simple, precise and economic UV methods have been developed for estimation of Cefixime in single component. Cefixime has the absorbance maxima in zero order spectra in 230 nm (method A). Method B applied was first order derivative for the analysis of Cefixime at 238.5 nm .Method C applied was area under curve in the wavelength range of 234-228 nm. Drug followed Beer-Lamberts law in the concentration range of 503.5 μg/ml for zero order, 10-60 μg for area under curve methods and first order derivative spectrum. The percentage recovery of Cefixim ranged from 98.05 to 101.075 in pharmaceutical dosage from result of analysis was validated statistically and by recovered study.

Journal of Soils and Crops, 2006

The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proli... more The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proliferative activity of different extract of bark of Belanites aegyptiaca. The Anti-mitotic activity was screened using Allium cepa root meristamatic cells which have been used extensively in screening of drug with antimitotic activity using methotrexate as a standard. The anti-proliferative activity was screened using Yeast as a model system. The methanolic extract showed lowest mitotic index. Methanolic extract have maximum growth inhibition of yeast cells, growth inhibition increases as concentration of extract increases.

International Journal of Drug Development and Research, 2012

Drug Delivery System relates to the production of a drug, its delivery medium, and the way of adm... more Drug Delivery System relates to the production of a drug, its delivery medium, and the way of administration. Drug delivery systems are even used for administering nitroglycerin. In addition, it is also used in nicotine patches thereby helping people to cease and withdraw tobacco consumption. Transdermal drug delivery(TDDS) is the noninvasive delivery of medications from the surface of

Int. J. Drug Dev. & …, 2012

Drug Delivery System relates to the production of a drug, its delivery medium, and the way of adm... more Drug Delivery System relates to the production of a drug, its delivery medium, and the way of administration. Drug delivery systems are even used for administering nitroglycerin. In addition, it is also used in nicotine patches thereby helping people to cease and withdraw tobacco consumption. Transdermal drug delivery(TDDS) is the noninvasive delivery of medications from the surface of

Research journal of pharmacy and technology, Jul 23, 2023

Research Journal of Pharmacy and Technology

Objective: Prostate cancer is a disease in which the malignant cells form in the tissues of the p... more Objective: Prostate cancer is a disease in which the malignant cells form in the tissues of the prostate. Once more, medicinal plants are being researched for the treatment of lung cancer. Prototypical compounds found in medicinal plants have been the source of many conventional medications. In-silico testing of Phyllanthus niruri phytoconstituents for anticancer efficacy was a part of our investigation. Design: Utilizing Discovery studio, molecular docking is done to assess the pattern of interaction between the phytoconstituents from the Phyllanthus niruri plant and the crystal structure of the anticancer proteins (PDB ID: 5OTE). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that luteolin (-8.2kcal/mol), and caffeic acid (-6.5kcal/mol), for 5OTE macromolecule has best binding affinity towards MRCK for anticancer activity on prostate as compared to the standard drug lenvatinib mesylate (-3.4kc...

Asian Journal of Pharmacy and Technology, 2014

The aim of present study was to screen of fungus capable of degrading and decolorizing Direct Ora... more The aim of present study was to screen of fungus capable of degrading and decolorizing Direct Orange 102 dye. The said fungus was isolated from soil of dumping area near Nagpur (MH) India. Decolourization of fungus carried out by isolation of fungus by serial dilution of soil followed by pour plate technique was followed the colonies showing zone of decolourization are picked for further study. The isolated fungus was identified by macroscopic and microscopic study. Isolated fungus was named as green fungi and white fungi. This fungus showed decolourization at room temperature under static condition. Enzyme assay was performed at different weather conditions. The decolourization was due to bioabsorption or biodegradation, fungus were grown in liquid culture growth medium using bagasse particles as a natural lignin source using n-propanol as a substrate at wavelength 300 nm, spectrophotometrically. The enzymatic characteristics (pH and temperature) of ligninperoxidase were studied using n-propanol as substrate. The isolated fungus was co-immobilized in Ca-alginate beads and their decolourization efficiency was determined. The isolated bacteria and fungus were immobilized and showed decolourizing activity.

Der Pharmacia Lettre, 2010

The present study aimed to explore antioxidant potential of bark of Erythrina indica (Leguminosea... more The present study aimed to explore antioxidant potential of bark of Erythrina indica (Leguminoseae). The antioxidant activity of the methanolic extracts of the Erythrina indica was evaluated in-vitro by various Experimental Parameters such as DPPH free radical scarvenging activity, reducing power and nitric oxide scarvenging activity, total phenolic content were also determined. Result showed that Erythrina indica displayed potent antioxidant.

International Journal of Ayurvedic Medicine, Jul 3, 2023

Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequat... more Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequate or dysfunctional insulin. Once more, medicinal plants are being researched for the treatment of diabetes. Prototypical compounds found in medicinal plants have been the source of many conventional medications. The part of our investigation was to test the phytoconstituents of Manilkara hexandra for antidiabetic efficacy, in-silico. Methods: The pattern of interaction between the phytoconstituents from the Manilkara hexandra (Roxb.) Dubard, plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 4LY9). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that quercetin (-9.3 kcal/mol), kaempferol (-9.1 kcal/mol), p-coumaric acid (-6.4 kcal/mol) and cinnamic acid (-6.3 kcal/mol) for 4LY9 macromolecule has best binding towards antidiabetic activity as compared to the standard drug metformin (-5.0 kcal/mol). According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds. Conclusion: Results from the binding potential of phytoconstituents aimed at antidiabetic activity were encouraging. It promotes the usage of Manilkara hexandra and offers crucial details on pharmaceutical research and clinical care. 491

Asian Journal of Pharmacy and Technology, May 25, 2022

Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herba... more Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Hair loss problem is of great significance to both men and women. Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetics, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs. Herbs are starting material for any medicine research. Approximately about 80% residents recommended herbal drugs for their beneficial effects along with fewer side effects as compared synthetic drugs.

Research Journal of Pharmacy and Technology, 2015

The aim of the present study was to evaluate the decolourizing and degradation activity of isolat... more The aim of the present study was to evaluate the decolourizing and degradation activity of isolated Pseudomonas sp. on Direct Orange 102 dye. The said bacterial spp. was isolated from soil of dumping area of Nagpur (MH) India. Bacterial decolourization and screening of decolorizing bacteria were done by using dye. Colorless colonies was obtained and then it's characterization including morphological characteristics, biochemical characterization was carried out and from biochemical analysis bacteria found to be Pseudomonas sp. In further study, effect of physiochemical parameter such as temperature, pH, concentration, carbon source, nitrogen source and potassium source on decolourization of Direct Orange 102 dye at wavelength 480 nm was carried out. The analysis on dye degraded metabolite was done with TLC show difference in the Rf value confirms the degradation of dye. The isolated bacteria were co-immobilized in Ca-alginate beads and its decolourization efficiency was determined and found to be increase with increase in time.

Research Journal of Pharmacy and Technology, Apr 28, 2012

The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proli... more The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proliferative activity of different extract of bark of Belanites aegyptiaca. The Anti-mitotic activity was screened using Allium cepa root meristamatic cells which have been used extensively in screening of drug with antimitotic activity using methotrexate as a standard. The anti-proliferative activity was screened using Yeast as a model system. The methanolic extract showed lowest mitotic index. Methanolic extract have maximum growth inhibition of yeast cells, growth inhibition increases as concentration of extract increases.

Research Square (Research Square), Dec 29, 2022

Insulin de ciency or malfunction leads to diabetes mellitus, a serious metabolic disorder. Once m... more Insulin de ciency or malfunction leads to diabetes mellitus, a serious metabolic disorder. Once more, studies on the use of medicinal plants to treat diabetes are ongoing. Many common drugs have been made from prototypical substances derived from medicinal plants. Our work included in-silico testing of Manilkara hexandra phytoconstituents for antidiabetic activity. Design: The pattern of interaction between the phytoconstituents from the Manilkara hexandra plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 3REE). Later, the toxicity and pharmacokinetic pro le were screened using SwissADME and pkCSM. Results The docking data reveal that compared to the common medication metformin (-4.1 kcal/mol); quercetin (-7.1 kcal/mol), kaempferol (-7.1 kcal/mol), P-coumaric acid (-6.2 kcal/mol), and cinnamic acid (-6.0 kcal/mol) have the greatest binding a nity for mitoNEET for antidiabetic action. According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds. Conclusion The binding potential of phytoconstituents with an eye on antidiabetic activities produced positive results. It provides vital information on clinical treatment and pharmacological research while advocating the use of Manilkara hexandra.

Asian Journal of Pharmaceutical and Clinical Research

High-performance liquid chromatography (HPLC) technique for cyamemazine tartrate (CYMT) was devel... more High-performance liquid chromatography (HPLC) technique for cyamemazine tartrate (CYMT) was developed and validated according to the International Conference on Harmonization (ICH) Q2 (R1) guidelines. The developed and validated method for estimating CYMT from a bulk and its pharmaceutical dosage form was found to be a simple, precise, accurate, fast, and stable reverse phase HPLC (RP-HPLC) approach. For chromatographic separation, a Hypersil BDS C18 (250 mm × 4.6 mm, particle size: 5 μm) column was employed with a mobile phase of methanol and buffer (80:20 v/v) flow rate at 1.0 ml/min at room temperature. For detection, a wavelength of 270 nm was utilized. With a run period of 10 min, the CYMT was eluted at 4.38 min. With a correlation coefficient (r2) of above 0.9996, and limits of detection and quantitation (LOD and LOQ) of 0.27 and 0.80 μg, respectively, the method exhibited a dynamic linear response across 30–90 μg/ml. The repeatability of batch injections for intra- and inter-...

Asian Journal of Pharmaceutical and Clinical Research

Many drug molecules comprises of benzo fused heterocycles with two nitrogen atoms, that is, benzi... more Many drug molecules comprises of benzo fused heterocycles with two nitrogen atoms, that is, benzimidazole and its derivatives. Many biological active molecules contain that 2-aminobenzimidazole cores are among the foremost common structural components in medicinal chemistry. 2-aminobenzimidazole and its derivative have wide range of biological and pharmaceutical activities. In this review, the authors summarize synthesis, various chemical reactions, and biological activities of 2-aminobenzimidazole and its derivative.

Asian Journal of Pharmacy and Technology

Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herba... more Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Hair loss problem is of great significance to both men and women. Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetics, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs. Herbs are starting material for any medicine research. Approximately about 80% residents recommended herbal drugs for their beneficial effects ...

Research Journal of Pharmacy and Technology, 2012

The dried bark of Manilkara hexandra is used traditionally, as an antidiabetic agent in India. To... more The dried bark of Manilkara hexandra is used traditionally, as an antidiabetic agent in India. To determine if there is a scientific basis for this use, the effects of the methanolic extracts on blood glucose levels were assessed in normoglycemic and alloxan induced diabetic rats. Blood glucose levels were evaluated at the intervals of 0, 1, 2, 3 and 6 h. Treatment of alloxan induced diabetic rats with Manilkara hexandra reduced glucose levels significantly and the extract is devoid of a significant hypoglycemic effect in normal rats. The finding of the present study in Manilkara hexandra lends credence to its folklore use in the management and/or control of type II diabetes.

Research Journal of Pharmaceutical Dosage Forms and Technology, 2010

Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing differ... more Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing different superdisintegrants and disintegrants such as microcrystalline cellulose and sodium starch glycolate, crosscarmellose sodium, crosspovidon, in different concentrations by direct compression method, formulation were evaluated for the standard of dispersible tablets and were compare with marketed product. The formulated tablets fulfilled all official (I.P.) requirement of dispersible tablet and give fast dissolution of amoxicillin plus cloxacillin sodium when compared to conventional marketed tablet of same drug. Study reveals that Dispersible tablet formulated by osscarmellose sodium employing gave fastest dissolution of amoxicillin plus cloxacillin sodium.

Research Journal of Pharmacy and Technology, 2010

The work presented here deals with formulation, evaluation and validation of liquid oral preparat... more The work presented here deals with formulation, evaluation and validation of liquid oral preparation of Gymnema sylvestre and Stevia rebaudiana and their combination to study its antidiabetic activity. The antihyperglycemic activity of aqueous extract of Gymnema sylvestre and their combination were evaluated; diabetes was induced in albino rats of either sex by a single intraperitoneal injection of aqueous alloxan monohydrate (120 mg/kg). Single dose study with aqueous extract of Gymnema sylvestre (100 mg/kg) -Combination treated, equal proportion, 100 ml/kg and showed significant (p < 0.001) decrease in serum glucose level at 2, 4 and 6 hr. Continuous treatment with aqueous extract of Gymnema sylvestre (100 mg/kg), Combination treated, equal proportion, 100 ml/kg for a period of 28 days showed a significant decrease (p < 0.001) in serum glucose level in diabetic rats. Maximum reduction of serum glucose level occurred -Combination treated, equal proportion, 100 ml/kg. It may b...

International Journal of Research and Development in Pharmacy and Life Sciences, 2013

The simple, precise and economic UV methods have been developed for estimation of Cefixime in sin... more The simple, precise and economic UV methods have been developed for estimation of Cefixime in single component. Cefixime has the absorbance maxima in zero order spectra in 230 nm (method A). Method B applied was first order derivative for the analysis of Cefixime at 238.5 nm .Method C applied was area under curve in the wavelength range of 234-228 nm. Drug followed Beer-Lamberts law in the concentration range of 503.5 μg/ml for zero order, 10-60 μg for area under curve methods and first order derivative spectrum. The percentage recovery of Cefixim ranged from 98.05 to 101.075 in pharmaceutical dosage from result of analysis was validated statistically and by recovered study.

Journal of Soils and Crops, 2006

The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proli... more The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proliferative activity of different extract of bark of Belanites aegyptiaca. The Anti-mitotic activity was screened using Allium cepa root meristamatic cells which have been used extensively in screening of drug with antimitotic activity using methotrexate as a standard. The anti-proliferative activity was screened using Yeast as a model system. The methanolic extract showed lowest mitotic index. Methanolic extract have maximum growth inhibition of yeast cells, growth inhibition increases as concentration of extract increases.