Parth Shah - Academia.edu (original) (raw)

Papers by Parth Shah

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Oct 1, 2016

Physician communication about human papillomavirus (HPV) vaccine is a key determinant of uptake. ... more Physician communication about human papillomavirus (HPV) vaccine is a key determinant of uptake. To support physician communication, we sought to identify messages that would motivate HPV vaccination. From 2014 to 2015, we surveyed national samples of parents of adolescents ages 11 to 17 (n = 1,504) and primary care physicians (n = 776). Parents read motivational messages, selected from nine longer messages developed by the Centers for Disease Control and Prevention and six brief messages developed by the study team. Parents indicated whether each message would persuade them to get HPV vaccine for their adolescents. Physicians read the brief messages and indicated whether they would use them to persuade parents to get HPV vaccine for 11- to 12-year-old children. The highest proportion of parents (65%) and physicians (69%) found this brief message to be persuasive: "I strongly believe in the importance of this cancer-preventing vaccine for [child's name]." Parents disin...

The Journal of …, 2011

IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs target... more IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this disease. The efficacy of these drugs has been attributed to blocking the function of IL-17producing T cells and their ...

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Sep 19, 2016

The number of states proposing school-entry requirements for human papillomavirus (HPV) vaccinati... more The number of states proposing school-entry requirements for human papillomavirus (HPV) vaccination has increased over the last decade. However, data are currently limited regarding parents' support of such laws. We sought to obtain the first national estimates of parents' support of HPV vaccination school-entry requirements. A national sample of 1,501 parents of 11- to 17-year-old children completed a web-based survey between November 2014 and January 2015. Analyses used multivariable logistic regression to assess correlates of support for school-entry requirements for HPV vaccination. Overall, 21% of parents agreed that laws requiring HPV vaccination for school attendance "are a good idea," and 54% disagreed. If school-entry requirements included opt-out provisions, agreement increased to 57%, and only 21% disagreed. Parents more often agreed with requirements without opt-out provisions if they were Hispanic [OR = 1.53; 95% confidence interval (CI), 1.05-2.22], b...

International Journal of Engineering Research and, 2015

In today's world, the technology has transitioned at such a great extent, that the mobile devices... more In today's world, the technology has transitioned at such a great extent, that the mobile devices can do all the functions and tasks which were previously done by a personal digital assistant. The mobile phones have the ability to store sensitive and confidential information like digital certificates, financial records and company records, making them primary target for intruders. Thus to secure that, Personal Identification Number (PIN) is used currently, which has limitations from both end user and technological perspective. Therefore, there is a need for non-intrusive and stronger subscriber verification technique. This paper presents the viability of one such technique, the usage of keystroke dynamics to provide an additional layer of security along with PIN. In this paper, we discuss different approaches and methodologies to authenticate users based on their interactions with a mobile phone keypad, comprising a number of investigators into the ability of neural networks.

Chemical Engineering Science, 2016

Journal of Strength and Conditioning Research, 2013

Journal of Adolescent Health, 2014

Schools are increasingly a part of vaccine provision, because of laws mandating provision of info... more Schools are increasingly a part of vaccine provision, because of laws mandating provision of information by schools about vaccination, school entry requirements, and mass vaccination campaigns. We examined preferences for programmatic aspects of voluntary school mass vaccination programs (i.e., "vaccination days"). Methods: We analyzed data from a national sample of United States parents of adolescent males ages 11e19 years (n ¼ 308) and their sons (n ¼ 216), who completed an online survey in November 2011. Results: Sons believed that adolescents should be able to get vaccinated without parental consent at a younger age than parents did (p < .001) and were more willing to participate in vaccination days without a parent present (p ¼ .04). Parents perceived school vaccination days to be a more convenient way to get their sons recommended vaccines if they were younger parents, had older adolescent sons, supported laws letting schools share vaccination records with health care providers, or had sons who were previously immunized at school (all p < .05). Parents of older sons were less likely to want their sons' vaccination records sent home (odds ratio [OR] ¼ .47; 95% confidence interval [CI], .29e.77) or to their sons' physicians (OR ¼ .61; 95% CI, .37e.98) compared with parents of younger sons, but more likely to prefer their sons' records be entered in an immunization registry (OR ¼ 1.66; 95% CI, 1.05e2.63). Conclusions: Sons' age had an important role in support for vaccination days and preferences for sharing vaccination information with health care professionals. Parents and sons had similar beliefs about vaccination in schools, but the sons' responses suggested an interest in greater autonomy.

ACS Nano, 2013

The use of nebulizable, nanoparticle-based antimicrobial delivery systems can improve efficacy an... more The use of nebulizable, nanoparticle-based antimicrobial delivery systems can improve efficacy and reduce toxicity for treatment of multi-drug-resistant bacteria in the chronically infected lungs of cystic fibrosis patients. Nanoparticle vehicles are particularly useful for applying broad-spectrum silver-based antimicrobials, for instance, to improve the residence time of small-molecule silver carbene complexes (SCCs) within the lung. Therefore, we have synthesized multifunctional, shell cross-linked knedel-like polymeric nanoparticles (SCK NPs) and capitalized on the ability to independently load the shell and core with silver-based antimicrobial agents. We formulated three silver-loaded variants of SCK NPs: shell-loaded with silver cations, coreloaded with SCC10, and combined loading of shell silver cations and core SCC10. All three formulations provided a sustained delivery of silver over the course of at least 2À4 days. The two SCK NP formulations with SCC10 loaded in the core each exhibited excellent antimicrobial activity and efficacy in vivo in a mouse model of Pseudomonas aeruginosa pneumonia. SCK NPs with shell silver cationload only, while efficacious in vitro, failed to demonstrate efficacy in vivo. However, a single dose of core SCC10-loaded SCK NPs (0.74 (0.16 mg Ag) provided a 28% survival advantage over sham treatment, and administration of two doses (0.88 mg Ag) improved survival to 60%. In contrast, a total of 14.5 mg of Ag þ delivered over 5 doses at 12 h intervals was necessary to achieve a 60% survival advantage with a free-drug (SCC1) formulation. Thus, SCK NPs show promise for clinical impact by greatly reducing antimicrobial dosage and dosing frequency, which could minimize toxicity and improve patient adherence. KEYWORDS: shell cross-linked knedel-like polymeric nanoparticles. silver carbene complexes. cystic fibrosis. nebulizable nanoparticles. multi-drug-resistant bacteria. Pseudomonas aeruginosa pneumonia ARTICLE This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.