Patrice Darmon - Academia.edu (original) (raw)
Papers by Patrice Darmon
Diabetologia Notes de lecture, 2010
Un dé ficit en vitamine B12 pendant la grossesse est associé à une augmentation du risque de diab... more Un dé ficit en vitamine B12 pendant la grossesse est associé à une augmentation du risque de diabè te gestationnel et de diabè te de type 2 à cinq ans Patrice Darmon,, service de nutrition, des maladies mé taboliques et d'endocrinologie, hô pital Sainte-Marguerite,
Médecine des Maladies Métaboliques, 2011
Diabetologia Notes de lecture, 2009
Journal of the American College of Cardiology, 2016
Clin Neurol Neurosurg, 2011
Clin Neurol Neurosurg, 2011
Clin Neurol Neurosurg, 2011
Médecine des Maladies Métaboliques, 2011
Médecine des Maladies Métaboliques, 2011
Médecine des Maladies Métaboliques, 2011
Diabetologia Notes de lecture, 2009
Médecine des Maladies Métaboliques, 2011
Médecine des Maladies Métaboliques, 2011
Dossier thématique 6 Médecine des maladies Métaboliques -Mars 2011 -Hors série 1 © 2011 -Elsevier... more Dossier thématique 6 Médecine des maladies Métaboliques -Mars 2011 -Hors série 1 © 2011 -Elsevier Masson SAS -Tous droits réservés. Statines : pour quelques diabètes de plus… Sattar NE et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials Lancet 2010 ; 375 : 735-742 Le coin biblio de la SFD E
Médecine des Maladies Métaboliques, 2011
Diabetologia Notes de lecture, 2009
Aims/hypothesis: Diabetes has been related to Alzheimer's disease with inconsistent findings. We ... more Aims/hypothesis: Diabetes has been related to Alzheimer's disease with inconsistent findings. We aimed to clarify the association of diabetes with different dementing disorders taking into account glycaemic control, and to explore the link between glucose dysregulation and neurodegeneration.
Medecine Des Maladies Metaboliques, Mar 1, 2011
Hum Genet, 1998
Alström syndrome is a rare autosomal recessive disorder characterized by retinal pigment degenera... more Alström syndrome is a rare autosomal recessive disorder characterized by retinal pigment degeneration, neurogenic deafness, infantile obesity, hyperlipidemia, and non-insulin-dependent diabetes mellitus. While the disease-related gene remains unknown, studies of the genetic isolate of French Acadians provisionally locate the Alström syndrome on chromosome 2p12-13 within a 14.9-cM interval. To confirm this finding in another ethnic population and refine the candidate region we investigated by linkage analysis a consanguineous family of North African origin, in which three of seven siblings displayed all major neurological and metabolic features of Alström syndrome. Genotyping was performed on an ABI377 DNA automatic sequencer and LOD scores were obtained with the Fastlink program. Five markers previously investigated in French Acadians confirmed the involvement of the candidate region, although pairwise LOD scores were of poor significance (Zmax = 2.9). To further confirm homogeneity and refine the candidate region, 20 additional markers were investigated. Haplotype analysis and allele segregation revealed that affected children shared a single haplotype and were homozygous for the eight most centromeric markers (D2S291-D2S2114), over a 6.1-cM interval. Significative multipoint LOD scores (Zmax = 3.96) were obtained between markers D2S2110/145 and D2S286. Two clusters of known genes are present in this refined region of chromosome 2p, the most attractive candidate being the hexokinase II gene. However, except for several known polymorphisms, no mutations were detected in the coding region of this gene. In conclusion, the location of Alström syndrome on chromosome 2p12-13 is confirmed, reducing the genetic interval to 6.1 cM.
Clinical Nutrition, Jan 12, 2008
Background & aims: Optimal implementation of parenteral nutrition (PN) is required to promote cli... more Background & aims: Optimal implementation of parenteral nutrition (PN) is required to promote clinical outcome and costs control. This prospective quality control study examined if PN prescription was justified and PN administration was adequate to cover the nutritional needs of patients hospitalized in the Geneva University Hospital. Methods: Two-hundred consecutive patients receiving PN were included from Medicine, Intensive Care or Surgery Units. PN prescription was considered justified if oral feeding or enteral nutrition were contraindicated or provided less than 40% of the energy target after 5 days. PN was considered adequate if it covered 90%e110% of the recommended need for energy (i.e., 110% of the HarriseBenedict formula) and proteins (i.e., 1.2 or 1.0 g protein/kg body weight/day for patients or >65 years, respectively), and was supplemented with vitamins and trace elements. Results: PN prescription was justified in all but 14 patients (7%). However, PN administration was frequently inadequate: overfeeding (62%) was more often observed than underfeeding (14%), particularly among thin, elderly and female patients (P < 0.01). Moreover, PN was not supplemented with vitamins and/or trace elements in 47 patients (24%). Conclusion: PN prescription is generally justified but PN administration is often inadequate. Further teaching of medical teams and quality control surveys are warranted to optimize PN practices. ª
Annales Francaises D Anesthesie Et De Reanimation, 1997
R&km 1991;16:492-7 0 Elsevier. Paris
Diabetologia Notes de lecture, 2010
Un dé ficit en vitamine B12 pendant la grossesse est associé à une augmentation du risque de diab... more Un dé ficit en vitamine B12 pendant la grossesse est associé à une augmentation du risque de diabè te gestationnel et de diabè te de type 2 à cinq ans Patrice Darmon,, service de nutrition, des maladies mé taboliques et d'endocrinologie, hô pital Sainte-Marguerite,
Médecine des Maladies Métaboliques, 2011
Diabetologia Notes de lecture, 2009
Journal of the American College of Cardiology, 2016
Clin Neurol Neurosurg, 2011
Clin Neurol Neurosurg, 2011
Clin Neurol Neurosurg, 2011
Médecine des Maladies Métaboliques, 2011
Médecine des Maladies Métaboliques, 2011
Médecine des Maladies Métaboliques, 2011
Diabetologia Notes de lecture, 2009
Médecine des Maladies Métaboliques, 2011
Médecine des Maladies Métaboliques, 2011
Dossier thématique 6 Médecine des maladies Métaboliques -Mars 2011 -Hors série 1 © 2011 -Elsevier... more Dossier thématique 6 Médecine des maladies Métaboliques -Mars 2011 -Hors série 1 © 2011 -Elsevier Masson SAS -Tous droits réservés. Statines : pour quelques diabètes de plus… Sattar NE et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials Lancet 2010 ; 375 : 735-742 Le coin biblio de la SFD E
Médecine des Maladies Métaboliques, 2011
Diabetologia Notes de lecture, 2009
Aims/hypothesis: Diabetes has been related to Alzheimer's disease with inconsistent findings. We ... more Aims/hypothesis: Diabetes has been related to Alzheimer's disease with inconsistent findings. We aimed to clarify the association of diabetes with different dementing disorders taking into account glycaemic control, and to explore the link between glucose dysregulation and neurodegeneration.
Medecine Des Maladies Metaboliques, Mar 1, 2011
Hum Genet, 1998
Alström syndrome is a rare autosomal recessive disorder characterized by retinal pigment degenera... more Alström syndrome is a rare autosomal recessive disorder characterized by retinal pigment degeneration, neurogenic deafness, infantile obesity, hyperlipidemia, and non-insulin-dependent diabetes mellitus. While the disease-related gene remains unknown, studies of the genetic isolate of French Acadians provisionally locate the Alström syndrome on chromosome 2p12-13 within a 14.9-cM interval. To confirm this finding in another ethnic population and refine the candidate region we investigated by linkage analysis a consanguineous family of North African origin, in which three of seven siblings displayed all major neurological and metabolic features of Alström syndrome. Genotyping was performed on an ABI377 DNA automatic sequencer and LOD scores were obtained with the Fastlink program. Five markers previously investigated in French Acadians confirmed the involvement of the candidate region, although pairwise LOD scores were of poor significance (Zmax = 2.9). To further confirm homogeneity and refine the candidate region, 20 additional markers were investigated. Haplotype analysis and allele segregation revealed that affected children shared a single haplotype and were homozygous for the eight most centromeric markers (D2S291-D2S2114), over a 6.1-cM interval. Significative multipoint LOD scores (Zmax = 3.96) were obtained between markers D2S2110/145 and D2S286. Two clusters of known genes are present in this refined region of chromosome 2p, the most attractive candidate being the hexokinase II gene. However, except for several known polymorphisms, no mutations were detected in the coding region of this gene. In conclusion, the location of Alström syndrome on chromosome 2p12-13 is confirmed, reducing the genetic interval to 6.1 cM.
Clinical Nutrition, Jan 12, 2008
Background & aims: Optimal implementation of parenteral nutrition (PN) is required to promote cli... more Background & aims: Optimal implementation of parenteral nutrition (PN) is required to promote clinical outcome and costs control. This prospective quality control study examined if PN prescription was justified and PN administration was adequate to cover the nutritional needs of patients hospitalized in the Geneva University Hospital. Methods: Two-hundred consecutive patients receiving PN were included from Medicine, Intensive Care or Surgery Units. PN prescription was considered justified if oral feeding or enteral nutrition were contraindicated or provided less than 40% of the energy target after 5 days. PN was considered adequate if it covered 90%e110% of the recommended need for energy (i.e., 110% of the HarriseBenedict formula) and proteins (i.e., 1.2 or 1.0 g protein/kg body weight/day for patients or >65 years, respectively), and was supplemented with vitamins and trace elements. Results: PN prescription was justified in all but 14 patients (7%). However, PN administration was frequently inadequate: overfeeding (62%) was more often observed than underfeeding (14%), particularly among thin, elderly and female patients (P < 0.01). Moreover, PN was not supplemented with vitamins and/or trace elements in 47 patients (24%). Conclusion: PN prescription is generally justified but PN administration is often inadequate. Further teaching of medical teams and quality control surveys are warranted to optimize PN practices. ª
Annales Francaises D Anesthesie Et De Reanimation, 1997
R&km 1991;16:492-7 0 Elsevier. Paris