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Endocrinology and Metabolism Clinics of North America, 2008
The close genotype-phenotype relationship that characterizes thyroid oncology stimulated the auth... more The close genotype-phenotype relationship that characterizes thyroid oncology stimulated the authors to address this article by using a mixed, genetic and phenotypic approach. Within the group of well differentiated carcinomas, RET/PTC1 and the BRAF V600E mutation tend to concentrate in cases of conventional papillary carcinoma (PTC); RET/PTC3 and, perhaps, BRAF VK600-1E appear to be associated with the solid variant of PTC; N-RAS Q61R and BRAF K601E mutations tend to concentrate in cases of the follicular variant of PTC (FVPTC), while a PAX8-peroxisome proliferator-activated receptor-g (PPARg) rearrangement is found in benign and malignant tumors displaying a prominent follicular growth pattern (follicular thyroid adenoma or FTA, follicular thyroid carcinoma or FTC, and FVPTC). The same holds true regarding Hu¨rthle cell tumors (HCT) and anaplastic thyroid carcinomas (ATC), which also present quite characteristic genetic alterations.
Endocrinology and Metabolism Clinics of North America, 2008
The close genotype-phenotype relationship that characterizes thyroid oncology stimulated the auth... more The close genotype-phenotype relationship that characterizes thyroid oncology stimulated the authors to address this article by using a mixed, genetic and phenotypic approach. Within the group of well differentiated carcinomas, RET/PTC1 and the BRAF V600E mutation tend to concentrate in cases of conventional papillary carcinoma (PTC); RET/PTC3 and, perhaps, BRAF VK600-1E appear to be associated with the solid variant of PTC; N-RAS Q61R and BRAF K601E mutations tend to concentrate in cases of the follicular variant of PTC (FVPTC), while a PAX8-peroxisome proliferator-activated receptor-g (PPARg) rearrangement is found in benign and malignant tumors displaying a prominent follicular growth pattern (follicular thyroid adenoma or FTA, follicular thyroid carcinoma or FTC, and FVPTC). The same holds true regarding Hu¨rthle cell tumors (HCT) and anaplastic thyroid carcinomas (ATC), which also present quite characteristic genetic alterations.