Patricia El Beitune - Academia.edu (original) (raw)
Papers by Patricia El Beitune
Revista Brasileira de Ginecologia e Obstetrícia, 2023
Rbm Revista Brasileira De Medicina, 2009
Revista Brasileira de Ginecologia e Obstetrícia, Dec 1, 2002
Objetivo: avaliar os efeitos de drogas anti-retrovirais isoladas e em associação sobre as taxas d... more Objetivo: avaliar os efeitos de drogas anti-retrovirais isoladas e em associação sobre as taxas de fertilidade em ratas prenhes expostas a estes fármacos, bem como o efeito perinatal nas crias. Métodos: foram utilizadas ratas fêmeas prenhes adultas da raça Wistar, pesando inicialmente entre 200 e 230 g. Foram testadas a azidotimidina (AZT), lamivudina (3TC) e nelfinavir (NFV), cujas dosagens foram padronizadas em 10 vezes a dose normalmente utilizada em gestantes, proporcionalmente ao peso dos animais. No total foram avaliados sete grupos, incluindo o controle. O início da experimentação foi o dia zero da prenhez e as cesarianas foram realizadas com 21 dias de prenhez. Para o cálculo das taxas de fertilidade, avaliaram-se o número de fetos vivos e mortos, sítios de implantação e número de corpos lúteos. Utilizaram-se o teste t de Student e Mann-Whitney para a análise estatística. Resultados: não houve alterações significativas nas taxas de perdas pré-implantação e da eficiência de implantação de ratas tratadas com anti-retrovirais isolados e em associação. No entanto, houve aumento significativo nas taxas de perdas pós-implantação (grupo controle: 7,6%; grupos medicamentos: de 20,2 a 26,7%), redução significativa nas taxas de viabilidade fetal (grupo controle: 92,4%; grupos medicamentos: de 73,3 a 79,8%) e redução significativa no número de fetos por ninhada (grupo controle: 14,7, grupos medicamentos: de 11,1 a 12,7). Observou-se também que houve redução do peso materno e dos fetos nos grupos tratados com 3TC, AZT + 3TC e AZT + 3TC + NFV. Conclusão: com a utilização de doses elevadas de medicamentos anti-retrovirais na presente casuística, efeitos importantes sobre a fertilidade foram encontrados, o que sinaliza para a necessidade de se pesquisarem outros fármacos anti-retrovirais com menor potencial histotóxico e que possam, com segurança, ser utilizados por gestantes portadoras da infecção pelo vírus da imunodeficiência humana.
Medicina, Mar 30, 2003
RESUMO: Importante foco de atenção em Saúde Pública tem sido a avaliação de determinados micronut... more RESUMO: Importante foco de atenção em Saúde Pública tem sido a avaliação de determinados micronutrientes no ser humano, em especial aqueles que se encontram associados à vulnerabilidade orgânica, conseqüente ao desiquilíbrio ou à deficiência desses micronutrientes. Entre os micronutrientes, a hipovitaminose A tem sido objeto de realce devido à significante prevalência em populações de países em desenvolvimento. Este artigo aborda a Vitamina A, enfocando seu metabolismo e as repercussões deletérias, decorrentes de sua deficiência sobre o organismo, suas manifestações no ciclo gravidopuerperal, e sua interação em situações clínicas, específicas.
Femina, 2005
Base de dados : LILACS. Pesquisa : 418595 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 418595 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 418595. ...
Journal of Acquired Immune Deficiency Syndromes, Oct 1, 2006
A prospective study was conducted on 207 pregnant women divided into two groups: HIV group (n = 1... more A prospective study was conducted on 207 pregnant women divided into two groups: HIV group (n = 101) and a control group consisting of HIV-uninfected pregnant women (n = 106) to assess regional colonization by GBS. Anal and vaginal swabs were collected and cultured in ...
To evaluate operating data, disease-free (DFS) and overall survival (OS) for women with cancer cl... more To evaluate operating data, disease-free (DFS) and overall survival (OS) for women with cancer clinically restricted to the uterine corpus underwent to laparoscopy and the effects of the Gomes-daSilveira manipulator on surgical time and intraoperative complications, sixteen patients treated for endometrial cancer with laparoscopy and followed up for at least 5 years were divided into 2 groups. Group 1, no uterine manipulator; Group 2, with the Gomes-da-Silveira manipulator used during surgery. Mean follow-up was 75 months. Surgery time ranged from 56-230 minutes. Blood loss ranged from 50-250 ml. All patients were discharged before 48 hours after the end of the surgery. Five-year OS and DFS were 100%, and 94%, respectively. Median time was 125 minutes for Group 1 and 63 minutes for Group 2 (p=0.0002). Following the principles of oncologic safety and in the hands of experienced surgeons, laparoscopy is safe, feasible and effective in the treatment of stage I endometrial cancer.
Revista brasileira de medicina, Aug 1, 2010
The urinary tract infection (UTI) is a commom complication in pregnancy. Cystitis occurs in about... more The urinary tract infection (UTI) is a commom complication in pregnancy. Cystitis occurs in about 1-1,5% of pregnant women. Escherichia coli is the most common uropathogen, found in approximately 80% of the infected patients. Prematurity, low weight birth and even fetal death can be associated to UTI in pregnancy. The purpose of this is to discuss the antibiotic therapy for the treatment of the lower tract urinary infection (acute cystitis) in different trimesters of pregnancy. Ampicillin is safe in any stage of the gestation however the Escherichia coli shows high rates of the resistance to this drug. Cephalexin appears to be a safe drug at all stages of pregnancy. Nitrofurantoin should be avoided in the end of the gestation by the risk of neonatal hemolysis. The complications decrease by appropriated investigation and treatment. The early screening of the bacteriuria in the gestation, even if it is asymptomatic, has maternal and fetal benefits
European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2006
The objective was to determine the frequency and risk factors of anogenital colonization by Strep... more The objective was to determine the frequency and risk factors of anogenital colonization by Streptococcus agalactiae (GBS) in pregnant women infected with human immunodeficiency virus type 1 (HIV-1). A prospective study was conducted on 207 pregnant women divided into two groups: HIV group (n=101) and a control group consisting of HIV-uninfected pregnant women (n=106) to assess regional colonization by GBS. Anal and vaginal swabs were collected and cultured in Todd-Hewitt broth, followed by a confirmatory test. For a control group with an anticipated proportion based on literature research of 10-30% and alpha=0.05, a sample size of 100 would have a power of 80% to detect a difference of 15% or greater with a study group. The mothers were studied in terms of frequency of anogenital colonization by GBS, maternal epidemiological data, and TCD4 lymphocyte counts. The results were analyzed using the chi(2)-test, Fisher's exact test and the Student's t-test, with the level of significance set at p<0.05. Twenty (19.8%) HIV-1-infected pregnant women were found to be colonized by GBS at between 35 and 37 weeks' gestation. In the control group, the prevalence of GBS was 14.1%. No significant increase in GBS colonization was observed in HIV-1-infected pregnant women. Maternal colonization of GBS in HIV-infected pregnant women was not found to be associated with their immunological status. Sexual contact does not seem to be the principal way of transmitting GBS.
Revista Brasileira de Ginecologia e Obstetrícia, Nov 1, 2020
Objective Recent observations support the hypothesis that an imbalance between angiogenic factors... more Objective Recent observations support the hypothesis that an imbalance between angiogenic factors has a fundamental role in the pathogenesis of pre-eclampsia and is responsible for the clinical manifestations of the disease. The goal of the present study was to evaluate the sensitivity, specificity, and the best accuracy level of Soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in maternal serum and protein/creatinine ratio in urine sample to define the best cutoff point of these tests to discriminate between the patients with gestational hypertension and the patients with pre-eclampsia, to evaluate the possibility of using them as diagnostic methods. Methods A prospective longitudinal study was performed, and blood samples were collected from 95 pregnant patients with hypertension to measure serum concentrations of biomarkers sFlt-1 and PlGF. Urine samples were collected for protein screening. Significance was set as p < 0.05. Results The sFlt-1/PlGF ratio demonstrated a sensitivity of 57.5% and a specificity of 60% using 50.4 as a cutoff point. The test that showed the best accuracy in the diagnosis of pre-eclampsia was protein/creatinine ratio, with a sensitivity of 78.9% and a specificity of 70% using 0.4 as a cutoff point and showing an area under the receiver operating characteristic curve of 0.80 (p < 0.001). Conclusion No studied laboratory test proved to be fairly accurate for the diagnosis of pre-eclampsia, except for the protein/creatinine ratio. The evidence is insufficient to recommend biomarkers sFlt-1 and PlGF to be used for the diagnosis of pre-eclampsia. Resumo Objetivo Pesquisas recentes sustentam a hipótese de que um desequilíbrio entre fatores angiogênicos desempenhe um papel fundamental na patogênese da préeclâmpsia e seja responsável pelas manifestações clínicas da doença. O objetivo do presente estudo foi avaliar a sensibilidade, a especificidade e o nível de melhor acurácia
Revista Brasileira de Ginecologia e Obstetrícia, Dec 14, 2018
Objective To evaluate the accuracy of the diagnosis of fetal heart diseases obtained through ultr... more Objective To evaluate the accuracy of the diagnosis of fetal heart diseases obtained through ultrasound examinations performed during the prenatal period compared with the postnatal evaluation. Methods A retrospective cohort study with 96 pregnant women who were attended at the Echocardiography Service and whose deliveries occurred at the Complexo Hospitalar Santa Casa de Porto Alegre, in the state of Rio Grande do Sul, Brazil. Risk factor assessment plus sensitivity and specificity analysis were used, comparing the accuracy of the screening for congenital heart disease by means of obstetrical ultrasound and morphological evaluation and fetal echocardiography, considering p < 0.05 as significant. The present study was approved by the Research Ethics Committee of the Institution. Results The analysis of risk factors shows that 31.3% of the fetuses with congenital heart disease could be identified by anamnesis. The antepartum echocardiography demonstrated a sensitivity of 97.7%, a specificity of 88.9%, and accuracy of 93% in the diagnosis of congenital heart disease. A sensitivity of 29.3% was found for the obstetric ultrasound, of 54.3% for the morphological ultrasound, and of 97.7% for the fetal echocardiography. The fetal echocardiography detected fetal heart disease in 67.7% of the cases, the morphological ultrasound in 16.7%, and the obstetric ultrasound in 11.5% of the cases. Conclusion There is a high proportion of congenital heart disease in pregnancies with no risk factors for this outcome. Faced with the disappointing results of obstetric ultrasound for the detection of congenital heart diseases and the current unfeasibility of universal screening of congenital heart diseases through fetal echocardiography, the importance of the fetal morphological ultrasound and its performance by qualified professionals is reinforced for a more appropriate management of these pregnancies.
European Journal of Obstetrics & Gynecology and Reproductive Biology, Jul 1, 2016
Research design and methods A prospective cohort study was conducted between 2007 and 2011 in a s... more Research design and methods A prospective cohort study was conducted between 2007 and 2011 in a sample of 213 ENG implant recipients with a mean age of
Obstetrics and Gynecology International, 2009
To estimate HPV prevalence among pregnant women from Ribeirão Preto, Brazil, and the possible inf... more To estimate HPV prevalence among pregnant women from Ribeirão Preto, Brazil, and the possible influence of HIV-1 infection on this prevalence. Methods. A cross-sectional study with 44 HIV-positive and 53 HIV-negative pregnant women was conducted. Cervicovaginal specimens were obtained from all women during gynecologic exam. HPV DNA, low and high risk HPV types, was detected using conventional PCR. Statistical analysis used Student's t-test, Mann-Whitney test, Fischer's Exact test, and prevalence ratios with 95% confidence interval. Results. HIV-positive pregnant women had higher proportion of HPV infection than HIV-negative pregnant women (79.5% versus 58.5%; P < .05). HPV positivity prevalence ratio for HIV-positive women was 1.36 (95% CI 1.04-1.8; P = .03). There was significant association between HIV viral load levels and HPV positivity (P < .05). Conclusions. Our results demonstrate higher HPV positivity in HIV-infected pregnant women. Higher values of HIV viral load were associated with HPV positivity.
Revista Brasileira de Ginecologia e Obstetrícia, 2023
Rbm Revista Brasileira De Medicina, 2009
Revista Brasileira de Ginecologia e Obstetrícia, Dec 1, 2002
Objetivo: avaliar os efeitos de drogas anti-retrovirais isoladas e em associação sobre as taxas d... more Objetivo: avaliar os efeitos de drogas anti-retrovirais isoladas e em associação sobre as taxas de fertilidade em ratas prenhes expostas a estes fármacos, bem como o efeito perinatal nas crias. Métodos: foram utilizadas ratas fêmeas prenhes adultas da raça Wistar, pesando inicialmente entre 200 e 230 g. Foram testadas a azidotimidina (AZT), lamivudina (3TC) e nelfinavir (NFV), cujas dosagens foram padronizadas em 10 vezes a dose normalmente utilizada em gestantes, proporcionalmente ao peso dos animais. No total foram avaliados sete grupos, incluindo o controle. O início da experimentação foi o dia zero da prenhez e as cesarianas foram realizadas com 21 dias de prenhez. Para o cálculo das taxas de fertilidade, avaliaram-se o número de fetos vivos e mortos, sítios de implantação e número de corpos lúteos. Utilizaram-se o teste t de Student e Mann-Whitney para a análise estatística. Resultados: não houve alterações significativas nas taxas de perdas pré-implantação e da eficiência de implantação de ratas tratadas com anti-retrovirais isolados e em associação. No entanto, houve aumento significativo nas taxas de perdas pós-implantação (grupo controle: 7,6%; grupos medicamentos: de 20,2 a 26,7%), redução significativa nas taxas de viabilidade fetal (grupo controle: 92,4%; grupos medicamentos: de 73,3 a 79,8%) e redução significativa no número de fetos por ninhada (grupo controle: 14,7, grupos medicamentos: de 11,1 a 12,7). Observou-se também que houve redução do peso materno e dos fetos nos grupos tratados com 3TC, AZT + 3TC e AZT + 3TC + NFV. Conclusão: com a utilização de doses elevadas de medicamentos anti-retrovirais na presente casuística, efeitos importantes sobre a fertilidade foram encontrados, o que sinaliza para a necessidade de se pesquisarem outros fármacos anti-retrovirais com menor potencial histotóxico e que possam, com segurança, ser utilizados por gestantes portadoras da infecção pelo vírus da imunodeficiência humana.
Medicina, Mar 30, 2003
RESUMO: Importante foco de atenção em Saúde Pública tem sido a avaliação de determinados micronut... more RESUMO: Importante foco de atenção em Saúde Pública tem sido a avaliação de determinados micronutrientes no ser humano, em especial aqueles que se encontram associados à vulnerabilidade orgânica, conseqüente ao desiquilíbrio ou à deficiência desses micronutrientes. Entre os micronutrientes, a hipovitaminose A tem sido objeto de realce devido à significante prevalência em populações de países em desenvolvimento. Este artigo aborda a Vitamina A, enfocando seu metabolismo e as repercussões deletérias, decorrentes de sua deficiência sobre o organismo, suas manifestações no ciclo gravidopuerperal, e sua interação em situações clínicas, específicas.
Femina, 2005
Base de dados : LILACS. Pesquisa : 418595 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 418595 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 418595. ...
Journal of Acquired Immune Deficiency Syndromes, Oct 1, 2006
A prospective study was conducted on 207 pregnant women divided into two groups: HIV group (n = 1... more A prospective study was conducted on 207 pregnant women divided into two groups: HIV group (n = 101) and a control group consisting of HIV-uninfected pregnant women (n = 106) to assess regional colonization by GBS. Anal and vaginal swabs were collected and cultured in ...
To evaluate operating data, disease-free (DFS) and overall survival (OS) for women with cancer cl... more To evaluate operating data, disease-free (DFS) and overall survival (OS) for women with cancer clinically restricted to the uterine corpus underwent to laparoscopy and the effects of the Gomes-daSilveira manipulator on surgical time and intraoperative complications, sixteen patients treated for endometrial cancer with laparoscopy and followed up for at least 5 years were divided into 2 groups. Group 1, no uterine manipulator; Group 2, with the Gomes-da-Silveira manipulator used during surgery. Mean follow-up was 75 months. Surgery time ranged from 56-230 minutes. Blood loss ranged from 50-250 ml. All patients were discharged before 48 hours after the end of the surgery. Five-year OS and DFS were 100%, and 94%, respectively. Median time was 125 minutes for Group 1 and 63 minutes for Group 2 (p=0.0002). Following the principles of oncologic safety and in the hands of experienced surgeons, laparoscopy is safe, feasible and effective in the treatment of stage I endometrial cancer.
Revista brasileira de medicina, Aug 1, 2010
The urinary tract infection (UTI) is a commom complication in pregnancy. Cystitis occurs in about... more The urinary tract infection (UTI) is a commom complication in pregnancy. Cystitis occurs in about 1-1,5% of pregnant women. Escherichia coli is the most common uropathogen, found in approximately 80% of the infected patients. Prematurity, low weight birth and even fetal death can be associated to UTI in pregnancy. The purpose of this is to discuss the antibiotic therapy for the treatment of the lower tract urinary infection (acute cystitis) in different trimesters of pregnancy. Ampicillin is safe in any stage of the gestation however the Escherichia coli shows high rates of the resistance to this drug. Cephalexin appears to be a safe drug at all stages of pregnancy. Nitrofurantoin should be avoided in the end of the gestation by the risk of neonatal hemolysis. The complications decrease by appropriated investigation and treatment. The early screening of the bacteriuria in the gestation, even if it is asymptomatic, has maternal and fetal benefits
European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2006
The objective was to determine the frequency and risk factors of anogenital colonization by Strep... more The objective was to determine the frequency and risk factors of anogenital colonization by Streptococcus agalactiae (GBS) in pregnant women infected with human immunodeficiency virus type 1 (HIV-1). A prospective study was conducted on 207 pregnant women divided into two groups: HIV group (n=101) and a control group consisting of HIV-uninfected pregnant women (n=106) to assess regional colonization by GBS. Anal and vaginal swabs were collected and cultured in Todd-Hewitt broth, followed by a confirmatory test. For a control group with an anticipated proportion based on literature research of 10-30% and alpha=0.05, a sample size of 100 would have a power of 80% to detect a difference of 15% or greater with a study group. The mothers were studied in terms of frequency of anogenital colonization by GBS, maternal epidemiological data, and TCD4 lymphocyte counts. The results were analyzed using the chi(2)-test, Fisher&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s exact test and the Student&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s t-test, with the level of significance set at p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05. Twenty (19.8%) HIV-1-infected pregnant women were found to be colonized by GBS at between 35 and 37 weeks&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; gestation. In the control group, the prevalence of GBS was 14.1%. No significant increase in GBS colonization was observed in HIV-1-infected pregnant women. Maternal colonization of GBS in HIV-infected pregnant women was not found to be associated with their immunological status. Sexual contact does not seem to be the principal way of transmitting GBS.
Revista Brasileira de Ginecologia e Obstetrícia, Nov 1, 2020
Objective Recent observations support the hypothesis that an imbalance between angiogenic factors... more Objective Recent observations support the hypothesis that an imbalance between angiogenic factors has a fundamental role in the pathogenesis of pre-eclampsia and is responsible for the clinical manifestations of the disease. The goal of the present study was to evaluate the sensitivity, specificity, and the best accuracy level of Soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in maternal serum and protein/creatinine ratio in urine sample to define the best cutoff point of these tests to discriminate between the patients with gestational hypertension and the patients with pre-eclampsia, to evaluate the possibility of using them as diagnostic methods. Methods A prospective longitudinal study was performed, and blood samples were collected from 95 pregnant patients with hypertension to measure serum concentrations of biomarkers sFlt-1 and PlGF. Urine samples were collected for protein screening. Significance was set as p < 0.05. Results The sFlt-1/PlGF ratio demonstrated a sensitivity of 57.5% and a specificity of 60% using 50.4 as a cutoff point. The test that showed the best accuracy in the diagnosis of pre-eclampsia was protein/creatinine ratio, with a sensitivity of 78.9% and a specificity of 70% using 0.4 as a cutoff point and showing an area under the receiver operating characteristic curve of 0.80 (p < 0.001). Conclusion No studied laboratory test proved to be fairly accurate for the diagnosis of pre-eclampsia, except for the protein/creatinine ratio. The evidence is insufficient to recommend biomarkers sFlt-1 and PlGF to be used for the diagnosis of pre-eclampsia. Resumo Objetivo Pesquisas recentes sustentam a hipótese de que um desequilíbrio entre fatores angiogênicos desempenhe um papel fundamental na patogênese da préeclâmpsia e seja responsável pelas manifestações clínicas da doença. O objetivo do presente estudo foi avaliar a sensibilidade, a especificidade e o nível de melhor acurácia
Revista Brasileira de Ginecologia e Obstetrícia, Dec 14, 2018
Objective To evaluate the accuracy of the diagnosis of fetal heart diseases obtained through ultr... more Objective To evaluate the accuracy of the diagnosis of fetal heart diseases obtained through ultrasound examinations performed during the prenatal period compared with the postnatal evaluation. Methods A retrospective cohort study with 96 pregnant women who were attended at the Echocardiography Service and whose deliveries occurred at the Complexo Hospitalar Santa Casa de Porto Alegre, in the state of Rio Grande do Sul, Brazil. Risk factor assessment plus sensitivity and specificity analysis were used, comparing the accuracy of the screening for congenital heart disease by means of obstetrical ultrasound and morphological evaluation and fetal echocardiography, considering p < 0.05 as significant. The present study was approved by the Research Ethics Committee of the Institution. Results The analysis of risk factors shows that 31.3% of the fetuses with congenital heart disease could be identified by anamnesis. The antepartum echocardiography demonstrated a sensitivity of 97.7%, a specificity of 88.9%, and accuracy of 93% in the diagnosis of congenital heart disease. A sensitivity of 29.3% was found for the obstetric ultrasound, of 54.3% for the morphological ultrasound, and of 97.7% for the fetal echocardiography. The fetal echocardiography detected fetal heart disease in 67.7% of the cases, the morphological ultrasound in 16.7%, and the obstetric ultrasound in 11.5% of the cases. Conclusion There is a high proportion of congenital heart disease in pregnancies with no risk factors for this outcome. Faced with the disappointing results of obstetric ultrasound for the detection of congenital heart diseases and the current unfeasibility of universal screening of congenital heart diseases through fetal echocardiography, the importance of the fetal morphological ultrasound and its performance by qualified professionals is reinforced for a more appropriate management of these pregnancies.
European Journal of Obstetrics & Gynecology and Reproductive Biology, Jul 1, 2016
Research design and methods A prospective cohort study was conducted between 2007 and 2011 in a s... more Research design and methods A prospective cohort study was conducted between 2007 and 2011 in a sample of 213 ENG implant recipients with a mean age of
Obstetrics and Gynecology International, 2009
To estimate HPV prevalence among pregnant women from Ribeirão Preto, Brazil, and the possible inf... more To estimate HPV prevalence among pregnant women from Ribeirão Preto, Brazil, and the possible influence of HIV-1 infection on this prevalence. Methods. A cross-sectional study with 44 HIV-positive and 53 HIV-negative pregnant women was conducted. Cervicovaginal specimens were obtained from all women during gynecologic exam. HPV DNA, low and high risk HPV types, was detected using conventional PCR. Statistical analysis used Student's t-test, Mann-Whitney test, Fischer's Exact test, and prevalence ratios with 95% confidence interval. Results. HIV-positive pregnant women had higher proportion of HPV infection than HIV-negative pregnant women (79.5% versus 58.5%; P < .05). HPV positivity prevalence ratio for HIV-positive women was 1.36 (95% CI 1.04-1.8; P = .03). There was significant association between HIV viral load levels and HPV positivity (P < .05). Conclusions. Our results demonstrate higher HPV positivity in HIV-infected pregnant women. Higher values of HIV viral load were associated with HPV positivity.