Patricia Heyn - Academia.edu (original) (raw)
Papers by Patricia Heyn
Innovation in Aging
Living environments profoundly influence the aging process. This symposium presents research on t... more Living environments profoundly influence the aging process. This symposium presents research on two main aspects of the living environment and their relationships with cognitive health. The living environment is broadly defined, including both physical and social aspects. The physical environment is the characteristics of the built environment, such as tripping hazard in the home, cleanness of the community streets, and presence of deserted buildings, etc. The social environment is the cohesiveness with other people living in the neighborhood. Living environments have multiple layers; the physical environments encompass both in-home and in-community domains, whereas the social environment can be categorized as domestic versus community cohesiveness. This symposium includes studies with investigation scopes spanning from the micro to mezzo levels. The first presentation scrutinizes the buffering effect of marital relationships, as a form of domestic social environments, on cognition ...
Innovation in Aging, 2020
Since the publishing of our meta-analysis evaluating the effects of randomized exercise trials on... more Since the publishing of our meta-analysis evaluating the effects of randomized exercise trials on cognitive function of Older Adults with Cognitive Impairments (OAwCIs) (Heyn et al 2004), several meta-analysis reviews were published addressing similar question. We currently appraised this evidence and preliminary synthesis of twelve, well-designed meta-analysis reports resulted in 193 RCTs and 15,614 participants over the age of 65 years old diagnosed with MCI or Alzheimer’s disease (AD). Exercise prescription paradigms averaged 156 minutes per week for 20-week. The combined cognitive function outcome mean effect size was medium; 0.67 (0.06-1.34 95% CI). Grounded in this unique umbrella study results, sustained and prolonged exercise training might provide an effective intervention for the maintenance or enhancement of cognitive function for MCI and AD. This comprehensive meta-analysis umbrella offers valuable and strong exercise recommendations for OAwCIs. This study results will b...
Innovation in Aging, 2020
Effective exercise training and regular physical activity (PA) practice are important for healthy... more Effective exercise training and regular physical activity (PA) practice are important for healthy aging and are key modalities for chronic disease management. Approaches that enhance exercise prescriptions and adherence for older adults should be innovative and based on evidence. Thus, the exercise prescription should be tailored accordingly to the person’s health status, functional capacity, and living arrangements. To properly achieve the desirable health outcomes, the PA should be performed at higher intensity, greater frequency, and longer duration. National PA Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity and at least two days of muscle-strengthening activities per week. Each prescribed modality (aerobic exercise, strength training, flexibility/stretching exercises, and balance training) has unique benefits. Therefore, it is critical to investigate and integrate novel techniques and tools to...
Brain Gaming (BG) Interventions have been shown to improve the cognitive function of older adults... more Brain Gaming (BG) Interventions have been shown to improve the cognitive function of older adults with cognitive impairments (CIs). However, rigorous evaluation supporting BG effectiveness is needed. Thus, we used meta-analysis to evaluate the effectiveness of BG. Several search databases (i.e. Pubmed) were used to identify relevant randomized controlled trials (RCTs). Cochrane RoB tool evaluated risk of bias. The main outcome was the composite score of cognitive function. Inverse-variance random effects model was used to compare the pooled standardized mean difference (SMD) across studies. A total of 16 RCTs included 909 participants. The RCTs varied in sample size, gaming platform, training prescription, and cognition. The meta-analysis showed no significant effects of BG on overall cognitive function (pooled SMD = 0.08, 95% CI [-0.24 – 0.41], p = 0.61, I2 = 77%. However, due to high heterogeneity, we cannot confidently refute that BG is an effective cognitive training approach.
Individuals with disabilities usually have difficulty in finding and maintaining employment prosp... more Individuals with disabilities usually have difficulty in finding and maintaining employment prospects and thus, they are extremely underrepresented in the workforce. These challenges are even greater when the person has both cognitive and physical disabilities. While there is evidence supporting the benefits of employing individuals with disabilities in the workforce, employers are usually unprepared to hire individuals with disabilities. They are also concerned that the work productivity may be impacted by the employee with a disability. Thus, technology can play an important role in helping a person with cognitive and /or physical impairment work on tasks that require memorization and assembly performance. We will present a mobile technology system that was planned and piloted with working adults with physical and cognitive impairments. Founded on our pilot study, mobile technologies hold the potential to help people with disabilities to perform jobs that require memorization as w...
FLUORIDE RELEASE AND UPTAKE INTO HYDROXYAPATITE FROM EXPERIMENTAL DENTAL VARNISH. I Ahmed (D.D.S.... more FLUORIDE RELEASE AND UPTAKE INTO HYDROXYAPATITE FROM EXPERIMENTAL DENTAL VARNISH. I Ahmed (D.D.S., SODM), S Coleman, and CM Carey, School of Dental Medicine, University of Colorado, Denver, CO. Fluoride releasing dental varnishes (F-varnish) typically contain 5% sodium fluoride (NaF) within a resin or rosin base. The concentration NaF that yields optimal fluoride enamel uptake, release, and anticaries efficacy is unknown. Also, there is controversy on whether the release rate of fluoride into saliva is predictive of the fluoride uptake into enamel. Objectives: measure fluoride uptake (looselyand tightly-bound) into hydroxyapatite (HAp) discs and fluoride release as a function of NaF concentration in F-varnish. Methods: triplicate sets of F-varnish containing 5.0%, 2.5%, 1.25%, and 0.625% (wt/wt) NaF were prepared. 0.01-0.02 g F-varnish was applied to one side of an HAp disc. Fluoride release into a continuous flow of 30 mmol/L KCl at 1 mL/min was measured over 3 h. The HAp discs wer...
Encyclopedia of Behavioral Medicine
Gerontology
Introduction: Hearing, vision, and cognitive impairment commonly co-occur in older people. Howeve... more Introduction: Hearing, vision, and cognitive impairment commonly co-occur in older people. However, the rate of recognition and appropriate management of combined hearing and vision impairment in people with dementia impairment is low. The aim of this work was to codevelop internationally relevant, multidisciplinary practice recommendations for professionals involved in the diagnosis, care, and management of older people with these concurrent conditions. Methods: We applied consensus methods with professional and lay expert stakeholders, using an adapted version of the World Health Organization Handbook for Guideline Development. The development involved 4 phases and included: (1) collating existing evidence, (2) filling the gaps in evidence, (3) prioritising evidence, and (4) refining the final list of recommendations. Each phase encompassed various methodologies including a review of existing guidelines within the 3 clinical domains, systematic reviews, qualitative studies, a clin...
Aging
Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological ag... more Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological aging. Accumulative deficits in both molecular underpinnings and functions in young adults with CP can lead to premature aging, such as heart disease and mild cognitive impairment (MCI). MCI is an intermediate stage between healthy aging and dementia that normally develops at old age. Owing to their intriguingly parallel yet "inverted" disease trajectories, CP might share similar pathology and phenotypes with MCI, conferring increased risk for developing dementia at a much younger age. Thus, we examined this hypothesis by evaluating these two distinct populations (MCI= 55, CP = 72). A total of nine measures (e.g., blood biomarkers, neurocognition, Framingham Heart Study Score (FHSS) were compared between the groups. Compared to MCI, upon controlling for covariates, delta FHSS, brain-derived neurotrophic factor (BDNF) levels, and systolic blood pressure were significantly lower in CP. Intriguingly, high-sensitivity CRP, several metabolic outcomes, and neurocognitive function were similar between the two groups. This study supports a shared biological underpinning and key phenotypes between CP and MCI. Thus, we proposed a double-hit model for the development of premature aging outcomes in CP through shared biomarkers. Future longitudinal follow-up studies are warranted to examine accelerated biological aging.
Disability & Rehabilitation: Assistive Technology, 2010
Alzheimer's & Dementia, 2005
Journal of Rehabilitation and Assistive Technologies Engineering
We designed a feasibility study to evaluate a mobile-based vocational skill building coaching tec... more We designed a feasibility study to evaluate a mobile-based vocational skill building coaching technology (aka Mobile Coach) intervention by using an ecological design approach. We compared the Mobile Coach to a standard job coach (no Mobile Coach technology) assistance in a facility that employs adults with significant cognitive disabilities (CDs). Twenty working-age adults with CDs were enrolled in this feasibility study and were asked to use the Vocational Mobile Coach Technology (on an iPad) to assist with their daily job functions. Project-specific usability and self-satisfaction survey was used to evaluate the user experience in performing the selected work assembly tasks with the Mobile Coach and without it. This report has the goal to describe our feasibility study design, methods, and results.
Archives of Physical Medicine and Rehabilitation
Archives of Physical Medicine and Rehabilitation
Archives of Physical Medicine and Rehabilitation
Archives of Physical Medicine and Rehabilitation
Innovation in Aging
Living environments profoundly influence the aging process. This symposium presents research on t... more Living environments profoundly influence the aging process. This symposium presents research on two main aspects of the living environment and their relationships with cognitive health. The living environment is broadly defined, including both physical and social aspects. The physical environment is the characteristics of the built environment, such as tripping hazard in the home, cleanness of the community streets, and presence of deserted buildings, etc. The social environment is the cohesiveness with other people living in the neighborhood. Living environments have multiple layers; the physical environments encompass both in-home and in-community domains, whereas the social environment can be categorized as domestic versus community cohesiveness. This symposium includes studies with investigation scopes spanning from the micro to mezzo levels. The first presentation scrutinizes the buffering effect of marital relationships, as a form of domestic social environments, on cognition ...
Innovation in Aging, 2020
Since the publishing of our meta-analysis evaluating the effects of randomized exercise trials on... more Since the publishing of our meta-analysis evaluating the effects of randomized exercise trials on cognitive function of Older Adults with Cognitive Impairments (OAwCIs) (Heyn et al 2004), several meta-analysis reviews were published addressing similar question. We currently appraised this evidence and preliminary synthesis of twelve, well-designed meta-analysis reports resulted in 193 RCTs and 15,614 participants over the age of 65 years old diagnosed with MCI or Alzheimer’s disease (AD). Exercise prescription paradigms averaged 156 minutes per week for 20-week. The combined cognitive function outcome mean effect size was medium; 0.67 (0.06-1.34 95% CI). Grounded in this unique umbrella study results, sustained and prolonged exercise training might provide an effective intervention for the maintenance or enhancement of cognitive function for MCI and AD. This comprehensive meta-analysis umbrella offers valuable and strong exercise recommendations for OAwCIs. This study results will b...
Innovation in Aging, 2020
Effective exercise training and regular physical activity (PA) practice are important for healthy... more Effective exercise training and regular physical activity (PA) practice are important for healthy aging and are key modalities for chronic disease management. Approaches that enhance exercise prescriptions and adherence for older adults should be innovative and based on evidence. Thus, the exercise prescription should be tailored accordingly to the person’s health status, functional capacity, and living arrangements. To properly achieve the desirable health outcomes, the PA should be performed at higher intensity, greater frequency, and longer duration. National PA Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity and at least two days of muscle-strengthening activities per week. Each prescribed modality (aerobic exercise, strength training, flexibility/stretching exercises, and balance training) has unique benefits. Therefore, it is critical to investigate and integrate novel techniques and tools to...
Brain Gaming (BG) Interventions have been shown to improve the cognitive function of older adults... more Brain Gaming (BG) Interventions have been shown to improve the cognitive function of older adults with cognitive impairments (CIs). However, rigorous evaluation supporting BG effectiveness is needed. Thus, we used meta-analysis to evaluate the effectiveness of BG. Several search databases (i.e. Pubmed) were used to identify relevant randomized controlled trials (RCTs). Cochrane RoB tool evaluated risk of bias. The main outcome was the composite score of cognitive function. Inverse-variance random effects model was used to compare the pooled standardized mean difference (SMD) across studies. A total of 16 RCTs included 909 participants. The RCTs varied in sample size, gaming platform, training prescription, and cognition. The meta-analysis showed no significant effects of BG on overall cognitive function (pooled SMD = 0.08, 95% CI [-0.24 – 0.41], p = 0.61, I2 = 77%. However, due to high heterogeneity, we cannot confidently refute that BG is an effective cognitive training approach.
Individuals with disabilities usually have difficulty in finding and maintaining employment prosp... more Individuals with disabilities usually have difficulty in finding and maintaining employment prospects and thus, they are extremely underrepresented in the workforce. These challenges are even greater when the person has both cognitive and physical disabilities. While there is evidence supporting the benefits of employing individuals with disabilities in the workforce, employers are usually unprepared to hire individuals with disabilities. They are also concerned that the work productivity may be impacted by the employee with a disability. Thus, technology can play an important role in helping a person with cognitive and /or physical impairment work on tasks that require memorization and assembly performance. We will present a mobile technology system that was planned and piloted with working adults with physical and cognitive impairments. Founded on our pilot study, mobile technologies hold the potential to help people with disabilities to perform jobs that require memorization as w...
FLUORIDE RELEASE AND UPTAKE INTO HYDROXYAPATITE FROM EXPERIMENTAL DENTAL VARNISH. I Ahmed (D.D.S.... more FLUORIDE RELEASE AND UPTAKE INTO HYDROXYAPATITE FROM EXPERIMENTAL DENTAL VARNISH. I Ahmed (D.D.S., SODM), S Coleman, and CM Carey, School of Dental Medicine, University of Colorado, Denver, CO. Fluoride releasing dental varnishes (F-varnish) typically contain 5% sodium fluoride (NaF) within a resin or rosin base. The concentration NaF that yields optimal fluoride enamel uptake, release, and anticaries efficacy is unknown. Also, there is controversy on whether the release rate of fluoride into saliva is predictive of the fluoride uptake into enamel. Objectives: measure fluoride uptake (looselyand tightly-bound) into hydroxyapatite (HAp) discs and fluoride release as a function of NaF concentration in F-varnish. Methods: triplicate sets of F-varnish containing 5.0%, 2.5%, 1.25%, and 0.625% (wt/wt) NaF were prepared. 0.01-0.02 g F-varnish was applied to one side of an HAp disc. Fluoride release into a continuous flow of 30 mmol/L KCl at 1 mL/min was measured over 3 h. The HAp discs wer...
Encyclopedia of Behavioral Medicine
Gerontology
Introduction: Hearing, vision, and cognitive impairment commonly co-occur in older people. Howeve... more Introduction: Hearing, vision, and cognitive impairment commonly co-occur in older people. However, the rate of recognition and appropriate management of combined hearing and vision impairment in people with dementia impairment is low. The aim of this work was to codevelop internationally relevant, multidisciplinary practice recommendations for professionals involved in the diagnosis, care, and management of older people with these concurrent conditions. Methods: We applied consensus methods with professional and lay expert stakeholders, using an adapted version of the World Health Organization Handbook for Guideline Development. The development involved 4 phases and included: (1) collating existing evidence, (2) filling the gaps in evidence, (3) prioritising evidence, and (4) refining the final list of recommendations. Each phase encompassed various methodologies including a review of existing guidelines within the 3 clinical domains, systematic reviews, qualitative studies, a clin...
Aging
Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological ag... more Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological aging. Accumulative deficits in both molecular underpinnings and functions in young adults with CP can lead to premature aging, such as heart disease and mild cognitive impairment (MCI). MCI is an intermediate stage between healthy aging and dementia that normally develops at old age. Owing to their intriguingly parallel yet "inverted" disease trajectories, CP might share similar pathology and phenotypes with MCI, conferring increased risk for developing dementia at a much younger age. Thus, we examined this hypothesis by evaluating these two distinct populations (MCI= 55, CP = 72). A total of nine measures (e.g., blood biomarkers, neurocognition, Framingham Heart Study Score (FHSS) were compared between the groups. Compared to MCI, upon controlling for covariates, delta FHSS, brain-derived neurotrophic factor (BDNF) levels, and systolic blood pressure were significantly lower in CP. Intriguingly, high-sensitivity CRP, several metabolic outcomes, and neurocognitive function were similar between the two groups. This study supports a shared biological underpinning and key phenotypes between CP and MCI. Thus, we proposed a double-hit model for the development of premature aging outcomes in CP through shared biomarkers. Future longitudinal follow-up studies are warranted to examine accelerated biological aging.
Disability & Rehabilitation: Assistive Technology, 2010
Alzheimer's & Dementia, 2005
Journal of Rehabilitation and Assistive Technologies Engineering
We designed a feasibility study to evaluate a mobile-based vocational skill building coaching tec... more We designed a feasibility study to evaluate a mobile-based vocational skill building coaching technology (aka Mobile Coach) intervention by using an ecological design approach. We compared the Mobile Coach to a standard job coach (no Mobile Coach technology) assistance in a facility that employs adults with significant cognitive disabilities (CDs). Twenty working-age adults with CDs were enrolled in this feasibility study and were asked to use the Vocational Mobile Coach Technology (on an iPad) to assist with their daily job functions. Project-specific usability and self-satisfaction survey was used to evaluate the user experience in performing the selected work assembly tasks with the Mobile Coach and without it. This report has the goal to describe our feasibility study design, methods, and results.
Archives of Physical Medicine and Rehabilitation
Archives of Physical Medicine and Rehabilitation
Archives of Physical Medicine and Rehabilitation
Archives of Physical Medicine and Rehabilitation